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ZFP91 (human)

Overview ZFP91 Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: C2H2-type zinc finger protein; EC 6.3.2.- Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function: nucleic acid binding; zinc ion binding; ubiquitin-protein ligase activity Biological Process: activation of NF-kappaB-inducing kinase Reference #:  Q96JP5 (UniProtKB) Alt. Names/Synonyms: FKSG11; PZF; Zfp-91; ZFP91; Zinc finger protein 91 homolog; zinc finger protein 91 homolog (mouse); zinc finger protein homologous to Zfp91 in mouse; ZNF757 Gene Symbols: ZFP91 Molecular weight: 63,445 Da Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states

Select Structure to View Below ZFP91

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		P10	GETEEPRPPEQQDQE
0	3		Y76-p	SRRRKAEyPRRRRss
0	7		S82-p	EyPRRRRssPsARPP
0	22		S83-p	yPRRRRssPsARPPD
0	3		S85-p	RRRRssPsARPPDVP
0	4		S101-p	QQPQAAKsPsPVQGK
0	17		S103-p	PQAAKsPsPVQGKKs
0	3		S110-p	sPVQGKKsPRLLCIE
0	1		S149-p	SIAASRPsRGWRSSR
0	1		T157	RGWRSSRTSVSRHRD
0	1		S158	GWRSSRTSVSRHRDT
0	1		T165	SVSRHRDTENTRSSR
0	1		T168	RHRDTENTRSSRSKT
0	1		S170	RDTENTRSSRSKTGS
0	1		S171	DTENTRSSRSKTGSL
0	1		S250	TPKPRRKSGKVKEEK
0	1		S296-p	RRRKDDKsPRLPKRR
0	1		T320	CEMEGCGTVLAHPRY
0	1		K333-u	RYLQHHIkYQHLLKK
0	1		T367-p	LRHAKHHtDQRDYIC
0	3		T395-p	AVHRMIHtGEKPLQC
0	1		K438-a	SCNICGKkFEkkDSV
0	1		K441-a	ICGKkFEkkDSVVAH
0	1		K442-a	CGKkFEkkDSVVAHk
0	1		K449-a	kDSVVAHkAKSHPEV

	mouse
S10-p	GETEEPRsPEQQDQE
Y79-p	SRRRKAEyPRRRRss
S85-p	EyPRRRRssPsNRPP
S86-p	yPRRRRssPsNRPPD
S88-p	RRRRssPsNRPPDGP
P104	HQPAAAKPPsPAQGK
S106-p	PAAAKPPsPAQGKKS
S113	sPAQGKKSPRLQCIE
S150	SITTTRASRSWRSSS
T159-p	SWRSSSRtsISRLRD
S160-p	WRSSSRtsISRLRDs
S167-p	sISRLRDsENtRssR
T170-p	RLRDsENtRssRSKT
S172-p	RDsENtRssRSKTGS
S173-p	DsENtRssRSKTGSL
S252-p	TPKPRRKsGKVKEEK
S298	RRRKDDKSPRLPKRR
T322-p	CEMEGCGtVLAHPRY
K335	RYLQHHIKYQHLLKK
T369	LRHAKHHTDQRDYIC
T397	AVHRMIHTGEKPLQC
K440	SCNICGKKFEKKDSV
K443	ICGKKFEKKDSVVAH
K444	CGKKFEKKDSVVAHK
K451	KDSVVAHKAKSHPEV

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