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Protein Page:
HUWE1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HUWE1 E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Interacts with isoform p14ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity. Interacts with MYCN, POLB and CDC6. Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas. Belongs to the TOM1/PTR1 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; ubiquitin-protein ligase activity
Biological Process: protein monoubiquitination; protein polyubiquitination; base-excision repair; histone ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; cell differentiation
Reference #:  Q7Z6Z7 (UniProtKB)
Alt. Names/Synonyms: ARF binding protein 1; ARF-binding protein 1; ARF-BP1; BJ-HCC-24 tumor antigen; E3 ubiquitin-protein ligase HUWE1; HECT domain protein LASU1; HECT, UBA and WWE domain containing 1; HECT, UBA and WWE domain-containing protein 1; HectH9; Homologous to E6AP carboxyl terminus homologous protein 9; HSPC272; HUWE1; Ib772; KIAA0312; KIAA1578; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; Mule; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1; UREB1
Gene Symbols: HUWE1
Molecular weight: 481,891 Da
Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HUWE1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y52 NIGKCELYHWVDLLD
0 1 K324-u DKQLMEIkAASLRTL
0 3 T484-p PKIQRPNtTQEGEEM
0 1 K509-a PQRAALLkSMLNFLK
0 1 K632-u QPFERLFkVLLSPDY
0 4 S648-p PAMRRRRssDPLGDt
0 15 S649-p AMRRRRssDPLGDtA
0 4 T655-p ssDPLGDtASNLGSA
0 3 K674-u MRHQPTLkTDATTAI
0 4 S740-p EEVQAMQsFNSTQQN
1 1 S927-p ISVNQWGsQLGLSVL
0 1 K1050-u AARIKQIkPLLSASS
0 2 S1077-p LVKLCVGsPVRQRRs
0 8 S1084-p sPVRQRRsHHAASTT
0 5 K1107-u STASALTkLLTkGLS
0 2 K1111-u ALTkLLTkGLSWQPP
0 1 K1147-u PMLFDERkYPYHLML
0 2 K1156-u PYHLMLQkFLCSGGH
0 5 K1225-u SPHSLPAkLPGGVQN
0 1 K1247-u RFLVVTQkAAFTCIK
0 3 K1295-u RERLSKEkEGSRGEE
0 2 Y1351-p TMEQATEyLLTHPPP
0 15 S1368-p GGVVRDLsMsEEDQM
0 3 S1370-p VVRDLsMsEEDQMMR
0 1 S1382-p MMRAIAMsLGQDIPM
0 23 S1395-p PMDQRAEsPEEVACR
0 7 K1470-u DLIMTAIkRNGADyR
0 2 Y1476-p IkRNGADyRDMILkQ
0 2 K1482-a DyRDMILkQVVNQVW
0 2 K1608-u KRRAQMTkYLQSNSN
0 3 K1693-u PRLNKNSkNSNGQEL
0 1 S1695 LNKNSkNSNGQELEk
0 2 K1702-u SNGQELEkTLEESkE
0 1 K1708-u EkTLEESkEMDIKRK
0 1 K1718-u DIKRKENkGNDtPLA
0 2 T1722-p KENkGNDtPLALEST
0 2 K1733-u LESTNTEkETSLEET
0 1 K1799-u AMMFAELkSTRMILN
0 1 K1840-a TLRHTMEkVVRSAAT
0 3 K1840-u TLRHTMEkVVRSAAT
0 1 Y1869-p LGSREINyILRVLGP
0 2 S1903-p ALPAPRGsGtAsDDE
0 3 T1905-p PAPRGsGtAsDDEFE
0 53 S1907-p PRGsGtAsDDEFENL
0 9 K1917-u EFENLRIkGPNAVQL
0 2 K1926-u PNAVQLVkTTPLkPS
0 2 K1931-u LVkTTPLkPSPLPVI
0 35 Y1988-p QDMGDDVyQQyRSLT
0 11 Y1991-p GDDVyQQyRSLTRQS
0 6 S1999-p RSLTRQSsDFDTQSG
0 1 S2052-p DKEGDRAsEEGKQKG
0 1 T2193 IMESCPSTSSFysSA
0 1 S2194 MESCPSTSSFysSAT
0 1 S2195 ESCPSTSSFysSATA
0 5 Y2197-p CPSTSSFysSATAKT
0 2 S2198-p PSTSSFysSATAKTQ
0 1 S2199 STSSFysSATAKTQH
0 1 T2201 SSFysSATAKTQHNG
0 1 T2204 ysSATAKTQHNGMNN
0 1 K2218-u NIIRLFLkkGLVNDL
0 4 K2219-u IIRLFLkkGLVNDLA
0 1 K2248-a NTVNAALkPLETLSR
0 3 K2248-u NTVNAALkPLETLSR
0 2 S2261-p SRIVNQPssLFGskS
0 2 S2262-p RIVNQPssLFGskSA
0 2 S2266-p QPssLFGskSASSKN
0 5 K2267-u PssLFGskSASSKNK
1 1 S2339-p GQPEVLSsQEMQVEN
0 29 S2362-p LLERDGGsGNstIIV
0 19 S2365-p RDGGsGNstIIVsRs
0 7 T2366-p DGGsGNstIIVsRsG
0 1 S2370-p GNstIIVsRsGEDEs
0 4 S2372-p stIIVsRsGEDEsQE
0 16 S2377-p sRsGEDEsQEDVLMD
0 7 S2388-p VLMDEAPsNLsQAst
0 46 S2391-p DEAPsNLsQAstLQA
0 3 S2394-p PsNLsQAstLQANRE
0 4 T2395-p sNLsQAstLQANRED
0 36 Y2471-p EMELDEDyPDMNASP
0 1 S2526-p MVRHADHssLtLGsG
0 2 S2527-p VRHADHssLtLGsGs
0 9 T2529-p HADHssLtLGsGsst
0 2 S2532-p HssLtLGsGssttRL
0 1 S2534-p sLtLGsGssttRLtQ
0 4 S2535-p LtLGsGssttRLtQG
0 3 T2536-p tLGsGssttRLtQGI
0 3 T2537-p LGsGssttRLtQGIG
0 6 T2540-p GssttRLtQGIGrsQ
0 3 R2545-m1 RLtQGIGrsQRTLRQ
0 8 S2546-p LtQGIGrsQRTLRQL
0 2 T2554-p QRTLRQLtANTGHTI
0 4 S2595-p DILQLSSsLPLQSRG
0 2 S2619-p DVHIIARsDDELLDD
1 10 S2636-p HDQSTATsQAGTLSS
0 9 K2671-u HDCVSVVkVSIVNHL
0 3 K2695-u ERREKRRkQLAEEET
0 3 K2703-u QLAEEETkITDKGkE
0 6 K2709-u TkITDKGkEDkENRD
0 3 K2712-u TDKGkEDkENRDQSA
0 1 Y2744 GTPMPDSYPttPSSt
0 12 T2746-p PMPDSYPttPSStDA
0 20 T2747-p MPDSYPttPSStDAA
0 2 T2751-p YPttPSStDAATSES
0 20 S2887-p SEQPRAGsstPGDAP
0 14 S2888-p EQPRAGsstPGDAPP
0 24 T2889-p QPRAGsstPGDAPPA
0 1 S2917-p SAQPPEDssPPASSE
0 6 S2918-p AQPPEDssPPASSES
0 3 S2940-p VAISGADsRGILEEP
0 2 S3116-p HERLFGHssTSALsA
0 4 S3117-p ERLFGHssTSALsAI
0 1 S3122-p HssTSALsAILRsPA
0 24 S3127-p ALsAILRsPAFTsRL
0 1 T3131 ILRsPAFTsRLsGNR
0 2 S3132-p LRsPAFTsRLsGNRG
0 1 S3135-p PAFTsRLsGNRGVQy
0 2 Y3142-p sGNRGVQytRLAVQr
0 2 T3143-p GNRGVQytRLAVQrG
0 4 R3149-m1 ytRLAVQrGGTFQMG
0 4 S3165-p SSSHNRPsGSNVDtL
0 2 T3171-p PsGSNVDtLLRLRGR
0 3 K3244-u ELCIETPkLTTSEEk
0 2 K3251-u kLTTSEEkGKKSSKS
0 95 K3345-u DTLIQLAkVFPSHFT
0 5 K3357-u HFTQQRTkETNCESD
0 5 S3373-p ERGNKACsPCSsQSS
1 3 S3377-p KACsPCSsQSSSSGI
0 2 Y3424-p GEGETSPySLEASPL
0 69 K3452-u RSSLLTEkLLRLLSL
0 3 S3555-p PTTKGSKsPAkVSDG
0 2 K3558-u KGSKsPAkVSDGGSS
0 10 K3621-u GTRDTVLkLLLNGAR
0 11 K3636-u HLGYTLCkQIGTLLA
0 2 T3660-p QRRAQCEtLsPdGLP
0 15 S3662-p RAQCEtLsPdGLPEE
0 1 D3664-ca QCEtLsPdGLPEEQP
0 5 K3675-u EEQPQTTkLkGKMQS
0 6 K3677-u QPQTTkLkGKMQSRF
1 1 S3695-p ENVVIVAsQkRPLGG
0 2 K3697-u VVIVAsQkRPLGGRE
0 4 S3752-p KQTGRLGssGLGsAs
0 1 S3753-p QTGRLGssGLGsAss
0 16 S3757-p LGssGLGsAssIQAA
0 2 S3759-p ssGLGsAssIQAAVR
0 4 S3760-p sGLGsAssIQAAVRQ
0 1 D3773-ca RQLEAEAdAIIQMVR
1 9 S3797-p QAATSESsQSEASVR
0 4 S3808-p ASVRREEsPMDVDQP
0 10 S3816-p PMDVDQPsPSAQDtQ
0 1 T3822-p PsPSAQDtQSIAsDG
0 1 S3827-p QDtQSIAsDGtPQGE
0 1 T3830-p QSIAsDGtPQGEkEK
0 1 K3835-u DGtPQGEkEKEERPP
0 11 S3906-p PVRDTREsQLAHIkD
0 4 K3912-u EsQLAHIkDEPPPLs
0 95 S3919-p kDEPPPLsPAPLtPA
0 107 T3924-p PLsPAPLtPAtPssL
0 87 T3927-p PAPLtPAtPssLDPF
0 14 S3929-p PLtPAtPssLDPFFS
0 15 S3930-p LtPAtPssLDPFFSR
0 1 K3954-u SLPPDTQkFLRFAET
0 3 Y4078-p REMFNPMyALFRTSP
0 6 K4116-u FVGRIVAkAVYDNRL
0 1 K4134 YFTRSFYKHILGkSV
0 2 K4139-u FYKHILGkSVRYTDM
0 1 K4190-u VCEVRDLkPNGANIL
0 13 K4221-u RMTGAIRkQLAAFLE
1 0 Y4271 SNTEYHKYQSNSIQI
0 8 K4295-u FDQADRAkFLQFVTG
0 4 K4305-u QFVTGTSkVPLQGFA
0 1 K4322-u EGMNGIQkFQIHRDD
  mouse

 
Y52-p NIGKCELyHWVDLLD
K324 DKQLMEIKAASLRTL
T484 PKIQRPSTTQEGEEM
K509 PQRAALLKSMLNFLK
K632 QPFERLFKVLLSPDY
S648-p PAMRRRRssDPLGDt
S649-p AMRRRRssDPLGDtA
T655-p ssDPLGDtASNLGSA
K674 MRHQPTLKTDATTAI
S740 EEVQAMQSFNSAQQN
S927 ISVNQWGSQLGLSVL
K1050 AARIKQIKPLLSASS
S1077-p LVKLCVGsPVRQRRs
S1084-p sPVRQRRsHHAASTT
K1107-u STASALTkLLTKGLS
K1111 ALTkLLTKGLSWQPP
K1147 PMLFDERKYPYHLML
K1156 PYHLMLQKFLCSGGH
K1225 SPHSLPAKLPGGVQS
K1247 RFLVVTQKAAFTCIK
K1295 RERLSKEKEGSRGEE
Y1351 TMEQATEYLLTHPPP
S1368-p GGVVRDLsMsEEDQM
S1370-p VVRDLsMsEEDQMMR
S1382 MMRAIAMSLGQDIPM
S1395-p PMDQRAEsPEEVACR
K1470-u DLIMTAIkRNGADYR
Y1476 IkRNGADYRDMILkQ
K1482-a DYRDMILkQVVNQVW
K1608 KRRAQMTKYLQSNSN
K1693-u PRLSKNSkSsNGQEL
S1695-p LSKNSkSsNGQELEK
K1702 sNGQELEKTLEESKE
K1708 EKTLEESKETDIKHK
K1718 DIKHKENKGNDIPLA
I1722 KENKGNDIPLALEST
K1733-u LESTNTEkEASLDET
K1799 AMMFAELKSTRMILN
K1840 TLRHTMEKVVRSAAT
K1840-u TLRHTMEkVVRSAAT
Y1869 LGSREINYILRVLGP
S1903-p ALPAPRGsGtAsDDE
T1905-p PAPRGsGtAsDDEFE
S1907-p PRGsGtAsDDEFENL
K1917-u EFENLRIkGPNAVQL
K1926 PNAVQLVKTTPLKPS
K1931 LVKTTPLKPSSLPVI
Y1988 QDMGDDVYQQYRSLT
Y1991 GDDVYQQYRSLTRQS
S1999-p RSLTRQSsDFDTQSG
S2052 DKEGDRTSEEGKQKS
T2193-p IMESCPStssFyssA
S2194-p MESCPStssFyssAt
S2195-p ESCPStssFyssAtA
Y2197-p CPStssFyssAtAKt
S2198-p PStssFyssAtAKtQ
S2199-p StssFyssAtAKtQH
T2201-p ssFyssAtAKtQHNG
T2204-p yssAtAKtQHNGMNN
K2218 NIIRLFLKKGLVNDL
K2219 IIRLFLKKGLVNDLA
K2248 NTVNAALKPLETLSR
K2248 NTVNAALKPLETLSR
S2261 SRIVNQPSsLFGskS
S2262-p RIVNQPSsLFGskSA
S2266-p QPSsLFGskSASSKN
K2267-u PSsLFGskSASSKNK
S2339 GQPEVLSSQEMQVEN
S2362-p LLERDGGsGNstIIV
S2365-p RDGGsGNstIIVsRS
T2366-p DGGsGNstIIVsRSG
S2370-p GNstIIVsRSGEDEs
S2372 stIIVsRSGEDEsQE
S2377-p sRSGEDEsQEDVLMD
S2388-p VLMDEAPsNLsQASt
S2391-p DEAPsNLsQAStLQA
S2394 PsNLsQAStLQANRE
T2395-p sNLsQAStLQANRED
Y2471 EMELDEDYPDMNASP
S2526 MVRHADHSSLTLGsG
S2527 VRHADHSSLTLGsGS
T2529 HADHSSLTLGsGSST
S2532-p HSSLTLGsGSSTTRL
S2534 SLTLGsGSSTTRLTQ
S2535 LTLGsGSSTTRLTQG
T2536 TLGsGSSTTRLTQGI
T2537 LGsGSSTTRLTQGIG
T2540 GSSTTRLTQGIGRSQ
R2545 RLTQGIGRSQRTLRQ
S2546 LTQGIGRSQRTLRQL
T2554 QRTLRQLTANTGHTI
S2595-p DILQLSSsLPLQSRG
S2619-p DVHIIARsDDELLDD
S2636 HDQSTATSQAGTLSS
K2671-u HDCVSVVkVPIVNHL
K2695-u ERREKRRkQLAEEET
K2703-u QLAEEETkIIDKGkE
K2709-u TkIIDKGkEDKENRD
K2712 IDKGkEDKENRDQSA
Y2744-p GTPMPDSyPTtPSST
T2746 PMPDSyPTtPSSTDA
T2747-p MPDSyPTtPSSTDAP
T2751 yPTtPSSTDAPTSES
S2887 SEQPTAGSSTPGDAP
S2888 EQPTAGSSTPGDAPS
T2889 QPTAGSSTPGDAPSV
S2917-p SNQPPEDssPPASSE
S2918-p NQPPEDssPPASSES
S2940-p VAISGADsRGILEEP
S3116-p HERLFGHssTSALsA
S3117-p ERLFGHssTSALsAI
S3122-p HssTSALsAILRsPA
S3127-p ALsAILRsPAFtsRL
T3131-p ILRsPAFtsRLSGNR
S3132-p LRsPAFtsRLSGNRG
S3135 PAFtsRLSGNRGVQY
Y3142 SGNRGVQYtRLAVQr
T3143-p GNRGVQYtRLAVQrG
R3149-m1 YtRLAVQrGGTFQMG
S3165 SSSHNRPSGSNVDTL
T3171 PSGSNVDTLLRLRGR
K3244-u ELCIETPkLSTSEER
R3251 kLSTSEERGKKSSKS
K3345-u DTLIQLAkVFPSHFT
K3357-u HFTQQRTkETNCESD
S3374 RGSKQACSPCSSQSS
S3378 QACSPCSSQSSSSGI
H3425 GEGETSPHSLEASPL
K3453-u RSSLLTEkLLRLLSL
S3557-p STTKGSKsPAKVGEG
K3560 KGSKsPAKVGEGGSG
K3622 GTRDTVLKLLLNGAR
K3637 HLGYTLCKQIGTLLA
T3661-p QRRAQCEtLsPDGLP
S3663-p RAQCEtLsPDGLPEE
D3665 QCEtLsPDGLPEEQP
K3676 EEQPQTTKLKGKMQS
K3678 QPQTTKLKGKMQSRF
S3696 ENVVIVASQKRPLGG
K3698 VVIVASQKRPLGGRE
S3753-p KQTGRLGssGLGsAs
S3754-p QTGRLGssGLGsAss
S3758-p LGssGLGsAssIQAA
S3760-p ssGLGsAssIQAAVR
S3761-p sGLGsAssIQAAVRQ
D3774 RQLEAEADAIIQMVR
S3798 QAATSESSNQSETSV
S3810-p TSVRREEsPMDVDQP
S3818-p PMDVDQPsPSAQDtQ
T3824-p PsPSAQDtQSIVISD
S3830 DtQSIVISDGTPQGE
T3833 SIVISDGTPQGEKEK
K3838 DGTPQGEKEKEEKPP
S3909 PVRDTRESQLAHIkD
K3915-u ESQLAHIkDEPPPLs
S3922-p kDEPPPLsPAPLtPA
T3927-p PLsPAPLtPAtPssL
T3930-p PAPLtPAtPssLDPF
S3932-p PLtPAtPssLDPFFS
S3933-p LtPAtPssLDPFFSR
K3957 SLPPDTQKFLRFAET
Y4081-p REMFNPMyALFRTSP
K4119 FVGRIVAKAVYDNRL
K4137-u YFTRSFYkHILGKSV
K4142 FYkHILGKSVRYTDM
K4193 VCEVRDLKPNGANIL
K4224-u RMTGAIRkQLAAFLE
Y4274 SNTEYHKYQSNSIQI
K4298-u FDQADRAkFLQFVTG
K4308-u QFVTGTSkVPLQGFA
K4325 EGMNGIQKFQIHRDD
  rat

 
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- gap
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- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K27 RERLSKEKEGSRGEE
Y83 TMEQATEYLLTHPPP
S100 GGVVRDLSMSEEDQM
S102 VVRDLSMSEEDQMMR
- under review  
S127-p PMDQRAEsPEEVACR
K202 DLIMTAIKRNGADyR
Y208-p IKRNGADyRDMILKQ
K214 DyRDMILKQVVNQVW
K340 KRRAQMTKYLQSNSN
K425 PRLSKNSKSSNGQEL
S427 LSKNSKSSNGQELEK
K434 SNGQELEKTLEESKE
K440 EKTLEESKETDIKRK
K450 DIKRKENKGNDIPLA
I454 KENKGNDIPLALEST
K465 LESTNTEKDASLEET
K531 AMMFAELKSTRMILN
K572 TLRHTMEKVVRSAAT
K572 TLRHTMEKVVRSAAT
Y601 LGSREINYILRVLGP
S635 ALPAPRGSGTAsDDE
T637 PAPRGSGTAsDDEFE
S639-p PRGSGTAsDDEFENL
K649 EFENLRIKGPNAVQL
K658 PNAVQLVKTTPLKPS
K663 LVKTTPLKPSSLPVI
Y720 QDMGDDVYQQYRSLT
Y723 GDDVYQQYRSLTRQS
S731 RSLTRQSSDFDTQSG
S785 DKEGDRTSEEGKQKG
- under review  
- under review  
- under review  
Y930 CPSTSSFYSSATAKT
S931 PSTSSFYSSATAKTQ
- under review  
- under review  
- under review  
K951 NIIRLFLKKGLVNDL
K952 IIRLFLKKGLVNDLA
K981 NTVNAALKPLETLSR
K981 NTVNAALKPLETLSR
S994 SRIVNQPSSLFGSKS
S995 RIVNQPSSLFGSKSA
S999 QPSSLFGSKSASSKS
K1000 PSSLFGSKSASSKSK
S1072 GQPEVLSSQEMQVEN
S1095 LLERDGGSGNSTIIV
S1098 RDGGSGNSTIIVSRS
T1099 DGGSGNSTIIVSRSG
S1103 GNSTIIVSRSGEDES
S1105 STIIVSRSGEDESQE
S1110 SRSGEDESQEDVLMD
S1121 VLMDEAPSNLSQAST
S1124 DEAPSNLSQASTLQA
S1127 PSNLSQASTLQANRE
T1128 SNLSQASTLQANRED
Y1204 EMELDEDYPDMNASP
S1259 MVRHADHSSLTLGSG
S1260 VRHADHSSLTLGSGS
T1262 HADHSSLTLGSGSST
S1265 HSSLTLGSGSSTTRL
S1267 SLTLGSGSSTTRLTQ
S1268 LTLGSGSSTTRLTQG
T1269 TLGSGSSTTRLTQGI
T1270 LGSGSSTTRLTQGIG
T1273 GSSTTRLTQGIGRSQ
R1278 RLTQGIGRSQRTLRQ
S1279 LTQGIGRSQRTLRQL
T1287 QRTLRQLTANTGHTI
S1328 DILQLSSSLPLQSRG
S1352 DVHIIARSDDELLDD
S1369 HDQSTATSQAGTLSS
K1404 HDCVSVVKVPIVNHL
K1428 ERREKRRKQLAEEET
K1436 QLAEEETKIIDKGKE
K1442 TKIIDKGKEDKENRD
K1445 IDKGKEDKENRDQSA
Y1477 GTPMPDSYPTTPSST
T1479 PMPDSYPTTPSSTDA
T1480 MPDSYPTTPSSTDAP
T1484 YPTTPSSTDAPTSES
S1620 SEQPTAGSSTPGDAP
S1621 EQPTAGSSTPGDAPS
T1622 QPTAGSSTPGDAPSV
S1650 STQPPEDSSPPASSE
S1651 TQPPEDSSPPASSES
S1673 VAISGADSRGILEEP
S1849 HERLFGHSSTSALSA
S1850 ERLFGHSSTSALSAI
S1855 HSSTSALSAILRSPA
S1860 ALSAILRSPAFTSRL
T1864 ILRSPAFTSRLSGNR
S1865 LRSPAFTSRLSGNRG
S1868 PAFTSRLSGNRGVQY
Y1875 SGNRGVQYTRLAVQR
T1876 GNRGVQYTRLAVQRG
R1882 YTRLAVQRGGTFQMG
S1898 SSSHNRPSGSNVDTL
T1904 PSGSNVDTLLRLRGR
K1977 ELCIETPKLSTSEER
R1984 KLSTSEERGKKSSKS
K2078 DTLIQLAKVFPSHFT
K2090 HFTQQRTKETNCESD
S2107 RGSKQACSPCSSQSS
S2111 QACSPCSSQSSSSGI
H2158 GEGETSLHSLEASPL
K2186 RSSLLTEKLLRLLSL
S2289 STTKGNKSPAKVGEG
K2292 KGNKSPAKVGEGGSS
K2355 GTRDTVLKLLLNGAR
K2370 HLGYTLCKQIGTLLA
T2394 QRRAQCETLSPDGLP
S2396 RAQCETLSPDGLPEE
D2398 QCETLSPDGLPEEQP
K2409 EEQPQTTKLKGKMQS
K2411 QPQTTKLKGKMQSRF
S2429 ENVVIVASQKRPLGG
K2431 VVIVASQKRPLGGRE
S2486 KQTGRLGSSGLGsAS
S2487 QTGRLGSSGLGsASs
S2491-p LGSSGLGsASsIQAA
S2493 SSGLGsASsIQAAVR
S2494-p SGLGsASsIQAAVRQ
D2507 RQLEAEADAIIQMVR
S2531 QAATSESSNQSETSV
S2543 TSVRREESPMDVDQP
S2551 PMDVDQPSPSAQDTQ
T2557 PSPSAQDTQSIVVSD
- under review  
T2566 SIVVSDGTPQGEKEK
K2571 DGTPQGEKEKEERPP
S2642 PVRDTRESQLAHIKD
K2648 ESQLAHIKDEPPPLS
S2655 KDEPPPLSPAPLTPA
T2660 PLSPAPLTPATPSSL
T2663 PAPLTPATPSSLDPF
S2665 PLTPATPSSLDPFFS
S2666 LTPATPSSLDPFFSR
K2690 SLPPDTQKFLRFAET
Y2814 REMFNPMYALFRTSP
K2852 FVGRIVAKAVYDNRL
K2870 YFTRSFYKHILGKSV
K2875 FYKHILGKSVRYTDM
K2926 VCEVRDLKPNGANIL
K2957 RMTGAIRKQLAAFLE
Y3007-p SNTEYHKyQSNSIQI
K3031 FDQADRAKFLQFVTG
K3041 QFVTGTSKVPLQGFA
K3058 EGMNGIQKFQIHRDD
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