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PAK2 (human)

Overview PAK2 a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; PAKA subfamily Cellular Component: perinuclear region of cytoplasm; plasma membrane; nucleus; cytosol Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; protein tyrosine kinase activator activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: axon guidance; viral reproduction; apoptosis; protein amino acid autophosphorylation; signal transduction; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of defense response to virus by virus; regulation of apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-serine phosphorylation; regulation of growth; virus-host interaction; T cell costimulation; negative regulation of protein kinase activity; phosphorylation; negative regulation of apoptosis; cell structure disassembly during apoptosis Reference #:  Q13177 (UniProtKB) Alt. Names/Synonyms: C-t-PAK2; Gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p27; p34; p58; PAK-2; PAK-2p27; PAK-2p34; PAK2; PAK65; PAKgamma; S6/H4 kinase; Serine/threonine-protein kinase PAK 2 Gene Symbols: PAK2 Molecular weight: 58,043 Da Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation  |  Regulation of Microtubule Dynamics  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PAK2 3PCS - H/F/G/E=121-136 (human) Substrate Sequence Logo

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	Sites Implicated In
enzymatic activity, induced: S141‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	13		S2-p	______MsDNGELED
1	12		S19-p	PAPPVRMsstIFstG
4	96		S20-p	APPVRMsstIFstGG
0	13		T21-p	PPVRMsstIFstGGK
0	1		S24-p	RMsstIFstGGKDPL
0	1		T25-p	MsstIFstGGKDPLs
0	5		S32-p	tGGKDPLsANHsLkP
0	12		S36-p	DPLsANHsLkPLPsV
0	3		K38-a	LsANHsLkPLPsVPE
0	24		S42-p	HsLkPLPsVPEEKKP
0	1		K52-u	EEKKPRHkIIsIFsG
1	2		S55-p	KPRHkIIsIFsGtEk
0	2		S58-p	HkIIsIFsGtEkGSK
0	1		T60-p	IIsIFsGtEkGSKKK
0	3		K62-a	sIFsGtEkGSKKKEK
0	1		S64	FsGtEkGSKKKEKER
0	1		K128-a	QAVLDVLkFyDsNtV
1	126		Y130-p	VLDVLkFyDsNtVkQ
0	6		S132-p	DVLkFyDsNtVkQKy
0	6		T134-p	LkFyDsNtVkQKyLs
0	2		K136-u	FyDsNtVkQKyLsFt
0	30		Y139-p	sNtVkQKyLsFtPPE
6	108		S141-p	tVkQKyLsFtPPEKd
0	39		T143-p	kQKyLsFtPPEKdGF
0	1		D148-ca	sFtPPEKdGFPsGtP
0	11		S152-p	PEKdGFPsGtPALNA
0	9		T154-p	KdGFPsGtPALNAKG
0	4		A159	sGtPALNAKGTEAPA
1	0		P165	NAKGTEAPAVVtEEE
0	19		T169-p	TEAPAVVtEEEDDDE
5	0		S192-p	PRPDHTKsIytRsVI
0	13		Y194-p	PDHTKsIytRsVIDP
0	3		T195-p	DHTKsIytRsVIDPV
5	11		S197-p	TKsIytRsVIDPVPA
0	1		D212-ca	PVGDSHVdGAAKSLD
0	1		G213	VGDSHVdGAAKSLDK
0	1		T228-p	QKKKTKMtDEEIMEk
0	2		K235-u	tDEEIMEkLRTIVSI
0	2		Y252-p	PKKKYTRyEkIGQGA
0	1		K254-u	KKYTRyEkIGQGASG
0	1		K278-u	LGQEVAIkQINLQKQ
0	2		K299-u	INEILVMkELkNPNI
0	1		K302-u	ILVMkELkNPNIVNF
0	12		K370-u	QVIHRDIkSDNVLLG
0	1		S381-p	VLLGMEGsVKLTDFG
0	1		K399-a	QITPEQSkRstMVGt
0	10		K399-u	QITPEQSkRstMVGt
0	3		S401-p	TPEQSkRstMVGtPY
10	10		T402-p	PEQSkRstMVGtPYW
0	3		T406-p	kRstMVGtPYWMAPE
0	14		Y453-p	ENPLRALyLIATNGT
0	26		K468-u	PELQNPEkLSPIFRD
0	1		R474	EkLSPIFRDFLNRCL
0	1		R474	EkLSPIFRDFLNRCL
0	1		R479	IFRDFLNRCLEMDVE
0	1		R488	LEMDVEKRGSAkELL
0	1		K492-a	VEKRGSAkELLQHPF
0	8		K492-u	VEKRGSAkELLQHPF
0	1		S507-p	LKLAKPLsSLTPLIM

	mouse
S2-p	______MsDNGELED
S19	PAPPVRMSstIFSTG
S20-p	APPVRMSstIFSTGG
T21-p	PPVRMSstIFSTGGK
S24	RMSstIFSTGGKDPL
T25	MSstIFSTGGKDPLS
S32	TGGKDPLSANHSLKP
S36	DPLSANHSLKPLPsV
K38	LSANHSLKPLPsVPE
S42-p	HSLKPLPsVPEEKKP
K52	EEKKPRNKIIsIFSG
S55-p	KPRNKIIsIFSGTEK
S58	NKIIsIFSGTEKGsK
T60	IIsIFSGTEKGsKKK
K62	sIFSGTEKGsKKKEK
S64-p	FSGTEKGsKKKEKER
K128	QAVLDVLKFYDsNTV
Y130	VLDVLKFYDsNTVkQ
S132-p	DVLKFYDsNTVkQKy
T134	LKFYDsNTVkQKyLs
K136-u	FYDsNTVkQKyLsFt
Y139-p	sNTVkQKyLsFtPPE
S141-p	TVkQKyLsFtPPEKD
T143-p	kQKyLsFtPPEKDGF
D148	sFtPPEKDGFPsGtP
S152-p	PEKDGFPsGtPALNt
T154-p	KDGFPsGtPALNtKG
T159-p	sGtPALNtKGSETSA
S165	NtKGSETSAVVTEED
T169	SETSAVVTEEDDDDE
S192-p	PRPDHTKsIYTRsVI
Y194	PDHTKsIYTRsVIDP
T195	DHTKsIYTRsVIDPI
S197-p	TKsIYTRsVIDPIPA
D212	PVGDSNVDsGAKSSD
S213-p	VGDSNVDsGAKSSDK
T228	QKKKAKMTDEEIMEk
K235-u	TDEEIMEkLRTIVSI
Y252-p	PKKKYTRyEKIGQGA
K254	KKYTRyEKIGQGASG
K278	LGQEVAIKQINLQKQ
K299	INEILVMKELKNPNI
K302	ILVMKELKNPNIVNF
K370-u	QVIHRDIkSDNVLLG
S381	VLLGMEGSVKLTDFG
K399	QITPEQSKRstMVGt
K399	QITPEQSKRstMVGt
S401-p	TPEQSKRstMVGtPY
T402-p	PEQSKRstMVGtPYW
T406-p	KRstMVGtPYWMAPE
Y453	ENPLRALYLIATNGT
K468	PELQNPEKLSPIFrD
R474-m2	EKLSPIFrDFLNRCL
R474	EKLSPIFRDFLNRCL
R479	IFrDFLNRCLEMDVE
R488	LEMDVEKRGSAKELL
K492	VEKRGSAKELLQHPF
K492	VEKRGSAKELLQHPF
S507	LKLAKPLSSLTPLIL

	rat
S2	______MSDNGELED
S19	PAPPVRMSSTIFSTG
S20	APPVRMSSTIFSTGG
T21	PPVRMSSTIFSTGGK
S24	RMSSTIFSTGGKDPL
T25	MSSTIFSTGGKDPLS
S32	TGGKDPLSANHSLKP
S36	DPLSANHSLKPLPSV
K38	LSANHSLKPLPSVPE
S42	HSLKPLPSVPEEKKP
K52	EEKKPRNKIISIFSS
S55	KPRNKIISIFSSTEK
S58	NKIISIFSSTEKGSK
T60	IISIFSSTEKGSKKK
K62	SIFSSTEKGSKKKEK
S64	FSSTEKGSKKKEKER
K128	QAVLDVLKFYDSNTV
Y130	VLDVLKFYDSNTVKQ
S132	DVLKFYDSNTVKQKy
T134	LKFYDSNTVKQKyLs
K136	FYDSNTVKQKyLsFt
Y139-p	SNTVKQKyLsFtPPE
S141-p	TVKQKyLsFtPPEKD
T143-p	KQKyLsFtPPEKDGF
D148	sFtPPEKDGFPsGtP
S152-p	PEKDGFPsGtPALNT
T154-p	KDGFPsGtPALNTKG
T159	sGtPALNTKGSETSA
S165	NTKGSETSAVVTEED
T169	SETSAVVTEEDDDDE
S192	PRPDHTKSIYTRsVI
Y194	PDHTKSIYTRsVIDP
T195	DHTKSIYTRsVIDPI
S197-p	TKSIYTRsVIDPIPA
D212	PVGDSNVDSGAKSSD
S213	VGDSNVDSGAKSSDK
T228	QKKKAKMTDEEIMEK
K235	TDEEIMEKLRTIVSI
Y252	PKKKYTRYEKIGQGA
K254	KKYTRYEKIGQGASG
K278	LGQEVAIKQINLQKQ
K299	INEILVMKELKNPNI
K302	ILVMKELKNPNIVNF
K370	QVIHRDIKSDNVLLG
S381	VLLGMEGSVKLTDFG
K399	QITPEQSKRstMVGT
K399	QITPEQSKRstMVGT
S401-p	TPEQSKRstMVGTPY
T402-p	PEQSKRstMVGTPYW
T406	KRstMVGTPYWMAPE
Y453	ENPLRALYLIATNGT
K468	PELQNPEKLSPIFrD
R474	EKLSPIFRDFLNrCL
R474-m1	EKLSPIFrDFLNrCL
R479-m1	IFrDFLNrCLEMDVE
R488-m1	LEMDVEKrGSAKELL
K492	VEKrGSAKELLQHPF
K492	VEKrGSAKELLQHPF
S507	LKLAKPLSSLTPLIL

	rabbit
S2	______MSDNGELED
S19-p	PAPPVRMssTIFSTG
S20-p	APPVRMssTIFSTGG
T21	PPVRMssTIFSTGGK
S24	RMssTIFSTGGKDPL
T25	MssTIFSTGGKDPLS
S32	TGGKDPLSANHSLKP
S36	DPLSANHSLKPLPSV
K38	LSANHSLKPLPSVPE
S42	HSLKPLPSVPEEKKP
K52	EEKKPRNKIIsIFSG
S55-p	KPRNKIIsIFSGTEK
S58	NKIIsIFSGTEKGSK
T60	IIsIFSGTEKGSKKK
K62	sIFSGTEKGSKKKEK
S64	FSGTEKGSKKKEKER
K128	QAVLDVLKFYDSNTV
Y130	VLDVLKFYDSNTVKQ
S132	DVLKFYDSNTVKQKY
T134	LKFYDSNTVKQKYLs
K136	FYDSNTVKQKYLsFT
Y139	SNTVKQKYLsFTPPE
S141-p	TVKQKYLsFTPPEKD
T143	KQKYLsFTPPEKDGF
D148	sFTPPEKDGFPSGAP
S152	PEKDGFPSGAPALNT
A154	KDGFPSGAPALNTKV
T159	SGAPALNTKVSETsA
S165-p	NTKVSETsAVVTEED
T169	SETsAVVTEEDDDDE
S192-p	PRPDHTKsIYTRsVI
Y194	PDHTKsIYTRsVIDP
T195	DHTKsIYTRsVIDPI
S197-p	TKsIYTRsVIDPIPA
D212	PVGDSHVDSGAKSSD
S213	VGDSHVDSGAKSSDK
T228	QKKKTKMTDEEIMEK
K235	TDEEIMEKLRTIVSI
Y252	PKKKYTRYEKIGQGA
K254	KKYTRYEKIGQGASG
K278	LGQEVAIKQINLQKQ
K299	INEILVMKELKNPNI
K302	ILVMKELKNPNIVNF
K370	QVIHRDIKSDNVLLG
S381	VLLGMEGSVKLTDFG
K399	QITPEQSKRStMVGT
K399	QITPEQSKRStMVGT
S401	TPEQSKRStMVGTPY
T402-p	PEQSKRStMVGTPYW
T406	KRStMVGTPYWMAPE
Y453	ENPLRALYLIATNGT
K468	PELQNPEKLSPIFRD
R474	EKLSPIFRDFLNRCL
R474	EKLSPIFRDFLNRCL
R479	IFRDFLNRCLEMDVE
R488	LEMDVEKRGSAKELL
K492	VEKRGSAKELLQHPF
K492	VEKRGSAKELLQHPF
S507	LKLAKPLSSLTPLIM

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