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Protein Page:
SMARCC2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMARCC2 a core component of the BAF (SWI/SNF) complex. This family of complexes remodels chromatin structures, enabling transcription factors to gain access to DNA. They play important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling is due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain BAF53A and PHF10, are exchanged for homologous alternative BAF53B and BAF45B or BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. Component of 6 multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I), WINAC and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, BAF53A or BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. Component of the BAF (hSWI/SNF) complex, which includes at least actin (ACTB), ARID1A, ARID1B, SMARCA2, SMARCA4, BAF53A, BAF53B, SMARCE1 SMARCC1, SMARCC2, SMARCB1, and one or more of SMARCD1, SMARCD2, or SMARCD3. In muscle cells, the BAF complex also contains DPF3. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Ubiquitously expressed. Belongs to the SMARCC family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; DNA binding protein
Cellular Component: SWI/SNF complex; protein complex; transcriptional repressor complex; nuclear chromatin; nucleolus; nucleus
Molecular Function: protein binding; nucleosomal DNA binding; transcription coactivator activity
Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter; nervous system development; transcription, DNA-dependent; nucleosome disassembly; positive regulation of transcription, DNA-dependent; ATP-dependent chromatin remodeling; negative regulation of transcription, DNA-dependent
Reference #:  Q8TAQ2 (UniProtKB)
Alt. Names/Synonyms: BAF170; BRG1-associated factor 170; chromatin remodeling complex BAF170 subunit; CRACC2; DKFZp313D0632; mammalian chromatin remodeling complex BRG1-associated factor 170; Rsc8; SMARCC2; SMRC2; SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI3-like protein
Gene Symbols: SMARCC2
Molecular weight: 132,879 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMARCC2

Protein Structure Not Found.


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Sites Implicated In
chromatin organization, altered: S969‑p
molecular association, regulation: S969‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K33 NVRLWLGKNYKKYIQ
0 1 S69-p EVFGKHVsNAPLTKL
0 1 S102-p AAAYKFKsDQGWRRY
0 1 T230-p ASVEDAPtPEKPRKV
0 1 S273 VSRRKKISAktLTDE
0 1 K275-ub RRKKISAktLTDEVN
0 1 T276-p RKKISAktLTDEVNs
0 39 S283-p tLTDEVNsPDsDRRD
0 19 S286-p DEVNsPDsDRRDKKG
0 1 Y296-p RDKKGGNyKKRKRsP
0 50 S302-p NyKKRKRsPsPsPtP
0 47 S304-p KKRKRsPsPsPtPEA
0 22 S306-p RKRsPsPsPtPEAKK
0 30 T308-p RsPsPsPtPEAKKKN
0 3 S321-p KNAKKGPstPyTksK
0 30 T322-p NAKKGPstPyTksKR
0 4 Y324-p KKGPstPyTksKRGH
0 1 K326-ac GPstPyTksKRGHRE
0 1 S327-p PstPyTksKRGHREE
0 43 S347-p TKDMDEPsPVPNVEE
0 1 S369-p NTKKDSEsAPVKGGt
0 1 T376-p sAPVKGGtMtDLDEQ
0 7 T378-p PVKGGtMtDLDEQED
0 6 S387-p LDEQEDEsMEtTGKD
0 1 T390-p QEDEsMEtTGKDEDE
0 3 S399-p GKDEDENstGNKGEQ
0 2 T400-p KDEDENstGNKGEQT
0 5 T548-p LVPLQPKtPQQTsAs
0 1 S553-p PKtPQQTsAsQQMLN
0 3 S555-p tPQQTsAsQQMLNFP
0 1 K564-ub QMLNFPDkGKEkPTD
0 2 K568-ub FPDkGKEkPTDMQNF
0 1 T579-p MQNFGLRtDMytKKN
0 2 Y582-p FGLRtDMytKKNVPS
0 1 T583-p GLRtDMytKKNVPSK
0 3 K694-ub RVASAAAksALEEFS
0 1 S695-p VASAAAksALEEFSK
0 1 K704 LEEFSKMKEEVPTAL
0 1 T726-p VEEAAKVtGKADPAF
0 1 S738-p PAFGLESsGIAGTTS
0 1 K769-ac EGQATDEkKEPKEPR
0 1 K795-ac EKTSEAPkKDEEKGK
0 2 S806-p EKGKEGDsEKEsEKs
0 2 S810-p EGDsEKEsEKsDGDP
0 10 S813-p sEKEsEKsDGDPIVD
0 1 K825 IVDPEKEKEPKEGQE
0 2 S841-p VLKEVVEsEGERKTK
0 10 K872-ub ALAAAAVkAkHLAAV
0 23 K874-ub AAAAVkAkHLAAVEE
0 4 K897-ub LLVETQMkkLEIkLR
0 2 K898-ub LVETQMkkLEIkLRH
0 10 K902-ub QMkkLEIkLRHFEEL
0 2 K940-ub AFHMEQLkyAEMRAR
0 1 Y941-p FHMEQLkyAEMRARQ
1 0 S969-p PPALPPGsQPIPPTG
  SMARCC2 iso2  
K33 NVRLWLGKNYKKYIQ
S69 EVFGKHVSNAPLTKL
S102 AAAYKFKSDQGWRRY
T230 ASVEDAPTPEKPRKV
S273 VSRRKKISAKTLTDE
K275 RRKKISAKTLTDEVN
T276 RKKISAKTLTDEVNS
S283 TLTDEVNSPDSDRRD
S286 DEVNSPDSDRRDKKG
Y296 RDKKGGNYKKRKRSP
S302 NYKKRKRSPSPSPTP
S304 KKRKRSPSPSPTPEA
S306 RKRSPSPSPTPEAKK
T308 RSPSPSPTPEAKKKN
S321 KNAKKGPSTPYTKSK
T322 NAKKGPSTPYTKSKR
Y324 KKGPSTPYTKSKRGH
K326 GPSTPYTKSKRGHRE
S327 PSTPYTKSKRGHREE
S347 TKDMDEPSPVPNVEE
S369 NTKKDSESAPVKGGT
T376 SAPVKGGTMTDLDEQ
T378 PVKGGTMTDLDEQED
S387 LDEQEDESMETTGKD
T390 QEDESMETTGKDEDE
S399 GKDEDENSTGNKGEQ
T400 KDEDENSTGNKGEQT
T548 LVPLQPKTPQGRQVD
S584 GKPELQTSAsQQMLN
S586-p PELQTSAsQQMLNFP
K595 QMLNFPDKGKEKPTD
K599 FPDKGKEKPTDMQNF
T610 MQNFGLRTDMYTKKN
Y613 FGLRTDMYTKKNVPS
T614 GLRTDMYTKKNVPSK
K725 RVASAAAKSALEEFS
S726 VASAAAKSALEEFSK
K735 LEEFSKMKEEVPTAL
T757 VEEAAKVTGKADPAF
S769 PAFGLESSGIAGTTS
K800 EGQATDEKKEPKEPR
K826 EKTSEAPKKDEEKGK
S837 EKGKEGDSEKESEKS
S841 EGDSEKESEKSDGDP
S844 SEKESEKSDGDPIVD
K856 IVDPEKEKEPKEGQE
S872 VLKEVVESEGERKTK
K903 ALAAAAVKAKHLAAV
K905 AAAAVKAKHLAAVEE
K928 LLVETQMKKLEIKLR
K929 LVETQMKKLEIKLRH
K933 QMKKLEIKLRHFEEL
K971 AFHMEQLKYAEMRAR
Y972 FHMEQLKYAEMRARQ
S1000 PPALPPGSQPIPPTG
  mouse

 
K33-ub NVRLWLGkNYKKYIQ
S69 EVFGKHVSNAPLTKL
S102 AAAYKFKSDQGWRRY
T230 ASVEDAPTPEKPRKV
S273-p VSRRKKIsAKTLTDE
K275 RRKKIsAKTLTDEVN
T276 RKKIsAKTLTDEVNs
S283-p TLTDEVNsPDsDRRD
S286-p DEVNsPDsDRRDKKG
Y296 RDKKGGNYKKRKRsP
S302-p NYKKRKRsPsPsPtP
S304-p KKRKRsPsPsPtPEA
S306-p RKRsPsPsPtPEAKK
T308-p RsPsPsPtPEAKKKN
S321 KNAKKGPStPyTKSK
T322-p NAKKGPStPyTKSKR
Y324-p KKGPStPyTKSKRGH
K326 GPStPyTKSKRGHRE
S327 PStPyTKSKRGHREE
S347-p TKDMDEPsPVPNVEE
S369 NTKKDSESAPVKGGT
T376 SAPVKGGTMtDLDEQ
T378-p PVKGGTMtDLDEQDD
S387-p LDEQDDEsMETTGKD
T390 QDDEsMETTGKDEDE
S399-p GKDEDENsTGNKGEQ
T400 KDEDENsTGNKGEQT
P548 LVPLQPKPPQQSSAS
S553 PKPPQQSSASQQMLN
S555 PPQQSSASQQMLNFP
K564 QMLNFPEKGKEkPAD
K568-ub FPEKGKEkPADMQNF
T579 MQNFGLRTDMYTKKN
Y582 FGLRTDMYTKKNVPS
T583 GLRTDMYTKKNVPSK
K694-ub RVASAAAkSALEEFS
S695 VASAAAkSALEEFSK
K704-ub LEEFSKMkEEVPTAL
T726 VEEAAKVTGKADPAF
S738 PAFGLESSGIAGTAS
K769 EGQAADEKKEPKEPR
K795 EEISEVPKKDEEKGK
S806-p EKGKEGDsEKEsEKs
S810-p EGDsEKEsEKsDGDP
S813-p sEKEsEKsDGDPIVD
K825-ub IVDPEKDkEPTEGQE
P841 VLKEVAEPEGERKTK
K872-ub ALAAAAVkAkHLAAV
K874-ub AAAAVkAkHLAAVEE
K897 LLVETQMKKLEIKLR
K898 LVETQMKKLEIKLRH
K902 QMKKLEIKLRHFEEL
K940-ub AFHMEQLkYAEMRAR
Y941 FHMEQLkYAEMRARQ
S969 PPTLPPGSQPIPPTG
  rat

 
K33 NVRLWLGKNYKKYIQ
S69 EVFGKHVSNAPLTKL
S102 AAAYKFKSDQGWRRY
T230 ASVEDAPTPEKPRKV
S273 VSRRKKISAKTLTDE
K275 RRKKISAKTLTDEVN
T276 RKKISAKTLTDEVNs
S283-p TLTDEVNsPDADRRD
A286 DEVNsPDADRRDKKG
Y296 RDKKGGNYKKRKRsP
S302-p NYKKRKRsPsPSPtP
S304-p KKRKRsPsPSPtPEA
S306 RKRsPsPSPtPEAKK
T308-p RsPsPSPtPEAKKKN
S321 KNAKKGPSTPYTKSK
T322 NAKKGPSTPYTKSKR
Y324 KKGPSTPYTKSKRGH
K326 GPSTPYTKSKRGHRE
S327 PSTPYTKSKRGHREE
S347-p TKDMDEPsPVPNVEE
S369 NTKKDSESAPVKGGT
T376 SAPVKGGTMTDLDEQ
T378 PVKGGTMTDLDEQDD
S387 LDEQDDESMETTGKD
T390 QDDESMETTGKDEDE
S399 GKDEDENSTGNKGEQ
T400 KDEDENSTGNKGEQT
P548 LVPLQPKPPQGRQVD
S584 GKPELQGSASQQMLN
S586 PELQGSASQQMLNFP
K595 QMLNFPDKGKEKPAD
K599 FPDKGKEKPADMQNF
T610 MQNFGLRTDMYTKKN
Y613 FGLRTDMYTKKNIPS
T614 GLRTDMYTKKNIPSK
K725 RVASAAAKSALEEFS
S726 VASAAAKSALEEFSK
K735 LEEFSKMKEEVPTAL
T757 VEEAAKVTGKADPAF
S769 PAFGLESSGIAGTAS
K800-ac ESQAADEkKEPKEPR
K826 EEISEAPKKDEEKGK
S837-p EKGKEADsEKEsEKs
S841-p EADsEKEsEKsDGDP
S844-p sEKEsEKsDGDPIVD
K856 IVDPEKDKEPTEGQE
P872 GLKEVAEPEGERKAK
K903 ALAAAAVKAKHLAAV
K905 AAAAVKAKHLAAVEE
K928 LLVETQMKKLEIKLR
K929 LVETQMKKLEIKLRH
K933 QMKKLEIKLRHFEEL
K971 AFHMEQLKYAEMRAR
Y972 FHMEQLKYAEMRARQ
S1000 PPPLPPGSQPIPPTG
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