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MLK3 (human)

Overview MLK3 a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.25; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; MLK family; MLK subfamily Cellular Component: microtubule; centrosome Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; JUN kinase kinase kinase activity; protein homodimerization activity; mitogen-activated protein kinase kinase binding; protein-tyrosine kinase activity; Rac GTPase binding; mitogen-activated protein kinase kinase kinase binding; ATP binding; protein kinase activity Biological Process: cell death; cell proliferation; positive regulation of JNK activity; activation of MAPK activity; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; JNK cascade; positive regulation of JNK cascade; G1 phase of mitotic cell cycle; protein amino acid phosphorylation; activation of JNK activity; microtubule-based process Reference #:  Q16584 (UniProtKB) Alt. Names/Synonyms: M3K11; MAP3K11; MEKK11; MGC17114; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; MLK-3; MLK3; protein-tyrosine kinase PTK1; PTK1; SH3 domain-containing proline-rich kinase; SPRK; Src-homology 3 domain-containing proline-rich kinase Gene Symbols: MAP3K11 Molecular weight: 92,688 Da Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Regulation of Actin Dynamics  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MLK3

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	Sites Implicated In
apoptosis, inhibited: S674‑p enzymatic activity, induced: T277‑p, S281‑p molecular association, regulation: T277‑p, S281‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S11-p	LKSLFLKsPLGSWNG
0	4		S35-p	GGGRPEGsPKAAGYA
6	0		T277-p	LAREWHKtTQMsAAG
6	0		S281-p	WHKtTQMsAAGTYAW
0	1		S394-p	MPRDSFHsMQEGWKR
0	2		S493-p	RDGGERIsMPLDFKH
0	7		S507-p	HRITVQAsPGLDrRR
0	1		R512-m1	QAsPGLDrRRNVFEV
1	10		S524-p	FEVGPGDsPtFPRFR
0	1		T526-p	VGPGDsPtFPRFRAI
0	2		S548-p	GQAWGRQsPRRLEDs
1	1		S555-p	sPRRLEDssNGERRA
1	1		S556-p	PRRLEDssNGERRAC
1	1		S654-p	RGTALLAsLGLGRDL
2	0		S674-p	PGRERGEsPTtPPTP
0	1		T677-p	ERGEsPTtPPTPTPA
0	1		S693-p	CPTEPPPsPLICFSL
0	1		T702-p	LICFSLKtPDsPPtP
1	3		S705-p	FSLKtPDsPPtPAPL
0	1		T708-p	KtPDsPPtPAPLLLD
1	1		S724-p	GIPVGQRsAKsPRRE
1	1		S727-p	VGQRsAKsPRREEEP
0	1		T738-p	EEEPRGGtVsPPPGT
0	8		S740-p	EPRGGtVsPPPGTSR
0	5		S748-p	PPPGTSRsAPGtPGt
0	1		T752-p	TSRsAPGtPGtPRsP
0	2		T755-p	sAPGtPGtPRsPPLG
1	5		S758-p	GtPGtPRsPPLGLIS
0	1		S765	sPPLGLISRPRPsPL
1	1		S770-p	LISRPRPsPLRSRID
1	11		S789-p	VSAGPRPsPLPsPQP
2	13		S793-p	PRPsPLPsPQPAPRR
0	1		S815-p	DSDPFWDsPPANPFQ

	mouse
S11	LKNLFLKSPLGSWNG
S35-p	GGVRPEGsPKATAAY
T278-p	LAREWHKtTQMsAAG
S282-p	WHKtTQMsAAGTYAW
S395	MPRDSFHSMQEGWKR
S494	RDGGERISMPLDFKH
S508-p	HRITVQAsPGLDRRR
R513	QAsPGLDRRRNVFEV
S525-p	FEVGAGDsPtFPRFR
T527-p	VGAGDsPtFPRFRAI
S549	GQTWGRQSPRRLEDS
S556	SPRRLEDSSNGERRA
S557	PRRLEDSSNGERRAC
S655	RGTALLASLGLGRDL
S675	LSRERGESPTAPPPA
A678	ERGESPTAPPPAQMP
T695	CPPELPSTPLIRLSQ
T704	LIRLSQTTPDAHSSP
S709	QTTPDAHSSPTPGPL
T712	PDAHSSPTPGPLLLD
S728	GVPSGQPSAKSPRRE
S731	SGQPSAKSPRREETR
T741	REETRGRTVsPPPGI
S743-p	ETRGRTVsPPPGISR
S751	PPPGISRSAPGTPGt
T755	ISRSAPGTPGtPRsP
T758-p	SAPGTPGtPRsPPLG
S761-p	GTPGtPRsPPLGLIs
S768-p	sPPLGLIsRPRPSPL
S773	LIsRPRPSPLRSRID
S792-p	VSAGPRPsPLPsPQP
S796-p	PRPsPLPsPQPAPRR
S818	DSDPFWDSPPANPFR

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