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RRAGC (human)

Overview RRAGC Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. Note: This description may include information from UniProtKB. Cellular Component: lysosome; cytoplasm; nucleus Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein heterodimerization activity; magnesium ion binding Biological Process: transcription, DNA-dependent; apoptosis; GTP catabolic process; small GTPase mediated signal transduction; RNA splicing; cell growth; positive regulation of TOR signaling pathway Reference #:  Q9HB90 (UniProtKB) Alt. Names/Synonyms: FLJ13311; GTPase-interacting protein 2; GTR2; Rag C; Rag C protein; RagC; Ras-related GTP binding C; Ras-related GTP-binding protein C; RRAGC; TIB929 Gene Symbols: RRAGC Molecular weight: 44,224 Da Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RRAGC 3LLU - A=60-237 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	5		S2-p	______MsLQYGAEE
0	7		S15-p	EETPLAGsYGAADsF
0	2		Y16	ETPLAGsYGAADsFP
0	2		S21-p	GsYGAADsFPKDFGY
0	2		K79-u	SGKSSIQkVVFHKMS
0	1		S86	kVVFHKMSPNETLFL
0	14		S95-p	NETLFLEstNKIYKD
0	6		T96-p	ETLFLEstNKIYKDD
0	1		Y150	VIDAQDDYMEALTRL
0	1		Y165	HITVSKAYKVNPDMN
0	1		Y327-p	LNNTTVLyLKEVTKF
0	1		T381-p	HRSCGHQtsAssLKA
0	22		S382-p	RSCGHQtsAssLKAL
0	2		S384-p	CGHQtsAssLKALTH
0	23		S385-p	GHQtsAssLKALTHN
0	7		T394-p	KALTHNGtPRNAI__

	mouse
S2-p	______MsLQYGAEE
S15-p	EETPLAGsyGAADsF
Y16-p	ETPLAGsyGAADsFP
S21-p	GsyGAADsFPKDFGY
K78-u	SGKSSIQkVVFHKMs
S85-p	kVVFHKMsPNETLFL
S94-p	NETLFLEstNKIYKD
T95-p	ETLFLEstNKIYKDD
Y149	VIDAQDDYMEALTRL
Y164	HITVSKAYKVNPDMN
Y326	LNNTTVLYLKEVTKF
T380	HRSCSHQTsAPsLKA
S381-p	RSCSHQTsAPsLKAL
P383	CSHQTsAPsLKALAH
S384-p	SHQTsAPsLKALAHN
T393	KALAHNGTPRNAI__

	rat
S2	______MSLQYGAEE
S15	EETPLAGSYGAADSF
Y16	ETPLAGSYGAADSFP
S21	GSYGAADSFPKDFGY
K78	SGKSSIQKVVFHKMS
S85	KVVFHKMSPNETLFL
S94	NETLFLESTNKIYKD
T95	ETLFLESTNKIYKDD
Y149-p	VIDAQDDyMEALTRL
Y164-p	HITVSKAyKVNPDMN
Y326	LNNTTVLYLKEVTKF
T380	HRSCSHQTSAPSLKA
S381	RSCSHQTSAPSLKAL
P383	CSHQTSAPSLKALAH
S384	SHQTSAPSLKALAHN
T393	KALAHNGTPRNAI__

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