a protein kinase of the STE20 family. A mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Interacts specifically with the GTP-bound form of Cdc42 and weakly activates the JNK family of MAP kinases. Overexpressed in several cancers. Required for ras-dependent anchorage-independent growth of tumor cell lines. Four alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKB subfamily
Molecular Function: protein serine/threonine kinase activity; protein binding; Rac GTPase binding; ATP binding; protein kinase activity
Biological Process: cell migration; apoptosis; regulation of mitotic cell cycle; cytoskeleton organization and biogenesis; signal transduction; cell cycle; Rho protein signal transduction; regulation of apoptosis; cell proliferation; regulation of MAPKKK cascade; activation of protein kinase activity; stress-activated protein kinase signaling pathway; cell motility; actin cytoskeleton organization and biogenesis; cell growth
Alt. Names/Synonyms: KIAA1142; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; PAK-4; PAK4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; Serine/threonine-protein kinase PAK 4
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.