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Protein Page:
P38B (human)

Overview
P38B a proline-directed ser/thr MAP kinase, and one of four p38 kinases that play important roles in cellular responses to inflammatory cytokines, DNA damage, oxidative stress, and some GPCRs, leading to direct activation of transcription factors and of other downstream kinases including MSK1, MSK2, eEF2K, MK2, and PRAK. MSK1 and -2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli. MK2 and -3 control gene expression mostly at the post-transcriptional level. eEF2K is important for the elongation of mRNA during translation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17, which then cleaves the ectodomain of TGF-alpha family ligands, a process leading to the activation of EGFR signaling and cell proliferation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, CHOPO, p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. Interacts directly with HDAC3 interacts directly and selectively to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.1.37; Kinase, protein; EC 2.7.11.24; CMGC group; MAPK family; MAPK/p38 subfamily; p38 subfamily
Cellular Component: nucleoplasm; cytosol
Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: nerve growth factor receptor signaling pathway; transcription, DNA-dependent; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; toll-like receptor 2 signaling pathway; mRNA metabolic process; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; regulation of transcription factor activity; RNA metabolic process; Ras protein signal transduction; toll-like receptor signaling pathway; positive regulation of muscle cell differentiation; innate immune response; response to stress; gene expression; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  Q15759 (UniProtKB)
Alt. Names/Synonyms: MAP kinase 11; MAP kinase p38 beta; MAPK 11; MAPK11; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; MK11; p38-2; p38b; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B; Stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase-2b
Gene Symbols: MAPK11
Molecular weight: 41,357 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  B Cell Receptor Signaling  |  NF-kB Signaling  |  Phospholipase Signaling  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Toll-Like Receptor Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

P38B

Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 57 T180-p RQADEEMtGyVATRW
1 667 Y182-p ADEEMtGyVATRWYR
0 1 S243-p MEVVGTPsPEVLAKI
1 0 Y323 DEPEAEPYDESVEAK
  mouse

 
T180-p RQADEEMtGyVATRW
Y182-p ADEEMtGyVATRWYR
S243 MEVVGTPSPEVLAKI
Y323-p DEPEAEPyDESVEAK
  rat

 
T192 RQADEEMTGyVATRW
Y194-p ADEEMTGyVATRWYR
S255 MEVVGTPSPEVLAKI
Y335 DEPEAEPYDESVEAK
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