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Protein Page:
PDGFRB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDGFRB a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; PDGFR family
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: lysosomal lumen; membrane; cytoplasm; cytoplasmic membrane-bound vesicle; apical plasma membrane; integral to membrane; plasma membrane; nucleus; intrinsic to plasma membrane
Molecular Function: protein binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; protein-tyrosine kinase activity; platelet-derived growth factor receptor binding; phosphoinositide 3-kinase binding; platelet-derived growth factor receptor activity; protein kinase binding; ATP binding; receptor binding
Biological Process: positive regulation of phosphoprotein phosphatase activity; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; wound healing; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; response to toxin; positive regulation of collagen biosynthetic process; platelet-derived growth factor receptor signaling pathway; cardiac myofibril assembly; positive regulation of smooth muscle cell migration; signal transduction; response to estradiol stimulus; smooth muscle development; positive regulation of MAP kinase activity; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; tissue homeostasis; phosphatidylinositol metabolic process; regulation of peptidyl-tyrosine phosphorylation; inner ear development; epidermal growth factor receptor signaling pathway; cell migration; response to retinoic acid; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; positive regulation of chemotaxis; in utero embryonic development; adrenal gland development; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; glycosaminoglycan biosynthetic process; response to hyperoxia; response to hydrogen peroxide; skeletal morphogenesis; regulation of actin cytoskeleton organization and biogenesis; innate immune response; positive regulation of cell migration; negative regulation of apoptosis
Reference #:  P09619 (UniProtKB)
Alt. Names/Synonyms: Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; JTK12; PDGF-R-beta; PDGFR; PDGFR1; PDGFRB; PGFRB; platelet-derived growth factor receptor, beta polypeptide
Gene Symbols: PDGFRB
Molecular weight: 123,968 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDGFRB

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell cycle regulation: Y740‑p, Y751‑p
cell growth, altered: Y579‑p, Y581‑p, Y857‑p, Y1009‑p
cell motility, altered: Y686‑p, Y934‑p, Y970‑p
activity, induced: Y716‑p, Y740‑p, Y751‑p, Y1009‑p, Y1021‑p
enzymatic activity, induced: Y579‑p, Y581‑p, Y686‑p, Y740‑p, Y751‑p, Y857‑p, Y934‑p, Y970‑p
molecular association, regulation: Y579‑p, Y581‑p, Y716‑p, Y740‑p, Y751‑p, Y763‑p, Y771‑p, Y775‑p, Y1009‑p, Y1021‑p, S1104‑p
phosphorylation: Y579‑p, Y581‑p, Y857‑p, Y1009‑p, Y1021‑p
protein conformation: Y751‑p
receptor desensitization, altered: S1104‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S212-p YVYRLQVssINVSVN
0 1 S213-p VYRLQVssINVSVNA
2 0 Y562-p LWQKKPRyEIRWKVI
0 1 S571 IRWKVIESVSSDGHE
0 1 S573 WKVIESVSSDGHEyI
0 1 S574 KVIESVSSDGHEyIy
11 1 Y579-p VSSDGHEyIyVDPMQ
6 1 Y581-p SDGHEyIyVDPMQLP
0 1 Y589 VDPMQLPYDSTWELP
0 1 T605-p DQLVLGRtLGsGAFG
0 1 S608-p VLGRtLGsGAFGQVV
0 1 Y678-p CTKGGPIyIITEyCR
0 1 Y683-p PIyIITEyCRyGDLV
1 1 Y686-p IITEyCRyGDLVDyL
0 3 Y692-p RyGDLVDyLHRNKHT
0 1 K707-ub FLQHHSDkRRPPSAE
5 0 Y716-p RPPSAELySNALPVG
11 4 Y740-p TGESDGGyMDMSKDE
0 1 S748 MDMSKDESVDyVPML
22 2 Y751-p SKDESVDyVPMLDMK
0 1 K762 LDMKGDVKyADIESS
6 3 Y763-p DMKGDVKyADIESSN
0 1 N770 yADIESSNyMAPyDN
12 5 Y771-p ADIESSNyMAPyDNy
3 1 Y775-p SSNyMAPyDNyVPSA
2 22 Y778-p yMAPyDNyVPSAPER
0 1 K841 ICEGKLVKICDFGLA
12 1 Y857-p DIMRDSNyISKGSTF
0 1 K860 RDSNyISKGSTFLPL
0 1 Y921-p YNAIKRGyRMAQPAH
0 1 S930-p MAQPAHAsDEIyEIM
1 3 Y934-p AHAsDEIyEIMQKCW
1 2 Y970-p GEGYKKKyQQVDEEF
0 1 G997 ARLPGFHGLRSPLDT
16 0 Y1009-p LDTSSVLyTAVQPNE
20 0 Y1021-p PNEGDNDyIIPLPDP
1 0 S1104-p PRAEAEDsFL_____
3168 : Phospho-PDGF Receptor beta (Tyr740) (32A9) Rabbit mAb
3161 : Phospho-PDGF Receptor beta (Tyr751) Antibody
3166 : Phospho-PDGF Receptor beta (Tyr751) (88H8) Mouse mAb
4549 : Phospho-PDGF Receptor beta (Tyr751) (C63G6) Rabbit mAb
3173 : Phospho-PDGF Receptor beta (Tyr771) (76D6) Rabbit mAb
3170 : Phospho-PDGF Receptor alpha (Tyr849)/PDGF Receptor beta (Tyr857) (C43E9) Rabbit mAb
3124 : Phospho-PDGF Receptor beta (Tyr1009) (42F9) Rabbit mAb
2227 : Phospho-PDGF Receptor beta (Tyr1021) (6F10) Rabbit mAb
  mouse

 
S211 YVYSLQVSSINVSVN
S212 VYSLQVSSINVSVNA
Y561 LWQKKPRYEIRWKVI
S570-p IRWKVIEsVssDGHE
S572-p WKVIEsVssDGHEyI
S573-p KVIEsVssDGHEyIy
Y578-p VssDGHEyIyVDPVQ
Y580-p sDGHEyIyVDPVQLP
Y588-p VDPVQLPyDSTWELP
T604 DQLVLGRTLGSGAFG
S607 VLGRTLGSGAFGQVV
Y677 CTKGGPIYIITEYCR
Y682 PIYIITEYCRYGDLV
Y685 IITEYCRYGDLVDyL
Y691-p RYGDLVDyLHRNKHT
K706 FLQRHSNKHCPPSAE
Y715 CPPSAELYSNALPVG
Y739-p TGESDGGyMDMSKDE
S747-p MDMSKDEsIDyVPML
Y750-p SKDEsIDyVPMLDMK
K761-ub LDMKGDIkyADIESP
Y762-p DMKGDIkyADIESPs
S769-p yADIESPsyMAPyDN
Y770-p ADIESPsyMAPyDNy
Y774-p SPsyMAPyDNyVPSA
Y777-p yMAPyDNyVPSAPER
K840-ub ICEGKLVkICDFGLA
Y856-p DIMRDSNyISkGSTY
K859-ub RDSNyISkGSTYLPL
Y920 YNAIKRGYRMAQPAH
S929 MAQPAHASDEIYEIM
Y933 AHASDEIYEIMQKCW
Y969-p GEGYKKKyQQVDEEF
S996-p ARFPGIHsLRSPLDT
Y1008-p LDTSSVLyTAVQPNE
Y1020-p PNESDNDyIIPLPDP
S1096 PLAEAEDSFL_____
3168 : Phospho-PDGF Receptor beta (Tyr740) (32A9) Rabbit mAb
3161 : Phospho-PDGF Receptor beta (Tyr751) Antibody
3166 : Phospho-PDGF Receptor beta (Tyr751) (88H8) Mouse mAb
4549 : Phospho-PDGF Receptor beta (Tyr751) (C63G6) Rabbit mAb
3173 : Phospho-PDGF Receptor beta (Tyr771) (76D6) Rabbit mAb
3170 : Phospho-PDGF Receptor alpha (Tyr849)/PDGF Receptor beta (Tyr857) (C43E9) Rabbit mAb
3124 : Phospho-PDGF Receptor beta (Tyr1009) (42F9) Rabbit mAb
2227 : Phospho-PDGF Receptor beta (Tyr1021) (6F10) Rabbit mAb
  rat

 
- under review  
- under review  
Y561 LWQRKPRYEIRWKVI
S570 IRWKVIESVSSDGHE
S572 WKVIESVSSDGHEyI
S573 KVIESVSSDGHEyIY
Y578-p VSSDGHEyIYVDPVQ
Y580 SDGHEyIYVDPVQLP
Y588 VDPVQLPYDSTWELP
T604 DQLVLGRTLGSGAFG
S607 VLGRTLGSGAFGQVV
Y677 CTKGGPIYIITEYCR
Y682 PIYIITEYCRYGDLV
Y685 IITEYCRYGDLVDYL
Y691 RYGDLVDYLHRNKHT
K706 FLQRHSNKHCPPSTE
Y715-p CPPSTELySNALPVG
Y739 TGESDGGYMDMSKDE
S747 MDMSKDESVDyVPML
Y750-p SKDESVDyVPMLDMK
K761 LDMKGHIKYADIESS
Y762 DMKGHIKYADIESSS
S769 YADIESSSYMAPYDN
Y770 ADIESSSYMAPYDNY
Y774 SSSYMAPYDNYVPSA
Y777 YMAPYDNYVPSAPER
K840 ICEGKLVKICDFGLA
Y856 DIMRDSNYISKGSTF
K859 RDSNYISKGSTFLPL
Y920 YNAIKRGYRMAQPAH
S929 MAQPAHASDEIYEIM
Y933 AHASDEIYEIMQKCW
Y969 GEGYKKKYQQVDEEF
S996 ARLPGLHSLRSPLDT
Y1008 LDTSSVLYTAVQPNE
Y1020-p PNETDNDyIIPLPDP
S1095 PLAEAEDSFL_____
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