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Protein Page:
Mnk1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Mnk1 a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Translation; EC 2.7.11.1; CAMK group; MAPKAPK family; MNK subfamily
Cellular Component: nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: regulation of translation; peptidyl-serine phosphorylation; fibroblast growth factor receptor signaling pathway; protein amino acid phosphorylation; response to salt stress
Reference #:  Q9BUB5 (UniProtKB)
Alt. Names/Synonyms: MAP kinase interacting kinase 1; MAP kinase interacting serine/threonine kinase 1; MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MKNK1; MNK1
Gene Symbols: MKNK1
Molecular weight: 51,342 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Mnk1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: T250‑p, T255‑p
cell growth, altered: T250‑p, T255‑p
enzymatic activity, induced: T250‑p, T255‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 G34 RRKKKRRGRATDsLP
1 1 S39-p RRGRATDsLPGKFED
0 1 Y60-p ELLGEGAyAKVQGAV
0 1 S148-p HFNEREAsRVVRDVA
0 6 S221-p PENILCEsPEKVsPV
0 6 S226-p CEsPEKVsPVKICDF
0 1 S237-p ICDFDLGsGMKLNNS
1 0 S244 sGMKLNNSCTPITtP
11 1 T250-p NSCTPITtPELTtPC
11 0 T255-p ITtPELTtPCGSAEY
3 15 T385-p APEKGLPtPQVLQRN
0 2 S393-p PQVLQRNsSTMDLTL
0 12 S413-p IALNRQLsQHEENEL
1 1 S437 GLCSMKLSPPCKSRL
0 1 R455-m1 RALAQAGrGEDRsPP
0 4 S460-p AGrGEDRsPPTAL__
2111 : Phospho-Mnk1 (Thr197/202) Antibody
2111 : Phospho-Mnk1 (Thr197/202) Antibody
  Mnk1 iso2  
G34 RRKKKRRGRATDSLP
S39 RRGRATDSLPGKFED
Y60 ELLGEGAYAKVQGAV
S148 HFNEREASRVVRDVA
S180 PENILCESPEKVSPV
S185 CESPEKVSPVKICDF
S196 ICDFDLGSGMKLNNS
S203 SGMKLNNSCTPITtP
T209-p NSCTPITtPELTtPC
T214-p ITtPELTtPCGSAEY
T344 APEKGLPTPQVLQRN
S352 PQVLQRNSSTMDLTL
S372 IALNRQLSQHEENEL
S396 GLCSMKLSPPCKSRL
R414 RALAQAGRGEDRSPP
S419 AGRGEDRSPPTAL__
  mouse

 
T34-p RRKKKRKtRATDsLP
S39-p RKtRATDsLPGKFED
Y60 ELLGEGAYAKVQGAV
S148 HFNEREASRVVRDVA
S180-p PENILCEsPEKVsPV
S185-p CEsPEKVsPVKICDF
S196 ICDFDLGSGVKLNNs
S203-p SGVKLNNsCTPITtP
T209-p NsCTPITtPELTtPC
T214-p ITtPELTtPCGSAEY
T344-p APERGLPtPQVLQRN
S352 PQVLQRNSSTMDLTL
S372-p IALNRQLsQHEENEL
S396-p GLCSMKLsPPSKSRL
R414 RALAQAGRSRDANPC
N419 AGRSRDANPCLTPAG
2111 : Phospho-Mnk1 (Thr197/202) Antibody
2111 : Phospho-Mnk1 (Thr197/202) Antibody
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