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IWS1 (human)

Overview IWS1 a Pol II transcription elongation factor essential for mammalian cell proliferation. Interacts with Spt6 and Spt5. Depletion of endogenous human IWS1 results in mRNA processing defects. Three alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Transcription factor Cellular Component: nucleus Molecular Function: DNA binding Biological Process: transcription, DNA-dependent Reference #:  Q96ST2 (UniProtKB) Alt. Names/Synonyms: DKFZp761G0123; FLJ10006; FLJ14655; FLJ32319; interacts with Spt6; IWS1; IWS1 homolog (S. cerevisiae); IWS1-like protein; IWS1L; MGC126375; MGC126376; Protein IWS1 homolog Gene Symbols: IWS1 Molecular weight: 91,955 Da Basal Isoelectric point: 4.58  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IWS1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T17-p	QSDDGGAtPVQDERD
0	1		S27-p	QDERDSGsDGEDDVN
0	1		S40-p	VNEQHSGsDTGSVER
0	1		S54-p	RHSENETsDREDGLP
0	20		T67-p	LPKGHHVtDsENDEP
0	23		S69-p	KGHHVtDsENDEPLN
0	19		S80-p	EPLNLNAsDsEsEEL
0	15		S82-p	LNLNAsDsEsEELHR
0	8		S84-p	LNAsDsEsEELHRQK
0	3		S93-p	ELHRQKDsDsEsEER
0	4		S95-p	HRQKDsDsEsEERAE
0	1		S97-p	QKDsDsEsEERAEPP
0	3		S106-p	ERAEPPAsDsENEDV
0	2		S108-p	AEPPAsDsENEDVNQ
0	1		S118-p	EDVNQHGsDsESEET
0	2		S120-p	VNQHGsDsESEETRK
0	7		S131-p	ETRKLPGsDsENEEL
0	7		S133-p	RKLPGsDsENEELLN
0	4		S144-p	ELLNGHAsDsENEDV
0	4		S146-p	LNGHAsDsENEDVGK
0	8		S157-p	DVGKHPAsDsEIEEL
0	8		S159-p	GKHPAsDsEIEELQK
0	1		S170-p	ELQKSPAsDSETEDA
0	3		S183-p	DALKPQIsDSESEEP
0	24		S196-p	EPPRHQAsDsENEEP
0	24		S198-p	PRHQAsDsENEEPPK
0	12		S209	EPPKPRMSDsESEEL
0	12		S211-p	PKPRMSDsESEELPK
0	7		S213	PRMSDsESEELPKPQ
0	1		S226-p	PQVSDSEsEEPPRHQ
0	29		S235-p	EPPRHQAsDsENEEL
0	28		S237-p	PRHQAsDsENEELPK
0	21		S248-p	ELPKPRIsDsEsEDP
0	16		S250-p	PKPRIsDsEsEDPPR
0	5		S252-p	PRIsDsEsEDPPRHQ
0	36		S261-p	DPPRHQAsDsENEEL
0	34		S263-p	PRHQAsDsENEELPK
0	2		N265	HQAsDsENEELPKPR
0	18		S274-p	ELPKPRIsDsEsEDP
0	15		S276-p	PKPRIsDsEsEDPPR
0	5		S278-p	PRIsDsEsEDPPRNQ
0	30		S287-p	DPPRNQAsDsENEEL
0	29		S289-p	PRNQAsDsENEELPK
0	2		N291	NQAsDsENEELPKPR
0	12		S300-p	ELPKPRVsDsEsEGP
0	5		S302-p	PKPRVsDsEsEGPQK
0	1		S304-p	PRVsDsEsEGPQKGP
0	23		S313-p	GPQKGPAsDsEtEDA
0	23		S315-p	QKGPAsDsEtEDAsR
0	6		T317-p	GPAsDsEtEDAsRHK
0	1		S321-p	DsEtEDAsRHKQKPE
0	18		S329-p	RHKQKPEsDDDsDRE
0	18		S333-p	KPEsDDDsDRENKGE
0	8		T342-p	RENKGEDtEMQNDsF
0	3		S348-p	DtEMQNDsFHsDSHM
0	15		S351-p	MQNDsFHsDSHMDRK
0	2		M355	sFHsDSHMDRKKFHs
0	17		S362-p	MDRKKFHssDsEEEE
0	19		S363-p	DRKKFHssDsEEEEH
0	19		S365-p	KKFHssDsEEEEHKK
0	1		K372	sEEEEHKKQKMDsDE
0	19		S377-p	HKKQKMDsDEDEKEG
0	41		S398-p	KRKAAVLsDsEDEEK
0	45		S400-p	KAAVLsDsEDEEKAs
0	4		S407-p	sEDEEKAsAkKsRVV
0	1		K409-a	DEEKAsAkKsRVVsD
0	1		S411-p	EKAsAkKsRVVsDAD
0	15		S415-p	AkKsRVVsDADDsDs
0	40		S420-p	VVsDADDsDsDAVsD
0	38		S422-p	sDADDsDsDAVsDKs
0	22		S426-p	DsDsDAVsDKsGKRE
0	11		S429-p	sDAVsDKsGKREktI
0	1		K434	DKsGKREKtIAsDsE
0	1		K434-a	DKsGKREktIAsDsE
0	8		T435-p	KsGKREktIAsDsEE
0	31		S438-p	KREktIAsDsEEEAG
0	32		S440-p	EktIAsDsEEEAGKE
0	2		S449-p	EEAGKELsDKKNEEK
0	1		-	gap
0	1		K451	AGKELsDKKNEEKDL
0	18		S511-p	QVKEAEDsDsDDNIk
0	18		S513-p	KEAEDsDsDDNIkRG
0	1		K518-u	sDsDDNIkRGkHMDF
0	1		K521-u	DDNIkRGkHMDFLsD
0	5		S527-p	GkHMDFLsDFEMMLQ
0	1		T589-p	KPALKKLtLLPAVVM
0	1		K600-a	AVVMHLKkQDLkETF
0	1		K604-a	HLKkQDLkETFIDSG
0	1		K675	PKESRSNKDMAGKLI
0	91		N719	MPQRRRMNstGGQtP
0	729		S720-p	PQRRRMNstGGQtPR
0	78		T721-p	QRRRMNstGGQtPRR
0	223		T725-p	MNstGGQtPRRDLEK
0	3		Y762-p	PMPSNKDyVVRPkWN
0	1		K767-u	KDyVVRPkWNVEMES

	mouse
T17	QSDDGGATPVQDERD
S27	QDERDSGSDGEDGVT
S40	VTEQHSGSDTGSVDH
S54	HHSENETSDREDGLA
T67	LAKIHNGTDSENDEP
S69	KIHNGTDSENDEPSN
S80	EPSNANASDSESEEL
S82	SNANASDSESEELHR
S84	ANASDSESEELHRPK
S93	ELHRPKDSDSDSEEH
S95	HRPKDSDSDSEEHAE
S97	PKDSDSDSEEHAESP
S106	EHAESPASDSENEPV
S108	AESPASDSENEPVNQ
S118	EPVNQHGSDSENEEL
S120	VNQHGSDSENEELLN
-	gap
-	gap
S131	ELLNGHASDSEKEEV
S133	LNGHASDSEKEEVSK
S144	EVSKHAASDSEAEDT
S146	SKHAASDSEAEDTLQ
-	gap
S157	DTLQPQVSESDSEDP
S170-p	DPPRPQAsDsENEEP
S172-p	PRPQAsDsENEEPPK
S183-p	EPPKPRIsDsEsEEL
S185-p	PKPRIsDsEsEELPK
S187-p	PRIsDsEsEELPKPR
-	gap
-	gap
-	gap
S196-p	ELPKPRVsDsEsEDP
S198-p	PKPRVsDsEsEDPPR
S200-p	PRVsDsEsEDPPRPQ
S209-p	DPPRPQAsDsEsEEL
S211-p	PRPQAsDsEsEELPK
S213-p	PQAsDsEsEELPKPR
S222-p	ELPKPRVsDsEsEDP
S224-p	PKPRVsDsEsEDPPR
S226-p	PRVsDsEsEDPPRPQ
S235-p	DPPRPQAsDsEsEEL
S237-p	PRPQAsDsEsEELPK
S239-p	PQAsDsEsEELPKPR
S248-p	ELPKPRVsDsESEDP
S250-p	PKPRVsDsESEDPQK
S252	PRVsDsESEDPQKGP
S261-p	DPQKGPAsDsEAEDA
S263-p	QKGPAsDsEAEDASR
A265	GPAsDsEAEDASRHK
S269	DsEAEDASRHKEKPD
S277-p	RHKEKPDsDDsDGEN
S280-p	EKPDsDDsDGENKRE
S289-p	GENKREDsEVQNEsD
-	gap
S295-p	DsEVQNEsDGHtDRK
T299-p	QNEsDGHtDRKGLHs
S306-p	tDRKGLHssDsEEEE
S307-p	DRKGLHssDsEEEEP
S309-p	KGLHssDsEEEEPKr
R316-m1	sEEEEPKrQKIDsDD
S321-p	PKrQKIDsDDDEEKE
S343-p	KRKAAVLsDsEDDAG
S345-p	KAAVLsDsEDDAGNA
S353-p	EDDAGNAsAKKSRVV
K355	DAGNAsAKKSRVVCD
S357	GNAsAKKSRVVCDAD
C361	AKKSRVVCDADDsDs
S366-p	VVCDADDsDsDVVsD
S368-p	CDADDsDsDVVsDKs
S372-p	DsDsDVVsDKsGKRE
S375-p	sDVVsDKsGKREtTV
T380-p	DKsGKREtTVAsDsE
T380	DKsGKRETTVAsDsE
T381	KsGKREtTVAsDsEE
S384-p	KREtTVAsDsEEEAG
S386-p	EtTVAsDsEEEAGKE
S395	EEAGKEESsVkKKED
S396-p	EAGKEESsVkKKEDK
K398-a	GKEESsVkKKEDKDL
S458-p	QLKEAEDsDsDDNIK
S460-p	KEAEDsDsDDNIKRG
K465	sDsDDNIKRGKHMDF
K468	DDNIKRGKHMDFLsD
S474-p	GKHMDFLsDFEMMLQ
T536	KPALKKLTLLPTVVM
K547	TVVMHLKKQDLKETF
K551	HLKKQDLKETFIDSG
K622-a	PKESRSNkDMAGKLI
S666-p	MPQRRRLsstGGQtP
S667-p	PQRRRLsstGGQtPR
T668-p	QRRRLsstGGQtPRR
T672-p	LsstGGQtPRRDLEK
Y709	PMPSNKDYVVRPKWN
K714	KDYVVRPKWNVEMES

	rat
T17	QSDDGGATPVQDERD
S27	QDERDSGSDGEDDVN
S40	VNEQHSGSDTGSVDR
S54	RHSENETSDREDGLT
T67	LTKIHNGTDSENDEP
S69	KIHNGTDSENDEPSN
S80	EPSNVHASDSESEEL
S82	SNVHASDSESEELHR
S84	VHASDSESEELHRPK
S93	ELHRPKDSDSESEEH
S95	HRPKDSDSESEEHAE
S97	PKDSDSESEEHAESP
S106	EHAESPASDSENEAV
S108	AESPASDSENEAVHQ
S118	EAVHQQGSDSEKEEL
S120	VHQQGSDSEKEELLN
-	gap
-	gap
S131	ELLNGHASDSEKEEG
S133	LNGHASDSEKEEGRK
S144	EGRKHAASDSETEDT
S146	RKHAASDSETEDTLQ
-	gap
S157	DTLQPQGSESDSEDP
S170	DPPRPQASDSESEEP
S172	PRPQASDSESEEPPK
S183	EPPKPRISDSESEEL
S185	PKPRISDSESEELPK
S187	PRISDSESEELPKPR
-	gap
-	gap
-	gap
S196	ELPKPRISDSESEDP
S198	PKPRISDSESEDPPR
S200	PRISDSESEDPPRPQ
S209	DPPRPQVSDSESEEL
S211	PRPQVSDSESEELPK
S213	PQVSDSESEELPKPR
S222	ELPKPRVSDSESEDP
S224	PKPRVSDSESEDPPR
S226	PRVSDSESEDPPRPQ
S235	DPPRPQASDSESEEL
S237	PRPQASDSESEELPK
S239	PQASDSESEELPKPR
S248	ELPKPRVSDSESEDP
S250	PKPRVSDSESEDPQK
S252	PRVSDSESEDPQKGP
S261	DPQKGPASDSEAEDA
S263	QKGPASDSEAEDASR
A265	GPASDSEAEDASRHK
S269	DSEAEDASRHKEKPE
S277	RHKEKPESEDSDGEN
S280	EKPESEDSDGENKRE
S289	GENKREDSEVQNESD
-	gap
S295	DSEVQNESDGHADRK
A299	QNESDGHADRKGLHS
S306	ADRKGLHSSDSEEEE
S307	DRKGLHSSDSEEEEP
S309	KGLHSSDSEEEEPKR
R316	SEEEEPKRQKIDsDD
S321-p	PKRQKIDsDDDGEKE
S342-p	KRKAAVLsDsEDEDK
S344-p	KAAVLsDsEDEDKAS
S351	sEDEDKASAAKKSRV
K354	EDKASAAKKSRVISD
S356	KASAAKKSRVISDAD
S360	AKKSRVISDADDsDs
S365-p	VISDADDsDsDVVSD
S367-p	SDADDsDsDVVSDKS
S371	DsDsDVVSDKSGKRE
S374	sDVVSDKSGKREKtV
K379	DKSGKREKtVAsDsE
K379	DKSGKREKtVAsDsE
T380-p	KSGKREKtVAsDsEE
S383-p	KREKtVAsDsEEEVG
S385-p	EKtVAsDsEEEVGKE
S394	EEVGKEESSVKKSEE
S395	EVGKEESSVKKSEEK
K397	GKEESSVKKSEEKDL
S457	QLKEAEDSDSDDNIK
S459	KEAEDSDSDDNIKRG
K464	SDSDDNIKRGKHMDF
K467	DDNIKRGKHMDFLSD
S473	GKHMDFLSDFEMMLQ
T535	KPALKKLTLLPTVVM
K546	TVVMHLKKQDLKETF
K550	HLKKQDLKETFIDSG
K621	PKESRSNKDMAGKLI
S665-p	MPQRRRMsStGGQtP
S666	PQRRRMsStGGQtPR
T667-p	QRRRMsStGGQtPRR
T671-p	MsStGGQtPRRDLEK
Y708	PMPSNKDYVVRPKWN
K713	KDYVVRPKWNVEMES

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