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p70S6K
an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, AGC; Kinase, protein; Translation; EC 2.7.11.1; EC 2.7.11.-; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; p70 subfamily |
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Cellular Component: mitochondrial outer membrane; neuron projection; cell surface; mitochondrion; perinuclear region of cytoplasm; cytoplasm; synapse; cell junction; cytosol; nucleus
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Molecular Function: protein binding; ribosomal protein S6 kinase activity; peptide binding; ATP binding; protein kinase activity
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Biological Process: skeletal muscle contraction; TOR signaling pathway; response to glucagon stimulus; positive regulation of translation; apoptosis; positive regulation of smooth muscle cell proliferation; response to toxin; response to glucocorticoid stimulus; negative regulation of insulin receptor signaling pathway; response to lipopolysaccharide; positive regulation of smooth muscle cell migration; positive regulation of mitotic cell cycle; signal transduction; protein amino acid phosphorylation; germ cell development; positive regulation of translational initiation; skeletal muscle atrophy; response to glucose stimulus; protein kinase B signaling cascade; response to wounding; response to nutrient; aging; response to drug; cell migration; phosphoinositide-mediated signaling; response to electrical stimulus involved in regulation of muscle adaptation; response to testosterone stimulus; response to ethanol; response to leucine; long-term memory; response to mechanical stimulus; response to heat; insulin receptor signaling pathway; regulation of glucose import; positive regulation of skeletal muscle growth; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
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Reference #:
P23443 (UniProtKB)
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| Alt. Names/Synonyms: 70 kDa ribosomal protein S6 kinase 1; KS6B1; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70-S6K 1; P70S6K1; PS6K; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kDa, polypeptide 1; RPS6KB1; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A; STK14A |
| Gene Symbols: RPS6KB1 |
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Molecular weight: 59,140 Da
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Basal Isoelectric point: 6.21
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Angiogenesis
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Mitochondrial Control of Apoptosis
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mTOR Signaling
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PI3K/Akt Signaling
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Protein Kinase C Signaling
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TGF-ß Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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