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Protein Page:
ZFP91 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZFP91 Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: nucleus
Molecular Function: nucleic acid binding; metal ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: activation of NF-kappaB-inducing kinase
Reference #:  Q96JP5 (UniProtKB)
Alt. Names/Synonyms: FKSG11; PZF; Zfp-91; ZFP91; Zinc finger protein 91 homolog; zinc finger protein 91 homolog (mouse); zinc finger protein homologous to Zfp91 in mouse; ZNF757
Gene Symbols: ZFP91
Molecular weight: 63,445 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
Select Structure to View Below

ZFP91

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 P10 GETEEPRPPEQQDQE
0 1 A40 PPEAVAAAPAGTTSS
0 2 S69-p AAAAAAVsRRRKAEy
0 6 Y76-p sRRRKAEyPRRRRss
0 10 S82-p EyPRRRRssPsARPP
0 29 S83-p yPRRRRssPsARPPD
0 3 S85-p RRRRssPsARPPDVP
0 7 S101-p QQPQAAKsPsPVQGK
0 23 S103-p PQAAKsPsPVQGKKs
0 3 S110-p sPVQGKKsPRLLCIE
0 2 S149-p SIAASRPsRGWRSSR
0 1 T157 RGWRSSRTSVSRHRD
0 1 S158 GWRSSRTSVSRHRDT
0 1 T165 SVSRHRDTENTRSSR
0 1 T168 RHRDTENTRSSRSkT
0 1 S170 RDTENTRSSRSkTGs
0 1 S171 DTENTRSSRSkTGsL
0 1 K174-m1 NTRSSRSkTGsLQLI
0 1 S177-p SSRSkTGsLQLICKS
0 1 T243-p KPHLEREtPKPRRKS
0 1 S250 tPKPRRKSGKVKEEK
0 2 S296-p RRRKDDKsPRLPKRR
0 1 T320 CEMEGCGTVLAHPRY
0 1 K333-ub RYLQHHIkYQHLLKK
0 1 T367-p LRHAKHHtDQRDYIC
0 5 T395-p AVHRMIHtGEKPLQC
0 1 S414-p FTCRQKAsLNWHMKK
0 1 K438-ac SCNICGKkFEkkDSV
0 1 K441-ac ICGKkFEkkDSVVAH
0 1 K442-ac CGKkFEkkDSVVAHk
0 1 K449-ac kDSVVAHkAKSHPEV
  ZFP91 iso2  
P10 GETEEPRPPEQQDQE
A40 PPEAVAAAPAGTTSS
S69 AAAAAAVSRRRKAEY
Y76 SRRRKAEYPRRRRSS
S82 EYPRRRRSSPSARPP
S83 YPRRRRSSPSARPPD
S85 RRRRSSPSARPPDVP
S101 QQPQAAKSPSPVQGK
S103 PQAAKSPSPVQGKKS
S110 SPVQGKKSPRLLCIE
S149 SIAASRPSRGWRSSR
T157 RGWRSSRTSVSRHRD
S158 GWRSSRTSVSRHRDT
T165 SVSRHRDTENTRSSR
T168 RHRDTENTRSSRSKT
S170 RDTENTRSSRSKTGS
S171 DTENTRSSRSKTGSL
K174 NTRSSRSKTGSLQLI
S177 SSRSKTGSLQLICKS
T243 KPHLERETPKPRRKS
S250 TPKPRRKSGKVKEEK
S296 RRRKDDKSPRLPKRR
T320 CEMEGCGTVLAHPRY
K333 RYLQHHIKYQHLLKK
T367 LRHAKHHTDQRDYIC
T395 AVHRMIHTGEKPLQC
S414 FTCRQKASLNWHMKK
K438 SCNICGKKFEKKDSV
K441 ICGKKFEKKDSVVAH
K442 CGKKFEKKDSVVAHK
K449 KDSVVAHKAKSHPEV
  mouse

 
S10-p GETEEPRsPEQQDQE
A41 GAAAAPAAPAETASS
S72 AAAAAAVSRRRKAEy
Y79-p SRRRKAEyPRRRRss
S85-p EyPRRRRssPsNRPP
S86-p yPRRRRssPsNRPPD
S88-p RRRRssPsNRPPDGP
P104 HQPAAAKPPsPAQGK
S106-p PAAAKPPsPAQGKKS
S113 sPAQGKKSPRLQCIE
S150 SITTTRASRSWRSSS
T159-p SWRSSSRtsISRLRD
S160-p WRSSSRtsISRLRDs
S167-p sISRLRDsENtRssR
T170-p RLRDsENtRssRSKT
S172-p RDsENtRssRSKTGS
S173-p DsENtRssRSKTGSL
K176 NtRssRSKTGSLQLV
S179 ssRSKTGSLQLVCKT
T245 KPHLERETPKPRRKs
S252-p TPKPRRKsGKVKEEK
S298 RRRKDDKSPRLPKRR
T322-p CEMEGCGtVLAHPRY
K335 RYLQHHIKYQHLLKK
T369 LRHAKHHTDQRDYIC
T397 AVHRMIHTGEKPLQC
S416 FTCRQKASLNWHMKK
K440 SCNICGKKFEKKDSV
K443 ICGKKFEKKDSVVAH
K444 CGKKFEKKDSVVAHK
K451 KDSVVAHKAKSHPEV
  rat

 
S10-p GETEEPRsPEQQDQE
K40-ac SGVAAAAkPAETASS
S69 AAAAAAVSRRRKAEY
Y76 SRRRKAEYPRRRRSS
S82 EYPRRRRSSPSNRPP
S83 YPRRRRSSPSNRPPD
S85 RRRRSSPSNRPPDGH
P101 HQPAAAKPPSPAQGK
S103 PAAAKPPSPAQGKKS
S110 SPAQGKKSPRLQCIE
S149 TATRPSRSWRSSSRT
T156 SWRSSSRTSISRLRD
S157 WRSSSRTSISRLRDS
S164 SISRLRDSENTRSSR
T167 RLRDSENTRSSRSKT
S169 RDSENTRSSRSKTGS
S170 DSENTRSSRSKTGSL
K173 NTRSSRSKTGSLQLV
S176 SSRSKTGSLQLVCKT
T241 KPHLERETPKPRRKS
S248 TPKPRRKSGKVKEEK
S294 RRRKDDKSPRLPKRR
T318 CEMEGCGTVLAHPRY
K331 RYLQHHIKYQHLLKK
T365 LRHAKHHTDQRDYIC
T393 AVHRMIHTGEKPLQC
S412 FTCRQKASLNWHMKK
K436 SCNICGKKFEKKDSV
K439 ICGKKFEKKDSVVAH
K440 CGKKFEKKDSVVAHK
K447 KDSVVAHKAKSHPEV
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