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Protein Page:
SLC5A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC5A1 Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: brush border membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; intercellular junction
Molecular Function: protein binding; glucose:sodium symporter activity
Biological Process: hexose transport; sodium ion transport; carbohydrate metabolic process; glucose transport; transmembrane transport; intestinal absorption
Reference #:  P13866 (UniProtKB)
Alt. Names/Synonyms: D22S675; High affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter 1; NAGT; SC5A1; SGLT1; SLC5A1; Sodium/glucose cotransporter 1; solute carrier family 5 (sodium/glucose cotransporter), member 1; Solute carrier family 5 member 1; solute carrier family 5, member 1
Gene Symbols: SLC5A1
Molecular weight: 73,498 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC5A1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y236-p YDAFMEKyMKAIPtI
0 1 T242-p KyMKAIPtIVSDGNT
0 2 T271-p HIFRDPLtGDLPWPG
0 1 S335-p MVMPGMIsRILYTEK
0 1 S437-p ILVLIGIsIAWVPIV
0 1 P584 EENIQEGPKEtIEIE
0 2 T587-p IQEGPKEtIEIETQV
0 1 Y606-p KGIFRRAyDLFCGLE
0 1 E622 HGAPKMTEEEEKAMK
0 1 K629 EEEEKAMKMKMTDTS
0 1 K631 EEKAMKMKMTDTSEK
  mouse

 
Y236 YEAFMDKYMKAIPTK
T242 KYMKAIPTKVSNGNF
T271 HIFRDPITGDMPWPG
S335 MVMPGMISRILYTEK
S437 ILVLIGISIAWVPIV
S585-p EEDIPEDsKDtIEID
T588-p IPEDsKDtIEIDTEA
Y607 KGCFRRAYDLFCGLD
K623-ub DKGPKMTkEEEEAMk
K630-ub kEEEEAMkMkMTDTS
K632-ub EEEAMkMkMTDTSEK
  rat

 
Y236 YEAFMDKYMKAIPTL
T242 KYMKAIPTLVSDGNI
T271 HIFRDPITGDMPWPG
S335 MVMPGMISRILYTDK
S437 ILVLIGISIAWVPIV
P585 EEPVEEDPKDTIEID
T588 VEEDPKDTIEIDAEA
Y607 KGCFRKAYDLFCGLD
K623 DKGPKMTKEEEEAMK
K630 KEEEEAMKLKMTDTS
K632 EEEAMKLKMTDTSEK
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