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PDGFRb (human)

Overview PDGFRb a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; EC 2.7.10.1; TK group; PDGFR family Cellular Component: lysosomal lumen; membrane; integral to plasma membrane; apical plasma membrane; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; nucleus; intrinsic to plasma membrane Molecular Function: vascular endothelial growth factor receptor activity; protein binding; platelet activating factor receptor activity; protein-tyrosine kinase activity; platelet-derived growth factor binding; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor receptor binding; platelet-derived growth factor receptor activity; ATP binding; receptor binding Biological Process: positive regulation of phosphoprotein phosphatase activity; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; platelet-derived growth factor receptor signaling pathway; cardiac myofibril assembly; positive regulation of smooth muscle cell migration; signal transduction; smooth muscle development; positive regulation of MAP kinase activity; nitrogen compound metabolic process; positive regulation of cell proliferation; tissue homeostasis; phosphatidylinositol metabolic process; regulation of peptidyl-tyrosine phosphorylation; cell migration; phosphoinositide-mediated signaling; positive regulation of mitosis; positive regulation of chemotaxis; adrenal gland development; in utero embryonic development; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; skeletal morphogenesis; regulation of actin cytoskeleton organization and biogenesis; vascular endothelial growth factor receptor signaling pathway; positive regulation of cell migration Reference #:  P09619 (UniProtKB) Alt. Names/Synonyms: Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; JTK12; PDGF-R-beta; PDGFR; PDGFR1; PDGFRB; PGFRB; platelet-derived growth factor receptor, beta polypeptide Gene Symbols: PDGFRB Molecular weight: 123,968 Da Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PDGFRb 1GQ5 - A=1102-1106 (human) 1H9O - B=751-755 (human) 1LWP - A=600-962 (human) 2L6W - A/B=526-563 (human) 3MJG - X/Y=33-314 (human) 1AYA - P/Q=1005-1015 (mouse) 1AYC - P=736-744 (mouse) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1GQ5 1H9O 1LWP 2L6W 3MJG  |  ENZYME  |  Phospho3D  |  DISEASE 131440 173410  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: Y740‑p, Y751‑p cell growth, altered: Y579‑p, Y581‑p, Y857‑p, Y1009‑p cell motility, altered: Y686‑p, Y934‑p, Y970‑p activation: Y716‑p, Y740‑p, Y751‑p, Y1009‑p, Y1021‑p enzymatic activity, induced: Y579‑p, Y581‑p, Y686‑p, Y740‑p, Y751‑p, Y857‑p, Y934‑p, Y970‑p molecular association, regulation: Y579‑p, Y581‑p, Y716‑p, Y740‑p, Y751‑p, Y763‑p, Y771‑p, Y775‑p, Y1009‑p, Y1021‑p, S1104‑p phosphorylation: Y579‑p, Y581‑p, Y857‑p, Y1009‑p, Y1021‑p protein conformation: Y751‑p receptor desensitization, altered: S1104‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		Y562-p	LWQKKPRyEIRWKVI
0	1		S571	IRWKVIESVSSDGHE
0	1		S573	WKVIESVSSDGHEyI
0	1		S574	KVIESVSSDGHEyIy
10	1		Y579-p	VSSDGHEyIyVDPMQ
6	1		Y581-p	SDGHEyIyVDPMQLP
0	1		Y589	VDPMQLPYDSTWELP
0	1		T605-p	DQLVLGRtLGsGAFG
0	1		S608-p	VLGRtLGsGAFGQVV
0	1		Y678-p	CTKGGPIyIITEYCR
1	1		Y686-p	IITEYCRyGDLVDyL
0	3		Y692-p	RyGDLVDyLHRNKHT
0	1		K707-u	FLQHHSDkRRPPSAE
4	0		Y716-p	RPPSAELySNALPVG
10	4		Y740-p	TGESDGGyMDMSKDE
0	1		S748	MDMSKDESVDyVPML
18	2		Y751-p	SKDESVDyVPMLDMK
0	1		K762	LDMKGDVKyADIESS
6	3		Y763-p	DMKGDVKyADIESSN
0	1		N770	yADIESSNyMAPyDN
12	5		Y771-p	ADIESSNyMAPyDNy
3	1		Y775-p	SSNyMAPyDNyVPSA
2	23		Y778-p	yMAPyDNyVPSAPER
0	1		K841	ICEGKLVKICDFGLA
12	1		Y857-p	DIMRDSNyISKGSTF
0	1		K860	RDSNyISKGSTFLPL
0	1		Y921-p	YNAIKRGyRMAQPAH
0	1		S930-p	MAQPAHAsDEIyEIM
1	3		Y934-p	AHAsDEIyEIMQKCW
1	2		Y970-p	GEGYKKKyQQVDEEF
0	1		G997	ARLPGFHGLRSPLDT
16	0		Y1009-p	LDTSSVLyTAVQPNE
19	0		Y1021-p	PNEGDNDyIIPLPDP
1	0		S1104-p	PRAEAEDsFL_____

	mouse
Y561	LWQKKPRYEIRWKVI
S570-p	IRWKVIEsVssDGHE
S572-p	WKVIEsVssDGHEyI
S573-p	KVIEsVssDGHEyIy
Y578-p	VssDGHEyIyVDPVQ
Y580-p	sDGHEyIyVDPVQLP
Y588-p	VDPVQLPyDSTWELP
T604	DQLVLGRTLGSGAFG
S607	VLGRTLGSGAFGQVV
Y677	CTKGGPIYIITEYCR
Y685	IITEYCRYGDLVDyL
Y691-p	RYGDLVDyLHRNKHT
K706	FLQRHSNKHCPPSAE
Y715	CPPSAELYSNALPVG
Y739-p	TGESDGGyMDMSKDE
S747-p	MDMSKDEsIDyVPML
Y750-p	SKDEsIDyVPMLDMK
K761-u	LDMKGDIkyADIESP
Y762-p	DMKGDIkyADIESPs
S769-p	yADIESPsyMAPyDN
Y770-p	ADIESPsyMAPyDNy
Y774-p	SPsyMAPyDNyVPSA
Y777-p	yMAPyDNyVPSAPER
K840-u	ICEGKLVkICDFGLA
Y856-p	DIMRDSNyISkGSTY
K859-u	RDSNyISkGSTYLPL
Y920	YNAIKRGYRMAQPAH
S929	MAQPAHASDEIYEIM
Y933	AHASDEIYEIMQKCW
Y969-p	GEGYKKKyQQVDEEF
S996-p	ARFPGIHsLRSPLDT
Y1008-p	LDTSSVLyTAVQPNE
Y1020-p	PNESDNDyIIPLPDP
S1096	PLAEAEDSFL_____

	rat
Y561	LWQRKPRYEIRWKVI
S570	IRWKVIESVSSDGHE
S572	WKVIESVSSDGHEYI
S573	KVIESVSSDGHEYIY
Y578	VSSDGHEYIYVDPVQ
Y580	SDGHEYIYVDPVQLP
Y588	VDPVQLPYDSTWELP
T604	DQLVLGRTLGSGAFG
S607	VLGRTLGSGAFGQVV
Y677	CTKGGPIYIITEYCR
Y685	IITEYCRYGDLVDYL
Y691	RYGDLVDYLHRNKHT
K706	FLQRHSNKHCPPSTE
Y715	CPPSTELYSNALPVG
Y739	TGESDGGYMDMSKDE
S747	MDMSKDESVDYVPML
Y750	SKDESVDYVPMLDMK
K761	LDMKGHIKYADIESS
Y762	DMKGHIKYADIESSS
S769	YADIESSSYMAPYDN
Y770	ADIESSSYMAPYDNY
Y774	SSSYMAPYDNYVPSA
Y777	YMAPYDNYVPSAPER
K840	ICEGKLVKICDFGLA
Y856	DIMRDSNYISKGSTF
K859	RDSNYISKGSTFLPL
Y920	YNAIKRGYRMAQPAH
S929	MAQPAHASDEIYEIM
Y933	AHASDEIYEIMQKCW
Y969	GEGYKKKYQQVDEEF
S996	ARLPGLHSLRSPLDT
Y1008	LDTSSVLYTAVQPNE
Y1020-p	PNETDNDyIIPLPDP
S1095	PLAEAEDSFL_____

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