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Protein Page:
PKACA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PKACA catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.11; Protein kinase, AGC; AGC group; PKA family
Cellular Component: centrosome; membrane; mitochondrion; plasma membrane; nucleus; cytosol; neuromuscular junction; cilium; cAMP-dependent protein kinase complex; AMP-activated protein kinase complex
Molecular Function: protein binding; cAMP-dependent protein kinase activity; ubiquitin protein ligase binding; protein serine/threonine/tyrosine kinase activity; protein kinase binding; ATP binding
Biological Process: nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; water transport; signal transduction; protein amino acid phosphorylation; positive regulation of protein export from nucleus; triacylglycerol catabolic process; G2/M transition of mitotic cell cycle; transmembrane transport; sperm capacitation; epidermal growth factor receptor signaling pathway; regulation of synaptic transmission; fibroblast growth factor receptor signaling pathway; cytosolic calcium ion homeostasis; regulation of osteoblast differentiation; regulation of heart rate; activation of protein kinase A; glucose metabolic process; gluconeogenesis; peptidyl-serine phosphorylation; mesoderm formation; phospholipase C activation; regulation of protein binding; carbohydrate metabolic process; energy reserve metabolic process; innate immune response; mitotic cell cycle; blood coagulation; regulation of insulin secretion
Reference #:  P17612 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; KAPCA; MGC102831; MGC48865; PKA C-alpha; PKACA; PRKACA; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha
Gene Symbols: PRKACA
Molecular weight: 40,590 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKACA

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: T198‑p
protein conformation: T198‑p
protein stabilization: T198‑p, S339‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
4 4 S11-p AAAAKKGsEQEsVKE
0 2 S15-p KKGsEQEsVKEFLAK
0 1 A35 LKKWESPAQNTAHLD
0 3 T49-p DQFERIKtLGtGsFG
0 2 T52-p ERIKtLGtGsFGRVM
0 2 S54-p IKtLGtGsFGRVMLV
0 6 K93-ub IEHTLNEkRILQAVN
0 1 S110 FLVKLEFSFKDNSNL
2 3 S140-p LRRIGRFsEPHARFY
0 1 T184 QQGYIQVTDFGFAkR
0 1 K190-ub VTDFGFAkRVKGRtW
0 91 T196-p AkRVKGRtWtLCGtP
21 289 T198-p RVKGRtWtLCGtPEY
0 13 T202-p RtWtLCGtPEYLAPE
0 1 S213 LAPEIILSKGYNKAV
0 1 K214 APEIILSKGYNKAVD
0 2 S260-p SGKVRFPsHFSSDLK
0 4 K280-ac LLQVDLTkRFGNLkN
0 4 K280-ub LLQVDLTkRFGNLkN
0 7 K286-ub TkRFGNLkNGVNDIK
0 1 K320-ub APFIPKFkGPGDTSN
0 1 S326 FkGPGDTSNFDDyEE
2 2 Y331-p DTSNFDDyEEEEIRV
12 47 S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  PKACA iso2  
S4 ____MMASNSSDVKE
D8 MMASNSSDVKEFLAK
A28 LKKWESPAQNTAHLD
T42 DQFERIKTLGTGSFG
T45 ERIKTLGTGSFGRVM
S47 IKTLGTGSFGRVMLV
K86 IEHTLNEKRILQAVN
S103 FLVKLEFSFKDNSNL
S133 LRRIGRFSEPHARFY
T177 QQGYIQVTDFGFAKR
K183 VTDFGFAKRVKGRtW
T189-p AKRVKGRtWtLCGTP
T191-p RVKGRtWtLCGTPEY
T195 RtWtLCGTPEYLAPE
S206 LAPEIILSKGYNKAV
K207 APEIILSKGYNKAVD
S253 SGKVRFPSHFSSDLK
K273 LLQVDLTKRFGNLKN
K273 LLQVDLTKRFGNLKN
K279 TKRFGNLKNGVNDIK
K313 APFIPKFKGPGDTSN
S319 FKGPGDTSNFDDYEE
Y324 DTSNFDDYEEEEIRV
S332 EEEEIRVSINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  mouse

 
S11-p AAAAKKGsEQESVKE
S15 KKGsEQESVKEFLAK
S35-p LKKWETPsQNTAQLD
T49 DQFDRIKTLGtGSFG
T52-p DRIKTLGtGSFGRVM
S54 IKTLGtGSFGRVMLV
K93 IEHTLNEKRILQAVN
S110-p FLVKLEFsFKDNSNL
S140-p LRRIGRFsEPHARFY
T184-p QQGYIQVtDFGFAKR
K190 VtDFGFAKRVKGRtW
T196-p AKRVKGRtWtLCGtP
T198-p RVKGRtWtLCGtPEY
T202-p RtWtLCGtPEYLAPE
S213 LAPEIILSkGYNKAV
K214-ub APEIILSkGYNKAVD
S260 SGKVRFPSHFSSDLK
K280 LLQVDLTKRFGNLkN
K280-ub LLQVDLTkRFGNLkN
K286-ub TkRFGNLkNGVNDIK
K320 APFIPKFKGPGDTSN
S326 FKGPGDTSNFDDyEE
Y331-p DTSNFDDyEEEEIRV
S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  rat

 
S11 AAAAKKGSEQESVKE
S15 KKGSEQESVKEFLAK
S35 LKKWEDPSQNTAQLD
T49 DHFDRIKTLGTGSFG
T52 DRIKTLGTGSFGRVM
S54 IKTLGTGSFGRVMLV
K93-ub IEHTLNEkRILQAVN
S110 FLVKLEFSFKDNSNL
S140 LRRIGRFSEPHARFY
T184 QQGYIQVTDFGFAKR
K190 VTDFGFAKRVKGRtW
T196-p AKRVKGRtWtLCGTP
T198-p RVKGRtWtLCGTPEY
T202 RtWtLCGTPEYLAPE
S213 LAPEIILSKGYNKAV
K214 APEIILSKGYNKAVD
S260 SGKVRFPSHFSSDLK
K280 LLQVDLTKRFGNLKN
K280 LLQVDLTKRFGNLKN
K286 TKRFGNLKNGVNDIK
K320 APFIPKFKGPGDTSN
S326 FKGPGDTSNFDDYEE
Y331 DTSNFDDYEEEEIRV
S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  pig

 
S11-p AAAAKKGsEQESVKE
S15 KKGsEQESVKEFLAK
A35 LKKWENPAQNTAHLD
T49 DQFERIKTLGTGSFG
T52 ERIKTLGTGSFGRVM
S54 IKTLGTGSFGRVMLV
K93 IEHTLNEKRILQAVN
S110 FLVKLEYSFKDNSNL
S140 LRRIGRFSEPHARFY
T184 QQGYIQVTDFGFAKR
K190 VTDFGFAKRVKGRTW
T196 AKRVKGRTWTLCGTP
T198 RVKGRTWTLCGTPEY
T202 RTWTLCGTPEYLAPE
S213 LAPEIILSKGYNKAV
K214 APEIILSKGYNKAVD
S260 SGKVRFPSHFSSDLK
K280 LLQVDLTKRFGNLKN
K280 LLQVDLTKRFGNLKN
K286 TKRFGNLKNGVNDIK
K320 APFIPKFKGPGDTSN
S326 FKGPGDTSNFDDYEE
Y331 DTSNFDDYEEEEIRV
S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  dog

 
S10 NAAAKKGSEQESVKE
S14 KKGSEQESVKEFLAK
A34 LKKWENPAQNTAHLD
T48 DQFERIKTLGTGSFG
T51 ERIKTLGTGSFGRVM
S53 IKTLGTGSFGRVMLV
K92 IEHTLNEKRILQAVN
S109 FLVKLEFSFKDNSNL
S139 LRRIGRFSEPHARFY
T183 QQGYIQVTDFGFAKR
K189 VTDFGFAKRVKGRTW
T195 AKRVKGRTWTLCGTP
T197 RVKGRTWTLCGTPEY
T201 RTWTLCGTPEYLAPE
S212 LAPEIILSKGYNKAV
K213 APEIILSKGYNKAVD
S259 SGKVRFPSHFSSDLK
K279 LLQVDLTKRFGNLKN
K279 LLQVDLTKRFGNLKN
K285 TKRFGNLKNGVNDIK
K319 APFIPKFKGPGDTSN
S325 FKGPGDTSNFDDYEE
Y330 DTSNFDDYEEEEIRV
S338 EEEEIRVSINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  cow

 
S11-p AAAAKKGsEQEsVKE
S15-p KKGsEQEsVKEFLAK
A35 LKKWENPAQNTAHLD
T49-p DQFERIKtLGTGsFG
T52 ERIKtLGTGsFGRVM
S54-p IKtLGTGsFGRVMLV
K93 IEHTLNEKRILQAVN
S110 FLVKLEFSFKDNSNL
S140-p LRRIGRFsEPHARFY
T184 QQGYIQVTDFGFAKR
K190 VTDFGFAKRVKGRTW
T196 AKRVKGRTWtLCGTP
T198-p RVKGRTWtLCGTPEY
T202 RTWtLCGTPEYLAPE
S213-p LAPEIILsKGYNKAV
K214 APEIILsKGYNKAVD
S260-p SGKVRFPsHFSSDLK
K280 LLQVDLTKRFGNLKN
K280 LLQVDLTKRFGNLKN
K286 TKRFGNLKNGVNDIK
K320 APFIPKFKGPGDTsN
S326-p FKGPGDTsNFDDYEE
Y331 DTsNFDDYEEEEIRV
S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
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