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PKACa (human)

Overview PKACa catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.11; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; PKA family Cellular Component: Golgi apparatus; centrosome; mitochondrion; membrane; perinuclear region of cytoplasm; plasma membrane; cytosol; neuromuscular junction; nucleus; cAMP-dependent protein kinase complex Molecular Function: protein binding; cAMP-dependent protein kinase activity; ubiquitin protein ligase binding; protein kinase binding; ATP binding Biological Process: regulation of synaptic transmission, glutamatergic; nerve growth factor receptor signaling pathway; water transport; protein amino acid autophosphorylation; protein kinase cascade; negative regulation of meiotic cell cycle; signal transduction; protein amino acid phosphorylation; regulation of cellular respiration; positive regulation of protein export from nucleus; triacylglycerol catabolic process; G2/M transition of mitotic cell cycle; transmembrane transport; sperm capacitation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; regulation of osteoblast differentiation; activation of protein kinase A; glucose metabolic process; gluconeogenesis; peptidyl-serine phosphorylation; mesoderm formation; phospholipase C activation; carbohydrate metabolic process; energy reserve metabolic process; mitotic cell cycle; lipid metabolic process; blood coagulation; regulation of insulin secretion Reference #:  P17612 (UniProtKB) Alt. Names/Synonyms: cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; KAPCA; MGC102831; MGC48865; PKA C-alpha; PKACA; PRKACA; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha Gene Symbols: PRKACA Molecular weight: 40,590 Da Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  GPCRs Signaling to MAPK/Erk  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Parkinson's Disease  |  Regulation of Actin Dynamics  |  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PKACa 2GU8 - A=15-351 (human) 3AGL - A/B=1-351 (human) 3AGM - A=1-351 (human) 3AMA - A=1-351 (human) 3AMB - A=1-351 (human) 3L9L - A/B=1-351 (human) 3L9M - A/B=1-351 (human) 3L9N - A=1-351 (human) 3MVJ - A/E/B=1-351 (human) 3NX8 - A=1-351 (human) 3OOG - A=1-351 (human) 3OVV - A=1-351 (human) 3OWP - A=1-351 (human) 3OXT - A=1-351 (human) 3P0M - A=1-351 (human) 3POO - A=1-351 (human) 3VQH - B=6-25 (human) 4AE6 - A/B=1-343 (human) 4AE9 - A/B=1-343 (human) 1APM - E=1-351 (mouse) 1ATP - E=1-351 (mouse) 1BKX - A=1-351 (mouse) 1BX6 - A=1-351 (mouse) 1FMO - E=1-351 (mouse) 1J3H - A/B=1-351 (mouse) 1JBP - E=2-351 (mouse) 1JLU - E=1-351 (mouse) 1L3R - E=1-351 (mouse) 1PVK - B=16-351 (mouse) 1RDQ - E=1-351 (mouse) 1RE8 - A=1-351 (mouse) 1REJ - A=1-351 (mouse) 1REK - A=1-351 (mouse) 1SYK - A/B=1-351 (mouse) 1U7E - A=1-351 (mouse) 2CPK - E=1-351 (mouse) 2ERZ - E=1-351 (mouse) 2QUR - A=2-351 (mouse) 2QVS - E=2-351 (mouse) 3FHI - A=2-351 (mouse) 3FJQ - E=2-351 (mouse) 3IDB - A=2-351 (mouse) 3IDC - A=2-351 (mouse) 3O7L - D/B=2-351 (mouse) 3OW3 - A=2-351 (mouse) 3PVB - A=7-351 (mouse) 3QAL - E=2-351 (mouse) 3QAM - E=2-351 (mouse) 4DFX - E=2-351 (mouse) 4DFY - A/E=1-351 (mouse) 4DFZ - E=2-351 (mouse) 4DG0 - E=2-351 (mouse) 4DG2 - E=2-351 (mouse) 4DG3 - E=1-351 (mouse) 4DH1 - A=16-351 (mouse) 4DH3 - A=2-351 (mouse) 4DH5 - A=2-351 (mouse) 4DH7 - A=2-351 (mouse) 4DH8 - A=2-351 (mouse) 4DIN - A=2-351 (mouse) 4HPT - E=2-351 (mouse) 4HPU - E=2-351 (mouse) 1CDK - A/B=2-351 (pig) 1CMK - E=2-351 (pig) 1CTP - E=1-351 (pig) 1Q24 - A=1-350 (cow) 1Q61 - A=1-350 (cow) 1Q62 - A=1-350 (cow) 1Q8U - A=1-350 (cow) 1SVH - A=1-350 (cow) 1SZM - A/B=1-350 (cow) 1VEB - A=1-350 (cow) 1YDS - E=1-350 (cow) 1YDT - E=1-350 (cow) 2F7X - E=0-350 (cow) 2GNF - A=1-350 (cow) 2GNG - A=1-350 (cow) 2GNJ - A=1-350 (cow) 2OH0 - E=1-351 (cow) 2OJF - E=1-351 (cow) 2UZT - A=15-350 (cow) 2UZU - E=15-350 (cow) 2UZV - A=15-350 (cow) 2UZW - E=15-350 (cow) 2VNW - A=1-351 (cow) 2VNY - A=1-351 (cow) 2VO0 - A=1-351 (cow) 2VO3 - A=1-351 (cow) 2VO6 - A=1-351 (cow) 2VO7 - A=1-351 (cow) 3AG9 - A/B=1-351 (cow) 3BWJ - A=2-351 (cow) 3DND - A=2-351 (cow) 3DNE - A=2-351 (cow) 3E8C - F/A/D/C/E/B=2-351 (cow) 3E8E - A/P/I/L/E/B=2-351 (cow) 3KKV - A=2-351 (cow) 3ZO1 - A=1-351 (cow) 3ZO2 - A=1-351 (cow) 3ZO3 - A=1-351 (cow) 3ZO4 - A=1-351 (cow) 4AXA - A=1-351 (cow) 4IE9 - A=1-351 (cow) 4IJ9 - A=2-351 (cow) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2GU8 3AGL 3AGM 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AE6 4AE9  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: T198‑p protein conformation: T198‑p protein stabilization: T198‑p, S339‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
4	4		S11-p	AAAAKKGsEQESVKE
0	1		S15	KKGsEQESVKEFLAK
0	1		A35	LKKWESPAQNTAHLD
0	2		T49-p	DQFERIKtLGTGSFG
0	1		S54	IKtLGTGSFGRVMLV
0	6		K93-u	IEHTLNEkRILQAVN
0	1		S110	FLVKLEFSFKDNSNL
2	3		S140-p	LRRIGRFsEPHARFY
0	1		T184	QQGYIQVTDFGFAkR
0	1		K190-u	VTDFGFAkRVKGRtW
0	89		T196-p	AkRVKGRtWtLCGtP
20	279		T198-p	RVKGRtWtLCGtPEy
0	9		T202-p	RtWtLCGtPEyLAPE
0	1		Y205-p	tLCGtPEyLAPEIIL
0	1		S213	LAPEIILSKGYNKAV
0	1		K214	APEIILSKGYNKAVD
0	1		S260-p	SGKVRFPsHFSSDLK
0	4		K280-a	LLQVDLTkRFGNLkN
0	4		K280-u	LLQVDLTkRFGNLkN
0	7		K286-u	TkRFGNLkNGVNDIK
0	1		K320-u	APFIPKFkGPGDTSN
0	1		S326	FkGPGDTSNFDDyEE
2	1		Y331-p	DTSNFDDyEEEEIRV
12	34		S339-p	EEEEIRVsINEKCGK

	PKACa iso2
S3	_____MASNSSDVKE
D7	_MASNSSDVKEFLAK
A27	LKKWESPAQNTAHLD
T41	DQFERIKTLGTGSFG
S46	IKTLGTGSFGRVMLV
K85	IEHTLNEKRILQAVN
S102	FLVKLEFSFKDNSNL
S132	LRRIGRFSEPHARFY
T176	QQGYIQVTDFGFAKR
K182	VTDFGFAKRVKGRtW
T188-p	AKRVKGRtWtLCGTP
T190-p	RVKGRtWtLCGTPEY
T194	RtWtLCGTPEYLAPE
Y197	tLCGTPEYLAPEIIL
S205	LAPEIILSKGYNKAV
K206	APEIILSKGYNKAVD
S252	SGKVRFPSHFSSDLK
K272	LLQVDLTKRFGNLKN
K272	LLQVDLTKRFGNLKN
K278	TKRFGNLKNGVNDIK
K312	APFIPKFKGPGDTSN
S318	FKGPGDTSNFDDYEE
Y323	DTSNFDDYEEEEIRV
S331	EEEEIRVSINEKCGK

	mouse
S11-p	AAAAKKGsEQESVKE
S15	KKGsEQESVKEFLAK
S35-p	LKKWETPsQNTAQLD
T49	DQFDRIKTLGTGSFG
S54	IKTLGTGSFGRVMLV
K93	IEHTLNEKRILQAVN
S110-p	FLVKLEFsFKDNSNL
S140-p	LRRIGRFsEPHARFY
T184-p	QQGYIQVtDFGFAKR
K190	VtDFGFAKRVKGRtW
T196-p	AKRVKGRtWtLCGtP
T198-p	RVKGRtWtLCGtPEY
T202-p	RtWtLCGtPEYLAPE
Y205	tLCGtPEYLAPEIIL
S213	LAPEIILSkGYNKAV
K214-u	APEIILSkGYNKAVD
S260	SGKVRFPSHFSSDLK
K280	LLQVDLTKRFGNLkN
K280-u	LLQVDLTkRFGNLkN
K286-u	TkRFGNLkNGVNDIK
K320	APFIPKFKGPGDTSN
S326	FKGPGDTSNFDDyEE
Y331-p	DTSNFDDyEEEEIRV
S339-p	EEEEIRVsINEKCGK

	rat
S11	AAAAKKGSEQESVKE
S15	KKGSEQESVKEFLAK
S35	LKKWEDPSQNTAQLD
T49	DHFDRIKTLGTGSFG
S54	IKTLGTGSFGRVMLV
K93-u	IEHTLNEkRILQAVN
S110	FLVKLEFSFKDNSNL
S140	LRRIGRFSEPHARFY
T184	QQGYIQVTDFGFAKR
K190	VTDFGFAKRVKGRtW
T196-p	AKRVKGRtWtLCGTP
T198-p	RVKGRtWtLCGTPEY
T202	RtWtLCGTPEYLAPE
Y205	tLCGTPEYLAPEIIL
S213	LAPEIILSKGYNKAV
K214	APEIILSKGYNKAVD
S260	SGKVRFPSHFSSDLK
K280	LLQVDLTKRFGNLKN
K280	LLQVDLTKRFGNLKN
K286	TKRFGNLKNGVNDIK
K320	APFIPKFKGPGDTSN
S326	FKGPGDTSNFDDYEE
Y331	DTSNFDDYEEEEIRV
S339	EEEEIRVSINEKCGK

	pig
S11-p	AAAAKKGsEQESVKE
S15	KKGsEQESVKEFLAK
A35	LKKWENPAQNTAHLD
T49	DQFERIKTLGTGSFG
S54	IKTLGTGSFGRVMLV
K93	IEHTLNEKRILQAVN
S110	FLVKLEYSFKDNSNL
S140	LRRIGRFSEPHARFY
T184	QQGYIQVTDFGFAKR
K190	VTDFGFAKRVKGRTW
T196	AKRVKGRTWTLCGTP
T198	RVKGRTWTLCGTPEY
T202	RTWTLCGTPEYLAPE
Y205	TLCGTPEYLAPEIIL
S213	LAPEIILSKGYNKAV
K214	APEIILSKGYNKAVD
S260	SGKVRFPSHFSSDLK
K280	LLQVDLTKRFGNLKN
K280	LLQVDLTKRFGNLKN
K286	TKRFGNLKNGVNDIK
K320	APFIPKFKGPGDTSN
S326	FKGPGDTSNFDDYEE
Y331	DTSNFDDYEEEEIRV
S339-p	EEEEIRVsINEKCGK

	dog
S10	NAAAKKGSEQESVKE
S14	KKGSEQESVKEFLAK
A34	LKKWENPAQNTAHLD
T48	DQFERIKTLGTGSFG
S53	IKTLGTGSFGRVMLV
K92	IEHTLNEKRILQAVN
S109	FLVKLEFSFKDNSNL
S139	LRRIGRFSEPHARFY
T183	QQGYIQVTDFGFAKR
K189	VTDFGFAKRVKGRTW
T195	AKRVKGRTWTLCGTP
T197	RVKGRTWTLCGTPEY
T201	RTWTLCGTPEYLAPE
Y204	TLCGTPEYLAPEIIL
S212	LAPEIILSKGYNKAV
K213	APEIILSKGYNKAVD
S259	SGKVRFPSHFSSDLK
K279	LLQVDLTKRFGNLKN
K279	LLQVDLTKRFGNLKN
K285	TKRFGNLKNGVNDIK
K319	APFIPKFKGPGDTSN
S325	FKGPGDTSNFDDYEE
Y330	DTSNFDDYEEEEIRV
S338	EEEEIRVSINEKCGK

	cow
S11-p	AAAAKKGsEQEsVKE
S15-p	KKGsEQEsVKEFLAK
A35	LKKWENPAQNTAHLD
T49-p	DQFERIKtLGTGsFG
S54-p	IKtLGTGsFGRVMLV
K93	IEHTLNEKRILQAVN
S110	FLVKLEFSFKDNSNL
S140-p	LRRIGRFsEPHARFY
T184	QQGYIQVTDFGFAKR
K190	VTDFGFAKRVKGRTW
T196	AKRVKGRTWtLCGTP
T198-p	RVKGRTWtLCGTPEY
T202	RTWtLCGTPEYLAPE
Y205	tLCGTPEYLAPEIIL
S213-p	LAPEIILsKGYNKAV
K214	APEIILsKGYNKAVD
S260-p	SGKVRFPsHFSSDLK
K280	LLQVDLTKRFGNLKN
K280	LLQVDLTKRFGNLKN
K286	TKRFGNLKNGVNDIK
K320	APFIPKFKGPGDTsN
S326-p	FKGPGDTsNFDDYEE
Y331	DTsNFDDYEEEEIRV
S339-p	EEEEIRVsINEKCGK

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