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Protein Page:
SLC22A4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC22A4 Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial
Cellular Component: mitochondrion; integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: protein binding; cation:cation antiporter activity; symporter activity; carnitine transporter activity; nucleotide binding; secondary active organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding
Biological Process: triacylglycerol metabolic process; organic cation transport; quaternary ammonium group transport; sodium ion transport; carnitine metabolic process; body fluid secretion; transmembrane transport; carnitine transport
Reference #:  Q9H015 (UniProtKB)
Alt. Names/Synonyms: Ergothioneine transporter; ET transporter; ETT; integral membrane transport protein; MGC34546; MGC40524; OCTN1; Organic cation/carnitine transporter 1; S22A4; SLC22A4; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; Solute carrier family 22 member 4; UT2H
Gene Symbols: SLC22A4
Molecular weight: 62,155 Da
Basal Isoelectric point: 6.85  Predict pI for various phosphorylation states
Select Structure to View Below

SLC22A4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T88-p CSRYRLAtIANFsAL
0 1 S93-p LAtIANFsALGLEPG
0 1 K299 EAEDIIQKAAKMNNI
0 1 K302 DIIQKAAKMNNIAVP
0 1 S468-p VGVTSTAsRVGSIIA
0 1 R535 FRSGKKTRDSMETEE
0 2 S537 SGKKTRDSMETEENP
0 1 N543 DSMETEENPKVLITA
0 1 K545 METEENPKVLITAF_
  mouse

 
T88 CRRYRLATIANFSAM
S93 LATIANFSAMGLEPG
K299-ub EAEQIIQkAAkMNSI
K302-ub QIIQkAAkMNSIVAP
S470 VGITSMASRVGSIIA
- under review  
S539-p CGKKSTVsVDREEsP
S545-p VsVDREEsPkVLITA
K547-ub VDREEsPkVLITAF_
  rat

 
T88 CRRYRLATIANFSAL
S93 LATIANFSALGLEPG
K299 EAEQIIQKAAKMNGI
K302 QIIQKAAKMNGIMAP
S470 VGITSMASRVGSIIA
T537-p FRCGKKStVsMDREE
S539-p CGKKStVsMDREENP
N545 VsMDREENPKVLITA
K547 MDREENPKVLITAF_
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