a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation. Note: This description may include information from UniProtKB.
Protein type: Translation
Cellular Component: growth cone; axon; stress granule; perinuclear region of cytoplasm; lamellipodium; cytoplasm; dendritic spine; ribonucleoprotein complex; nucleus; cytosol; filopodium
Alt. Names/Synonyms: Coding region determinant-binding protein; CRD-BP; CRDBP; IF2B1; IGF II mRNA binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IGF2BP1; IMP-1; IMP1; insulin-like growth factor 2 mRNA binding protein 1; Insulin-like growth factor 2 mRNA-binding protein 1; VICKZ family member 1; VICKZ1; ZBP-1; ZBP1; Zip code-binding protein 1; Zipcode-binding protein 1
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.