a postsynaptic scaffolding protein associated with human memory performance. Interacts via its WW domains with the postsynaptic protein DDN, which plays a role in synaptic plasticity. Expressed in the hypothalamus and cerebellum, and in the hippocampus and cortex, both regions of the brain that are related to memory. Co-localizes with PKCZ in the mouse hippocampus. Binds to synaptopodin, modulating podocyte directional migration. Forms a complex with dynein light chain 1 that is recruited to ER-responsive promoters, and that is required for ER transactivation in breast cancer cells. Binds the minus end-directed microtubule motor dynein. Its amino terminus binds the eight PDZ domain of the polarity protein INADL . Two human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q34
Cellular Component: protein complex; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding, bridging; protein binding; transcription coactivator activity; protein complex scaffold; kinase binding
Biological Process: cell migration; regulation of intracellular transport; transcription, DNA-dependent; positive regulation of MAPKKK cascade; establishment of cell polarity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of organ growth
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.