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PAK4 (human)

Overview PAK4 a protein kinase of the STE20 family. A mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Interacts specifically with the GTP-bound form of Cdc42 and weakly activates the JNK family of MAP kinases. Overexpressed in several cancers. Required for ras-dependent anchorage-independent growth of tumor cell lines. Four alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; STE group; STE20 family; PAKB subfamily Cellular Component: Golgi apparatus Molecular Function: protein serine/threonine kinase activity; ATP binding; protein kinase activity Biological Process: cell proliferation; cell migration; apoptosis; cytoskeleton organization and biogenesis; cell motility; cell cycle; signal transduction; cell growth Reference #:  O96013 (UniProtKB) Alt. Names/Synonyms: KIAA1142; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; PAK-4; PAK4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4 Gene Symbols: PAK4 Molecular weight: 64,072 Da Basal Isoelectric point: 9.76  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PAK4 2BVA - A/B=300-591 (human) 2CDZ - A=291-591 (human) 2J0I - A=291-591 (human) 2OV2 - I/J/K/L/M/N/O/P=10-44 (human) 2Q0N - A=291-591 (human) 2X4Z - A=296-591 (human) 4APP - A=300-591 (human) 4FIE - A/B=1-423 (human) 4FIF - A/B=1-318 D/C=49-56 (human) 4FIG - A/B=1-318 (human) 4FIH - A=1-318 (human) 4FII - A=1-318 B=49-56 (human) 4FIJ - A=1-318 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S474‑p enzymatic activity, induced: S474‑p intracellular localization: S474‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K31-u	GFDQHEQkFTGLPRQ
0	6		S41-p	GLPRQWQsLIEESAR
0	1		K51	EESARRPKPLVDPAC
0	4		S99-p	MSVTRSNsLRRDsPP
0	11		S104-p	SNsLRRDsPPPPARA
0	1		S142-p	RGRFAGHsEAGGGsG
0	4		S148-p	HsEAGGGsGDRRRAG
0	3		S167-p	PKSSREGsGGPQESS
0	20		S181-p	SRDKRPLsGPDVGtP
0	4		T187-p	LsGPDVGtPQPAGLA
0	1		S195-p	PQPAGLAsGAKLAAG
0	36		T207-p	AAGRPFNtyPRADTD
0	7		Y208-p	AGRPFNtyPRADTDH
0	6		S258-p	TRARGAPsPGVLGPH
0	8		S267-p	GVLGPHAsEPQLAPP
0	2		T277-p	QLAPPACtPAAPAVP
0	14		S291-p	PGPPGPRsPQREPQR
0	1		K455-a	LTHDGRVkLSDFGFC
0	1		K467-a	GFCAQVSkEVPRRKs
3	117		S474-p	kEVPRRKsLVGtPYW
0	11		T478-p	RRKsLVGtPYWMAPE
0	1		S488-p	WMAPELIsRLPYGPE
0	1		K546	HKVSPSLKGFLDRLL

	mouse
K31	GFDQHEQKFTGLPRQ
S41	GLPRQWQSLIEESAR
K51-u	EESARRPkPLIDPAC
S99-p	MSVTRSNsLRREsPP
S104-p	SNsLRREsPPPPARA
S142	RARATGHSEAGSGSG
S148	HSEAGSGSGDRRRVG
P167	PKSSRDGPGGPQEAS
S181-p	SRDKRPLsGPDVSTP
T187	LsGPDVSTPQPGSLT
S195	PQPGSLTSGTKLAAG
T207-p	AAGRPFNtYPRADTD
Y208	AGRPFNtYPRADTDH
S257-p	TRARGAPsPGVLGPH
S266-p	GVLGPHAsEPQLAPP
A276	QLAPPARALAAPAVP
S293-p	PGPPGPRsPQREPQR
K457	LTHDGRVKLSDFGFC
K469	GFCAQVSKEVPRRKs
S476-p	KEVPRRKsLVGtPYW
T480-p	RRKsLVGtPYWMAPE
S490	WMAPELISRLPYGPE
K548-u	HKASPSLkGFLDRLL

	rat
K31	GFDQHEQKFTGLPRQ
S41	GLPRQWQSLIEESAR
K51	EESARRPKPLIDPAC
S99-p	MSVTRSNsLRREsPP
S104-p	SNsLRREsPPPPARA
S142	RGRATGHSEAGSGSG
S148	HSEAGSGSGDRRRVG
P167	PKSSREGPGGPQEVS
S181	SRDKRPLSGPDVSTP
T187	LSGPDVSTPQPGSLA
S195	PQPGSLASETKLAAG
T207	AAGRPFNTYPRADTD
Y208	AGRPFNTYPRADTDH
S257	TRARGAPSPGVLGPH
S266	GVLGPHASEPQLAPP
A276	QLAPPARALAAPAVP
S293	PGPPGPRSPQREPQR
K457	LTHDGRVKLSDFGFC
K469	GFCAQVSKEVPRRKs
S476-p	KEVPRRKsLVGTPYW
T480	RRKsLVGTPYWMAPE
S490	WMAPELISRLPYGPE
K548	HKASPSLKGFLDRLL

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