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Protein Page:
NBA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NBA1 a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: positive regulation of DNA repair; double-strand break repair; chromatin modification; response to ionizing radiation; G2/M transition DNA damage checkpoint
Reference #:  Q9NWV8 (UniProtKB)
Alt. Names/Synonyms: BABAM1; BRCA1-A complex subunit MERIT40; C19orf62; chromosome 19 open reading frame 62; FLJ20571; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; Mediator of RAP80 interactions and targeting subunit of 40 kDa; MERIT40; MRI40; NBA1; New component of the BRCA1-A complex; new component of the BRCAA1 A complex
Gene Symbols: BABAM1
Molecular weight: 36,560 Da
Basal Isoelectric point: 4.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NBA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S7-p _MEVAEPssPtEEEE
0 7 S8-p MEVAEPssPtEEEEE
0 2 T10-p VAEPssPtEEEEEEE
0 14 T27-p SAEPRPRtRsNPEGA
0 259 S29-p EPRPRtRsNPEGAED
0 7 S44-p RAVGAQAsVGsRsEG
0 2 S47-p GAQAsVGsRsEGEGE
0 58 S49-p QAsVGsRsEGEGEAA
0 5 S57-p EGEGEAAsADDGsLN
0 7 S62-p AAsADDGsLNtsGAG
0 3 T65-p ADDGsLNtsGAGPKS
0 26 S66-p DDGsLNtsGAGPKSW
0 2 T86-p APEVQIRtPRVNCPE
0 1 S112 MSLPKLESFNGSkTN
0 6 K117-ub LESFNGSkTNALNVs
0 1 S124-p kTNALNVsQkMIEMF
0 1 K126-ub NALNVsQkMIEMFVR
0 1 K233 FSLTEPMKKMFQCPY
0 1 T252-p VVYIHNGtEEKEEEM
12110 : Phospho-MERIT40 (Ser29) Antibody
  mouse

 
N7 _MEVAEANSPTEEEE
S8 MEVAEANSPTEEEEE
T10 VAEANSPTEEEEEEE
T31 ISEPRPHTRSNPEGA
S33 EPRPHTRSNPEGAED
S48 RALGAQASVGSRsEG
S51 GAQASVGSRsEGEGE
S53-p QASVGSRsEGEGEAA
T61-p EGEGEAAtADGGAAS
A66 AAtADGGAASVPGAG
V69 ADGGAASVPGAGPKP
P70 DGGAASVPGAGPKPW
T90 ASEVQIRTPRVNCPE
S116-p MSVPKLEsFNGSRTN
R121 LEsFNGSRTNALNVS
S128 RTNALNVSQKMVEMF
K130 NALNVSQKMVEMFVR
K237-ub FSLTEPMkKMFQCPY
T256 IVYIHNGTEEKEEDM
  rat

 
N7 _MEVAEANsPTEEEE
S8-p MEVAEANsPTEEEEE
T10 VAEANsPTEEEEEEE
T32 ISEPRPHTRSNPEGA
S34 EPRPHTRSNPEGAED
N49 RAIGAQANVGSRsEG
S52 GAQANVGSRsEGEGE
S54-p QANVGSRsEGEGEAA
T62 EGEGEAATADDGAAS
A67 AATADDGAASVPGAV
V70 ADDGAASVPGAVPKP
P71 DDGAASVPGAVPKPW
T91 ASEVQIRTPRVNCPE
S117 MSVPKLESFNGSRTN
R122 LESFNGSRTNALNVS
S129 RTNALNVSQKMVEMF
K131 NALNVSQKMVEMFVR
K238 FSLTEPMKKMFQCPY
P257 IIYIHSGPEEKEDDM
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