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Protein Page:
SSH1 (human)

Overview
SSH1 a dual-specificity phosphatase of the Slingshot family involved in actin reorganization. Its calcineurin-dependent activation dephosphorylates cofilin. Plays a role in later stages of mitosis by dephosphorylating and activating cofilin. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16
Cellular Component: cytoskeleton; lamellipodium; cytoplasm; plasma membrane; nucleolus; midbody; nucleus; cleavage furrow
Molecular Function: protein binding; DNA binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; actin binding; phosphoprotein phosphatase activity
Biological Process: regulation of cellular protein metabolic process; regulation of actin polymerization and/or depolymerization; cell morphogenesis; actin cytoskeleton organization and biogenesis; protein amino acid dephosphorylation; regulation of axonogenesis
Reference #:  Q8WYL5 (UniProtKB)
Alt. Names/Synonyms: FLJ21928; FLJ38102; hSSH-1L; KIAA1298; Protein phosphatase Slingshot homolog 1; slingshot 1; slingshot homolog 1 (Drosophila); SSH-1L; SSH-like protein 1; SSH1; SSH1L
Gene Symbols: SSH1
Molecular weight: 115,511 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SSH1

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S402‑p, S937‑p, S978‑p
activity, inhibited: S937‑p, S978‑p
enzymatic activity, inhibited: S402‑p
intracellular localization: S937‑p, S978‑p
molecular association, regulation: S402‑p, S937‑p, S978‑p
phosphorylation: S978‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T5-p ___MALVtLQRSPTP
0 1 S22 ASSSASNSELEAGSE
0 1 S28 NSELEAGSEEDRKLN
0 1 S37-p EDRKLNLsLSESFFM
0 2 S57-p LFLQQGSsPQGQRSL
1 8 S402-p MGVSRSAstVIAYAM
0 4 T403-p GVSRSAstVIAYAMK
0 2 S441-p AGFMRQLsEYEGILD
0 2 T462-p NKLWRQQtDssLQQP
0 2 S464-p LWRQQtDssLQQPVD
0 2 S465-p WRQQtDssLQQPVDD
0 5 S515-p PCCFRRLsDPLLPSP
0 4 S576-p KKKLEFGsPKGRSGS
0 1 - gap
0 1 S583 sPKGRSGSLLQVEET
0 3 - gap
0 41 - gap
0 3 T606 GRWGQLPTQLDQNLL
0 2 - gap
1 1 S834-p KELERLKsVPADPAP
0 3 S854-p PASRLEAsIPEESQD
0 1 S894-p PASLEGGsLKsPPPF
0 3 S897-p LEGGsLKsPPPFFYR
0 4 S935-p MSSNLTRsssSDsIH
0 10 S936-p SSNLTRsssSDsIHS
3 19 S937-p SNLTRsssSDsIHSV
0 1 S940-p TRsssSDsIHSVRGK
0 1 S971-p LAGLTVSsPLKRSHs
6 0 S978-p sPLKRSHsLAKLGSL
0 2 T1021-p FLHEPQGtPRDPAAT
0 2 S1042-p PAPENLKsPSWMSKS
  SSH1 iso2  
T5 ___MALVTLQRSPTP
S22 ASSSASNSELEAGSE
S28 NSELEAGSEEDRKLN
S37 EDRKLNLSLSESFFM
S57 LFLQQGSSPQGQRSL
S402 MGVSRSASTVIAYAM
T403 GVSRSASTVIAYAMK
S441 AGFMRQLSEYEGILD
T462 NKLWRQQTDSSLQQP
S464 LWRQQTDSSLQQPVD
S465 WRQQTDSSLQQPVDD
S515 PCCFRRLSDPLLPSP
S576 KKKLEFGSPKGRSGS
- gap
S583 SPKGRSGSLLQVEET
- gap
- gap
T606 GRWGQLPTQLDQNLL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  SSH1 iso4  
- gap
- gap
- gap
- gap
- gap
S90 MGVSRSASTVIAYAM
T91 GVSRSASTVIAYAMK
S129 AGFMRQLSEYEGILD
T150 NKLWRQQTDSSLQQP
S152 LWRQQTDSSLQQPVD
S153 WRQQTDSSLQQPVDD
S203 PCCFRRLSDPLLPSP
S264 KKKLEFGSPKGRSGS
- gap
S271 SPKGRSGSLLQVEET
- gap
- gap
T294 GRWGQLPTQLDQNLL
- gap
S522 KELERLKSVPADPAP
S542 PASRLEASIPEESQD
S582 PASLEGGSLKSPPPF
S585 LEGGSLKSPPPFFYR
S623 MSSNLTRSSSSDSIH
S624 SSNLTRSSSSDSIHS
S625 SNLTRSSSSDSIHSV
S628 TRSSSSDSIHSVRGK
S659 LAGLTVSSPLKRSHS
S666 SPLKRSHSLAKLGSL
T709 FLHEPQGTPRDPAAT
S730 PAPENLKSPSWMSKS
  mouse

 
T5 ___MALVTLQRSPTP
S22-p ASSSASNsELEAGsD
S28-p NsELEAGsDEERKLN
S37 EERKLNLSLSESFFM
S57-p LFLQQGNsPQGQRSL
S402 MGVSRSASTVIAYAM
T403 GVSRSASTVIAYAMK
S441 AGFMRQLSEYEGILD
- gap
- gap
- gap
S516-p PCCFRRLsDPLLLPH
- gap
S579-p RKLEFGNsKPRSDsL
S585-p NsKPRSDsLPQVEEL
S597-p EELEKDGsPRTGRWR
S607-p TGRWRRAstQLDRsL
T608-p GRWRRAstQLDRsLL
S613-p AstQLDRsLLDQENL
S837 KELERLKSLPSDSPA
S857 ATCRLEASIPEEGSQ
- gap
S889-p VGGTLQKsPTSTLPR
S927 ISSNLTRSssSDSIH
S928-p SSNLTRSssSDSIHS
S929-p SNLTRSssSDSIHSV
S932 TRSssSDSIHSVRGK
S963 LAGLTVSSPLKRSHS
S970 SPLKRSHSLAKLGSL
- gap
S1035 SAPEHLKSPSRVNKS
  rat

 
- gap
- gap
- gap
- gap
S20 LFLQQGNSPQGQRSL
S365 MGVSRSASTVIAYAM
T366 GVSRSASTVIAYAMK
S404 AGFMRQLSEYEGILD
- gap
- gap
- gap
S479 PCCFRRLSDPLLLPH
S540 KRKLEFGSPKARSGS
- gap
S547 SPKARSGSLPQVEEL
S559-p EELEKDGsPRPGRWR
S569-p PGRWRRAstQLERGL
T570-p GRWRRAstQLERGLL
G575 AstQLERGLLDQENL
S798 KELERLKSLPSDSPS
S818 AASRLEASIPEEGQE
S846 EKPVGGASQKSPPPT
S849 VGGASQKSPPPTLLL
S889 ISSNLTRSSSSDSIH
S890 SSNLTRSSSSDSIHS
S891 SNLTRSSSSDSIHSV
S894 TRSSSSDSIHSVRGK
S925 LAGLTVSSPLKRSHS
S932 SPLKRSHSLAKLGSL
- gap
- gap
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