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NAC1 (human)

Overview NAC1 Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1. Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. Note: This description may include information from UniProtKB. Protein type: Transcription factor Cellular Component: nuclear body; intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus Biological Process: transcription, DNA-dependent; induction of apoptosis; positive regulation of cell proliferation; negative regulation of transcription, DNA-dependent; protein homooligomerization Reference #:  Q96RE7 (UniProtKB) Alt. Names/Synonyms: BEN domain containing 8; BEND8; BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B; BTBD14B; FLJ37383; NAC-1; NAC1; NACC1; nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; Nucleus accumbens-associated protein 1; transcriptional repressor NAC1 Gene Symbols: NACC1 Molecular weight: 57,258 Da Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NAC1 3GA1 - A/B=2-125 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S140-p	LHAEEAPssEPQsPV
0	1		S141-p	HAEEAPssEPQsPVA
0	4		S145-p	APssEPQsPVAQTSG
0	2		T158-p	SGWPACStPLPLVSR
0	2		S188-p	VAKRLWDsGQKEAGG
0	1		K202-a	GGGNGSRkMAkFSTP
0	1		K205-a	NGSRkMAkFSTPDLA
1	0		S259	VVSGPSTSERTsPGT
0	1		S263-p	PSTSERTsPGTSSAY
0	2		S274-p	SSAYTSDsPGsYHNE
0	1		S277-p	YTSDsPGsYHNEEDE
0	1		K368-u	DEGDPSEkLELVTGT
0	2		T411-p	ASFFDRNtLANSCGT
0	1		S422-p	SCGTGIRsStNDPRR
0	1		T424-p	GTGIRsStNDPRRKP
0	1		K483-u	MPKVKVLkAEDDAyT
0	4		Y489-p	LkAEDDAyTTFISET
0	1		K498-u	TFISETGkIEPDMMG
0	1		G505	kIEPDMMGVEHGFET
0	1		G509	DMMGVEHGFETASHE

	mouse
S140	LHPEEAPSSEPQsPV
S141	HPEEAPSSEPQsPVA
S145-p	APSSEPQsPVAQTLG
T158	LGWPACSTPLPLVSR
S187	MAKRLWDSSQKEAGG
K203	GGNNGSRKMAKFSTP
K206	NGSRKMAKFSTPDLA
S245	CVSGPSMSERTSPGT
S249	PSMSERTSPGTSSAY
S260	SSAYTSDSPSSYHNE
S263	YTSDSPSSYHNEEDE
K354	DEGDPSEKLELVTGT
T397	ASFFDRNTLANSCGT
S408	SCGTGIRSSTNDPRR
T410	GTGIRSSTNDPRRKP
H469	LPKTKPLHLVEGDNY
Y476	HLVEGDNYSSFISDT
K485	SFISDTCKIEPDMMs
S492-p	KIEPDMMsMEHsFET
S496-p	DMMsMEHsFETASHD

	rat
S140	LHPEEAPSSEPQSPV
S141	HPEEAPSSEPQSPVA
S145	APSSEPQSPVAQILG
T158	LGWPACSTPLPLVSR
S187	MAKRLWDSSQKEAGG
K203	GGNNGSRKMAKFSTP
K206	NGSRKMAKFSTPDLA
S245-p	CVSGPSMsERTSPGT
S249	PSMsERTSPGTSSAY
S260	SSAYTSDSPSSYHNE
S263	YTSDSPSSYHNEEDE
K354	DEGDPSEKLELVTGT
T397	ASFFDRNTLANSCGT
S408	SCGTGIRSSTNDPRR
T410	GTGIRSSTNDPRRKP
H469	LPKTKPLHLVEGDNY
Y476	HLVEGDNYSSFISDT
K485	SFISDTGKIEPDMMS
S492	KIEPDMMSMEHSFET
S496	DMMSMEHSFETASHD

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