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Protein Page:
PICH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PICH DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization. Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB.
Protein type: Helicase; EC 3.6.4.12
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: membrane; cytosol
Molecular Function: protein binding; DNA binding; helicase activity; ATP binding
Biological Process: mitosis; metabolic process; mitotic cell cycle
Reference #:  Q2NKX8 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; ERC6L; ERCC6L; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; excision repair protein ERCC6-like; FLJ20105; MGC131695; PICH; PLK1-interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ-HCC-15
Gene Symbols: ERCC6L
Molecular weight: 141,103 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PICH

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: T1063‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 10 S14-p FPEAEALsPEQAAHY
0 1 K48-m1 FKLFNLAkDIFPNEk
0 1 K55-ub kDIFPNEkVLSRIQK
0 1 K55-m1 kDIFPNEkVLSRIQK
0 1 T175-p TPGMRVKtFHGPsKD
0 1 S180-p VKtFHGPsKDERTRN
0 2 K312-ub GEKALGFkISENLMA
0 2 K364 EMPSLSRKNDLIIWI
0 1 S399-p ELLMETRsPLAELGV
0 1 T503-p LKNRHFKtLRIDGTV
0 1 Y618-p EKKNPFRyFSKQELR
0 1 S683 LMYTCDLSVKEELDV
0 1 S694 ELDVVEESHyIQQRV
0 8 Y696-p DVVEESHyIQQRVQK
0 1 S738-p LREPVFPssTKKKCP
0 1 S739-p REPVFPssTKKKCPK
0 1 P745 ssTKKKCPKLNKPQP
0 5 S755-p NKPQPQPsPLLstHH
0 2 S759-p PQPsPLLstHHtQEE
0 3 T760-p QPsPLLstHHtQEED
0 6 T763-p PLLstHHtQEEDIsS
0 1 S769-p HtQEEDIsSKMAsVV
0 6 S774-p DIsSKMAsVVIDDLP
0 1 S790-p EGEKQDLsSIKVNVt
0 1 T797-p sSIKVNVtTLQDGKG
0 4 T805-p TLQDGKGtGsADsIA
0 8 S807-p QDGKGtGsADsIAtL
0 8 S810-p KGtGsADsIAtLPkG
0 6 T813-p GsADsIAtLPkGFGs
0 1 K816-ub DsIAtLPkGFGsVEE
0 22 S820-p tLPkGFGsVEELCtN
0 2 T826-p GsVEELCtNssLGME
0 2 S828-p VEELCtNssLGMEKs
0 5 S829-p EELCtNssLGMEKsF
0 1 S835-p ssLGMEKsFAtKNEA
0 1 T838-p GMEKsFAtKNEAVQK
0 3 T847-p NEAVQKEtLQEGPKQ
0 7 G851 QKEtLQEGPKQEALQ
0 4 Q858 GPKQEALQEDPLEsF
0 11 S864-p LQEDPLEsFNyVLsK
0 34 Y867-p DPLEsFNyVLsKSTK
0 1 S870-p EsFNyVLsKSTKADI
0 1 S872 FNyVLsKSTKADIGP
0 3 D876 LsKSTKADIGPNLDQ
0 1 D886 PNLDQLKDDEILRHC
0 1 S945-p LEEEPSAsSPQYACD
0 2 S968-p ADNRQNFssQsLEHV
0 3 S969-p DNRQNFssQsLEHVE
0 3 S971-p RQNFssQsLEHVEKE
0 8 S980-p EHVEKENsLCGsAPN
0 1 - gap
0 3 S984-p KENsLCGsAPNsRAG
0 1 S988-p LCGsAPNsRAGFVHs
0 3 S995-p sRAGFVHsKtCLsWE
0 3 T997-p AGFVHsKtCLsWEFs
0 5 S1000-p VHsKtCLsWEFsEKD
0 1 F1003 KtCLsWEFsEKDDEP
0 7 S1004-p tCLsWEFsEKDDEPE
0 7 D1007 sWEFsEKDDEPEEVV
0 1 V1013 KDDEPEEVVVKAKIR
0 1 S1021 VVKAKIRSKARRIVs
0 76 S1028-p SKARRIVsDGEDEDD
0 2 S1036-p DGEDEDDsFKDtssI
0 2 T1040-p EDDsFKDtssINPFN
0 1 S1041-p DDsFKDtssINPFNT
0 2 S1042-p DsFKDtssINPFNTS
0 2 P1045 KDtssINPFNTSLFQ
0 5 S1049 sINPFNTSLFQFSSV
0 1 S1062-p SVKQFDAstPKNDIs
1 6 T1063-p VKQFDAstPKNDIsP
0 1 N1066 FDAstPKNDIsPPGR
0 25 S1069-p stPKNDIsPPGRFFs
0 4 S1076-p sPPGRFFssQIPssV
0 2 S1077-p PPGRFFssQIPssVN
0 2 I1079 GRFFssQIPssVNKs
0 2 S1081-p FFssQIPssVNKsMN
0 3 S1082-p FssQIPssVNKsMNs
0 1 S1086-p IPssVNKsMNsRRSL
0 1 S1089-p sVNKsMNsRRSLASR
0 12 S1098-p RSLASRRsLINMVLD
0 2 S1117-p MEERLDDsSEAKGPE
0 3 S1118 EERLDDsSEAKGPED
0 1 S1134-p PEEGVEEssGEASKY
0 2 S1135-p EEGVEEssGEASKYT
0 1 S1153-p PSGETLSsENkSSWL
0 1 K1156-m1 ETLSsENkSSWLMTS
0 2 S1181-p LGAPEPLsGEQLVGs
0 1 G1182 GAPEPLsGEQLVGsP
0 4 S1188-p sGEQLVGsPQDKAAE
0 6 Y1200-p AAEATNDyETLVKRG
0 1 T1202 EATNDyETLVKRGKE
0 2 S1242-p EVMLLTLsLYKQLNN
  mouse

 
S14 LAEVETLSPQLAESY
K48 LKLFNLAKDIFPTKK
K55 KDIFPTKKVMSRIQK
K55 KDIFPTKKVMSRIQK
T176 TPGMRVKTFHGSSKS
S181 VKTFHGSSKSERTRS
K313 GEKALGLKISENLME
K365-ac DMFSLARkNDLIVWI
S400 ELLMETRSPLAELGV
T506 LKNKHFKTLRIDGTV
Y621 EKKNPFRYFTKQELK
S686-p LMFTRDLsVKEELDM
S697-p ELDMLEDsQYIHQRV
Y699 DMLEDsQYIHQRVQK
S738 LKAQEFPSQQKKKGt
Q739 KAQEFPSQQKKKGtE
T745-p SQQKKKGtEFNKPQP
S755 NKPQPQPSRLLTKPT
- gap
T759 PQPSRLLTKPTQVEA
T762 SRLLTKPTQVEAISS
S768 PTQVEAISSQMASIT
S773 AISSQMASITICDQS
S789 ESEPQEHSEVHDVTS
T795 HSEVHDVTSLQGSHH
T806 GSHHFNSTSDAGTIA
S807 SHHFNSTSDAGTIAS
T811 NSTSDAGTIASLPQG
S814 SDAGTIASLPQGAES
Q817 GTIASLPQGAESIGE
S821 SLPQGAESIGEVSTD
T827 ESIGEVSTDSLLSPA
S829 IGEVSTDSLLSPAKG
L830 GEVSTDSLLSPAKGF
G836 SLLSPAKGFAAENDA
A839 SPAKGFAAENDAMQK
G848 NDAMQKKGLQAsPGQ
S852-p QKKGLQAsPGQEAPs
S859-p sPGQEAPsENLGsFH
S864-p APsENLGsFHYLPRE
Y867 ENLGsFHYLPREsSK
R870 GsFHYLPREsSKAsL
S872-p FHYLPREsSKAsLGP
S876-p PREsSKAsLGPNLDL
S886-p PNLDLQDsVVLYHRS
S942-p KEDDPLKsPPQYACD
S965 ADTRQNLSSKFLEHV
S966 DTRQNLSSKFLEHVE
F968 RQNLSSKFLEHVEKE
S977 EHVEKEKSLQsPAAN
S980-p EKEKSLQsPAANSRA
- gap
S985 LQsPAANSRAKsALt
S989-p AANSRAKsALtLsLD
T992-p SRAKsALtLsLDssP
S994-p AKsALtLsLDssPKs
S997-p ALtLsLDssPKsDEE
S998-p LtLsLDssPKsDEEs
S1001-p sLDssPKsDEEsEVI
S1005-p sPKsDEEsEVISVKT
S1014-p VISVKTKsKTRRILs
S1021-p sKTRRILsDDEDEDE
A1031 EDEDEEDAFKGSHtN
S1035 EEDAFKGSHtNsINI
H1036 EDAFKGSHtNsINIs
T1037-p DAFKGSHtNsINIsP
S1039-p FKGSHtNsINIsPFP
S1043-p HtNsINIsPFPFSSV
S1056 SVKQFDAStPQsGSN
T1057-p VKQFDAStPQsGSNP
S1060-p FDAStPQsGSNPSRR
N1063 StPQsGSNPSRRFFs
S1070-p NPSRRFFsPKtPGEV
P1071 PSRRFFsPKtPGEVN
T1073-p RRFFsPKtPGEVNTS
G1075 FFsPKtPGEVNTSLH
E1076 FsPKtPGEVNTSLHS
S1080 tPGEVNTSLHSRRSL
S1083 EVNTSLHSRRSLASR
S1092-p RSLASRRsLINVVLD
S1111-p MEERLDNssEEESEP
S1112-p EERLDNssEEESEPG
- gap
- gap
S1144 PSGATLASGNKSSNL
K1147 ATLASGNKSSNLTMS
S1172 PCAPEPSSsDPMPDP
S1173-p CAPEPSSsDPMPDPP
P1179 SsDPMPDPPQDLAVE
Y1191-p AVEAGNDyEsLVARG
S1193-p EAGNDyEsLVARGKE
S1233-p EVMLMTLsLYKQLNI
  rat

 
S14 LAEVGTLSPQLAESY
K48 LKLFNLAKDIFPTKK
K55 KDIFPTKKVISRIQK
K55 KDIFPTKKVISRIQK
T175 TPGMRVKTFHGSSKN
S180 VKTFHGSSKNERIRN
K312 GEKALGFKMSENLME
K364 EMLSLTRKNDLIVWI
S399 ELLMETRSPLAELGV
T505 LKNKHFKTLRIDGTV
Y620 DKKNPFRYFTKQELK
S685 LMFTCDLSVKEELDM
A696 ELDMLEDAQYIQHRV
Y698 DMLEDAQYIQHRVQK
S734 LKAQEFPSQQRKKGN
Q735 KAQEFPSQQRKKGNK
- gap
S748 NKPQPQPSRLLANPT
- gap
A752 PQPSRLLANPTQVEA
T755 SRLLANPTQVEAISS
S761 PTQVEAISSQMASIS
S766 AISSQMASISIYDQS
S782 ESEPQELSEAHDVTS
T788 LSEAHDVTSLQGDQH
T800 DQHHFESTSDAGTIA
S801 QHHFESTSDAGTIAS
T805 ESTSDAGTIASLPQG
S808 SDAGTIASLPQGAES
Q811 GTIASLPQGAESIGG
S815 SLPQGAESIGGVWTD
T821 ESIGGVWTDSLLSPA
S823 IGGVWTDSLLSPAKG
L824 GGVWTDSLLSPAKGF
G830 SLLSPAKGFAADNEA
A833 SPAKGFAADNEAVQK
E842 NEAVQKNELQAsPGQ
S846-p QKNELQAsPGQEALS
S853 sPGQEALSENLGSFH
S858 ALSENLGSFHYLPRQ
Y861 ENLGSFHYLPRQSSK
R864 GSFHYLPRQSSKADL
S866 FHYLPRQSSKADLEP
D870 PRQSSKADLEPNLDV
S880 PNLDVQDSVVLYHQS
S935 LKKDPLESPPQYECD
S958 ADTRQNLSSKFLEHV
S959 DTRQNLSSKFLEHVE
F961 RQNLSSKFLEHVEKE
S970 EHVEKENSLQRPAGN
R973 EKENSLQRPAGNsGE
- gap
S978-p LQRPAGNsGEESAHN
S982 AGNsGEESAHNLSLD
H984 NsGEESAHNLSLDSS
S987 EESAHNLSLDSSNKI
S990 AHNLSLDSSNKIDEE
S991 HNLSLDSSNKIDEES
I994 SLDSSNKIDEESEVI
S998 SNKIDEESEVITVKT
N1007 VITVKTKNKARRILs
S1014-p NKARRILsDDEDEED
A1022 DDEDEEDAFKDTSTN
T1026 EEDAFKDTSTNSFSV
S1027 EDAFKDTSTNSFSVs
T1028 DAFKDTSTNSFSVsP
S1030 FKDTSTNSFSVsPLT
S1034-p STNSFSVsPLTFSSV
S1047 SVKHFDASTPQNDSN
T1048 VKHFDASTPQNDSNP
N1051 FDASTPQNDSNPSRR
N1054 STPQNDSNPSRRFFS
S1061 NPSRRFFSPKIPDDV
P1062 PSRRFFSPKIPDDVN
I1064 RRFFSPKIPDDVNTS
D1066 FFSPKIPDDVNTSLH
D1067 FSPKIPDDVNTSLHP
S1071 IPDDVNTSLHPRRSL
P1074 DVNTSLHPRRSLASR
S1083 RSLASRRSLINVVLD
S1102 MEERLDTSSEEESEP
S1103 EERLDTSSEEESEPE
- gap
- gap
S1134 RSGATLASGNKHSSL
K1137 ATLASGNKHSSLTES
S1162 PCAPEPSSSDPLLDP
S1163 CAPEPSSSDPLLDPP
P1169 SSDPLLDPPQDPAVE
Y1181 AVEAANDYESLVARG
S1183 EAANDYESLVARGKE
S1223 EVMRMTLSLYKQLNT
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