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Protein Page:
KANSL1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
KANSL1 As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: nucleoplasm; nucleus; histone acetyltransferase complex
Molecular Function: protein binding; histone acetyltransferase activity (H4-K16 specific)
Biological Process: establishment and/or maintenance of chromatin architecture
Reference #:  Q7Z3B3 (UniProtKB)
Alt. Names/Synonyms: DKFZp686P06109; DKFZp727C091; hypothetical protein LOC284058; K1267; KIAA1267; LOC284058; MGC102843; MLL1/MLL complex subunit KIAA1267
Gene Symbols: KANSL1
Molecular weight: 121,025 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below

KANSL1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K104-a KLQGVFSkQTVLKSH
0 1 S115-p LKSHPLLsQsYELRA
0 1 S117-p SHPLLsQsYELRAEL
0 87 K180-a STSLNGGkRALtSSA
0 6 T184-p NGGkRALtSSALHGG
0 16 S249-p LQGSSRLsPGTDSSS
0 28 S268-p VKLEGKKsPLssILF
0 2 S271-p EGKKsPLssILFsAL
0 2 S272-p GKKsPLssILFsALD
0 1 S276-p PLssILFsALDsDTR
0 1 S280-p ILFsALDsDTRITAL
0 1 K372-u EGLSNFLkSNsISEE
0 1 S375-p SNFLkSNsISEELER
0 1 K601-a RPVLSCKkRRLVRPN
0 13 S792-p KMRLRDHsSERSEVL
0 3 T814-p SSSYLAAtHHPPHsP
0 39 S820-p AtHHPPHsPLVRQLs
0 26 S827-p sPLVRQLstssDSPA
0 26 T828-p PLVRQLstssDSPAP
0 3 S829-p LVRQLstssDSPAPA
0 6 S830-p VRQLstssDSPAPAS
0 9 S858-p VRRRRGEsSFDINNI
0 1 Y882-p TRVEKLQyKEILTPS
0 1 T955 YRSSDGRTTPQLGSA
0 4 T966-p LGSANPStPQPAsPD
0 4 S971-p PStPQPAsPDVSSSH
0 13 S991-p SHGQSPRsPIsPELH
0 6 S994-p QSPRsPIsPELHsAP
0 1 S999-p PIsPELHsAPLtPVA
0 18 T1003-p ELHsAPLtPVARDTP
0 2 S1021-p ASEDTRCstPELGLD
0 24 T1022-p SEDTRCstPELGLDE
0 26 S1045-p RTFPLAHsPQAECED
0 3 S1068-p ARCTRRTsGSKTGRE
0 1 T1076-p GSKTGREtEAAPTsP
0 4 S1082-p EtEAAPTsPPIVPLK
  mouse

► Hide Isoforms
 
K104 KLQGVFSKQTVLKSH
S115 LKSHPLLSQSYELRA
S117 SHPLLSQSYELRAEL
K180-a SSSLNGGkRSLTSSS
T184 NGGkRSLTSSSLQGG
S249-p LQGSSRLsPSTDSSS
S268-p VKLEVKKsPLssILF
S271-p EVKKsPLssILFSAL
S272-p VKKsPLssILFSALD
S276 PLssILFSALDSDTR
S280 ILFSALDSDTRITAL
K372 EGLSNFLKSDSISEE
S375 SNFLKSDSISEELER
K598 RPVLTCKKRRLVRPS
- gap
T746 SPSYLTATHHPPHSP
S752 ATHHPPHSPLVRQLS
S759 SPLVRQLStSsDTST
T760-p PLVRQLStSsDTSTP
S761 LVRQLStSsDTSTPT
S762-p VRQLStSsDTSTPTS
S789 VRRRRGESSFDINNI
Y813 TRVEKLQYKEILTPS
T886-p YRSSDGRtTPQLGSA
T897 LGSANPSTPQPAsPD
S902-p PSTPQPAsPDVSSSH
S922-p SHGQSPRsPIsPELH
S925-p QSPRsPIsPELHSAP
S930 PIsPELHSAPLtPVA
T934-p ELHSAPLtPVARDSL
S952 ASEDTRCSTPELGLD
T953 SEDTRCSTPELGLDE
S976-p RTFPLAYsPQAECEE
S999 ARCTRRTSGSKTGRE
A1007 GSKTGREAEVAPTsP
S1013-p EAEVAPTsPPVVPLK
  KANSL1 iso2  
K104 KLQGVFSKQTVLKSH
S115 LKSHPLLSQSYELRA
S117 SHPLLSQSYELRAEL
K180 SSSLNGGKRSLTSSS
T184 NGGKRSLTSSSLQGG
S249 LQGSSRLSPSTDSSS
S268 VKLEVKKSPLSSILF
S271 EVKKSPLSSILFSAL
S272 VKKSPLSSILFSALD
S276 PLSSILFSALDSDTR
S280 ILFSALDSDTRITAL
K372 EGLSNFLKSDSISEE
S375 SNFLKSDSISEELER
K598 RPVLTCKKRRLVRPS
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S623 AQRTGLRSALILSRV
- gap
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