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Protein Page:
KANSL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KANSL1 As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: nucleoplasm; nucleus; histone acetyltransferase complex
Molecular Function: protein binding; histone acetyltransferase activity (H4-K16 specific)
Biological Process: establishment and/or maintenance of chromatin architecture
Reference #:  Q7Z3B3 (UniProtKB)
Alt. Names/Synonyms: DKFZp686P06109; DKFZp727C091; hypothetical protein LOC284058; K1267; KIAA1267; LOC284058; MGC102843; MLL1/MLL complex subunit KIAA1267
Gene Symbols: KANSL1
Molecular weight: 121,025 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below

KANSL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S30-p APPSSTLsPGsAENN
0 1 S33-p SSTLsPGsAENNGNA
0 1 K69-ac DFRNNPTkEDLGKLQ
0 1 K104-ac KLQGVFSkQTVLKSH
0 1 S115-p LKSHPLLsQsYELRA
0 1 S117-p SHPLLsQsYELRAEL
0 1 S165-p AKKLTKSsTHSDHDN
0 1 S173-p THSDHDNstsLNGGk
0 1 T174-p HSDHDNstsLNGGkR
0 1 S175-p SDHDNstsLNGGkRA
0 87 K180-ac stsLNGGkRALtSsA
0 6 T184-p NGGkRALtSsALHGG
0 1 S186-p GkRALtSsALHGGEM
0 19 S249-p LQGSSRLsPGTDSSS
0 1 G251 GSSRLsPGTDSSSNL
0 30 S268-p VKLEGKKsPLssILF
0 3 S271-p EGKKsPLssILFsAL
0 2 S272-p GKKsPLssILFsALD
0 1 S276-p PLssILFsALDsDTR
0 1 S280-p ILFsALDsDTRITAL
0 1 K372-ub EGLSNFLkSNsISEE
0 1 S375-p SNFLkSNsISEELER
0 1 T384 SEELERFTASGIANL
0 1 S499-p TDLFLPLssEVKTDH
0 1 S500-p DLFLPLssEVKTDHG
0 1 S564-p ADHIPGDssDAEEQL
0 1 S565-p DHIPGDssDAEEQLH
0 1 K601-ac RPVLSCKkRRLVRPN
0 1 S609 RRLVRPNSIVPLSKK
0 1 S614 PNSIVPLSKKVHRNS
0 13 S792-p KMRLRDHsSERSEVL
0 1 S807-p KHHTDMSssSYLAAt
0 1 S808-p HHTDMSssSYLAAtH
0 3 T814-p ssSYLAAtHHPPHsP
0 50 S820-p AtHHPPHsPLVRQLs
0 26 S827-p sPLVRQLstssDsPA
0 26 T828-p PLVRQLstssDsPAP
0 3 S829-p LVRQLstssDsPAPA
0 6 S830-p VRQLstssDsPAPAS
0 1 S832-p QLstssDsPAPASSS
0 1 S847-p SQVTASTsQQPVRRR
0 9 S858-p VRRRRGEsSFDINNI
0 1 Y882-p TRVEKLQyKEILTPS
0 1 S945-p VPPQRRGsRsyRSsD
0 1 S947-p PQRRGsRsyRSsDGR
0 1 Y948-p QRRGsRsyRSsDGRT
0 1 S951-p GsRsyRSsDGRTtPQ
0 1 T955 yRSsDGRTtPQLGSA
0 1 T956-p RSsDGRTtPQLGSAN
0 5 T966-p LGSANPStPQPAsPD
0 5 S971-p PStPQPAsPDVSsSH
0 1 S976-p PAsPDVSsSHSLSEY
0 1 S988-p SEYSHGQsPRsPIsP
0 15 S991-p SHGQsPRsPIsPELH
0 6 S994-p QsPRsPIsPELHsAP
0 1 S999-p PIsPELHsAPLtPVA
0 19 T1003-p ELHsAPLtPVARDtP
0 1 T1009-p LtPVARDtPRHLASE
0 2 S1021-p ASEDTRCstPELGLD
0 22 T1022-p SEDTRCstPELGLDE
0 35 S1045-p RTFPLAHsPQAECED
0 3 S1068-p ARCTRRTsGSKTGRE
0 1 T1076-p GSKTGREtEAAPTsP
0 1 T1081 REtEAAPTsPPIVPL
0 6 S1082-p EtEAAPTsPPIVPLK
  mouse

► Hide Isoforms
 
S30 APPSSTLSPGSAENN
S33 SSTLSPGSAENNGNA
K69 DFRNNPTKEDLGKLQ
K104 KLQGVFSKQTVLKSH
S115 LKSHPLLSQSYELRA
S117 SHPLLSQSYELRAEL
S165 AKKLTKSSTHSDHDN
S173 THSDHDNSSSLNGGk
S174 HSDHDNSSSLNGGkR
S175 SDHDNSSSLNGGkRS
K180-ac SSSLNGGkRSLTSSS
T184 NGGkRSLTSSSLQGG
S186 GkRSLTSSSLQGGEV
S249-p LQGSSRLsPsTDSSS
S251-p GSSRLsPsTDSSSNL
S268-p VKLEVKKsPLssILF
S271-p EVKKsPLssILFSAL
S272-p VKKsPLssILFSALD
S276 PLssILFSALDSDTR
S280 ILFSALDSDTRITAL
K372 EGLSNFLKSDSISEE
S375 SNFLKSDSISEELER
T384-p SEELERFtASGIANL
S498 TTDLLSLSSEVKTDH
S499 TDLLSLSSEVKTDHG
S562 ADQVPGDSSDAEEQL
S563 DQVPGDSSDAEEQLH
K598 RPVLTCKKRRLVRPS
S606-p RRLVRPSsIVPLsKK
S611-p PSsIVPLsKKVHRNV
- gap
S739 KHHTDMSSPSYLTAT
P740 HHTDMSSPSYLTATH
T746 SPSYLTATHHPPHSP
S752 ATHHPPHSPLVRQLS
S759 SPLVRQLStSsDTST
T760-p PLVRQLStSsDTSTP
S761 LVRQLStSsDTSTPT
S762-p VRQLStSsDTSTPTS
T764 QLStSsDTSTPTSSG
S779 SQVAASTSQPVRRRR
S789 VRRRRGESSFDINNI
Y813 TRVEKLQYKEILTPS
S876 VPPQRRGSRSYRSSD
S878 PQRRGSRSYRSSDGR
Y879 QRRGSRSYRSSDGRt
S882 GSRSYRSSDGRtTPQ
T886-p YRSSDGRtTPQLGSA
T887 RSSDGRtTPQLGSAN
T897 LGSANPSTPQPAsPD
S902-p PSTPQPAsPDVSSSH
S907 PAsPDVSSSHSLSEF
S919 SEFSHGQSPRsPIsP
S922-p SHGQSPRsPIsPELH
S925-p QSPRsPIsPELHSAP
S930 PIsPELHSAPLtPVA
T934-p ELHSAPLtPVARDSL
S940 LtPVARDSLRHLASE
S952 ASEDTRCSTPELGLD
T953 SEDTRCSTPELGLDE
S976-p RTFPLAYsPQAECEE
S999 ARCTRRTSGSKTGRE
A1007 GSKTGREAEVAPtsP
T1012-p REAEVAPtsPPVVPL
S1013-p EAEVAPtsPPVVPLK
  KANSL1 iso2  
S30 APPSSTLSPGSAENN
S33 SSTLSPGSAENNGNA
K69 DFRNNPTKEDLGKLQ
K104 KLQGVFSKQTVLKSH
S115 LKSHPLLSQSYELRA
S117 SHPLLSQSYELRAEL
S165 AKKLTKSSTHSDHDN
S173 THSDHDNSSSLNGGK
S174 HSDHDNSSSLNGGKR
S175 SDHDNSSSLNGGKRS
K180 SSSLNGGKRSLTSSS
T184 NGGKRSLTSSSLQGG
S186 GKRSLTSSSLQGGEV
S249 LQGSSRLSPSTDSSS
S251 GSSRLSPSTDSSSNL
S268 VKLEVKKSPLSSILF
S271 EVKKSPLSSILFSAL
S272 VKKSPLSSILFSALD
S276 PLSSILFSALDSDTR
S280 ILFSALDSDTRITAL
K372 EGLSNFLKSDSISEE
S375 SNFLKSDSISEELER
T384 SEELERFTASGIANL
S498 TTDLLSLSSEVKTDH
S499 TDLLSLSSEVKTDHG
S562 ADQVPGDSSDAEEQL
S563 DQVPGDSSDAEEQLH
K598 RPVLTCKKRRLVRPS
S606 RRLVRPSSIVPLSKK
S611 PSSIVPLSKKVGAQR
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