Home

SLC5A1 (human)

Overview SLC5A1 Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: brush border membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; intercellular junction Molecular Function: protein binding; glucose:sodium symporter activity Biological Process: hexose transport; carbohydrate metabolic process; glucose transport; transmembrane transport; intestinal absorption Reference #:  P13866 (UniProtKB) Alt. Names/Synonyms: D22S675; High affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter 1; NAGT; SC5A1; SGLT1; SLC5A1; Sodium/glucose cotransporter 1; solute carrier family 5 (sodium/glucose cotransporter), member 1; Solute carrier family 5 member 1; solute carrier family 5, member 1 Gene Symbols: SLC5A1 Molecular weight: 73,498 Da Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SLC5A1

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 182380 606824  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y236-p	YDAFMEKyMKAIPtI
0	1		T242-p	KyMKAIPtIVSDGNT
0	2		T271-p	HIFRDPLtGDLPWPG
0	1		S335-p	MVMPGMIsRILYTEK
0	1		S437-p	ILVLIGIsIAWVPIV
0	1		P584	EENIQEGPKEtIEIE
0	2		T587-p	IQEGPKEtIEIETQV
0	1		Y606-p	KGIFRRAyDLFCGLE
0	1		E622	HGAPKMTEEEEKAMK
0	1		K629	EEEEKAMKMKMTDTS
0	1		K631	EEKAMKMKMTDTSEK

	mouse
Y236	YEAFMDKYMKAIPTK
T242	KYMKAIPTKVSNGNF
T271	HIFRDPITGDMPWPG
S335	MVMPGMISRILYTEK
S437	ILVLIGISIAWVPIV
S585-p	EEDIPEDsKDtIEID
T588-p	IPEDsKDtIEIDTEA
Y607	KGCFRRAYDLFCGLD
K623-u	DKGPKMTkEEEEAMk
K630-u	kEEEEAMkMkMTDTS
K632-u	EEEAMkMkMTDTSEK

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.