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MKK3 (human)

Overview MKK3 a dual-specificity protein kinase of the STE7 family. Activates p38 MAP kinase by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by cytokines and environmental stress in vivo. A deletion and two point mutants found in colon cancer cell lines. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity; Protein kinase, STE; STE group; STE7 family Cellular Component: nucleoplasm; cytosol Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; protein kinase binding; ATP binding Biological Process: activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of protein kinase activity; toll-like receptor signaling pathway; innate immune response; inflammatory response; toll-like receptor 4 signaling pathway; regulation of cytokine biosynthetic process; cardiac muscle contraction Reference #:  P46734 (UniProtKB) Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3; MEK 3; MEK3; mitogen-activated protein kinase kinase 3; MKK3; MP2K3; PRKMK3 Gene Symbols: MAP2K3 Molecular weight: 39,318 Da Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Jak/Stat/IL-6 Signaling  |  Regulation of Actin Dynamics  |  Signaling Pathways Activating p38 MAPK  |  TGF-ß Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MKK3

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	Sites Implicated In
cell cycle regulation: T222‑p transcription, altered: S218‑p, T222‑p activation: T222‑p enzymatic activity, induced: S218‑p, T222‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3-p	_____MEsPASSQPA
0	1		S15-p	QPASMPQsKGKSKRK
0	6		T39-p	KPPAPNPtPPRNLDS
0	6		K80-u	GAYGVVEkVRHAQSG
0	1		K192-u	SVIHRDVkPSNVLIN
0	2		S212-p	KMCDFGIsGyLVDsV
0	2		Y214-p	CDFGIsGyLVDsVAK
14	52		S218-p	IsGyLVDsVAKtMDA
4	3		T222-p	LVDsVAKtMDAGCKP
0	2		Y230-p	MDAGCKPyMAPERIN
0	3		K243-u	INPELNQkGYNVKsD
0	2		S249-p	QkGYNVKsDVWsLGI
0	1		S253-p	NVKsDVWsLGITMIE
0	1		K279-u	GTPFQQLkQVVEEPS
0	1		K340-u	TDIAAFVkEILGEDS

	mouse
S3	_____MESPAASPPA
T15	PPASLPQTKGKSKRK
T39	KPPVSNPTPPRNLDS
K80-u	GAYGVVEkVRHAQSG
K192	SVIHRDVKPSNVLIN
S212	KMCDFGISGYLVDsV
Y214	CDFGISGYLVDsVAK
S218-p	ISGYLVDsVAKTMDA
T222	LVDsVAKTMDAGCKP
Y230	MDAGCKPYMAPERIN
K243-u	INPELNQkGYNVKSD
S249	QkGYNVKSDVWSLGI
S253	NVKSDVWSLGITMIE
K279	GTPFQQLKQVVEEPS
K340	TDIAAFVKEILGEDS

	rat
S75	ATVRSMESPAASPPA
T87	PPASLPQTKGKSKRK
T111	KPPVSNPTPPRNLDS
K152	GAYGVVEKVRHAQSG
K264	SVIHRDVKPSNVLIN
S284	KMCDFGISGYLVDsV
Y286	CDFGISGYLVDsVAK
S290-p	ISGYLVDsVAKTMDA
T294	LVDsVAKTMDAGCKP
Y302	MDAGCKPYMAPERIN
K315	INPELNQKGYNVKSD
S321	QKGYNVKSDVWSLGI
S325	NVKSDVWSLGITMIE
K351	GTPFQQLKQVVEEPS
K412	TDIAAFVKEILGEDS

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