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Mnk1 (human)

Overview Mnk1 a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Translation; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; MAPKAPK family; MNK subfamily Cellular Component: cytosol; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding Biological Process: regulation of translation; peptidyl-serine phosphorylation; fibroblast growth factor receptor signaling pathway; protein kinase cascade; protein amino acid phosphorylation Reference #:  Q9BUB5 (UniProtKB) Alt. Names/Synonyms: MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MKNK1; MNK1 Gene Symbols: MKNK1 Molecular weight: 51,342 Da Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  MAPK/Erk in Growth and Differentiation  |  Phospholipase Signaling  |  Signaling Pathways Activating p38 MAPK  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Mnk1 2HW6 - A/B=37-382 (human) 2Y9Q - B=434-451 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2HW6 2Y9Q  |  ENZYME  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: T250‑p, T255‑p cell growth, altered: T250‑p, T255‑p enzymatic activity, induced: T250‑p, T255‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	0		G34	RRKKKRRGRATDSLP
1	0		S39	RRGRATDSLPGKFED
0	1		S148-p	HFNEREAsRVVRDVA
0	2		S221-p	PENILCEsPEKVsPV
0	2		S226-p	CEsPEKVsPVKICDF
0	1		S237-p	ICDFDLGsGMKLNNS
1	0		S244	sGMKLNNSCTPITtP
11	1		T250-p	NSCTPITtPELTtPC
11	0		T255-p	ITtPELTtPCGSAEY
3	10		T385-p	APEKGLPtPQVLQRN
0	2		S393-p	PQVLQRNsSTMDLTL
0	9		S413-p	IALNRQLsQHEENEL
1	1		S437	GLCSMKLSPPCKSRL
0	2		S460-p	AGRGEDRsPPTAL__

	Mnk1 iso2
G34	RRKKKRRGRATDSLP
S39	RRGRATDSLPGKFED
S148	HFNEREASRVVRDVA
S180	PENILCESPEKVSPV
S185	CESPEKVSPVKICDF
S196	ICDFDLGSGMKLNNS
S203	SGMKLNNSCTPITtP
T209-p	NSCTPITtPELTtPC
T214-p	ITtPELTtPCGSAEY
T344	APEKGLPTPQVLQRN
S352	PQVLQRNSSTMDLTL
S372	IALNRQLSQHEENEL
S396	GLCSMKLSPPCKSRL
S419	AGRGEDRSPPTAL__

	mouse
T34-p	RRKKKRKtRATDsLP
S39-p	RKtRATDsLPGKFED
S148	HFNEREASRVVRDVA
S180-p	PENILCEsPEKVsPV
S185-p	CEsPEKVsPVKICDF
S196	ICDFDLGSGVKLNNs
S203-p	SGVKLNNsCTPITtP
T209-p	NsCTPITtPELTtPC
T214-p	ITtPELTtPCGSAEY
T344-p	APERGLPtPQVLQRN
S352	PQVLQRNSSTMDLTL
S372-p	IALNRQLsQHEENEL
S396-p	GLCSMKLsPPSKSRL
N419	AGRSRDANPCLTPAG

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