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Protein Page:
SSH1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SSH1 a dual-specificity phosphatase of the Slingshot family involved in actin reorganization. Its calcineurin-dependent activation dephosphorylates cofilin. Plays a role in later stages of mitosis by dephosphorylating and activating cofilin. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16
Cellular Component: cytoskeleton; lamellipodium; cytoplasm; plasma membrane; nucleolus; midbody; nucleus; cleavage furrow
Molecular Function: protein binding; DNA binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; actin binding; phosphoprotein phosphatase activity
Biological Process: regulation of cellular protein metabolic process; regulation of actin polymerization and/or depolymerization; cell morphogenesis; protein amino acid dephosphorylation; actin cytoskeleton organization and biogenesis; regulation of axonogenesis
Reference #:  Q8WYL5 (UniProtKB)
Alt. Names/Synonyms: FLJ21928; FLJ38102; hSSH-1L; KIAA1298; Protein phosphatase Slingshot homolog 1; slingshot 1; slingshot homolog 1 (Drosophila); SSH-1L; SSH-like protein 1; SSH1; SSH1L
Gene Symbols: SSH1
Molecular weight: 115,511 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SSH1

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S402‑p, S937‑p, S978‑p
activity, inhibited: S937‑p, S978‑p
enzymatic activity, inhibited: S402‑p
intracellular localization: S937‑p, S978‑p
molecular association, regulation: S402‑p, S937‑p, S978‑p
phosphorylation: S978‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T5-p ___MALVtLQRsPtP
0 1 S9-p ALVtLQRsPtPSAAS
0 1 T11-p VtLQRsPtPSAASSS
0 1 S22 ASSSASNSELEAGSE
0 1 S28 NSELEAGSEEDRKLN
0 1 S37-p EDRKLNLsLSESFFM
0 3 S57-p LFLQQGSsPQGQRSL
0 1 K274 DLENVTSKEIRNELE
0 1 S325 LGSEWNASNLEELQG
1 8 S402-p MGVSRSAstVIAYAM
0 5 T403-p GVSRSAstVIAYAMK
0 1 S428-p NYVKQKRsItRPNAG
0 1 T430-p VKQKRsItRPNAGFM
0 3 S441-p AGFMRQLsEyEGILD
0 1 Y443-p FMRQLsEyEGILDAS
0 2 T462-p NKLWRQQtDssLQQP
0 2 S464-p LWRQQtDssLQQPVD
0 2 S465-p WRQQtDssLQQPVDD
0 7 S515-p PCCFRRLsDPLLPsP
0 1 S521-p LsDPLLPsPEDEtGS
0 1 T526-p LPsPEDEtGSLVHLE
0 5 S576-p KKKLEFGsPKGRSGS
0 1 - gap
0 1 S583 sPKGRSGSLLQVEEt
0 1 T590-p SLLQVEEtEREEGLG
0 3 G595 EEtEREEGLGAGRWG
0 41 P605 AGRWGQLPTQLDQNL
0 3 T606 GRWGQLPTQLDQNLL
0 2 N611 LPTQLDQNLLNSENL
0 1 - gap
0 1 S645-p ILNKVKPsyKSCADC
0 1 Y646-p LNKVKPsyKSCADCM
0 1 K647 NKVKPsyKSCADCMY
1 1 S834-p KELERLKsVPADPAP
0 3 S854-p PASRLEAsIPEESQD
0 1 S894-p PASLEGGsLKsPPPF
0 3 S897-p LEGGsLKsPPPFFYR
0 1 T908-p FFYRLDHtSSFSKDF
0 1 T933-p SSMSSNLtRssssDs
0 4 S935-p MSSNLtRssssDsIH
0 10 S936-p SSNLtRssssDsIHS
3 21 S937-p SNLtRssssDsIHSV
0 1 S938-p NLtRssssDsIHSVR
0 1 S940-p tRssssDsIHSVRGK
0 1 K952-ac RGKPGLVkQRTQEIE
0 2 S971-p LAGLTVSsPLKRSHs
8 0 S978-p sPLKRSHsLAKLGSL
0 2 T1021-p FLHEPQGtPRDPAAT
0 2 S1042-p PAPENLKsPSWMSKS
  SSH1 iso2  
T5 ___MALVTLQRSPTP
S9 ALVTLQRSPTPSAAS
T11 VTLQRSPTPSAASSS
S22 ASSSASNSELEAGSE
S28 NSELEAGSEEDRKLN
S37 EDRKLNLSLSESFFM
S57 LFLQQGSSPQGQRSL
K274 DLENVTSKEIRNELE
S325 LGSEWNASNLEELQG
S402 MGVSRSASTVIAYAM
T403 GVSRSASTVIAYAMK
S428 NYVKQKRSITRPNAG
T430 VKQKRSITRPNAGFM
S441 AGFMRQLSEYEGILD
Y443 FMRQLSEYEGILDAS
T462 NKLWRQQTDSSLQQP
S464 LWRQQTDSSLQQPVD
S465 WRQQTDSSLQQPVDD
S515 PCCFRRLSDPLLPSP
S521 LSDPLLPSPEDETGS
T526 LPSPEDETGSLVHLE
S576 KKKLEFGSPKGRSGS
- gap
S583 SPKGRSGSLLQVEET
T590 SLLQVEETEREEGLG
G595 EETEREEGLGAGRWG
P605 AGRWGQLPTQLDQNL
T606 GRWGQLPTQLDQNLL
N611 LPTQLDQNLLNSENL
S644-p PAGWHTPsLPSHSNW
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  SSH1 iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S90 MGVSRSASTVIAYAM
T91 GVSRSASTVIAYAMK
S116 NYVKQKRSITRPNAG
T118 VKQKRSITRPNAGFM
S129 AGFMRQLSEYEGILD
Y131 FMRQLSEYEGILDAS
T150 NKLWRQQTDSSLQQP
S152 LWRQQTDSSLQQPVD
S153 WRQQTDSSLQQPVDD
S203 PCCFRRLSDPLLPSP
S209 LSDPLLPSPEDETGS
T214 LPSPEDETGSLVHLE
S264 KKKLEFGSPKGRSGS
- gap
S271 SPKGRSGSLLQVEET
T278 SLLQVEETEREEGLG
G283 EETEREEGLGAGRWG
P293 AGRWGQLPTQLDQNL
T294 GRWGQLPTQLDQNLL
N299 LPTQLDQNLLNSENL
- gap
S333 ILNKVKPSYKSCADC
Y334 LNKVKPSYKSCADCM
K335 NKVKPSYKSCADCMY
S522 KELERLKSVPADPAP
S542 PASRLEASIPEESQD
S582 PASLEGGSLKSPPPF
S585 LEGGSLKSPPPFFYR
T596 FFYRLDHTSSFSKDF
T621 SSMSSNLTRSSSSDS
S623 MSSNLTRSSSSDSIH
S624 SSNLTRSSSSDSIHS
S625 SNLTRSSSSDSIHSV
S626 NLTRSSSSDSIHSVR
S628 TRSSSSDSIHSVRGK
K640 RGKPGLVKQRTQEIE
S659 LAGLTVSSPLKRSHS
S666 SPLKRSHSLAKLGSL
T709 FLHEPQGTPRDPAAT
S730 PAPENLKSPSWMSKS
  mouse

 
T5 ___MALVTLQRSPTP
S9 ALVTLQRSPTPSAAS
T11 VTLQRSPTPSAASSS
S22-p ASSSASNsELEAGsD
S28-p NsELEAGsDEERKLN
S37 EERKLNLSLSESFFM
S57-p LFLQQGNsPQGQRSL
K274-ac DLENVTSkEIRNELE
S325-p LGSEWNAsNLEELQG
S402 MGVSRSASTVIAYAM
T403 GVSRSASTVIAYAMK
S428 NYVKQKRSITRPNAG
T430 VKQKRSITRPNAGFM
S441 AGFMRQLSEYEGILD
Y443 FMRQLSEYEGILDAS
T463 KLWRQQPTDDTIAEP
- gap
- gap
S516-p PCCFRRLsDPLLLPH
P522 LsDPLLLPHHDETGG
T527 LLPHHDETGGLVHLE
- gap
S579-p RKLEFGNsKPRSDsL
S585-p NsKPRSDsLPQVEEL
L592 sLPQVEELEKDGsPR
S597-p EELEKDGsPRTGRWR
S607-p TGRWRRAstQLDRsL
T608-p GRWRRAstQLDRsLL
S613-p AstQLDRsLLDQENL
- gap
P648 ILSKVKPPYtSCADC
Y649 LSKVKPPYtSCADCM
T650-p SKVKPPYtSCADCMY
S837 KELERLKSLPSDSPA
S857 ATCRLEASIPEEGSQ
- gap
S889-p VGGTLQKsPTSTLPR
T900 TLPRLDHTSNFSKDF
T925 SSISSNLTRSssSDS
S927 ISSNLTRSssSDSIH
S928-p SSNLTRSssSDSIHS
S929-p SNLTRSssSDSIHSV
S930 NLTRSssSDSIHSVR
S932 TRSssSDSIHSVRGK
K944 RGKPGLVKQRAQEIE
S963 LAGLTVSSPLKRSHS
S970 SPLKRSHSLAKLGSL
A1014 FLPEPQSAPRDPAAT
S1035 SAPEHLKSPSRVNKS
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
S20 LFLQQGNSPQGQRSL
K237 DLENVTSKEIRNELE
S288 LGSEWNASNLEELQG
S365 MGVSRSASTVIAYAM
T366 GVSRSASTVIAYAMK
S391 NYVKQKRSITRPNAG
T393 VKQKRSITRPNAGFM
S404 AGFMRQLSEYEGILD
Y406 FMRQLSEYEGILDAS
A426 KLWRQQPADDTIAEP
- gap
- gap
S479 PCCFRRLSDPLLLPH
P485 LSDPLLLPHRDGAGG
A490 LLPHRDGAGGLVHLE
S540 KRKLEFGSPKARSGS
- gap
S547 SPKARSGSLPQVEEL
L554 SLPQVEELEKDGsPR
S559-p EELEKDGsPRPGRWR
S569-p PGRWRRAstQLERGL
T570-p GRWRRAstQLERGLL
G575 AstQLERGLLDQENL
- gap
P610 ILSKVKPPYTSCADC
Y611 LSKVKPPYTSCADCM
T612 SKVKPPYTSCADCMY
S798 KELERLKSLPSDSPS
S818 AASRLEASIPEEGQE
S846 EKPVGGASQKSPPPT
S849 VGGASQKSPPPTLLL
T861 LLLRLDHTSKDFSKD
T887 SSISSNLTRSSSSDS
S889 ISSNLTRSSSSDSIH
S890 SSNLTRSSSSDSIHS
S891 SNLTRSSSSDSIHSV
S892 NLTRSSSSDSIHSVR
S894 TRSSSSDSIHSVRGK
K906 RGKPGLVKQRAQEIE
S925 LAGLTVSSPLKRSHS
S932 SPLKRSHSLAKLGSL
A975 FLPEPQAAPRNPSAT
I996 SAPENLKIPVRVNKS
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