a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; STE group; STE20 family; PAKA subfamily
Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; protein tyrosine kinase activator activity; protein kinase binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: axon guidance; viral reproduction; apoptosis; protein amino acid autophosphorylation; signal transduction; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of defense response to virus by virus; regulation of apoptosis; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of growth; T cell costimulation; negative regulation of protein kinase activity; innate immune response; mitotic cell cycle; vascular endothelial growth factor receptor signaling pathway; phosphorylation; negative regulation of apoptosis; cell structure disassembly during apoptosis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.