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Protein Page:
DBC-1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DBC-1 Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Apoptosis
Cellular Component: spliceosome; mitochondrial matrix; nuclear chromatin; cytoplasm; nucleus
Molecular Function: enzyme inhibitor activity; protein binding; enzyme binding
Biological Process: positive regulation of apoptosis; RNA splicing; negative regulation of catalytic activity; mitochondrial fragmentation during apoptosis; mRNA processing; cell cycle; regulation of RNA elongation; response to DNA damage stimulus; response to UV
Reference #:  Q8N163 (UniProtKB)
Alt. Names/Synonyms: cell cycle and apoptosis regulator 2; DBC-1; DBC.1; DBC1; deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; K1967; KIAA1967; NET35; p30 DBC; p30 DBC protein
Gene Symbols: CCAR2
Molecular weight: 102,902 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DBC-1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 R16-m1 INPLPGGrNFSGTAS
0 34 T35-p GPPPGLLtPPVATEL
0 15 K93-u RLPQLGEkVLVKAAY
2 0 K112-a AVPWNAVkVQTLSNQ
0 10 K112-u AVPWNAVkVQTLSNQ
0 5 K123-u LSNQPLLksPAPPLL
0 1 K123-m1 LSNQPLLksPAPPLL
0 22 S124-p SNQPLLksPAPPLLH
0 2 K138-u HVAALGQkQGILGAQ
0 1 R180-m1 LHLSHLNrFPArGPH
0 1 R180-m2 LHLSHLNrFPArGPH
0 1 R184-m1 HLNrFPArGPHGRLD
2 1 K215-a GGEPWGAkKPRHDLP
0 10 P222 kKPRHDLPPYRVHLT
0 5 Y224 PRHDLPPYRVHLTPY
0 2 T229 PPYRVHLTPYTVDSP
0 3 K287-a RIQVSSEkEAAPDAG
0 1 K287-u RIQVSSEkEAAPDAG
0 4 I298 PDAGAEPITADSDPA
0 3 K309-u SDPAYSSkVLLLSSP
0 2 K347-u EHPLKQIkFLLGRKE
1 42 T454-p AAEAAPPtQEAQGET
0 4 T484-p TSRRNAEtPEATTQQ
0 1 T495-p TTQQETDtdLPEAPP
0 1 D496-ca TQQETDtdLPEAPPP
0 2 H521 GCVNLSLHGIVEDRR
0 1 S569-p SLPEKVVsPPEPEKE
0 4 S611 NEGPATESEAPLKED
0 15 A613 GPATESEAPLKEDGL
0 2 S626-p GLLPKPLssGGEEEE
0 5 S627-p LLPKPLssGGEEEEK
0 1 K667-u EEEFAGAkLEDsEVR
0 4 S671-p AGAkLEDsEVRsVAs
0 32 S675-p LEDsEVRsVAsNQsE
0 36 S678-p sEVRsVAsNQsEMEF
0 27 S681-p RsVAsNQsEMEFssL
0 2 F685 sNQsEMEFssLQDMP
0 3 S686-p NQsEMEFssLQDMPK
0 19 S687-p QsEMEFssLQDMPKE
0 3 K742-u RLSAEQAkQLVSRVV
0 4 S808-p ALVSHNGsLINVGSL
0 1 K832-u GRLYLENkIHTLELk
0 1 K839-u kIHTLELkLEESHNR
0 1 K855-u SATEVTNkTLAAEMQ
0 2 T897-p QELRRRLtPLQLEIQ
0 1 K916-u KADSWVEkEEPAPsN
0 1 S922-p EkEEPAPsN______
4880 : Phospho-DBC1 (Thr454) Antibody
  mouse

 
R16 INPLPGGRNFSGAAS
T35 GPPPGLLTPPVATDL
K93 RLPQLGEKVLVKAAY
K112 AVPWNAVKVQTLSNQ
K112 AVPWNAVKVQTLSNQ
K123 LSNQPLLKsPAPPLL
K123 LSNQPLLKsPAPPLL
S124-p SNQPLLKsPAPPLLH
K138 HVAALGQKQGILGAQ
R180 LHLSHLNRFPARGPH
R180 LHLSHLNRFPARGPH
R184 HLNRFPARGPHGRLD
K215 GGEPWGAKKPRHDLs
S222-p KKPRHDLsPyRVHLt
Y224-p PRHDLsPyRVHLtPY
T229-p sPyRVHLtPYTVDSP
K287 RIQVSSEKEAAPDTG
K287 RIQVSSEKEAAPDTG
S298-p PDTGAEPsPEDSDPT
K309 SDPTYSSKVLLLSSP
K347-u EHPLKQLkFLLGRKE
P454 ATEAAPQPHEASGEA
T483 TSKQNTETMEATTQQ
T494 TTQQDVDTDLPEAPP
D495 TQQDVDTDLPEAPPP
Y520-p RCVNLSLyGIVEDRR
S568 SLPEKVVSPPEPEKE
S610-p NEGTAAEsDsPLKED
S612-p GTAAEsDsPLKEDGL
S625-p GLLPKRPssGGEEEE
S626-p LLPKRPssGGEEEEK
K666 EDEFAGAKLEEtEVR
T670-p AGAKLEEtEVRsVAs
S674-p LEEtEVRsVAsNQsE
S677-p tEVRsVAsNQsEMEy
S680-p RsVAsNQsEMEyssL
Y684-p sNQsEMEyssLQDMP
S685-p NQsEMEyssLQDMPK
S686-p QsEMEyssLQDMPKE
K741 RLSAEQAKQLVSRVV
S807-p GLVPHNGsLINVGSL
K831 GRLYLENKIHTLELK
K838 KIHTLELKLEESHNR
K854 SATEVTNKTLAAEMQ
T896 QDFRRRLTPLHLEMQ
K915 KADSWVEKEEPTPsN
S921-p EKEEPTPsN______
  rat

 
R16 INPLPGGRNFSGAAS
T35 GPPPGLLTPPVATDL
K93 RLPQLGEKVLVKAAY
K112 AVPWNAVKVQTLSNQ
K112 AVPWNAVKVQTLSNQ
K123 LSNQPLLKSPAPPLL
K123 LSNQPLLKSPAPPLL
S124 SNQPLLKSPAPPLLH
K138 HVAALGQKQGILGAQ
R180 LHLSHLNRFPARGPH
R180 LHLSHLNRFPARGPH
R184 HLNRFPARGPHGRLD
K215 GGEPWGAKKPRHDLP
P222 KKPRHDLPPYRVHLT
Y224 PRHDLPPYRVHLTPY
T229 PPYRVHLTPYAVDSP
K287 RIQVSSEKEAAPDTG
K287 RIQVSSEKEAAPDTG
S298-p PDTGAEPsPEDSDPT
K309 SDPTYSSKVLLLSSP
K347 EHPLKQLKFLLGRKE
P454 ATEAAPQPQEASGEA
T483 TSKQDTETAEATTQQ
T494 TTQQDVDTELPEAPP
E495 TQQDVDTELPEAPPP
Y520 GCVNLSLYGIVEDRR
S568 SLPEKVVSPPEPEKE
A610 NEGTAAEADsPLKED
S612-p GTAAEADsPLKEDGL
S625 GLLPKQPSAGGEEEE
A626 LLPKQPSAGGEEEEK
K666 EEEFAGAKLEETEVR
T670 AGAKLEETEVRsVAs
S674-p LEETEVRsVAsNQsE
S677-p TEVRsVAsNQsEMEY
S680-p RsVAsNQsEMEYSSL
Y684 sNQsEMEYSSLQDMP
S685 NQsEMEYSSLQDMPK
S686 QsEMEYSSLQDMPKE
K741 RLSAEQAKQLVSRVV
S807 GLVPHNGSLINVGSL
K831 GRLYLENKIHTLELK
K838 KIHTLELKLEESHNR
K854 SATEVTNKTLAAEMQ
T896 QDFRRRLTPLHLEMQ
K915 KADSWVEKEEPTPSN
S921 EKEEPTPSN______
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