Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PKACA (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PKACA catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; EC 2.7.11.11; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; PKA family
Cellular Component: centrosome; mitochondrion; membrane; plasma membrane; neuromuscular junction; nucleus; cytosol; AMP-activated protein kinase complex; cilium; cAMP-dependent protein kinase complex
Molecular Function: protein binding; cAMP-dependent protein kinase activity; ubiquitin protein ligase binding; protein kinase binding; ATP binding
Biological Process: nerve growth factor receptor signaling pathway; water transport; protein amino acid autophosphorylation; signal transduction; protein amino acid phosphorylation; positive regulation of protein export from nucleus; triacylglycerol catabolic process; G2/M transition of mitotic cell cycle; transmembrane transport; sperm capacitation; regulation of synaptic transmission; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytosolic calcium ion homeostasis; regulation of osteoblast differentiation; regulation of heart rate; activation of protein kinase A; glucose metabolic process; gluconeogenesis; peptidyl-serine phosphorylation; mesoderm formation; phospholipase C activation; regulation of protein binding; carbohydrate metabolic process; energy reserve metabolic process; innate immune response; mitotic cell cycle; blood coagulation; regulation of insulin secretion
Reference #:  P17612 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; KAPCA; MGC102831; MGC48865; PKA C-alpha; PKACA; PRKACA; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha
Gene Symbols: PRKACA
Molecular weight: 40,590 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PKACA

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
enzymatic activity, induced: T198‑p
protein conformation: T198‑p
protein stabilization: T198‑p, S339‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
4 4 S11-p AAAAKKGsEQESVKE
0 1 S15 KKGsEQESVKEFLAK
0 1 A35 LKKWESPAQNTAHLD
0 2 T49-p DQFERIKtLGTGsFG
0 2 S54-p IKtLGTGsFGRVMLV
0 6 K93-u IEHTLNEkRILQAVN
0 1 S110 FLVKLEFSFKDNSNL
2 3 S140-p LRRIGRFsEPHARFY
0 1 T184 QQGYIQVTDFGFAKR
0 90 T196-p AKRVKGRtWtLCGtP
21 281 T198-p RVKGRtWtLCGtPEy
0 10 T202-p RtWtLCGtPEyLAPE
0 1 Y205-p tLCGtPEyLAPEIIL
0 1 S213 LAPEIILSKGYNKAV
0 2 S260-p SGKVRFPsHFSSDLK
0 4 K280-a LLQVDLTkRFGNLkN
0 4 K280-u LLQVDLTkRFGNLkN
0 7 K286-u TkRFGNLkNGVNDIK
0 1 K320-u APFIPKFkGPGDTSN
0 1 S326 FkGPGDTSNFDDyEE
2 2 Y331-p DTSNFDDyEEEEIRV
12 37 S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  PKACA iso2  
S3 _____MASNSSDVKE
D7 _MASNSSDVKEFLAK
A27 LKKWESPAQNTAHLD
T41 DQFERIKTLGTGSFG
S46 IKTLGTGSFGRVMLV
K85 IEHTLNEKRILQAVN
S102 FLVKLEFSFKDNSNL
S132 LRRIGRFSEPHARFY
T176 QQGYIQVTDFGFAKR
T188-p AKRVKGRtWtLCGTP
T190-p RVKGRtWtLCGTPEY
T194 RtWtLCGTPEYLAPE
Y197 tLCGTPEYLAPEIIL
S205 LAPEIILSKGYNKAV
S252 SGKVRFPSHFSSDLK
K272 LLQVDLTKRFGNLKN
K272 LLQVDLTKRFGNLKN
K278 TKRFGNLKNGVNDIK
K312 APFIPKFKGPGDTSN
S318 FKGPGDTSNFDDYEE
Y323 DTSNFDDYEEEEIRV
S331 EEEEIRVSINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  mouse

 
S11-p AAAAKKGsEQESVKE
S15 KKGsEQESVKEFLAK
S35-p LKKWETPsQNTAQLD
T49 DQFDRIKTLGTGSFG
S54 IKTLGTGSFGRVMLV
K93 IEHTLNEKRILQAVN
S110-p FLVKLEFsFKDNSNL
S140-p LRRIGRFsEPHARFY
T184-p QQGYIQVtDFGFAKR
T196-p AKRVKGRtWtLCGtP
T198-p RVKGRtWtLCGtPEY
T202-p RtWtLCGtPEYLAPE
Y205 tLCGtPEYLAPEIIL
S213 LAPEIILSKGYNKAV
S260 SGKVRFPSHFSSDLK
K280 LLQVDLTKRFGNLkN
K280-u LLQVDLTkRFGNLkN
K286-u TkRFGNLkNGVNDIK
K320 APFIPKFKGPGDTSN
S326 FKGPGDTSNFDDyEE
Y331-p DTSNFDDyEEEEIRV
S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  rat

 
S11 AAAAKKGSEQESVKE
S15 KKGSEQESVKEFLAK
S35 LKKWEDPSQNTAQLD
T49 DHFDRIKTLGTGSFG
S54 IKTLGTGSFGRVMLV
K93-u IEHTLNEkRILQAVN
S110 FLVKLEFSFKDNSNL
S140 LRRIGRFSEPHARFY
T184 QQGYIQVTDFGFAKR
T196-p AKRVKGRtWtLCGTP
T198-p RVKGRtWtLCGTPEY
T202 RtWtLCGTPEYLAPE
Y205 tLCGTPEYLAPEIIL
S213 LAPEIILSKGYNKAV
S260 SGKVRFPSHFSSDLK
K280 LLQVDLTKRFGNLKN
K280 LLQVDLTKRFGNLKN
K286 TKRFGNLKNGVNDIK
K320 APFIPKFKGPGDTSN
S326 FKGPGDTSNFDDYEE
Y331 DTSNFDDYEEEEIRV
S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  pig

 
S11-p AAAAKKGsEQESVKE
S15 KKGsEQESVKEFLAK
A35 LKKWENPAQNTAHLD
T49 DQFERIKTLGTGSFG
S54 IKTLGTGSFGRVMLV
K93 IEHTLNEKRILQAVN
S110 FLVKLEYSFKDNSNL
S140 LRRIGRFSEPHARFY
T184 QQGYIQVTDFGFAKR
T196 AKRVKGRTWTLCGTP
T198 RVKGRTWTLCGTPEY
T202 RTWTLCGTPEYLAPE
Y205 TLCGTPEYLAPEIIL
S213 LAPEIILSKGYNKAV
S260 SGKVRFPSHFSSDLK
K280 LLQVDLTKRFGNLKN
K280 LLQVDLTKRFGNLKN
K286 TKRFGNLKNGVNDIK
K320 APFIPKFKGPGDTSN
S326 FKGPGDTSNFDDYEE
Y331 DTSNFDDYEEEEIRV
S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  dog

 
S10 NAAAKKGSEQESVKE
S14 KKGSEQESVKEFLAK
A34 LKKWENPAQNTAHLD
T48 DQFERIKTLGTGSFG
S53 IKTLGTGSFGRVMLV
K92 IEHTLNEKRILQAVN
S109 FLVKLEFSFKDNSNL
S139 LRRIGRFSEPHARFY
T183 QQGYIQVTDFGFAKR
T195 AKRVKGRTWTLCGTP
T197 RVKGRTWTLCGTPEY
T201 RTWTLCGTPEYLAPE
Y204 TLCGTPEYLAPEIIL
S212 LAPEIILSKGYNKAV
S259 SGKVRFPSHFSSDLK
K279 LLQVDLTKRFGNLKN
K279 LLQVDLTKRFGNLKN
K285 TKRFGNLKNGVNDIK
K319 APFIPKFKGPGDTSN
S325 FKGPGDTSNFDDYEE
Y330 DTSNFDDYEEEEIRV
S338 EEEEIRVSINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
  cow

 
S11-p AAAAKKGsEQEsVKE
S15-p KKGsEQEsVKEFLAK
A35 LKKWENPAQNTAHLD
T49-p DQFERIKtLGTGsFG
S54-p IKtLGTGsFGRVMLV
K93 IEHTLNEKRILQAVN
S110 FLVKLEFSFKDNSNL
S140-p LRRIGRFsEPHARFY
T184 QQGYIQVTDFGFAKR
T196 AKRVKGRTWtLCGTP
T198-p RVKGRTWtLCGTPEY
T202 RTWtLCGTPEYLAPE
Y205 tLCGTPEYLAPEIIL
S213-p LAPEIILsKGYNKAV
S260-p SGKVRFPsHFSSDLK
K280 LLQVDLTKRFGNLKN
K280 LLQVDLTKRFGNLKN
K286 TKRFGNLKNGVNDIK
K320 APFIPKFKGPGDTsN
S326-p FKGPGDTsNFDDYEE
Y331 DTsNFDDYEEEEIRV
S339-p EEEEIRVsINEKCGK
4781 : Phospho-PKA C (Thr197) Antibody
5661 : Phospho-PKA C (Thr197) (D45D3) Rabbit mAb
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.