an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); EC 184.108.40.206; Kinase, protein; AGC group; PKB family
Molecular Function: protein serine/threonine kinase activity; protein binding; phospholipase binding; 3-phosphoinositide-dependent protein kinase activity; protein kinase binding; ATP binding; insulin receptor binding; phospholipase activator activity
Biological Process: stimulatory C-type lectin receptor signaling pathway; focal adhesion formation; regulation of mast cell degranulation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; T cell receptor signaling pathway; protein amino acid phosphorylation; synaptic transmission; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; regulation of I-kappaB kinase/NF-kappaB cascade; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; activation of protein kinase B; peptidyl-threonine phosphorylation; calcium-mediated signaling; hyperosmotic response; cellular response to insulin stimulus; T cell costimulation; negative regulation of toll-like receptor signaling pathway; insulin receptor signaling pathway; negative regulation of protein kinase activity; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.