a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); EC 126.96.36.199; STE group; STE20 family; PAKA subfamily
Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytosol
Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; Rac GTPase binding; protein tyrosine kinase activator activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: stimulatory C-type lectin receptor signaling pathway; axon guidance; viral reproduction; apoptosis; protein amino acid autophosphorylation; regulation of mitotic cell cycle; programmed cell death; signal transduction; T cell receptor signaling pathway; protein amino acid phosphorylation; Rho protein signal transduction; regulation of apoptosis; regulation of growth; small GTPase mediated signal transduction; stress-activated protein kinase signaling pathway; cell structure disassembly during apoptosis; cell migration; regulation of defense response to virus by virus; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; regulation of MAPKKK cascade; T cell costimulation; activation of protein kinase activity; negative regulation of protein kinase activity; innate immune response; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis; phosphorylation; negative regulation of apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.