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Protein Page:
MSK1 (human)

Overview
MSK1 an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Enzyme activity requires the presence of both kinase domains. Is phosphorylated and activated by Erk as well as p38 MAPK in response to growth factors and cellular stress. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; AGC group; RSK family; MSK subfamily
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: axon guidance; nerve growth factor receptor signaling pathway; positive regulation of histone phosphorylation; histone phosphorylation; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription, DNA-dependent; inflammatory response; toll-like receptor 4 signaling pathway; epidermal growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; activation of CREB transcription factor; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cytokine production; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; toll-like receptor 9 signaling pathway; negative regulation of transcription, DNA-dependent
Reference #:  O75582 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 5; KS6A5; MGC1911; MSK1; MSPK1; Nuclear mitogen- and stress-activated protein kinase 1; Ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; RLPK; RPS6KA5; RSK-like protein kinase; RSKL; S6K-alpha-5
Gene Symbols: RPS6KA5
Molecular weight: 89,865 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  NF-kB Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MSK1

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cytoskeletal reorganization: T581‑p
enzymatic activity, induced: S212‑p, S360‑p, S376‑p, T581‑p
intracellular localization: T581‑p
protein conformation: S360‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T38-p ELRTANLtGHAEKVG
0 1 Y60-p KVLGTGAyGKVFLVR
2 11 S212-p DETERAYsFCGTIEY
0 2 S346 IRDELDVSNFAEEFT
5 16 S360-p TEMDPTYsPAALPQS
0 5 Y375-p SEKLFQGysFVAPsI
19 44 S376-p EKLFQGysFVAPsIL
2 14 S381-p GysFVAPsILFKRNA
12 1 T581-p PDNQPLKtPCFTLHY
1 1 T630 QSHDRSLTCTSAVEI
1 1 S647 KIKKGDFSFEGEAWK
1 1 S657 GEAWKNVSQEAKDLI
0 1 Y683-p LKMSGLRyNEWLQDG
0 13 S691-p NEWLQDGsQLssNPL
0 10 S694-p LQDGsQLssNPLMtP
1 6 S695-p QDGsQLssNPLMtPD
1 17 T700-p LssNPLMtPDILGSS
2 1 S750-p RRKMKKTstsTETRs
0 1 T751-p RKMKKTstsTETRss
2 1 S752-p KMKKTstsTETRsss
1 0 S757-p stsTETRssssESSH
2 1 S758-p tsTETRssssESSHS
1 1 S759-p sTETRssssESSHSs
1 1 S760-p TETRssssESSHSsS
0 1 S766-p ssESSHSsSSHsHGK
0 2 S770-p SHSsSSHsHGKTTPT
0 1 T777 sHGKTTPTKTLQPSN
1 0 T793-p ADSNNPEtLFQFSDS
0 3 S798 PEtLFQFSDSVA___
9594 : Phospho-MSK1 (Ser360) Antibody
9591 : Phospho-MSK1 (Ser376) Antibody
9595 : Phospho-MSK1 (Thr581) Antibody
  mouse

 
T37 ELRTANLTGHAEKVG
Y59 KVLGTGAYGKVFLVR
S211-p DETERAYsFCGTIEY
S345-p IRDELDVsNFAEEFT
S359-p TEMDPTYsPAALPQS
Y374-p SERLFQGysFVAPsI
S375-p ERLFQGysFVAPsIL
S380-p GysFVAPsILFKRNA
T645-p PDNQPLKtPCFTLHY
T694-p QSHDRSLtCTSAVEI
S711-p KIKKGDFsFEGEAWK
S721-p GEAWKNVsQEAKDLI
Y747 LKMSGLRYNEWLQDG
S755-p NEWLQDGsQLssNPL
S758-p LQDGsQLssNPLMtP
S759-p QDGsQLssNPLMtPD
T764-p LssNPLMtPDILGSS
S814-p RRKMKRTsTsTETRS
T815 RKMKRTsTsTETRSS
S816-p KMKRTsTsTETRSSS
S821 sTsTETRSSSSESSR
S822 TsTETRSSSSESSRS
S823 sTETRSSSSESSRSS
S824 TETRSSSSESSRSSS
S830 SSESSRSSSSQsHGK
S834-p SRSSSSQsHGKTTPt
T841-p sHGKTTPtKTLQPSN
T857 TEGSNPDTLFQFsD_
S862-p PDTLFQFsD______
9591 : Phospho-MSK1 (Ser376) Antibody
9595 : Phospho-MSK1 (Thr581) Antibody
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