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Protein Page:
PAK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PAK3 a protein kinase of the STE20 family that regulates synapse formation and plasticity in the hippocampus. May be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Forms an activated complex with GTP-bound P21, CDC2 and RAC1 proteins. Missense and truncation mutations linked to nonsyndromic mental retardation type 30 (MRX30). Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.; Kinase, protein; Protein kinase, STE; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKA subfamily
Cellular Component: cytoplasm
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; Rho GTPase binding; metal ion binding; SH3 domain binding; ATP binding
Biological Process: regulation of actin filament polymerization; axonogenesis; activation of MAPK activity; MAPKKK cascade; dendrite development; synapse organization and biogenesis; protein amino acid phosphorylation
Reference #:  O75914 (UniProtKB)
Alt. Names/Synonyms: Beta-PAK; bPAK; CDKN1A; hPAK3; MRX30; MRX47; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; PAK-3; PAK3; PAK3beta; Serine/threonine-protein kinase PAK 3
Gene Symbols: PAK3
Molecular weight: 62,310 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PAK3

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S50‑p, S154‑p, S259‑p, T436‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K45 APEEKNKKARLRsIF
2 1 S50-p NKKARLRsIFPGGGD
0 1 K58-ub IFPGGGDktNKkKEK
0 1 T59-p FPGGGDktNKkKEKE
0 1 K62-ub GGDktNKkKEKERPE
0 1 T119 QWARLLQTSNITKLE
0 1 K139 QAVLDVLKFYDSKET
3 3 S154-p VNNQKYMsFTSGDKS
0 9 S186 PPLAPPVSEEEDEEE
0 1 T218-p EHTKSIYtRSVVESI
0 1 K257-ac RNTDRQRkKsKMTDE
1 0 S259-p TDRQRkKsKMTDEEI
0 1 K269-ac TDEEILEkLRSIVSV
0 1 Y298-p QGASGTVyTALDIAT
0 1 K433-ac QITPEQSkRstMVGt
0 10 K433-ub QITPEQSkRstMVGt
0 3 S435-p TPEQSkRstMVGtPY
3 11 T436-p PEQSkRstMVGtPYW
0 4 T440-p kRstMVGtPYWMAPE
0 8 K526-ub VDRRGSAkELLQHPF
0 1 S558-p KEAIKNSsR______
2606 : Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody
2601 : Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody
  PAK3 iso3  
K45 APEEKNKKARLRSIF
S50 NKKARLRSIFPGGGD
K58 IFPGGGDKTNKKKEK
T59 FPGGGDKTNKKKEKE
K62 GGDKTNKKKEKERPE
T140-p QWARLLQtSNITKLE
K160 QAVLDVLKFYDSKET
S175 VNNQKYMSFTSGDKS
S207 PPLAPPVSEEEDEEE
T239 EHTKSIYTRSVVESI
K278 RNTDRQRKKSKMTDE
S280 TDRQRKKSKMTDEEI
K290 TDEEILEKLRSIVSV
Y319 QGASGTVYTALDIAT
K454 QITPEQSKRSTMVGT
K454 QITPEQSKRSTMVGT
S456 TPEQSKRSTMVGTPY
T457 PEQSKRSTMVGTPYW
T461 KRSTMVGTPYWMAPE
K547 VDRRGSAKELLQHPF
S579 KEAIKNSSR______
2606 : Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody
2601 : Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody
  mouse

 
K45-ac APEEKNKkARLRSIF
S50 NKkARLRSIFPGGGD
K58 IFPGGGDKTNKKKEK
T59 FPGGGDKTNKKKEKE
K62 GGDKTNKKKEKERPE
T119 QWARLLQTSNITKLE
K139-ub QAVLDVLkFYDSKET
S154-p VNNQKYMsFTSGDKS
S186-p PPLAPPVsEEEDEEE
T218 EHTKSIYTRSVVESI
K257 RNTDRQRKKSKMTDE
S259 TDRQRKKSKMTDEEI
K269 TDEEILEKLRSIVSV
Y298 QGASGTVYTALDIAT
K433 QITPEQSKRstMVGt
K433 QITPEQSKRstMVGt
S435-p TPEQSKRstMVGtPY
T436-p PEQSKRstMVGtPYW
T440-p KRstMVGtPYWMAPE
K526 VDRRGSAKELLQHPF
S558 KEAIKNSSR______
2606 : Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody
2601 : Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody
  rat

 
K45 APEEKNKKARLRsIF
S50-p NKKARLRsIFPGGGD
K58 IFPGGGDKTNKKKEK
T59 FPGGGDKTNKKKEKE
K62 GGDKTNKKKEKERPE
T104 QWARLLQTSNITKLE
K124 QAVLDVLKFYDSKET
S139-p VNNQKYMsFTSGDKS
S171 PPLAPPVSEEEDEEE
T203 EHTKSIYTRSVVESI
K242 RNTDRQRKKSKMTDE
S244 TDRQRKKSKMTDEEI
K254 TDEEILEKLRSIVSV
Y283 QGASGTVYTALDIAT
K418 QITPEQSKRstMVGT
K418 QITPEQSKRstMVGT
S420-p TPEQSKRstMVGTPY
T421-p PEQSKRstMVGTPYW
T425 KRstMVGTPYWMAPE
K511 VDRRGSAKELLQHPF
S543 KEAIKNSSR______
2606 : Phospho-PAK1 (Ser144)/PAK2 (Ser141) Antibody
2601 : Phospho-PAK1 (Thr423)/PAK2 (Thr402) Antibody
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