Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
DBC-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DBC-1 Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; RNA-binding; Tumor suppressor; Mitochondrial; Apoptosis
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: nucleoplasm; spliceosome; mitochondrial matrix; nuclear chromatin; cytoplasm; nucleus
Molecular Function: enzyme inhibitor activity; protein binding; enzyme binding
Biological Process: positive regulation of apoptosis; RNA splicing; rhythmic process; regulation of protein stability; regulation of circadian rhythm; cell cycle; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of catalytic activity; mitochondrial fragmentation during apoptosis; mRNA processing; response to DNA damage stimulus; regulation of RNA elongation; response to UV
Reference #:  Q8N163 (UniProtKB)
Alt. Names/Synonyms: cell cycle and apoptosis regulator 2; DBC-1; DBC.1; DBC1; deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; K1967; KIAA1967; NET35; p30 DBC; p30 DBC protein
Gene Symbols: CCAR2
Molecular weight: 102,902 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DBC-1

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 R16-m1 INPLPGGrNFSGTAS
0 35 T35-p GPPPGLLtPPVATEL
0 1 K54-ub RHLQGGEkQRVFTGI
0 15 K93-ub RLPQLGEkVLVKAAY
2 0 K112-ac AVPWNAVkVQtLsNQ
0 10 K112-ub AVPWNAVkVQtLsNQ
0 1 T115-p WNAVkVQtLsNQPLL
0 1 S117-p AVkVQtLsNQPLLks
0 5 K123-ub LsNQPLLksPAPPLL
0 1 K123-m1 LsNQPLLksPAPPLL
0 28 S124-p sNQPLLksPAPPLLH
0 1 K138-ac HVAALGQkQGILGAQ
0 2 K138-ub HVAALGQkQGILGAQ
0 1 K162 IPPLFPQKPLSLFQT
0 1 R180-m1 LHLSHLNrFPArGPH
0 1 R180-m2 LHLSHLNrFPArGPH
0 1 R184-m1 HLNrFPArGPHGRLD
0 3 Y198-p DQGRSDDyDSKKRKQ
2 2 K215-ac GGEPWGAkKPRHDLP
0 12 P222 kKPRHDLPPYRVHLT
0 5 Y224 PRHDLPPYRVHLTPY
0 2 T229 PPYRVHLTPYTVDSP
0 1 Y231 YRVHLTPYTVDSPIC
0 3 K287-ac RIQVSSEkEAAPDAG
0 1 K287-ub RIQVSSEkEAAPDAG
0 6 I298 PDAGAEPITADSDPA
0 3 K309-ub SDPAYSSkVLLLssP
0 1 S314-p SSkVLLLssPGLEEL
0 1 S315-p SkVLLLssPGLEELY
0 2 K347-ub EHPLKQIkFLLGRKE
3 42 T454-p AAEAAPPtQEAQGET
0 6 T484-p TSRRNAEtPEAtTQQ
0 1 T488-p NAEtPEAtTQQETDt
0 1 T495-p tTQQETDtdLPEAPP
0 1 D496-ca TQQETDtdLPEAPPP
0 2 H521 GCVNLSLHGIVEDRR
0 5 S569-p SLPEKVVsPPEPEKE
0 1 K585-ac AAKEEATkEEEAIKE
0 1 P598 KEEVVKEPKDEAQNE
0 1 P607 DEAQNEGPATESEAP
0 4 S611 NEGPATESEAPLKED
0 20 A613 GPATESEAPLKEDGL
0 6 S626-p GLLPKPLssGGEEEE
0 10 S627-p LLPKPLssGGEEEEK
0 1 S640-p EKPRGEAsEDLCEMA
0 1 K667-ub EEEFAGAkLEDsEVR
0 7 S671-p AGAkLEDsEVRsVAs
0 43 S675-p LEDsEVRsVAsNQsE
0 49 S678-p sEVRsVAsNQsEMEF
0 40 S681-p RsVAsNQsEMEFssL
0 2 F685 sNQsEMEFssLQDMP
0 4 S686-p NQsEMEFssLQDMPK
0 20 S687-p QsEMEFssLQDMPKE
0 3 K742-ub RLSAEQAkQLVSRVV
0 1 S804-p TEHKALVsHNGsLIN
1 7 S808-p ALVsHNGsLINVGsL
0 2 S814-p GsLINVGsLLQRAEQ
0 1 Y828-p QQDSGRLyLENkIHT
0 1 K832-ub GRLyLENkIHTLELk
0 1 K839-ub kIHTLELkLEESHNR
0 1 K855-ub SATEVTNkTLAAEMQ
1 2 T897-p QELRRRLtPLQLEIQ
0 1 K909-ac EIQRVVEkADSWVEk
0 1 K916-ub kADSWVEkEEPAPsN
0 2 S922-p EkEEPAPsN______
4880 : Phospho-DBC1 (Thr454) Antibody
  DBC-1 iso2  
R16 INPLPGGRNFSGTAS
T35 GPPPGLLTPPVATEL
K54 RHLQGGEKQRVFTGI
K93 RLPQLGEKVLVKAAY
K112 AVPWNAVKVQTLSNQ
K112 AVPWNAVKVQTLSNQ
T115 WNAVKVQTLSNQPLL
S117 AVKVQTLSNQPLLKS
K123 LSNQPLLKSPAPPLL
K123 LSNQPLLKSPAPPLL
S124 SNQPLLKSPAPPLLH
K138 HVAALGQKQGILGAQ
K138 HVAALGQKQGILGAQ
K162 IPPLFPQKPLSLFQT
R180 LHLSHLNRFPARGPH
R180 LHLSHLNRFPARGPH
R184 HLNRFPARGPHGRLD
Y198 DQGRSDDYDSKKRKQ
K215 GGEPWGAKKPRHDLP
P222 KKPRHDLPPYRVHLT
Y224 PRHDLPPYRVHLTPY
T229 PPYRVHLTPYTVDSP
Y231 YRVHLTPYTVDSPIC
K287 RIQVSSEKEAAPDAG
K287 RIQVSSEKEAAPDAG
I298 PDAGAEPITADSDPA
K309 SDPAYSSKVLLLSSP
S314 SSKVLLLSSPGLEEL
S315 SKVLLLSSPGLEELY
K347 EHPLKQIKFLLGRKE
T454 AAEAAPPTQEAQGET
T484 TSRRNAETPEATTQQ
T488 NAETPEATTQQETDT
T495 TTQQETDTDLPEAPP
D496 TQQETDTDLPEAPPP
H521 GCVNLSLHGIVEDRR
S569 SLPEKVVSPPEPEKE
K585 AAKEEATKEEEAIKE
P598 KEEVVKEPKDEAQNE
P607 DEAQNEGPATESEAP
S611 NEGPATESEAPLKED
A613 GPATESEAPLKEDGL
S626 GLLPKPLSSGGEEEE
S627 LLPKPLSSGGEEEEK
S640 EKPRGEASEDLCEMA
K667 EEEFAGAKLEDSEVR
S671 AGAKLEDSEVRSVAS
S675 LEDSEVRSVASNQSE
S678 SEVRSVASNQSEMEF
S681 RSVASNQSEMEFSSL
F685 SNQSEMEFSSLQDMP
S686 NQSEMEFSSLQDMPK
S687 QSEMEFSSLQDMPKE
K742 RLSAEQAKQLVSRVV
S804 TEHKALVSHNGSLIN
S808 ALVSHNGSLINVGSL
S814 GSLINVGSLLQRAEQ
Y828 QQDSGRLYLENKIHT
K832 GRLYLENKIHTLELK
K839 KIHTLELKLEESHNR
K855 SATEVTNKTLAAEMQ
T897 QELRRRLTPLQLEIQ
K909 EIQRVVEKVRWGWTR
R917 VRWGWTRRQHSSFP_
P923 RRQHSSFP_______
  mouse

 
R16 INPLPGGRNFSGAAS
T35 GPPPGLLTPPVATDL
K54 RHLQSGEKQRVFTGI
K93 RLPQLGEKVLVKAAY
K112 AVPWNAVKVQTLSNQ
K112 AVPWNAVKVQTLSNQ
T115 WNAVKVQTLSNQPLL
S117 AVKVQTLSNQPLLKs
K123 LSNQPLLKsPAPPLL
K123 LSNQPLLKsPAPPLL
S124-p SNQPLLKsPAPPLLH
K138 HVAALGQKQGILGAQ
K138 HVAALGQKQGILGAQ
K162 IPPLFPQKPLSLFQT
R180 LHLSHLNRFPARGPH
R180 LHLSHLNRFPARGPH
R184 HLNRFPARGPHGRLD
Y198 DQGRSDDYDSKKRKQ
K215 GGEPWGAKKPRHDLs
S222-p KKPRHDLsPyRVHLt
Y224-p PRHDLsPyRVHLtPy
T229-p sPyRVHLtPyTVDSP
Y231-p yRVHLtPyTVDSPTC
K287 RIQVSSEKEAAPDTG
K287 RIQVSSEKEAAPDTG
S298-p PDTGAEPsPEDSDPT
K309 SDPTYSSKVLLLSSP
S314 SSKVLLLSSPGLEEF
S315 SKVLLLSSPGLEEFY
K347-ub EHPLKQLkFLLGRKE
P454 ATEAAPQPHEASGEA
T483 TSKQNTETMEATTQQ
T487 NTETMEATTQQDVDT
T494 TTQQDVDTDLPEAPP
D495 TQQDVDTDLPEAPPP
Y520-p RCVNLSLyGIVEDRR
S568-p SLPEKVVsPPEPEKE
K584 AAKEDAVKEEEAVKE
S597-p KEEAVKVsKDEVQNE
T606-p DEVQNEGtAAEsDsP
S610-p NEGtAAEsDsPLKED
S612-p GtAAEsDsPLKEDGL
S625-p GLLPKRPssGGEEEE
S626-p LLPKRPssGGEEEEK
A639 EKARGEAAEDLCEMA
K666 EDEFAGAKLEEtEVR
T670-p AGAKLEEtEVRsVAs
S674-p LEEtEVRsVAsNQsE
S677-p tEVRsVAsNQsEMEy
S680-p RsVAsNQsEMEyssL
Y684-p sNQsEMEyssLQDMP
S685-p NQsEMEyssLQDMPK
S686-p QsEMEyssLQDMPKE
K741 RLSAEQAKQLVSRVV
P803 TEHKGLVPHNGsLIN
S807-p GLVPHNGsLINVGSL
S813 GsLINVGSLLQRAEQ
Y827 QQDSGRLYLENKIHT
K831 GRLYLENKIHTLELK
K838 KIHTLELKLEESHNR
K854 SATEVTNKTLAAEMQ
T896 QDFRRRLTPLHLEMQ
K908 EMQRIVEKADSWVEK
K915 KADSWVEKEEPTPsN
S921-p EKEEPTPsN______
  rat

 
R16 INPLPGGRNFSGAAS
T35 GPPPGLLTPPVATDL
K54 RHLQSGEKQRVFTGI
K93 RLPQLGEKVLVKAAY
K112 AVPWNAVKVQTLSNQ
K112 AVPWNAVKVQTLSNQ
T115 WNAVKVQTLSNQPLL
S117 AVKVQTLSNQPLLKS
K123 LSNQPLLKSPAPPLL
K123 LSNQPLLKSPAPPLL
S124 SNQPLLKSPAPPLLH
K138 HVAALGQKQGILGAQ
K138 HVAALGQKQGILGAQ
K162-ac IPPLFPQkPLSLFQT
R180 LHLSHLNRFPARGPH
R180 LHLSHLNRFPARGPH
R184 HLNRFPARGPHGRLD
Y198 DQGRSDDYDSKKRKQ
K215-ac GGEPWGAkKPRHDLP
P222 kKPRHDLPPYRVHLT
Y224 PRHDLPPYRVHLTPY
T229 PPYRVHLTPYAVDSP
Y231 YRVHLTPYAVDSPTC
K287 RIQVSSEKEAAPDTG
K287 RIQVSSEKEAAPDTG
S298-p PDTGAEPsPEDSDPT
K309 SDPTYSSKVLLLSSP
S314 SSKVLLLSSPGLEEF
S315 SKVLLLSSPGLEEFY
K347 EHPLKQLKFLLGRKE
P454 ATEAAPQPQEASGEA
T483 TSKQDTETAEATTQQ
T487 DTETAEATTQQDVDT
T494 TTQQDVDTELPEAPP
E495 TQQDVDTELPEAPPP
Y520 GCVNLSLYGIVEDRR
S568-p SLPEKVVsPPEPEKE
K584 AAKEDVVKEEEAVKE
S597 KEEAVKVSKDEVQNE
T606 DEVQNEGTAAEADsP
A610 NEGTAAEADsPLKED
S612-p GTAAEADsPLKEDGL
S625 GLLPKQPSAGGEEEE
A626 LLPKQPSAGGEEEEK
A639 EKARGEAAEDLCEMA
K666 EEEFAGAKLEETEVR
T670 AGAKLEETEVRsVAs
S674-p LEETEVRsVAsNQsE
S677-p TEVRsVAsNQsEMEY
S680-p RsVAsNQsEMEYSSL
Y684 sNQsEMEYSSLQDMP
S685 NQsEMEYSSLQDMPK
S686 QsEMEYSSLQDMPKE
K741 RLSAEQAKQLVSRVV
P803 TEHKGLVPHNGSLIN
S807 GLVPHNGSLINVGSL
S813 GSLINVGSLLQRAEQ
Y827 QQDSGRLYLENKIHT
K831 GRLYLENKIHTLELK
K838 KIHTLELKLEESHNR
K854 SATEVTNKTLAAEMQ
T896 QDFRRRLTPLHLEMQ
K908 EMQRIVEKADSWVEK
K915 KADSWVEKEEPTPSN
S921 EKEEPTPSN______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.