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Protein Page:
MLK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MLK3 a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; EC 2.7.11.25; TKL group; MLK family; MLK subfamily
Chromosomal Location of Human Ortholog: 11q13.1-q13.3
Cellular Component: microtubule; centrosome; membrane; cytoplasm
Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; JUN kinase kinase kinase activity; protein homodimerization activity; mitogen-activated protein kinase kinase binding; protein-tyrosine kinase activity; Rac GTPase binding; mitogen-activated protein kinase kinase kinase binding; ATP binding; protein kinase activity
Biological Process: cell death; positive regulation of JNK activity; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of JNK cascade; protein amino acid phosphorylation; activation of JNK activity; microtubule-based process; cell proliferation; positive regulation of neuron apoptosis; JNK cascade; G1 phase of mitotic cell cycle; activation of JNKK activity
Reference #:  Q16584 (UniProtKB)
Alt. Names/Synonyms: M3K11; MAP3K11; MEKK11; MGC17114; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; MLK-3; MLK3; protein-tyrosine kinase PTK1; PTK1; SH3 domain-containing proline-rich kinase; SPRK; Src-homology 3 domain-containing proline-rich kinase
Gene Symbols: MAP3K11
Molecular weight: 92,688 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MLK3

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S674‑p
enzymatic activity, induced: T277‑p, S281‑p
molecular association, regulation: T277‑p, S281‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S11-p LKSLFLKsPLGSWNG
0 5 S35-p GGGRPEGsPKAAGYA
1 0 K264-ub DMEHKTLkITDFGLA
6 0 T277-p LAREWHKtTQMsAAG
6 0 S281-p WHKtTQMsAAGTYAW
0 1 S394-p MPRDSFHsMQEGWKR
1 0 T477-p HVRRRRGtFKRSKLR
0 3 S493-p RDGGERIsMPLDFKH
0 12 S507-p HRITVQAsPGLDrRR
0 1 R512-m1 QAsPGLDrRRNVFEV
1 17 S524-p FEVGPGDsPtFPRFR
0 2 T526-p VGPGDsPtFPRFRAI
0 3 S548-p GQAWGRQsPRRLEDs
1 1 S555-p sPRRLEDssNGERRA
1 1 S556-p PRRLEDssNGERRAC
1 1 S654-p RGTALLAsLGLGRDL
2 0 S674-p PGRERGEsPTtPPTP
0 1 T677-p ERGEsPTtPPTPTPA
0 1 S693-p CPTEPPPsPLICFSL
0 1 T702-p LICFSLKtPDsPPtP
1 3 S705-p FSLKtPDsPPtPAPL
0 1 T708-p KtPDsPPtPAPLLLD
1 1 S724-p GIPVGQRsAKsPRRE
1 1 S727-p VGQRsAKsPRREEEP
0 2 T738-p EEEPRGGtVsPPPGT
0 12 S740-p EPRGGtVsPPPGTsR
0 1 S746-p VsPPPGTsRsAPGtP
0 7 S748-p PPPGTsRsAPGtPGt
0 1 T752-p TsRsAPGtPGtPRsP
0 2 T755-p sAPGtPGtPRsPPLG
1 6 S758-p GtPGtPRsPPLGLIS
0 1 S765 sPPLGLISRPRPsPL
1 1 S770-p LISRPRPsPLRSRID
1 13 S789-p VSAGPRPsPLPsPQP
2 16 S793-p PRPsPLPsPQPAPRR
0 1 S815-p DSDPFWDsPPANPFQ
  mouse

 
S11 LKNLFLKSPLGSWNG
S35-p GGVRPEGsPKATAAY
- under review  
T278-p LAREWHKtTQMsAAG
S282-p WHKtTQMsAAGTYAW
S395 MPRDSFHSMQEGWKR
- under review  
S494 RDGGERISMPLDFKH
S508-p HRITVQAsPGLDRRR
R513 QAsPGLDRRRNVFEV
S525-p FEVGAGDsPtFPRFR
T527-p VGAGDsPtFPRFRAI
S549 GQTWGRQSPRRLEDS
S556 SPRRLEDSSNGERRA
S557 PRRLEDSSNGERRAC
S655 RGTALLASLGLGRDL
S675 LSRERGESPTAPPPA
A678 ERGESPTAPPPAQMP
T695 CPPELPSTPLIRLSQ
T704 LIRLSQTTPDAHSSP
S709 QTTPDAHSSPTPGPL
T712 PDAHSSPTPGPLLLD
S728 GVPSGQPSAKSPRRE
S731 SGQPSAKSPRREETR
T741 REETRGRTVsPPPGI
S743-p ETRGRTVsPPPGISR
S749 VsPPPGISRSAPGTP
S751 PPPGISRSAPGTPGt
T755 ISRSAPGTPGtPRsP
T758-p SAPGTPGtPRsPPLG
S761-p GTPGtPRsPPLGLIs
S768-p sPPLGLIsRPRPSPL
S773 LIsRPRPSPLRSRID
S792-p VSAGPRPsPLPsPQP
S796-p PRPsPLPsPQPAPRR
S818 DSDPFWDSPPANPFR
  rat

 
S11 LKNLFLKSPLGSWNG
S35 GGVRPEGSPKATAAY
- under review  
T278 LAREWHKTTQMSAAG
S282 WHKTTQMSAAGTYAW
S395 MPRDSFHSMQEGWKR
- under review  
S494 RDGGERISMPLDFKH
S508-p HRITVQAsPGLDRRR
R513 QAsPGLDRRRNVFEV
S525-p FEVGAGDsPTFPRFR
T527 VGAGDsPTFPRFRAI
S549 GQTWGRQSPRRLDDS
S556 SPRRLDDSSNGERRA
S557 PRRLDDSSNGERRAC
S655 RGTALLASLGLGRDL
S675 LSRERGESPTAPPPA
A678 ERGESPTAPPPAQMA
T695 CPPDLPSTPLIHLSQ
T704 LIHLSQATPDARGPL
- gap
T712 PDARGPLTPAPLLLD
S728 GVSSGQPSAKSPRRE
S731 SGQPSAKSPRREETR
T741 REETRGRTVSPPPGI
S743 ETRGRTVSPPPGISR
S749 VSPPPGISRSAPGTP
S751 PPPGISRSAPGTPGT
T755 ISRSAPGTPGTPRsP
T758 SAPGTPGTPRsPPLG
S761-p GTPGTPRsPPLGLIS
S768 sPPLGLISRPRPSPL
S773 LISRPRPSPLRNRID
S792 VSAGPRPSPLPSPQP
S796 PRPSPLPSPQPAPRR
S818 DSDPFWDSPPANPFR
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