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KIBRA (human)

Overview KIBRA a postsynaptic scaffolding protein associated with human memory performance. Interacts via its WW domains with the postsynaptic protein DDN, which plays a role in synaptic plasticity. Expressed in the hypothalamus and cerebellum, and in the hippocampus and cortex, both regions of the brain that are related to memory. Co-localizes with PKCZ in the mouse hippocampus. Binds to synaptopodin, modulating podocyte directional migration. Forms a complex with dynein light chain 1 that is recruited to ER-responsive promoters, and that is required for ER transactivation in breast cancer cells. Binds the minus end-directed microtubule motor dynein. Its amino terminus binds the eight PDZ domain of the polarity protein INADL . Two human isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus Molecular Function: protein binding; transcription coactivator activity Biological Process: cell migration; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; transcription, DNA-dependent Reference #:  Q8IX03 (UniProtKB) Alt. Names/Synonyms: FLJ10865; FLJ23369; HBeAg-binding protein 3; HBEBP3; HBEBP36; KIAA0869; KIBRA; Kidney and brain protein; Protein KIBRA; protein WWC1; WW and C2 domain containing 1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1; WWC1 Gene Symbols: WWC1 Molecular weight: 125,301 Da Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states CST Pathways:  Hippo Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below KIBRA 2Z0U - A/B=638-785 (human)

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	Sites Implicated In
cell cycle regulation: S539‑p molecular association, regulation: S539‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	36		Y128-p	LELAQQEyQQLHAVW
0	2		S141	VWEHKLGSQVSLVSG
0	2		S144	HKLGSQVSLVSGSSS
0	1		K154-a	SGSSSSSkYDPEILK
0	1		S241-p	EKQDLIKsLAMLKDG
0	1		S255-p	GFRTDRGsHSDLWSS
0	1		T284	YLDVSSQTDISGSFG
0	2		S427-p	HSQLKSLsSSMQSLS
0	1		S429	QLKSLsSSMQSLSSG
0	1		S432	SLsSSMQSLSSGSSP
0	1		S434	sSSMQSLSSGSSPGS
0	1		S530	SLSGTPKSMTSLsPR
0	1		S533	GTPKSMTSLsPRSsL
0	2		S535-p	PKSMTSLsPRSsLSs
3	0		S539-p	TSLsPRSsLSsPSPP
1	0		S542-p	sPRSsLSsPSPPCSP
0	24		Y781-p	GERSTRWyNLLSyKy
0	3		Y786-p	RWyNLLSyKyLKKQS
0	22		Y788-p	yNLLSyKyLKKQSRE
0	1		S815-p	PASTDAVsALLEQTA
0	1		S876-p	DVFTEKAsPDMDGYP
0	1		T891	ALKVDKETNtEtPAP
0	2		T893-p	KVDKETNtEtPAPsP
1	4		T895-p	DKETNtEtPAPsPtV
0	5		S899-p	NtEtPAPsPtVVRPK
0	1		T901-p	EtPAPsPtVVRPKDR
1	1		T912-p	PKDRRVGtPSQGPFL
0	2		S927	RGSTIIRSKtFsPGP
0	8		T929-p	STIIRSKtFsPGPQS
1	2		S931-p	IIRSKtFsPGPQSQy
0	1		Y938-p	sPGPQSQyVCRLNRs
0	1		S945-p	yVCRLNRsDsDSSTL
0	43		S947-p	CRLNRsDsDSSTLSK
0	1		T951	RsDsDSSTLSKKPPF
0	2		S967-p	RNSLERRsVRMKRPS
1	0		S975-p	VRMKRPSsVKsLRSE
1	0		S978-p	KRPSsVKsLRSERLI

	mouse
Y128-p	LELAQQEyQQLHAVW
S141-p	VWEHKLGsQVsLVSG
S144-p	HKLGsQVsLVSGSSS
K154	SGSSSSSKYDPEILK
S241	EKQDLIKSLAMLKDG
S255	GFRTDRGSHSDLWSS
T284-p	FLDVSSQtDISGSFS
S427-p	HSQLKSLsSsMQsLs
S429-p	QLKSLsSsMQsLsSG
S432-p	SLsSsMQsLsSGSSP
S434-p	sSsMQsLsSGSSPGS
S530-p	SLSGTPRsMTsLsPR
S533-p	GTPRsMTsLsPRSSL
S535-p	PRsMTsLsPRSSLSS
S539	TsLsPRSSLSSPSPP
S542	sPRSSLSSPSPPCSP
Y782	GERSTRWYNLLSYKY
Y787	RWYNLLSYKYLKKQC
Y789	YNLLSYKYLKKQCRE
S812	PDHVDAVSALLEQTA
S868-p	DVFTEKVsPEAEECP
T883-p	ALKVDREtNtDsVAP
T885-p	KVDREtNtDsVAPsP
S887-p	DREtNtDsVAPsPTV
S891-p	NtDsVAPsPTVVRPK
T893	DsVAPsPTVVRPKDR
A904	PKDRRVGAPSTGPFL
S919-p	RGNTIIRsKtFSPGP
T921-p	NTIIRsKtFSPGPQS
S923	IIRsKtFSPGPQSQY
Y930	SPGPQSQYVCRLNRS
S937	YVCRLNRSDsDSStL
S939-p	CRLNRSDsDSStLSK
T943-p	RSDsDSStLSKKPPF
S959-p	RNSLERRsVRMKRPS
S967	VRMKRPSSVKSLRTE
S970	KRPSSVKSLRTERLI

	rat
Y128	LELAQQEYQQLHAVW
S141	VWEHKLGSQVSLVSG
S144	HKLGSQVSLVSGSSS
K154	SGSSSSSKYDPEILK
S241	EKQDLIKSLAMLKDG
S255	GFRTDRGSHSDLWSS
T284	FLDVSSQTDISGSFS
S427	HSQLKSLSSSMQSLS
S429	QLKSLSSSMQSLSSG
S432	SLSSSMQSLSSGSSP
S434	SSSMQSLSSGSSPGS
S530	SLSGTPRSMTSLSPR
S533	GTPRSMTSLSPRSSL
S535	PRSMTSLSPRSSLSS
S539	TSLSPRSSLSSPSPP
S542	SPRSSLSSPSPPCSP
Y782-p	GERSTRWyNLLSyKY
Y787-p	RWyNLLSyKYLKKQG
Y789	yNLLSyKYLKKQGRE
S812	PDHVDAVSALLEQTA
S872	DVFAEKVSPEAEECP
T887	ALKVDRETNTDSVTP
T889	KVDRETNTDSVTPSP
S891	DRETNTDSVTPSPTV
S895	NTDSVTPSPTVVRPK
T897	DSVTPSPTVVRPKDR
A908	PKDRRVGAPSPGPFL
S923	RGNTIIRSKTFSPGP
T925	NTIIRSKTFSPGPQS
S927	IIRSKTFSPGPQSQY
Y934	SPGPQSQYVCRLNRS
S941	YVCRLNRSDSDSSTL
S943	CRLNRSDSDSSTLSK
T947	RSDSDSSTLSKKPPF
S963	RNSLERRSVRMKRPS
S971	VRMKRPSSVKSLRTE
S974	KRPSSVKSLRTERLI

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