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Protein Page:
NAC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NAC1 Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1. Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: nuclear body; intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus
Biological Process: transcription, DNA-dependent; positive regulation of cell proliferation; negative regulation of transcription, DNA-dependent; protein homooligomerization
Reference #:  Q96RE7 (UniProtKB)
Alt. Names/Synonyms: BEN domain containing 8; BEND8; BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B; BTBD14B; FLJ37383; NAC-1; NAC1; NACC1; nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; Nucleus accumbens-associated protein 1; transcriptional repressor NAC1
Gene Symbols: NACC1
Molecular weight: 57,258 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NAC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S140-p LHAEEAPssEPQsPV
0 2 S141-p HAEEAPssEPQsPVA
0 6 S145-p APssEPQsPVAQTSG
0 1 T150 PQsPVAQTSGWPACS
0 2 T158-p SGWPACStPLPLVSR
0 7 S188-p VAKRLWDsGQKEAGG
0 1 K202-ac GGGNGSRkMAkFSTP
0 1 K205-ac NGSRkMAkFSTPDLA
1 0 S259 VVSGPSTSERTsPGT
0 1 S263-p PSTSERTsPGTSSAY
0 2 S274-p SSAYTSDsPGsYHNE
0 1 S277-p YTSDsPGsYHNEEDE
0 1 S330-p PEQVAPEsRNRIRVR
0 1 K368-ub DEGDPSEkLELVTGT
0 2 T411-p ASFFDRNtLANSCGT
0 1 S422-p SCGTGIRsStNDPRR
0 1 T424-p GTGIRsStNDPRRKP
0 1 K483-ub MPKVKVLkAEDDAyT
0 5 Y489-p LkAEDDAyTTFISET
0 1 K498-ub TFISETGkIEPDMMG
0 1 G505 kIEPDMMGVEHGFET
0 1 G509 DMMGVEHGFETASHE
  mouse

 
S140 LHPEEAPSsEPQsPV
S141-p HPEEAPSsEPQsPVA
S145-p APSsEPQsPVAQtLG
T150-p PQsPVAQtLGWPACS
T158 LGWPACSTPLPLVSR
S187 MAKRLWDSSQKEAGG
K203 GGNNGSRKMAKFSTP
K206 NGSRKMAKFSTPDLA
S245 CVSGPSMSERTSPGT
S249 PSMSERTSPGTSSAY
S260 SSAYTSDSPSSYHNE
S263 YTSDSPSSYHNEEDE
S316 PEQVVLESRSRIRVR
K354 DEGDPSEKLELVTGT
T397 ASFFDRNTLANSCGT
S408 SCGTGIRSSTNDPRR
T410 GTGIRSSTNDPRRKP
H469 LPKTKPLHLVEGDNY
Y476 HLVEGDNYSSFISDT
K485 SFISDTCKIEPDMMs
S492-p KIEPDMMsMEHsFET
S496-p DMMsMEHsFETASHD
  rat

 
S140 LHPEEAPSSEPQSPV
S141 HPEEAPSSEPQSPVA
S145 APSSEPQSPVAQILG
I150 PQSPVAQILGWPACS
T158 LGWPACSTPLPLVSR
S187 MAKRLWDSSQKEAGG
K203 GGNNGSRKMAKFSTP
K206 NGSRKMAKFSTPDLA
S245-p CVSGPSMsERTSPGT
S249 PSMsERTSPGTSSAY
S260 SSAYTSDSPSSYHNE
S263 YTSDSPSSYHNEEDE
S316 PEQVVLESHSRIRVR
K354 DEGDPSEKLELVTGT
T397 ASFFDRNTLANSCGT
S408 SCGTGIRSSTNDPRR
T410 GTGIRSSTNDPRRKP
H469 LPKTKPLHLVEGDNY
Y476 HLVEGDNYSSFISDT
K485 SFISDTGKIEPDMMS
S492 KIEPDMMSMEHSFET
S496 DMMSMEHSFETASHD
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