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HUWE1 (human)

Overview HUWE1 E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Interacts with isoform p14ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity. Interacts with MYCN, POLB and CDC6. Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas. Belongs to the TOM1/PTR1 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system Cellular Component: cytoplasm; nucleolus; nucleus Molecular Function: protein binding; DNA binding; ubiquitin-protein ligase activity Biological Process: protein monoubiquitination; protein polyubiquitination; base-excision repair; histone ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; cell differentiation Reference #:  Q7Z6Z7 (UniProtKB) Alt. Names/Synonyms: ARF binding protein 1; ARF-binding protein 1; ARF-BP1; BJ-HCC-24 tumor antigen; E3 ubiquitin-protein ligase HUWE1; HECT domain protein LASU1; HECT, UBA and WWE domain containing 1; HECT, UBA and WWE domain-containing protein 1; HectH9; Homologous to E6AP carboxyl terminus homologous protein 9; HSPC272; HUWE1; Ib772; KIAA0312; KIAA1578; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; Mule; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1; UREB1 Gene Symbols: HUWE1 Molecular weight: 481,891 Da Basal Isoelectric point: 5.1  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HUWE1 2EKK - A=1317-1356 (human) 3G1N - A/B=4005-4374 (human) 3H1D - A=3993-4374 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2EKK 3G1N 3H1D  |  ENZYME  |  Phospho3D  |  DISEASE 300220 300697 300706  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y52	NIGKCELYHWVDLLD
0	1		K190-u	CRDLHMMkYPPSATT
0	1		K324-u	DKQLMEIkAASLRTL
0	3		T484-p	PKIQRPNttQEGEEM
0	1		T485-p	KIQRPNttQEGEEME
0	1		K509-a	PQRAALLkSMLNFLK
0	1		S525-p	AIQDPAFsDGIRHVM
0	1		K632-u	QPFERLFkVLLSPDY
0	4		S648-p	PAMRRRRssDPLGDt
0	13		S649-p	AMRRRRssDPLGDtA
0	4		T655-p	ssDPLGDtASNLGSA
0	3		K674-u	MRHQPTLkTDATTAI
0	4		S740-p	EEVQAMQsFNSTQQN
1	1		S927-p	ISVNQWGsQLGLSVL
0	1		K977	DMQKLVPKDEKAGTT
0	1		K1050-u	AARIKQIkPLLSASS
0	1		S1077-p	LVKLCVGsPVRQRRs
0	7		S1084-p	sPVRQRRsHHAASTT
0	5		K1107-u	STASALTkLLTkGLS
0	2		K1111-u	ALTkLLTkGLSWQPP
0	1		K1147-u	PMLFDERkYPYHLML
0	2		K1156-u	PYHLMLQkFLCSGGH
0	5		K1225-u	SPHSLPAkLPGGVQN
0	1		K1247-u	RFLVVTQkAAFTCIK
0	3		K1295-u	RERLSKEkEGSRGEE
0	2		Y1351-p	TMEQATEyLLtHPPP
0	1		T1354-p	QATEyLLtHPPPIMG
0	13		S1368-p	GGVVRDLsMsEEDQM
0	3		S1370-p	VVRDLsMsEEDQMMR
0	19		S1395-p	PMDQRAEsPEEVACR
0	7		K1470-u	DLIMTAIkRNGADyR
0	2		Y1476-p	IkRNGADyRDMILkQ
0	2		K1482-a	DyRDMILkQVVNQVW
0	2		K1608-u	KRRAQMTkYLQSNSN
0	1		Y1658-p	FTAGRRRyTVQFTTM
0	3		K1693-u	PRLNKNSkNSNGQEL
0	1		S1695	LNKNSkNSNGQELEk
0	2		K1702-u	SNGQELEkTLEESkE
0	1		K1708-u	EkTLEESkEMDIKRK
0	1		K1718-u	DIKRKENkGNDtPLA
0	1		T1722-p	KENkGNDtPLALESt
0	1		T1729-p	tPLALEStNTEkETS
0	2		K1733-u	LEStNTEkETSLEET
0	1		K1799-u	AMMFAELkSTRMILN
0	1		K1840-a	TLRHTMEkVVRSAAT
0	3		K1840-u	TLRHTMEkVVRSAAT
0	1		S1852-p	AATSGAGsTTSGVVs
0	1		S1859-p	sTTSGVVsGSLGSRE
0	1		Y1869-p	LGSREINyILRVLGP
0	1		S1903-p	ALPAPRGsGtAsDDE
0	2		T1905-p	PAPRGsGtAsDDEFE
0	47		S1907-p	PRGsGtAsDDEFENL
0	9		K1917-u	EFENLRIkGPNAVQL
0	2		K1926-u	PNAVQLVkTTPLkPS
0	2		K1931-u	LVkTTPLkPSPLPVI
0	35		Y1988-p	QDMGDDVyQQyRSLt
0	11		Y1991-p	GDDVyQQyRSLtRQs
0	1		T1995-p	yQQyRSLtRQssDFD
0	1		S1998-p	yRSLtRQssDFDTQS
0	6		S1999-p	RSLtRQssDFDTQSG
0	1		K2060-a	EEGKQKGkGSKPLMP
0	1		K2157-u	VALVNEVkAALGRAL
0	4		Y2197-p	CPSTSSFysSATAKT
0	1		S2198-p	PSTSSFysSATAKTQ
0	1		K2218-u	NIIRLFLkkGLVNDL
0	4		K2219-u	IIRLFLkkGLVNDLA
0	1		K2248-a	NTVNAALkPLETLSR
0	3		K2248-u	NTVNAALkPLETLSR
0	1		S2261-p	SRIVNQPssLFGskS
0	2		S2262-p	RIVNQPssLFGskSA
0	1		S2266-p	QPssLFGskSASSKN
0	5		K2267-u	PssLFGskSASSKNK
1	1		S2339-p	GQPEVLSsQEMQVEN
0	24		S2362-p	LLERDGGsGNstIIV
0	17		S2365-p	RDGGsGNstIIVSRs
0	7		T2366-p	DGGsGNstIIVSRsG
0	1		S2370	GNstIIVSRsGEDEs
0	4		S2372-p	stIIVSRsGEDEsQE
0	16		S2377-p	SRsGEDEsQEDVLMD
0	7		S2388-p	VLMDEAPsNLsQAst
0	45		S2391-p	DEAPsNLsQAstLQA
0	3		S2394-p	PsNLsQAstLQANRE
0	4		T2395-p	sNLsQAstLQANRED
0	36		Y2471-p	EMELDEDyPDMNASP
0	1		S2526-p	MVRHADHssLtLGSG
0	1		S2527-p	VRHADHssLtLGSGS
0	9		T2529-p	HADHssLtLGSGSst
0	1		S2532	HssLtLGSGSsttRL
0	3		S2535-p	LtLGSGSsttRLtQG
0	3		T2536-p	tLGSGSsttRLtQGI
0	2		T2537-p	LGSGSsttRLtQGIG
0	5		T2540-p	GSsttRLtQGIGrsQ
0	2		R2545-m1	RLtQGIGrsQRTLRQ
0	8		S2546-p	LtQGIGrsQRTLRQL
0	1		T2554-p	QRTLRQLtANTGHTI
0	3		S2595-p	DILQLSSsLPLQSRG
0	2		S2619-p	DVHIIARsDDELLDD
1	10		S2636-p	HDQSTATsQAGTLSS
0	9		K2671-u	HDCVSVVkVSIVNHL
0	3		K2695-u	ERREKRRkQLAEEET
0	3		K2703-u	QLAEEETkITDKGkE
0	6		K2709-u	TkITDKGkEDkENRD
0	1		K2712	TDKGkEDKENRDQSA
0	3		K2712-u	TDKGkEDkENRDQSA
0	1		S2735-p	DSTEQNLsDGtPMPD
0	1		T2738-p	EQNLsDGtPMPDSYP
0	1		Y2744	GtPMPDSYPttPSSt
0	12		T2746-p	PMPDSYPttPSStDA
0	20		T2747-p	MPDSYPttPSStDAA
0	2		T2751-p	YPttPSStDAATSES
0	19		S2887-p	SEQPRAGsstPGDAP
0	13		S2888-p	EQPRAGsstPGDAPP
0	24		T2889-p	QPRAGsstPGDAPPA
0	1		S2917	SAQPPEDSsPPASSE
0	6		S2918-p	AQPPEDSsPPASSES
0	2		S2940-p	VAISGADsRGILEEP
0	1		S2950-p	ILEEPLPstSSEEED
0	1		T2951-p	LEEPLPstSSEEEDP
0	1		T2995	QLGIRPPTRTAPSTN
0	1		T3060	DTPMDPVTFIQTLPS
0	1		S3116-p	HERLFGHssTSALSA
0	3		S3117-p	ERLFGHssTSALSAI
0	23		S3127-p	ALSAILRsPAFTsRL
0	1		T3131	ILRsPAFTsRLSGNR
0	2		S3132-p	LRsPAFTsRLSGNRG
0	2		Y3142-p	SGNRGVQytRLAVQr
0	2		T3143-p	GNRGVQytRLAVQrG
0	3		R3149-m1	ytRLAVQrGGTFQMG
0	4		S3165-p	SSSHNRPsGSNVDtL
0	2		T3171-p	PsGSNVDtLLRLRGR
0	3		K3244-u	ELCIETPkLttSEEk
0	1		T3246-p	CIETPkLttSEEkGK
0	1		T3247-p	IETPkLttSEEkGKK
0	2		K3251-u	kLttSEEkGKKSSKS
0	95		K3345-u	DTLIQLAkVFPSHFT
0	5		K3357-u	HFTQQRTkETNCESD
0	5		S3373-p	ERGNKACsPCSsQSS
1	3		S3377-p	KACsPCSsQSSSSGI
0	2		Y3424-p	GEGETSPySLEASPL
0	1		S3447-p	HPVIRRSsLLTEkLL
0	69		K3452-u	RSsLLTEkLLRLLSL
0	2		S3555-p	PTTKGSKsPAkVsDG
0	2		K3558-u	KGSKsPAkVsDGGSS
0	1		S3560-p	SKsPAkVsDGGSSST
0	10		K3621-u	GTRDTVLkLLLNGAR
0	11		K3636-u	HLGYTLCkQIGTLLA
0	2		T3660	QRRAQCETLsPdGLP
0	14		S3662-p	RAQCETLsPdGLPEE
0	1		D3664-ca	QCETLsPdGLPEEQP
0	5		K3675-u	EEQPQTTkLkGKMQS
0	6		K3677-u	QPQTTkLkGKMQSRF
1	1		S3695-p	ENVVIVAsQkRPLGG
0	2		K3697-u	VVIVAsQkRPLGGRE
0	1		T3747-p	ANKKAKQtGRLGssG
0	3		S3752-p	KQtGRLGssGLGsAs
0	1		S3753-p	QtGRLGssGLGsAss
0	14		S3757-p	LGssGLGsAssIQAA
0	1		S3759-p	ssGLGsAssIQAAVR
0	3		S3760-p	sGLGsAssIQAAVRQ
0	1		D3773-ca	RQLEAEAdAIIQMVR
0	1		T3793-p	RRQQQAAtsESsQSE
0	1		S3794-p	RQQQAAtsESsQSEA
1	9		S3797-p	QAAtsESsQSEASVR
0	3		S3808-p	ASVRREEsPMDVDQP
0	9		S3816-p	PMDVDQPsPSAQDtQ
0	1		T3822-p	PsPSAQDtQSIASDG
0	1		K3835-u	DGTPQGEkEKEERPP
0	11		S3906-p	PVRDTREsQLAHIkD
0	4		K3912-u	EsQLAHIkDEPPPLs
0	94		S3919-p	kDEPPPLsPAPLtPA
0	106		T3924-p	PLsPAPLtPAtPssL
0	87		T3927-p	PAPLtPAtPssLDPF
0	14		S3929-p	PLtPAtPssLDPFFS
0	15		S3930-p	LtPAtPssLDPFFSR
0	1		S3947-p	SSMHISSsLPPDTQk
0	1		K3954-u	sLPPDTQkFLRFAET
0	1		K4037-a	SYRELHRkSPEEMKN
0	1		Y4066-p	GGLLREWyMIISREM
0	3		Y4078-p	REMFNPMyALFRtsP
0	1		T4083-p	PMyALFRtsPGDRVT
0	1		S4084-p	MyALFRtsPGDRVTY
0	6		K4116-u	FVGRIVAkAVYDNRL
0	1		K4134	YFTRSFYKHILGkSV
0	2		K4139-u	FYKHILGkSVRYTDM
0	1		K4190-u	VCEVRDLkPNGANIL
0	13		K4221-u	RMTGAIRkQLAAFLE
1	0		Y4271	SNTEYHKYQSNSIQI
0	8		K4295-u	FDQADRAkFLQFVTG
0	4		K4305-u	QFVTGTSkVPLQGFA
0	1		K4322-u	EGMNGIQkFQIHRDD

	mouse
Y52-p	NIGKCELyHWVDLLD
K190	CRDLQMLKYPPSATT
K324	DKQLMEIKAASLRTL
T484	PKIQRPSTTQEGEEM
T485	KIQRPSTTQEGEEME
K509	PQRAALLKSMLNFLK
S525	AIQDPAFSDGIRHVM
K632	QPFERLFKVLLSPDY
S648-p	PAMRRRRssDPLGDt
S649-p	AMRRRRssDPLGDtA
T655-p	ssDPLGDtASNLGSA
K674	MRHQPTLKTDATTAI
S740	EEVQAMQSFNSAQQN
S927	ISVNQWGSQLGLSVL
K977-a	DMQKLVPkDEKAGTT
K1050	AARIKQIKPLLSASS
S1077-p	LVKLCVGsPVRQRRs
S1084-p	sPVRQRRsHHAASTT
K1107-u	STASALTkLLTKGLS
K1111	ALTkLLTKGLSWQPP
K1147	PMLFDERKYPYHLML
K1156	PYHLMLQKFLCSGGH
K1225	SPHSLPAKLPGGVQS
K1247	RFLVVTQKAAFTCIK
K1295	RERLSKEKEGSRGEE
Y1351	TMEQATEYLLTHPPP
T1354	QATEYLLTHPPPIIG
S1368-p	GGVVRDLsMsEEDQM
S1370-p	VVRDLsMsEEDQMMR
S1395-p	PMDQRAEsPEEVACR
K1470-u	DLIMTAIkRNGADYR
Y1476	IkRNGADYRDMILkQ
K1482-a	DYRDMILkQVVNQVW
K1608	KRRAQMTKYLQSNSN
Y1658	FTAGRRRYTVQFTTM
K1693-u	PRLSKNSkSsNGQEL
S1695-p	LSKNSkSsNGQELEK
K1702	sNGQELEKTLEESKE
K1708	EKTLEESKETDIKHK
K1718	DIKHKENKGNDIPLA
I1722	KENKGNDIPLALEST
T1729	IPLALESTNTEkEAS
K1733-u	LESTNTEkEASLDET
K1799	AMMFAELKSTRMILN
K1840	TLRHTMEKVVRSAAT
K1840-u	TLRHTMEkVVRSAAT
S1852	AATSGAGSTTSGVVS
S1859	STTSGVVSGSLGSRE
Y1869	LGSREINYILRVLGP
S1903-p	ALPAPRGsGtAsDDE
T1905-p	PAPRGsGtAsDDEFE
S1907-p	PRGsGtAsDDEFENL
K1917-u	EFENLRIkGPNAVQL
K1926	PNAVQLVKTTPLKPS
K1931	LVKTTPLKPSSLPVI
Y1988	QDMGDDVYQQYRSLT
Y1991	GDDVYQQYRSLTRQS
T1995	YQQYRSLTRQSsDFD
S1998	YRSLTRQSsDFDTQS
S1999-p	RSLTRQSsDFDTQSG
K2060	EEGKQKSKGSKPLMP
K2157	VALVNEVKAALGRAL
Y2197	CPSTSSFYSSATAKT
S2198	PSTSSFYSSATAKTQ
K2218	NIIRLFLKKGLVNDL
K2219	IIRLFLKKGLVNDLA
K2248	NTVNAALKPLETLSR
K2248	NTVNAALKPLETLSR
S2261	SRIVNQPSsLFGskS
S2262-p	RIVNQPSsLFGskSA
S2266-p	QPSsLFGskSASSKN
K2267-u	PSsLFGskSASSKNK
S2339	GQPEVLSSQEMQVEN
S2362-p	LLERDGGsGNstIIV
S2365-p	RDGGsGNstIIVsRS
T2366-p	DGGsGNstIIVsRSG
S2370-p	GNstIIVsRSGEDEs
S2372	stIIVsRSGEDEsQE
S2377-p	sRSGEDEsQEDVLMD
S2388-p	VLMDEAPsNLsQASt
S2391-p	DEAPsNLsQAStLQA
S2394	PsNLsQAStLQANRE
T2395-p	sNLsQAStLQANRED
Y2471	EMELDEDYPDMNASP
S2526	MVRHADHSSLTLGsG
S2527	VRHADHSSLTLGsGS
T2529	HADHSSLTLGsGSST
S2532-p	HSSLTLGsGSSTTRL
S2535	LTLGsGSSTTRLTQG
T2536	TLGsGSSTTRLTQGI
T2537	LGsGSSTTRLTQGIG
T2540	GSSTTRLTQGIGRSQ
R2545	RLTQGIGRSQRTLRQ
S2546	LTQGIGRSQRTLRQL
T2554	QRTLRQLTANTGHTI
S2595-p	DILQLSSsLPLQSRG
S2619-p	DVHIIARsDDELLDD
S2636	HDQSTATSQAGTLSS
K2671-u	HDCVSVVkVPIVNHL
K2695-u	ERREKRRkQLAEEET
K2703-u	QLAEEETkIIDKGkE
K2709-u	TkIIDKGkEDkENRD
K2712-a	IDKGkEDkENRDQSA
K2712	IDKGkEDKENRDQSA
S2735	DSTEQNVSDGTPMPD
T2738	EQNVSDGTPMPDSyP
Y2744-p	GTPMPDSyPTtPSST
T2746	PMPDSyPTtPSSTDA
T2747-p	MPDSyPTtPSSTDAP
T2751	yPTtPSSTDAPTSES
S2887	SEQPTAGSSTPGDAP
S2888	EQPTAGSSTPGDAPS
T2889	QPTAGSSTPGDAPSV
S2917-p	SNQPPEDssPPASSE
S2918-p	NQPPEDssPPASSES
S2940	VAISGADSRGILEEP
S2950	ILEEPLPSTSSEEED
T2951	LEEPLPSTSSEEEDP
T2995-p	QLGIRPPtRSAPSSN
T3060-p	DTPMDPVtFIQTLPS
S3116-p	HERLFGHssTSALSA
S3117-p	ERLFGHssTSALSAI
S3127-p	ALSAILRsPAFtsRL
T3131-p	ILRsPAFtsRLSGNR
S3132-p	LRsPAFtsRLSGNRG
Y3142	SGNRGVQYtRLAVQr
T3143-p	GNRGVQYtRLAVQrG
R3149-m1	YtRLAVQrGGTFQMG
S3165	SSSHNRPSGSNVDTL
T3171	PSGSNVDTLLRLRGR
K3244-u	ELCIETPkLSTSEER
S3246	CIETPkLSTSEERGK
T3247	IETPkLSTSEERGKK
R3251	kLSTSEERGKKSSKS
K3345-u	DTLIQLAkVFPSHFT
K3357-u	HFTQQRTkETNCESD
S3374	RGSKQACSPCSSQSS
S3378	QACSPCSSQSSSSGI
H3425	GEGETSPHSLEASPL
S3448	HPVIRRSSLLTEkLL
K3453-u	RSSLLTEkLLRLLSL
S3557-p	STTKGSKsPAKVGEG
K3560	KGSKsPAKVGEGGSG
G3562	SKsPAKVGEGGSGID
K3622	GTRDTVLKLLLNGAR
K3637	HLGYTLCKQIGTLLA
T3661-p	QRRAQCEtLsPDGLP
S3663-p	RAQCEtLsPDGLPEE
D3665	QCEtLsPDGLPEEQP
K3676	EEQPQTTKLKGKMQS
K3678	QPQTTKLKGKMQSRF
S3696	ENVVIVASQKRPLGG
K3698	VVIVASQKRPLGGRE
T3748	ANKKAKQTGRLGsSG
S3753-p	KQTGRLGsSGLGsAs
S3754	QTGRLGsSGLGsAss
S3758-p	LGsSGLGsAssIQAA
S3760-p	sSGLGsAssIQAAVR
S3761-p	SGLGsAssIQAAVRQ
D3774	RQLEAEADAIIQMVR
T3794	RRQQQAATSESSNQS
S3795	RQQQAATSESSNQSE
S3798	QAATSESSNQSETSV
S3810-p	TSVRREEsPMDVDQP
S3818-p	PMDVDQPsPSAQDTQ
T3824	PsPSAQDTQSIVISD
K3838	DGTPQGEKEKEEKPP
S3909	PVRDTRESQLAHIkD
K3915-u	ESQLAHIkDEPPPLs
S3922-p	kDEPPPLsPAPLtPA
T3927-p	PLsPAPLtPAtPssL
T3930-p	PAPLtPAtPssLDPF
S3932-p	PLtPAtPssLDPFFS
S3933-p	LtPAtPssLDPFFSR
S3950	SSMHISSSLPPDTQK
K3957	SLPPDTQKFLRFAET
K4040	SYRELHRKSPEEMKN
Y4069	GGLLREWYMIISREM
Y4081-p	REMFNPMyALFRTSP
T4086	PMyALFRTSPGDRVT
S4087	MyALFRTSPGDRVTY
K4119	FVGRIVAKAVYDNRL
K4137-u	YFTRSFYkHILGKSV
K4142	FYkHILGKSVRYTDM
K4193	VCEVRDLKPNGANIL
K4224-u	RMTGAIRkQLAAFLE
Y4274	SNTEYHKYQSNSIQI
K4298-u	FDQADRAkFLQFVTG
K4308-u	QFVTGTSkVPLQGFA
K4325	EGMNGIQKFQIHRDD

	rat
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K27	RERLSKEKEGSRGEE
Y83	TMEQATEYLLTHPPP
T86	QATEYLLTHPPPIIG
S100	GGVVRDLSMSEEDQM
S102	VVRDLSMSEEDQMMR
S127-p	PMDQRAEsPEEVACR
K202	DLIMTAIKRNGADyR
Y208-p	IKRNGADyRDMILKQ
K214	DyRDMILKQVVNQVW
K340	KRRAQMTKYLQSNSN
Y390	FTAGRRRYTVQFTTM
K425	PRLSKNSKSSNGQEL
S427	LSKNSKSSNGQELEK
K434	SNGQELEKTLEESKE
K440	EKTLEESKETDIKRK
K450	DIKRKENKGNDIPLA
I454	KENKGNDIPLALEST
T461	IPLALESTNTEKDAS
K465	LESTNTEKDASLEET
K531	AMMFAELKSTRMILN
K572	TLRHTMEKVVRSAAT
K572	TLRHTMEKVVRSAAT
S584	AATSGAGSTTSGVVS
S591	STTSGVVSGSLGSRE
Y601	LGSREINYILRVLGP
S635	ALPAPRGSGTAsDDE
T637	PAPRGSGTAsDDEFE
S639-p	PRGSGTAsDDEFENL
K649	EFENLRIKGPNAVQL
K658	PNAVQLVKTTPLKPS
K663	LVKTTPLKPSSLPVI
Y720	QDMGDDVYQQYRSLT
Y723	GDDVYQQYRSLTRQS
T727	YQQYRSLTRQSSDFD
S730	YRSLTRQSSDFDTQS
S731	RSLTRQSSDFDTQSG
K793	EEGKQKGKGSKPLMP
K890	VALVNEVKAALGRAL
Y930	CPSTSSFYSSATAKT
S931	PSTSSFYSSATAKTQ
K951	NIIRLFLKKGLVNDL
K952	IIRLFLKKGLVNDLA
K981	NTVNAALKPLETLSR
K981	NTVNAALKPLETLSR
S994	SRIVNQPSSLFGSKS
S995	RIVNQPSSLFGSKSA
S999	QPSSLFGSKSASSKS
K1000	PSSLFGSKSASSKSK
S1072	GQPEVLSSQEMQVEN
S1095	LLERDGGSGNSTIIV
S1098	RDGGSGNSTIIVSRS
T1099	DGGSGNSTIIVSRSG
S1103	GNSTIIVSRSGEDES
S1105	STIIVSRSGEDESQE
S1110	SRSGEDESQEDVLMD
S1121	VLMDEAPSNLSQAST
S1124	DEAPSNLSQASTLQA
S1127	PSNLSQASTLQANRE
T1128	SNLSQASTLQANRED
Y1204	EMELDEDYPDMNASP
S1259	MVRHADHSSLTLGSG
S1260	VRHADHSSLTLGSGS
T1262	HADHSSLTLGSGSST
S1265	HSSLTLGSGSSTTRL
S1268	LTLGSGSSTTRLTQG
T1269	TLGSGSSTTRLTQGI
T1270	LGSGSSTTRLTQGIG
T1273	GSSTTRLTQGIGRSQ
R1278	RLTQGIGRSQRTLRQ
S1279	LTQGIGRSQRTLRQL
T1287	QRTLRQLTANTGHTI
S1328	DILQLSSSLPLQSRG
S1352	DVHIIARSDDELLDD
S1369	HDQSTATSQAGTLSS
K1404	HDCVSVVKVPIVNHL
K1428	ERREKRRKQLAEEET
K1436	QLAEEETKIIDKGKE
K1442	TKIIDKGKEDKENRD
K1445	IDKGKEDKENRDQSA
K1445	IDKGKEDKENRDQSA
S1468	DSTEQNVSDGTPMPD
T1471	EQNVSDGTPMPDSYP
Y1477	GTPMPDSYPTTPSST
T1479	PMPDSYPTTPSSTDA
T1480	MPDSYPTTPSSTDAP
T1484	YPTTPSSTDAPTSES
S1620	SEQPTAGSSTPGDAP
S1621	EQPTAGSSTPGDAPS
T1622	QPTAGSSTPGDAPSV
S1650	STQPPEDSSPPASSE
S1651	TQPPEDSSPPASSES
S1673	VAISGADSRGILEEP
S1683	ILEEPLPSTSSEEED
T1684	LEEPLPSTSSEEEDP
T1728	QLGIRPPTRTAPSTN
T1793	DTPMDPVTFIQTLPS
S1849	HERLFGHSSTSALSA
S1850	ERLFGHSSTSALSAI
S1860	ALSAILRSPAFTSRL
T1864	ILRSPAFTSRLSGNR
S1865	LRSPAFTSRLSGNRG
Y1875	SGNRGVQYTRLAVQR
T1876	GNRGVQYTRLAVQRG
R1882	YTRLAVQRGGTFQMG
S1898	SSSHNRPSGSNVDTL
T1904	PSGSNVDTLLRLRGR
K1977	ELCIETPKLSTSEER
S1979	CIETPKLSTSEERGK
T1980	IETPKLSTSEERGKK
R1984	KLSTSEERGKKSSKS
K2078	DTLIQLAKVFPSHFT
K2090	HFTQQRTKETNCESD
S2107	RGSKQACSPCSSQSS
S2111	QACSPCSSQSSSSGI
H2158	GEGETSLHSLEASPL
S2181	HPVIRRSSLLTEKLL
K2186	RSSLLTEKLLRLLSL
S2289	STTKGNKSPAKVGEG
K2292	KGNKSPAKVGEGGSS
G2294	NKSPAKVGEGGSSSV
K2355	GTRDTVLKLLLNGAR
K2370	HLGYTLCKQIGTLLA
T2394	QRRAQCETLSPDGLP
S2396	RAQCETLSPDGLPEE
D2398	QCETLSPDGLPEEQP
K2409	EEQPQTTKLKGKMQS
K2411	QPQTTKLKGKMQSRF
S2429	ENVVIVASQKRPLGG
K2431	VVIVASQKRPLGGRE
T2481	ANKKAKQTGRLGSSG
S2486	KQTGRLGSSGLGsAS
S2487	QTGRLGSSGLGsASs
S2491-p	LGSSGLGsASsIQAA
S2493	SSGLGsASsIQAAVR
S2494-p	SGLGsASsIQAAVRQ
D2507	RQLEAEADAIIQMVR
T2527	RRQQQAATSESSNQS
S2528	RQQQAATSESSNQSE
S2531	QAATSESSNQSETSV
S2543	TSVRREESPMDVDQP
S2551	PMDVDQPSPSAQDTQ
T2557	PSPSAQDTQSIVVSD
K2571	DGTPQGEKEKEERPP
S2642	PVRDTRESQLAHIKD
K2648	ESQLAHIKDEPPPLS
S2655	KDEPPPLSPAPLTPA
T2660	PLSPAPLTPATPSSL
T2663	PAPLTPATPSSLDPF
S2665	PLTPATPSSLDPFFS
S2666	LTPATPSSLDPFFSR
S2683	SSMHISSSLPPDTQK
K2690	SLPPDTQKFLRFAET
K2773	SYRELHRKSPEEMKN
Y2802	GGLLREWYMIISREM
Y2814	REMFNPMYALFRTSP
T2819	PMYALFRTSPGDRVT
S2820	MYALFRTSPGDRVTY
K2852	FVGRIVAKAVYDNRL
K2870	YFTRSFYKHILGKSV
K2875	FYKHILGKSVRYTDM
K2926	VCEVRDLKPNGANIL
K2957	RMTGAIRKQLAAFLE
Y3007-p	SNTEYHKyQSNSIQI
K3031	FDQADRAKFLQFVTG
K3041	QFVTGTSKVPLQGFA
K3058	EGMNGIQKFQIHRDD

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