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PDK1 (human)

Overview PDK1 an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; EC 2.7.11.1; AGC group; PKB family Cellular Component: nucleoplasm; focal adhesion; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; cytosol Molecular Function: protein serine/threonine kinase activity; protein binding; 3-phosphoinositide-dependent protein kinase activity; kinase activity; protein kinase binding; ATP binding; insulin receptor binding Biological Process: focal adhesion formation; regulation of mast cell degranulation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of apoptosis; synaptic transmission; regulation of transcription, DNA-dependent; regulation of I-kappaB kinase/NF-kappaB cascade; epidermal growth factor receptor signaling pathway; platelet activation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; transcription, DNA-dependent; activation of protein kinase B; peptidyl-threonine phosphorylation; hyperosmotic response; cellular response to insulin stimulus; T cell costimulation; insulin receptor signaling pathway; negative regulation of toll-like receptor signaling pathway; negative regulation of protein kinase activity; negative regulation of transforming growth factor beta receptor signaling pathway; actin cytoskeleton organization and biogenesis; blood coagulation Reference #:  O15530 (UniProtKB) Alt. Names/Synonyms: 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; hPDK1; MGC20087; MGC35290; PDK1; PDPK1; PkB kinase like gene 1; PkB-like 1; PRO0461; protein kinase Gene Symbols: PDPK1 Molecular weight: 63,152 Da Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states CST Pathways:  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PDK1 1H1W - A=71-359 (human) 1OKY - A=51-360 (human) 1OKZ - A=51-360 (human) 1UU3 - A=51-360 (human) 1UU7 - A=51-360 (human) 1UU8 - A=51-360 (human) 1UU9 - A=72-357 (human) 1UVR - A=71-359 (human) 1W1D - A=409-556 (human) 1W1G - A=409-556 (human) 1W1H - A/B/C/D=409-556 (human) 1Z5M - A=74-359 (human) 2BIY - A=51-360 (human) 2PE0 - A=74-359 (human) 2PE1 - A=74-359 (human) 2PE2 - A=74-359 (human) 2R7B - A=48-359 (human) 2VKI - A=409-556 (human) 2XCH - A=1-309 (human) 2XCK - A=1-309 (human) 3H9O - A=48-359 (human) 3HRC - A=51-359 (human) 3HRF - A=51-359 (human) 3ION - A=48-359 (human) 3IOP - A=48-359 (human) 3NAX - A=66-362 (human) 3NAY - A/B=66-362 (human) 3ORX - F/A/E/B/H/C/D/G=51-359 (human) 3ORZ - A/D/C/B=51-359 (human) 3OTU - A=51-359 (human) 3PWY - A=51-359 (human) 3QC4 - A/B=51-359 (human) 3QCQ - A=48-359 (human) 3QCS - A=48-359 (human) 3QCX - A=48-359 (human) 3QCY - A=48-359 (human) 3QD0 - A=48-359 (human) 3QD3 - A=48-359 (human) 3QD4 - A=48-359 (human) 3RCJ - A=50-359 (human) 3RWP - A=51-359 (human) 3RWQ - A=51-359 (human) 3SC1 - A=50-359 (human) 4A06 - A=50-359 (human) 4A07 - A=50-359 (human) 4AW0 - A=51-359 (human) 4AW1 - A=51-359 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION 3IOP 3NAX 3NAY 3ORX 3ORZ 3OTU 3PWY 3QC4 3QCQ 3QCS 3QCX 3QCY 3QD0 3QD3 3QD4 3RCJ 3RWP 3RWQ 3SC1 4A06 4A07 4AW0 4AW1  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: T354‑p, Y373‑p, Y376‑p, S394‑p, S398‑p cell growth, altered: S394‑p, S398‑p cell growth, inhibited: T354‑p signaling pathway regulation: T354‑p transcription, altered: Y9‑p, S396‑p enzymatic activity, induced: Y9‑p, S241‑p, Y373‑p, Y376‑p, T513‑p enzymatic activity, inhibited: T354‑p intracellular localization: S396‑p molecular association, regulation: Y9‑p, S241‑p, T354‑p, T513‑p phosphorylation: Y9‑p protein degradation: Y9‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		R3	_____MARTTSQLyD
5	7		Y9-p	ARTTSQLyDAVPIQS
0	1		S22-p	QSSVVLCsCPsPSMV
1	2		S25-p	VVLCsCPsPSMVRTQ
0	17		T37-p	RTQTESStPPGIPGG
0	1		P49	PGGSRQGPAMDGTAA
0	1		T54	QGPAMDGTAAEPRPG
0	1		A55	GPAMDGTAAEPRPGA
0	1		A62	AAEPRPGAGSLQHAQ
0	1		T95	LGEGSFSTVVLAREL
0	1		K123	RHIIKENKVPyVTRE
0	1		Y126-p	IKENKVPyVTRERDV
0	1		T148-p	FFVKLYFtFQDDEKL
1	1		S160-p	EKLYFGLsyAKNGEL
0	1		Y161-p	KLYFGLsyAKNGELL
0	1		S176-p	KYIRKIGsFDETCTR
0	2		S231-p	FGTAKVLsPEsKQAR
0	1		S234-p	AKVLsPEsKQARANs
40	251		S241-p	sKQARANsFVGtAQy
0	12		T245-p	RANsFVGtAQyVSPE
0	5		Y248-p	sFVGtAQyVSPELLt
0	1		T255-p	yVSPELLtEKSACKS
0	1		K257	SPELLtEKSACKSSD
0	5		Y288-p	PFRAGNEyLIFQKII
0	1		K296	LIFQKIIKLEYDFPE
0	6		K304-a	LEYDFPEkFFPKARD
0	1		K304-u	LEYDFPEkFFPKARD
1	0		T354-p	WENLHQQtPPKLTAY
0	1		S366-p	TAYLPAMsEDDEDCy
9	1		Y373-p	sEDDEDCyGNyDNLL
8	1		Y376-p	DEDCyGNyDNLLSQF
2	1		S393-p	MQVSSSSssHsLsAS
2	0		S394-p	QVSSSSssHsLsASD
4	1		S396-p	SSSSssHsLsASDTG
2	0		S398-p	SSssHsLsASDTGLP
1	1		S410-p	GLPQRSGsNIEQYIH
0	10		K441-u	EKRLLLEkQAGGNPW
0	1		Y485-p	LTEGPHLyyVDPVNK
0	1		Y486-p	TEGPHLyyVDPVNKV
1	1		S501-p	LKGEIPWsQELRPEA
4	2		T513-p	PEAKNFKtFFVHTPN
1	0		S529	TYYLMDPSGNAHkWC
0	1		K534-a	DPSGNAHkWCRKIQE

	PDK1 iso4
R3	_____MARTTSQLYD
Y9	ARTTSQLYDAVPIQS
S22	QSSVVLCSCPSPSMV
S25	VVLCSCPSPSMVRTQ
T37-p	RTQTESStPPGIPGG
P49	PGGSRQGPAMDGTAA
T54	QGPAMDGTAAEPRPG
A55	GPAMDGTAAEPRPGA
A62	AAEPRPGAGSLQHAQ
T95	LGEGSFSTVVLAREL
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S114-p	EYATRANsFVGTAQY
T118	RANsFVGTAQYVSPE
Y121	sFVGTAQYVSPELLT
T128	YVSPELLTEKSACKS
K130	SPELLTEKSACKSSD
Y161	PFRAGNEYLIFQKII
K169	LIFQKIIKLEYDFPE
K177	LEYDFPEKFFPKARD
K177	LEYDFPEKFFPKARD
T227	WENLHQQTPPKLTAY
S239	TAYLPAMSEDDEDCY
Y246	SEDDEDCYGNYDNLL
Y249	DEDCYGNYDNLLSQF
S266	MQVSSSSSSHSLSAS
S267	QVSSSSSSHSLSASD
S269	SSSSSSHSLSASDTG
S271	SSSSHSLSASDTGLP
S283	GLPQRSGSNIEQYIH
K314-u	EKRLLLEkQAGGNPW
Y358	LTEGPHLYYVDPVNK
Y359	TEGPHLYYVDPVNKV
S374	LKGEIPWSQELRPEA
T386	PEAKNFKTFFVHTPN
S402	TYYLMDPSGNAHkWC
K407-a	DPSGNAHkWCRKIQE

	mouse
R3-m1	_____MArTTSQLYD
Y9	ArTTSQLYDAVPIQS
S22	QSSVVLCSCPSPSMV
S25	VVLCSCPSPSMVRSQ
S37	RSQTEPGSSPGIPSG
S50-p	SGVSRQGsTMDGttA
T55-p	QGsTMDGttAEARPS
T56-p	GsTMDGttAEARPSt
T63-p	tAEARPStNPLQQHP
T98-p	LGEGSFStVVLAREL
K126-u	RHIIKENkVPYVTRE
Y129	IKENkVPYVTRERDV
T151	FFVKLYFTFQDDEKL
S163-p	EKLYFGLsYAKNGEL
Y164	KLYFGLsYAKNGELL
S179	KYIRKIGSFDETCTR
S234-p	FGTAKVLsPESKQAR
S237	AKVLsPESKQARANs
S244-p	SKQARANsFVGtAQy
T248-p	RANsFVGtAQyVSPE
Y251-p	sFVGtAQyVSPELLT
T258	yVSPELLTEkSACKS
K260-u	SPELLTEkSACKSSD
Y291	PFRAGNEYLIFQKII
K299-u	LIFQKIIkLEYHFPE
K307-a	LEYHFPEkFFPKARD
K307	LEYHFPEKFFPKARD
T357	WENLHQQTPPKLTAY
S369	TAYLPAMSEDDEDCY
Y376	SEDDEDCYGNYDNLL
Y379	DEDCYGNYDNLLSQF
S396	MQVSSSSSSHsLSTV
S397	QVSSSSSSHsLSTVE
S399-p	SSSSSSHsLSTVETS
S401	SSSSHsLSTVETSLP
S413	SLPQRSGSNIEQYIH
K444	EKRLLLEKQAGGNPW
Y488	LTEGPHLYYVDPVNK
Y489	TEGPHLYYVDPVNKV
S504-p	LKGEIPWsQELRPEA
T516-p	PEAKNFKtFFVHTPN
S532-p	TYYLMDPsGNAHKWC
K537	DPsGNAHKWCRKIQE

	rat
R3	_____MARTTSQLyD
Y9-p	ARTTSQLyDAVPIQS
S22	QSSVVLCSCPSPSMV
S25	VVLCSCPSPSMVRSQ
S37	RSQTEPSSSPGIPSG
S50	SGVSRQGSTMDGTTA
T55	QGSTMDGTTAEARPS
T56	GSTMDGTTAEARPST
T63	TAEARPSTNPLQQHP
T98	LGEGSFSTVVLAREL
K126	RHIIKENKVPYVTRE
Y129	IKENKVPYVTRERDV
T151	FFVKLYFTFQDDEKL
S163	EKLYFGLSYAKNGEL
Y164	KLYFGLSYAKNGELL
S179	KYIRKIGSFDETCTR
S234	FGTAKVLSPDSKQAR
S237	AKVLSPDSKQARANs
S244-p	SKQARANsFVGTAQY
T248	RANsFVGTAQYVSPE
Y251	sFVGTAQYVSPELLT
T258	YVSPELLTEKSACKS
K260	SPELLTEKSACKSSD
Y291	PFRAGNEYLIFQKII
K299	LIFQKIIKLEYDFPE
K307	LEYDFPEKFFPKARD
K307	LEYDFPEKFFPKARD
T357	WENLHQQTPPKLTAY
S369	TAYLPAMSEDDEDCy
Y376-p	SEDDEDCyGNyDNLL
Y379-p	DEDCyGNyDNLLSQF
S396	MQVSSSSSSHSLSAV
S397	QVSSSSSSHSLSAVD
S399	SSSSSSHSLSAVDAS
S401	SSSSHSLSAVDASLP
S413	SLPQRSGSNIEQYIH
K444	EKRLLLEKQAGGNPW
Y488	LTEGPHLYYVDPVNK
Y489	TEGPHLYYVDPVNKV
S504	LKGEIPWSQELRPEA
T516	PEAKNFKTFFVHTPN
S532	TYYLMDPSGNAHKWC
K537	DPSGNAHKWCRKIQE

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