a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; PAKA subfamily
Molecular Function: collagen binding; protein serine/threonine kinase activity; protein binding; protein kinase binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: axon guidance; positive regulation of JNK activity; exocytosis; wound healing; apoptosis; protein amino acid autophosphorylation; positive regulation of estrogen receptor signaling pathway; MAPKKK cascade; T cell receptor signaling pathway; receptor clustering; positive regulation of peptidyl-serine phosphorylation; protein amino acid phosphorylation; branching morphogenesis of a tube; cellular response to insulin stimulus; axonogenesis; T cell costimulation; positive regulation of stress fiber formation; actin cytoskeleton reorganization; response to hypoxia; dendrite development; innate immune response; mitotic cell cycle; positive regulation of protein amino acid phosphorylation; neuromuscular junction development; neurite morphogenesis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.