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Protein Page:
IGF2BP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IGF2BP1 a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation. Note: This description may include information from UniProtKB.
Protein type: Translation
Cellular Component: growth cone; perinuclear region of cytoplasm; lamellipodium; axon; stress granule; cytoplasm; dendritic spine; ribonucleoprotein complex; nucleus; cytosol; filopodium
Molecular Function: mRNA binding; protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding
Biological Process: mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process
Reference #:  Q9NZI8 (UniProtKB)
Alt. Names/Synonyms: Coding region determinant-binding protein; CRD-BP; CRDBP; IF2B1; IGF II mRNA binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IGF2BP1; IMP-1; IMP1; insulin-like growth factor 2 mRNA binding protein 1; Insulin-like growth factor 2 mRNA-binding protein 1; VICKZ family member 1; VICKZ1; ZBP-1; ZBP1; Zip code-binding protein 1; Zipcode-binding protein 1
Gene Symbols: IGF2BP1
Molecular weight: 63,481 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IGF2BP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3-ub _____MNkLYIGNLN
0 5 S12-p YIGNLNEsVTPADLE
0 7 K20-ub VTPADLEkVFAEHkI
0 3 K26-ub EkVFAEHkISYSGQF
0 6 Y39-p QFLVKSGyAFVDCPD
0 3 S73-p KRLEIEHsVPKKQRS
0 1 K138-ub QTRQAIMkLNGHQLE
0 1 S173-p GRRGGFGsRGQPRQG
0 46 S181-p RGQPRQGsPVAAGAP
0 9 K190-ub VAAGAPAkQQQVDIP
0 14 K213-ub YVGAIIGkEGATIRN
0 9 K223-ub ATIRNITkQTQSkID
0 1 K228-ub ITkQTQSkIDVHRKE
0 3 T249-p KAISVHStPEGCSSA
0 14 K272-ub HKEAKDTktADEVPL
0 1 T273-p KEAKDTktADEVPLk
0 2 K280-ub tADEVPLkILAHNNF
0 1 K294-ub FVGRLIGkEGRNLkk
0 1 K300-ac GkEGRNLkkVEQDTE
0 1 K301-ac kEGRNLkkVEQDTET
0 1 K309-ac VEQDTETkITISSLQ
0 1 T326-p TLYNPERtItVkGAI
0 1 T328-p YNPERtItVkGAIEN
0 1 K330-ub PERtItVkGAIENCC
3 0 Y396 SVTGAAPYSSFMQAP
0 1 S397 VTGAAPYSSFMQAPE
0 1 S398 TGAAPYSSFMQAPEQ
0 2 S438-p LSRFASAsIkIAPPE
0 5 K440-ub RFASAsIkIAPPEtP
0 9 T446-p IkIAPPEtPDSkVRM
0 17 K450-ub PPEtPDSkVRMVIIT
0 14 K465-ub GPPEAQFkAQGRIYG
0 6 K475-ub GRIYGKLkEENFFGP
0 4 K483 EENFFGPKEEVKLET
0 1 K508 RVIGKGGKTVNELQN
0 4 T528-p VVVPRDQtPDENDQV
0 1 K538-ub ENDQVIVkIIGHFYA
0 1 S546-p IIGHFYAsQMAQRKI
0 1 K561-ub RDILAQVkQQHQKGQ
0 7 K566 QVkQQHQKGQSNQAQ
  mouse

 
K3 _____MNKLYIGNLN
S12 YIGNLNESVTPADLE
K20-ub VTPADLEkVFAEHkI
K26-ub EkVFAEHkISYSGQF
Y39-p QFLVKSGyAFVDCPD
S73 KRLEIEHSVPKKQRS
K138 QTRQAIMKLNGHQLE
S173 GRRGGFGSRGQPRQG
S181-p RGQPRQGsPVAAGAP
K190-ub VAAGAPAkQQPVDIP
K213-ub YVGAIIGkEGATIRN
K223-ub ATIRNITkQTQSKID
K228 ITkQTQSKIDVHRKE
T249 KAISVHSTPEGCSSA
K272-ub HKEAKDTkTADEVPL
T273 KEAKDTkTADEVPLK
K280 TADEVPLKILAHNNF
K294 FVGRLIGKEGRNLKK
K300 GKEGRNLKKVEQDTE
K301 KEGRNLKKVEQDTET
K309 VEQDTETKITISSLQ
T326 TLYNPERTITVKGAI
T328 YNPERTITVKGAIEN
K330 PERTITVKGAIENCC
Y396-p SVTGAAPyssFMQAP
S397-p VTGAAPyssFMQAPE
S398-p TGAAPyssFMQAPEQ
S438 LSRFASASIkIAPPE
K440-ub RFASASIkIAPPETP
T446 IkIAPPETPDSkVRM
K450-ub PPETPDSkVRMVVIT
K465 GPPEAQFKAQGRIYG
K475-ub GRIYGKLkEENFFGP
K483-ub EENFFGPkEEVKLET
K508-ub RVIGKGGkTVNELQN
T528 VVVPRDQTPDENDQV
K538 ENDQVIVKIIGHFYA
S546 IIGHFYASQMAQRKI
K561 RDILAQVKQQHQkGQ
K566-ub QVKQQHQkGQSNLAQ
  rat

 
K3 _____MNKLYIGNLN
S12 YIGNLNESVTPADLE
K20 VTPADLEKVFAEHKI
K26 EKVFAEHKISYSGQF
Y39 QFLVKSGYAFVDCPD
S73 KRLEIEHSVPKKQRS
K138 QTRQAIMKLNGHQLE
S173 GRRGGFGSRGQPRQG
S181 RGQPRQGSPVAAGAP
K190 VAAGAPAKQQQVDIP
K213 YVGAIIGKEGATIRN
K223 ATIRNITKQTQSKID
K228 ITKQTQSKIDVHRKE
T249 KAISVHSTPEGCSSA
K272 HKEAKDTKTADEVPL
T273 KEAKDTKTADEVPLK
K280 TADEVPLKILAHNNF
K294 FVGRLIGKEGRNLKK
K300 GKEGRNLKKVEQDTE
K301 KEGRNLKKVEQDTET
K309 VEQDTETKITISSLQ
T326 TLYNPERTITVKGAI
T328 YNPERTITVKGAIEN
K330 PERTITVKGAIENCC
Y396-p SVTGAAPyGSFMQAP
G397 VTGAAPyGSFMQAPE
S398 TGAAPyGSFMQAPEQ
S438 LSRFASASIKIAPPE
K440 RFASASIKIAPPETP
T446 IKIAPPETPDSKVRM
K450 PPETPDSKVRMVVIT
K465 GPPEAQFKAQGRIYG
K475 GRIYGKLKEENFFGP
K483 EENFFGPKEEVKLET
K508 RVIGKGGKTVNELQN
T528 VVVPRDQTPDENDQV
K538 ENDQVIVKIIGHFYA
S546 IIGHFYASQMAQRKI
K561 RDILAQVKQQHQKGQ
K566 QVKQQHQKGQSNQAQ
  chicken

 
K3 _____MNKLYIGNLN
S12 YIGNLNESVTPADLE
K20 VTPADLEKVFNDHKI
K26 EKVFNDHKISFSGQF
Y39 QFLVKSGYAFVDCPD
S73 KQLEIEHSVPKKQRS
K138 QTRQAIMKLNGHQLE
A173 GRRGGFGARGAPRQG
S181 RGAPRQGSPVTAGAP
K190 VTAGAPVKQQPVDIP
K213 YVGAIIGKEGATIRN
K223 ATIRNITKQTQSKID
K228 ITKQTQSKIDVHRKE
T249 KAISIHSTPEGCSAA
K272 QKEAKDTKTADEVPL
T273 KEAKDTKTADEVPLK
K280 TADEVPLKILAHNNF
K294 FVGRLIGKEGRNLKK
K300 GKEGRNLKKVEQDTE
K301 KEGRNLKKVEQDTET
K309 VEQDTETKITISSLQ
T326 TLYNPERTITVKGSI
T328 YNPERTITVKGSIEN
K330 PERTITVKGSIENCC
Y396-p SVSGAAPySSFMPPE
S397 VSGAAPySSFMPPEQ
S398 SGAAPySSFMPPEQE
S437 LSRFASASIKIAPPE
K439 RFASASIKIAPPETP
T445 IKIAPPETPDSKVRM
K449 PPETPDSKVRMVVIT
K464 GPPEAQFKAQGRIYG
K474 GRIYGKLKEENFFGP
K482 EENFFGPKEEVKLET
K507 RVIGKGGKTVNELQN
T527 VVVPRDQTPDENEQV
K537 ENEQVIVKIIGHFYA
S545 IIGHFYASQMAQRKI
K560 RDILAQVKQQHQKGQ
K565 QVKQQHQKGQSGQLQ
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