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Protein Page:
KIBRA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KIBRA a postsynaptic scaffolding protein associated with human memory performance. Interacts via its WW domains with the postsynaptic protein DDN, which plays a role in synaptic plasticity. Expressed in the hypothalamus and cerebellum, and in the hippocampus and cortex, both regions of the brain that are related to memory. Co-localizes with PKCZ in the mouse hippocampus. Binds to synaptopodin, modulating podocyte directional migration. Forms a complex with dynein light chain 1 that is recruited to ER-responsive promoters, and that is required for ER transactivation in breast cancer cells. Binds the minus end-directed microtubule motor dynein. Its amino terminus binds the eight PDZ domain of the polarity protein INADL . Two human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: protein complex; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding, bridging; protein binding; transcription coactivator activity; protein complex scaffold; kinase binding
Biological Process: cell migration; regulation of intracellular transport; positive regulation of MAPKKK cascade; transcription, DNA-dependent; establishment of cell polarity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of organ growth
Reference #:  Q8IX03 (UniProtKB)
Alt. Names/Synonyms: FLJ10865; FLJ23369; HBeAg-binding protein 3; HBEBP3; HBEBP36; KIAA0869; KIBRA; Kidney and brain protein; Protein KIBRA; protein WWC1; WW and C2 domain containing 1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1; WWC1
Gene Symbols: WWC1
Molecular weight: 125,301 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KIBRA

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S539‑p
cell growth, induced: S542‑p, S548‑p, T929‑p, S947‑p
cell motility, induced: T929‑p, S947‑p
molecular association, regulation: S539‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 41 Y128-p LELAQQEyQQLHAVW
0 3 S141 VWEHKLGSQVSLVSG
0 3 S144 HKLGSQVSLVSGSSS
0 1 K154-ac SGSSSSSkYDPEILK
0 1 S241-p EKQDLIKsLAMLKDG
0 1 S255-p GFRTDRGsHSDLWSS
0 1 T284 YLDVSSQTDISGSFG
0 2 S427-p HSQLKSLsSSMQSLS
0 1 S429 QLKSLsSSMQSLSSG
0 1 S432 SLsSSMQSLSSGSsP
0 1 S434 sSSMQSLSSGSsPGS
0 1 S438-p QSLSSGSsPGSLTSS
0 1 S530 SLSGTPKSMTSLsPR
0 1 S533 GTPKSMTSLsPRSsL
0 3 S535-p PKSMTSLsPRSsLSs
3 0 S539-p TSLsPRSsLSsPSPP
2 0 S542-p sPRSsLSsPSPPCsP
1 0 S548-p SsPSPPCsPLMADPL
0 24 Y781-p GERSTRWyNLLSyKy
0 3 Y786-p RWyNLLSyKyLKKQS
0 22 Y788-p yNLLSyKyLKKQSRE
0 1 S815-p PASTDAVsALLEQTA
0 1 S876-p DVFTEKAsPDMDGYP
0 1 T891 ALKVDKETNtEtPAP
0 3 T893-p KVDKETNtEtPAPsP
1 6 T895-p DKETNtEtPAPsPtV
0 7 S899-p NtEtPAPsPtVVRPK
0 1 T901-p EtPAPsPtVVRPKDR
1 2 T912-p PKDRRVGtPSQGPFL
0 3 S927 RGSTIIRSKtFsPGP
1 10 T929-p STIIRSKtFsPGPQS
1 3 S931-p IIRSKtFsPGPQSQy
0 1 Y938-p sPGPQSQyVCRLNRs
0 1 S945-p yVCRLNRsDsDSSTL
1 48 S947-p CRLNRsDsDSSTLSK
0 1 T951 RsDsDSSTLSKKPPF
0 1 S962-p KPPFVRNsLERRSVR
0 2 S967 RNsLERRSVRMKRPS
1 0 S975-p VRMKRPSsVKsLRSE
1 0 S978-p KRPSsVKsLRSERLI
  mouse

 
Y128-p LELAQQEyQQLHAVW
S141-p VWEHKLGsQVsLVSG
S144-p HKLGsQVsLVSGSSS
K154 SGSSSSSKYDPEILK
S241 EKQDLIKSLAMLKDG
S255 GFRTDRGSHSDLWSS
T284-p FLDVSSQtDISGSFS
S427-p HSQLKSLsSsMQsLs
S429-p QLKSLsSsMQsLsSG
S432-p SLsSsMQsLsSGSSP
S434-p sSsMQsLsSGSSPGS
S438 QsLsSGSSPGSLTSS
S530-p SLSGTPRsMTsLsPR
S533-p GTPRsMTsLsPRSSL
S535-p PRsMTsLsPRSSLSS
S539 TsLsPRSSLSSPSPP
S542 sPRSSLSSPSPPCSP
S548 SSPSPPCSPLITDPL
Y782 GERSTRWYNLLSYKY
Y787 RWYNLLSYKYLKKQC
Y789 YNLLSYKYLKKQCRE
S812 PDHVDAVSALLEQTA
S868-p DVFTEKVsPEAEECP
T883-p ALKVDREtNtDsVAP
T885-p KVDREtNtDsVAPsP
S887-p DREtNtDsVAPsPTV
S891-p NtDsVAPsPTVVRPK
T893 DsVAPsPTVVRPKDR
A904 PKDRRVGAPSTGPFL
S919-p RGNTIIRsKtFSPGP
T921-p NTIIRsKtFSPGPQS
S923 IIRsKtFSPGPQSQY
Y930 SPGPQSQYVCRLNRS
S937 YVCRLNRSDsDSStL
S939-p CRLNRSDsDSStLSK
T943-p RSDsDSStLSKKPPF
S954 KPPFVRNSLERRsVR
S959-p RNSLERRsVRMKRPS
S967 VRMKRPSSVKSLRTE
S970 KRPSSVKSLRTERLI
  rat

 
Y128 LELAQQEYQQLHAVW
S141 VWEHKLGSQVSLVSG
S144 HKLGSQVSLVSGSSS
K154 SGSSSSSKYDPEILK
S241 EKQDLIKSLAMLKDG
S255 GFRTDRGSHSDLWSS
T284 FLDVSSQTDISGSFS
S427 HSQLKSLSSSMQSLS
S429 QLKSLSSSMQSLSSG
S432 SLSSSMQSLSSGSSP
S434 SSSMQSLSSGSSPGS
S438 QSLSSGSSPGSLTSS
S530 SLSGTPRSMTSLSPR
S533 GTPRSMTSLSPRSSL
S535 PRSMTSLSPRSSLSS
S539 TSLSPRSSLSSPSPP
S542 SPRSSLSSPSPPCSP
S548 SSPSPPCSPLIADPL
Y782-p GERSTRWyNLLSyKY
Y787-p RWyNLLSyKYLKKQG
Y789 yNLLSyKYLKKQGRE
S812 PDHVDAVSALLEQTA
S872 DVFAEKVSPEAEECP
T887 ALKVDRETNTDSVTP
T889 KVDRETNTDSVTPSP
S891 DRETNTDSVTPSPTV
S895 NTDSVTPSPTVVRPK
T897 DSVTPSPTVVRPKDR
A908 PKDRRVGAPSPGPFL
S923 RGNTIIRSKTFSPGP
T925 NTIIRSKTFSPGPQS
S927 IIRSKTFSPGPQSQY
Y934 SPGPQSQYVCRLNRS
S941 YVCRLNRSDSDSSTL
S943 CRLNRSDSDSSTLSK
T947 RSDSDSSTLSKKPPF
S958 KPPFVRNSLERRSVR
S963 RNSLERRSVRMKRPS
S971 VRMKRPSSVKSLRTE
S974 KRPSSVKSLRTERLI
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