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Protein Page:
IWS1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
IWS1 a Pol II transcription elongation factor essential for mammalian cell proliferation. Interacts with Spt6 and Spt5. Depletion of endogenous human IWS1 results in mRNA processing defects. Three alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: mRNA transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA splicing; mRNA processing; regulation of mRNA processing
Reference #:  Q96ST2 (UniProtKB)
Alt. Names/Synonyms: DKFZp761G0123; FLJ10006; FLJ14655; FLJ32319; interacts with Spt6; IWS1; IWS1 homolog (S. cerevisiae); IWS1-like protein; IWS1L; MGC126375; MGC126376; Protein IWS1 homolog
Gene Symbols: IWS1
Molecular weight: 91,955 Da
Basal Isoelectric point: 4.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IWS1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T17-p QSDDGGAtPVQDERD
0 1 S27-p QDERDSGsDGEDDVN
0 2 S54-p RHSENETsDREDGLP
0 20 T67-p LPKGHHVtDsENDEP
0 23 S69-p KGHHVtDsENDEPLN
0 19 S80-p EPLNLNAsDsEsEEL
0 16 S82-p LNLNAsDsEsEELHR
0 8 S84-p LNAsDsEsEELHRQK
0 3 S93-p ELHRQKDsDsESEER
0 4 S95-p HRQKDsDsESEERAE
0 3 S106-p ERAEPPAsDsENEDV
0 2 S108-p AEPPAsDsENEDVNQ
0 1 S118-p EDVNQHGsDsESEET
0 2 S120-p VNQHGsDsESEETRK
0 7 S131-p ETRKLPGsDsENEEL
0 7 S133-p RKLPGsDsENEELLN
0 4 S144-p ELLNGHAsDsENEDV
0 4 S146-p LNGHAsDsENEDVGK
0 8 S157-p DVGKHPAsDsEIEEL
0 8 S159-p GKHPAsDsEIEELQK
0 1 S170-p ELQKSPAsDSETEDA
0 3 S183-p DALKPQIsDSESEEP
0 26 S196-p EPPRHQAsDsENEEP
0 25 S198-p PRHQAsDsENEEPPK
0 15 S209 EPPKPRMSDsESEEL
0 14 S211-p PKPRMSDsESEELPK
0 9 S213 PRMSDsESEELPKPQ
0 31 S235-p EPPRHQAsDsENEEL
0 29 S237-p PRHQAsDsENEELPK
0 23 S248-p ELPKPRIsDsEsEDP
0 17 S250-p PKPRIsDsEsEDPPR
0 5 S252-p PRIsDsEsEDPPRHQ
0 39 S261-p DPPRHQAsDsENEEL
0 36 S263-p PRHQAsDsENEELPK
0 2 N265 HQAsDsENEELPKPR
0 20 S274-p ELPKPRIsDsEsEDP
0 16 S276-p PKPRIsDsEsEDPPR
0 5 S278-p PRIsDsEsEDPPRNQ
0 32 S287-p DPPRNQAsDsENEEL
0 31 S289-p PRNQAsDsENEELPK
0 2 N291 NQAsDsENEELPKPR
0 12 S300-p ELPKPRVsDsEsEGP
0 5 S302-p PKPRVsDsEsEGPQK
0 1 S304-p PRVsDsEsEGPQKGP
0 25 S313-p GPQKGPAsDsEtEDA
0 24 S315-p QKGPAsDsEtEDAsR
0 6 T317-p GPAsDsEtEDAsRHK
0 1 S321-p DsEtEDAsRHKQKPE
0 20 S329-p RHKQKPEsDDDsDRE
0 18 S333-p KPEsDDDsDRENKGE
0 8 T342-p RENKGEDtEMQNDsF
0 3 S348-p DtEMQNDsFHsDSHM
0 15 S351-p MQNDsFHsDSHMDRK
0 2 M355 sFHsDSHMDRKKFHs
0 21 S362-p MDRKKFHssDsEEEE
0 21 S363-p DRKKFHssDsEEEEH
0 22 S365-p KKFHssDsEEEEHKK
0 24 S377-p HKKQKMDsDEDEKEG
0 48 S398-p KRKAAVLsDsEDEEK
0 51 S400-p KAAVLsDsEDEEKAs
0 4 S407-p sEDEEKAsAKKSRVV
0 18 S415-p AKKSRVVsDADDsDs
0 45 S420-p VVsDADDsDsDAVsD
0 42 S422-p sDADDsDsDAVsDKs
0 24 S426-p DsDsDAVsDKsGKRE
0 12 S429-p sDAVsDKsGKREKtI
0 9 T435-p KsGKREKtIAsDsEE
0 35 S438-p KREKtIAsDsEEEAG
0 36 S440-p EKtIAsDsEEEAGKE
0 2 S449-p EEAGKELsDKKNEEK
0 22 S511-p QVKEAEDsDsDDNIK
0 20 S513-p KEAEDsDsDDNIKRG
0 6 S527-p GKHMDFLsDFEMMLQ
0 1 K600-a AVVMHLKkQDLkETF
0 1 K604-a HLKkQDLkETFIDSG
0 1 S621-p SAIKEWLsPLPDRSL
0 93 N719 MPQRRRMNstGGQtP
1 730 S720-p PQRRRMNstGGQtPR
1 78 T721-p QRRRMNstGGQtPRR
0 225 T725-p MNstGGQtPRRDLEK
0 3 Y762-p PMPSNKDyVVRPkWN
0 1 K767-u KDyVVRPkWNVEMES
  mouse

 
T17 QSDDGGATPVQDERD
S27 QDERDSGSDGEDGVT
S54 HHSENETSDREDGLA
T67 LAKIHNGTDSENDEP
S69 KIHNGTDSENDEPSN
S80 EPSNANASDSESEEL
S82 SNANASDSESEELHR
S84 ANASDSESEELHRPK
S93 ELHRPKDSDSDSEEH
S95 HRPKDSDSDSEEHAE
S106 EHAESPASDSENEPV
S108 AESPASDSENEPVNQ
S118 EPVNQHGSDSENEEL
S120 VNQHGSDSENEELLN
- gap
- gap
S131 ELLNGHASDSEKEEV
S133 LNGHASDSEKEEVSK
S144 EVSKHAASDSEAEDT
S146 SKHAASDSEAEDTLQ
- gap
S157 DTLQPQVSESDSEDP
S170-p DPPRPQAsDsENEEP
S172-p PRPQAsDsENEEPPK
S183-p EPPKPRIsDsEsEEL
S185-p PKPRIsDsEsEELPK
S187-p PRIsDsEsEELPKPR
- gap
- gap
S196-p ELPKPRVsDsEsEDP
S198-p PKPRVsDsEsEDPPR
S200-p PRVsDsEsEDPPRPQ
S209-p DPPRPQAsDsEsEEL
S211-p PRPQAsDsEsEELPK
S213-p PQAsDsEsEELPKPR
S222-p ELPKPRVsDsEsEDP
S224-p PKPRVsDsEsEDPPR
S226-p PRVsDsEsEDPPRPQ
S235-p DPPRPQAsDsEsEEL
S237-p PRPQAsDsEsEELPK
S239-p PQAsDsEsEELPKPR
S248-p ELPKPRVsDsESEDP
S250-p PKPRVsDsESEDPQK
S252 PRVsDsESEDPQKGP
S261-p DPQKGPAsDsEAEDA
S263-p QKGPAsDsEAEDASR
A265 GPAsDsEAEDASRHK
S269 DsEAEDASRHKEKPD
S277-p RHKEKPDsDDsDGEN
S280-p EKPDsDDsDGENKRE
S289-p GENKREDsEVQNEsD
- gap
S295-p DsEVQNEsDGHtDRK
T299-p QNEsDGHtDRKGLHs
S306-p tDRKGLHssDsEEEE
S307-p DRKGLHssDsEEEEP
S309-p KGLHssDsEEEEPKR
S321-p PKRQKIDsDDDEEKE
S343-p KRKAAVLsDsEDDAG
S345-p KAAVLsDsEDDAGNA
S353-p EDDAGNAsAKKSRVV
C361 AKKSRVVCDADDsDs
S366-p VVCDADDsDsDVVsD
S368-p CDADDsDsDVVsDKs
S372-p DsDsDVVsDKsGKRE
S375-p sDVVsDKsGKRETtV
T381-p KsGKRETtVAsDsEE
S384-p KRETtVAsDsEEEAG
S386-p ETtVAsDsEEEAGKE
S395 EEAGKEESSVKKKED
S458-p QLKEAEDsDsDDNIK
S460-p KEAEDsDsDDNIKRG
S474-p GKHMDFLsDFEMMLQ
K547 TVVMHLKKQDLKETF
K551 HLKKQDLKETFIDSG
S568 SAIKEWLSPLPDRSL
S666-p MPQRRRLsstGGQtP
S667-p PQRRRLsstGGQtPR
T668-p QRRRLsstGGQtPRR
T672-p LsstGGQtPRRDLEK
Y709 PMPSNKDYVVRPKWN
K714 KDYVVRPKWNVEMES
  rat

 
T17 QSDDGGATPVQDERD
S27 QDERDSGSDGEDDVN
S54 RHSENETSDREDGLT
T67 LTKIHNGTDSENDEP
S69 KIHNGTDSENDEPSN
S80 EPSNVHASDSESEEL
S82 SNVHASDSESEELHR
S84 VHASDSESEELHRPK
S93 ELHRPKDSDSESEEH
S95 HRPKDSDSESEEHAE
S106 EHAESPASDSENEAV
S108 AESPASDSENEAVHQ
S118 EAVHQQGSDSEKEEL
S120 VHQQGSDSEKEELLN
- gap
- gap
S131 ELLNGHASDSEKEEG
S133 LNGHASDSEKEEGRK
S144 EGRKHAASDSETEDT
S146 RKHAASDSETEDTLQ
- gap
S157 DTLQPQGSESDSEDP
S170 DPPRPQASDSESEEP
S172 PRPQASDSESEEPPK
S183-p EPPKPRIsDsEsEEL
S185-p PKPRIsDsEsEELPK
S187-p PRIsDsEsEELPKPR
- gap
- gap
S196 ELPKPRISDSESEDP
S198 PKPRISDSESEDPPR
S200 PRISDSESEDPPRPQ
S209 DPPRPQVSDSESEEL
S211 PRPQVSDSESEELPK
S213 PQVSDSESEELPKPR
S222 ELPKPRVSDSESEDP
S224 PKPRVSDSESEDPPR
S226 PRVSDSESEDPPRPQ
S235 DPPRPQASDSESEEL
S237 PRPQASDSESEELPK
S239 PQASDSESEELPKPR
S248 ELPKPRVSDSESEDP
S250 PKPRVSDSESEDPQK
S252 PRVSDSESEDPQKGP
S261 DPQKGPASDSEAEDA
S263 QKGPASDSEAEDASR
A265 GPASDSEAEDASRHK
S269 DSEAEDASRHKEKPE
S277 RHKEKPESEDSDGEN
S280 EKPESEDSDGENKRE
S289 GENKREDSEVQNESD
- gap
S295 DSEVQNESDGHADRK
A299 QNESDGHADRKGLHs
S306-p ADRKGLHssDsEEEE
S307-p DRKGLHssDsEEEEP
S309-p KGLHssDsEEEEPKR
S321-p PKRQKIDsDDDGEKE
S342-p KRKAAVLsDsEDEDK
S344-p KAAVLsDsEDEDKAS
S351 sEDEDKASAAKKSRV
S360-p AKKSRVIsDADDsDs
S365-p VIsDADDsDsDVVSD
S367-p sDADDsDsDVVSDKS
S371 DsDsDVVSDKSGKRE
S374 sDVVSDKSGKREKtV
T380-p KSGKREKtVAsDsEE
S383-p KREKtVAsDsEEEVG
S385-p EKtVAsDsEEEVGKE
S394 EEVGKEESSVKKSEE
S457-p QLKEAEDsDsDDNIK
S459-p KEAEDsDsDDNIKRG
S473 GKHMDFLSDFEMMLQ
K546 TVVMHLKKQDLKETF
K550 HLKKQDLKETFIDSG
S567 SAIKEWLSPLPDRSL
S665-p MPQRRRMsStGGQtP
S666 PQRRRMsStGGQtPR
T667-p QRRRMsStGGQtPRR
T671-p MsStGGQtPRRDLEK
Y708 PMPSNKDYVVRPKWN
K713 KDYVVRPKWNVEMES
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