a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation; Kinase, protein; CAMK group; MAPKAPK family; MNK subfamily
Cellular Component: nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: regulation of translation; peptidyl-serine phosphorylation; fibroblast growth factor receptor signaling pathway; protein amino acid phosphorylation; response to salt stress
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.