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Protein Page:
Met (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Met a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; Met family
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: cell surface; integral to plasma membrane; basal plasma membrane; extracellular region; integral to membrane; plasma membrane
Molecular Function: protein binding; protein-tyrosine kinase activity; hepatocyte growth factor receptor activity; protein phosphatase binding; ATP binding
Biological Process: axon guidance; skeletal muscle development; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; myoblast proliferation; myotube differentiation; muscle cell migration; hepatocyte growth factor receptor signaling pathway; glucose homeostasis; liver development; signal transduction; cell proliferation; cell surface receptor linked signal transduction; positive chemotaxis; branching morphogenesis of a tube; adult behavior; positive regulation of transcription from RNA polymerase II promoter; brain development; endothelial cell morphogenesis; placenta development
Disease: Hepatocellular Carcinoma; Renal Cell Carcinoma, Papillary, 1
Reference #:  P08581 (UniProtKB)
Alt. Names/Synonyms: AUTS9; c-Met; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; HGFR; MET; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; oncogene MET; Proto-oncogene c-Met; RCCP2; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
Gene Symbols: MET
Molecular weight: 155,541 Da
Basal Isoelectric point: 7.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Met

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: Y1003‑p, Y1234‑p, Y1235‑p, Y1349‑p, Y1356‑p
cell motility, altered: Y1234‑p, Y1235‑p, Y1349‑p, Y1356‑p
activity, induced: Y1003‑p, Y1234‑p, Y1235‑p
activity, inhibited: Y1349‑p, Y1356‑p
enzymatic activity, induced: Y1003‑p, Y1234‑p, Y1235‑p
enzymatic activity, inhibited: S985‑p, Y1349‑p, Y1356‑p
intracellular localization: S985‑p
molecular association, regulation: Y1003‑p, Y1349‑p, Y1356‑p
phosphorylation: Y1234‑p, Y1235‑p
protein conformation: Y1234‑p, Y1235‑p
protein degradation: Y1003‑p
protein stabilization: Y1003‑p
receptor desensitization, altered: Y1003‑p
ubiquitination: Y1003‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T17-p GILVLLFtLVQRSNG
0 1 K189-ub AKVLSSVkDRFINFF
0 1 K223-ub VRRLKETkDGFMFLT
0 1 S283 TRIIRFCSINSGLHS
0 1 K324-ub LQAAYVSkPGAQLAR
0 1 T474 VSRSGPSTPHVNFLL
0 1 S637-p MNKHFNMsIIIsNGH
0 1 S641-p FNMsIIIsNGHGTTQ
0 1 Y745-p YREDPIVyEIHPtKS
0 1 T750-p IVyEIHPtKSFIsGG
0 1 S755-p HPtKSFIsGGstITG
0 1 S758-p KSFIsGGstITGVGk
0 1 T759-p SFIsGGstITGVGkN
0 1 K765-ub stITGVGkNLNSVSV
1 0 Y830-p LDGILSKyFDLIYVH
0 2 K962-ub LKKRKQIkDLGsELV
0 6 S966-p KQIkDLGsELVRyDA
0 5 Y971-p LGsELVRyDARVHtP
0 8 T977-p RyDARVHtPHLDRLV
6 0 S985-p PHLDRLVsARsVsPt
0 19 S988-p DRLVsARsVsPttEM
0 33 S990-p LVsARsVsPttEMVs
0 11 T992-p sARsVsPttEMVsNE
0 7 T993-p ARsVsPttEMVsNEs
0 20 S997-p sPttEMVsNEsVDyR
1 44 S1000-p tEMVsNEsVDyRAtF
12 366 Y1003-p VsNEsVDyRAtFPED
0 9 T1006-p EsVDyRAtFPEDQFP
0 2 S1016-p EDQFPNSsQNGsCRQ
0 1 S1020-p PNSsQNGsCRQVQyP
0 15 Y1026-p GsCRQVQyPLTDMSP
0 31 Y1093-p RGHFGCVyHGtLLDN
0 3 T1096-p FGCVyHGtLLDNDGK
0 3 K1104-ub LLDNDGKkIHCAVKS
0 3 Y1159-p SPLVVLPyMkHGDLR
0 1 K1161-ub LVVLPyMkHGDLRNF
0 1 K1190-ac GFGLQVAkGMkyLAS
0 3 K1190-ub GFGLQVAkGMkyLAS
0 1 K1193-ub LQVAkGMkyLASKKF
1 2 Y1194-p QVAkGMkyLASKKFV
0 1 R1227 VADFGLARDMyDkEy
5 114 Y1230-p FGLARDMyDkEyysV
0 1 K1232-ub LARDMyDkEyysVHN
41 740 Y1234-p RDMyDkEyysVHNkt
40 445 Y1235-p DMyDkEyysVHNktG
1 177 S1236-p MyDkEyysVHNktGA
0 1 K1240-ub EyysVHNktGAKLPV
0 5 T1241-p yysVHNktGAKLPVK
0 1 K1259 LESLQTQKFTTKSDV
0 4 T1289-p PPYPDVNtFDITVYL
0 3 Y1307-p RRLLQPEyCPDPLyE
6 5 Y1313-p EyCPDPLyEVMLkCW
0 2 K1318-ub PLyEVMLkCWHPKAE
0 3 S1342-p SRISAIFstFIGEHy
0 6 T1343-p RISAIFstFIGEHyV
25 123 Y1349-p stFIGEHyVHVNAty
0 40 T1355-p HyVHVNAtyVNVKCV
22 120 Y1356-p yVHVNAtyVNVKCVA
8 117 Y1365-p NVKCVAPyPsLLssE
0 8 S1367-p KCVAPyPsLLssEDN
0 2 S1370-p APyPsLLssEDNADD
0 1 S1371-p PyPsLLssEDNADDE
3135 : Phospho-Met (Tyr1003) (13D11) Rabbit mAb
3077 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb
3126 : Phospho-Met (Tyr1234/1235) Antibody
3129 : Phospho-Met (Tyr1234/1235) (3D7) Rabbit mAb
4033 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Biotinylated)
4091 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
8564 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
12468 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (PE Conjugate)
3077 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb
3126 : Phospho-Met (Tyr1234/1235) Antibody
3129 : Phospho-Met (Tyr1234/1235) (3D7) Rabbit mAb
4033 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Biotinylated)
4091 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
8564 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
12468 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (PE Conjugate)
3121 : Phospho-Met (Tyr1349) Antibody
3133 : Phospho-Met (Tyr1349) (130H2) Rabbit mAb
  Met iso2  
T17 GILVLLFTLVQRSNG
K189 AKVLSSVKDRFINFF
K223 VRRLKETKDGFMFLT
S283 TRIIRFCSINSGLHS
K324 LQAAYVSKPGAQLAR
T474 VSRSGPSTPHVNFLL
S637 MNKHFNMSIIISNGH
S641 FNMSIIISNGHGTTQ
Y745 YREDPIVYEIHPTKS
T750 IVYEIHPTKSFISTW
S755 HPTKSFISTWWKEPL
S776 FCFASGGSTITGVGK
T777 CFASGGSTITGVGKN
K783 STITGVGKNLNSVSV
Y848 LDGILSKYFDLIYVH
K980 LKKRKQIKDLGSELV
S984 KQIKDLGSELVRYDA
Y989 LGSELVRYDARVHTP
T995 RYDARVHTPHLDRLV
S1003 PHLDRLVSARSVSPT
S1006 DRLVSARSVSPTTEM
S1008 LVSARSVSPTTEMVS
T1010 SARSVSPTTEMVSNE
T1011 ARSVSPTTEMVSNES
S1015 SPTTEMVSNESVDYR
S1018 TEMVSNESVDYRATF
Y1021 VSNESVDYRATFPED
T1024 ESVDYRATFPEDQFP
S1034 EDQFPNSSQNGSCRQ
S1038 PNSSQNGSCRQVQYP
Y1044 GSCRQVQYPLTDMSP
Y1111 RGHFGCVYHGTLLDN
T1114 FGCVYHGTLLDNDGK
K1122 LLDNDGKKIHCAVKS
Y1177 SPLVVLPYMKHGDLR
K1179 LVVLPYMKHGDLRNF
K1208 GFGLQVAKGMKYLAS
K1208 GFGLQVAKGMKYLAS
K1211 LQVAKGMKYLASKKF
Y1212 QVAKGMKYLASKKFV
R1245 VADFGLARDMYDKEY
Y1248 FGLARDMYDKEYYSV
K1250 LARDMYDKEYYSVHN
Y1252 RDMYDKEYYSVHNKT
Y1253 DMYDKEYYSVHNKTG
S1254 MYDKEYYSVHNKTGA
K1258 EYYSVHNKTGAKLPV
T1259 YYSVHNKTGAKLPVK
K1277 LESLQTQKFTTKSDV
T1307 PPYPDVNTFDITVYL
Y1325 RRLLQPEYCPDPLYE
Y1331 EYCPDPLYEVMLKCW
K1336 PLYEVMLKCWHPKAE
S1360 SRISAIFSTFIGEHY
T1361 RISAIFSTFIGEHYV
Y1367 STFIGEHYVHVNATY
T1373 HYVHVNATYVNVKCV
Y1374 YVHVNATYVNVKCVA
Y1383 NVKCVAPYPSLLSSE
S1385 KCVAPYPSLLSSEDN
S1388 APYPSLLSSEDNADD
S1389 PYPSLLSSEDNADDE
  mouse

 
S17 GILVLLLSLVQRSHG
K188 AKVLLSEKDRFINFF
Q222 VRRLKETQDGFKFLT
S282-p TRIIRFCsVDSGLHS
K323 LQAAYVSKPGANLAK
T473-p LSRTAHLtPHVNFLL
S636 MSEHFNVSVIISNSR
S640 FNVSVIISNSRETTQ
Y744 YREDPVVYEIHPTKS
T749 VVYEIHPTKSFISGG
S754 HPTKSFISGGSTITG
S757 KSFISGGSTITGIGK
T758 SFISGGSTITGIGKT
K764 STITGIGKTLNSVSL
H829 LDGILSKHFDLTYVH
K960 WMRKRKHKDLGSELV
S964 RKHKDLGSELVRYDA
Y969 LGSELVRYDARVHtP
T975-p RYDARVHtPHLDRLV
S983-p PHLDRLVsARSVsPT
S986 DRLVsARSVsPTTEM
S988-p LVsARSVsPTTEMVs
T990 sARSVsPTTEMVsNE
T991 ARSVsPTTEMVsNEs
S995-p sPTTEMVsNEsVDyR
S998-p TEMVsNEsVDyRATF
Y1001-p VsNEsVDyRATFPED
T1004 EsVDyRATFPEDQFP
S1014 EDQFPNSSQNGACRQ
A1018 PNSSQNGACRQVQYP
Y1024 GACRQVQYPLTDLSP
Y1091 RGHFGCVYHGTLLDN
T1094 FGCVYHGTLLDNDGK
K1102 LLDNDGKKIHCAVKS
Y1157 SPLVVLPYMKHGDLR
K1159 LVVLPYMKHGDLRNF
K1188 GFGLQVAKGMKyLAS
K1188 GFGLQVAKGMKyLAS
K1191 LQVAKGMKyLASKKF
Y1192-p QVAKGMKyLASKKFV
R1225-m1 VADFGLArDMyDKEy
Y1228-p FGLArDMyDKEyysV
K1230 LArDMyDKEyysVHN
Y1232-p rDMyDKEyysVHNKt
Y1233-p DMyDKEyysVHNKtG
S1234-p MyDKEyysVHNKtGA
K1238 EyysVHNKtGAKLPV
T1239-p yysVHNKtGAKLPVK
K1257-ub LESLQTQkFTTKSDV
T1287 PPYPDVNTFDITIYL
Y1305 RRLLQPEYCPDALyE
Y1311-p EYCPDALyEVMLKCW
K1316 ALyEVMLKCWHPKAE
S1340 SRISSIFSTFIGEHy
T1341 RISSIFSTFIGEHyV
Y1347-p STFIGEHyVHVNATy
T1353 HyVHVNATyVNVKCV
Y1354-p yVHVNATyVNVKCVA
Y1363-p NVKCVAPyPSLLPSQ
S1365 KCVAPyPSLLPSQDN
P1368 APyPSLLPSQDNIDG
S1369 PyPSLLPSQDNIDGE
3135 : Phospho-Met (Tyr1003) (13D11) Rabbit mAb
3077 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb
3126 : Phospho-Met (Tyr1234/1235) Antibody
3129 : Phospho-Met (Tyr1234/1235) (3D7) Rabbit mAb
4033 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Biotinylated)
4091 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
8564 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
12468 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (PE Conjugate)
3077 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb
3126 : Phospho-Met (Tyr1234/1235) Antibody
3129 : Phospho-Met (Tyr1234/1235) (3D7) Rabbit mAb
4033 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Biotinylated)
4091 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
8564 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
12468 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (PE Conjugate)
3121 : Phospho-Met (Tyr1349) Antibody
3133 : Phospho-Met (Tyr1349) (130H2) Rabbit mAb
  rat

 
T17 GILLLLLTLAQRSHG
K190 AKVLLSEKDRFINFF
Q224 VRRLKETQDGFKFLT
S284 TRIIRFCSVDSGLHS
K325 LQAAYVSKPGANLAK
T475 LSRTAHFTPHVNFLL
S638 MSEHFNVSVIVSNSR
S642 FNVSVIVSNSRETTQ
S746 YREDPVVSEIHPTKS
T751 VVSEIHPTKSFISGG
S756 HPTKSFISGGSTITG
S759 KSFISGGSTITGIGK
T760 SFISGGSTITGIGKN
K766 STITGIGKNLNSVST
H831 LDGILSKHFDLTYVH
K963 WLRKRKHKDLGSELV
S967 RKHKDLGSELVRYDA
Y972 LGSELVRYDARVHTP
T978 RYDARVHTPHLDRLV
S986-p PHLDRLVsARSVSPT
S989 DRLVsARSVSPTTEM
S991 LVsARSVSPTTEMVS
T993 sARSVSPTTEMVSNE
T994 ARSVSPTTEMVSNES
S998 SPTTEMVSNESVDYR
S1001 TEMVSNESVDYRATF
Y1004 VSNESVDYRATFPED
T1007 ESVDYRATFPEDQFP
S1017 EDQFPNSSQNGACRQ
A1021 PNSSQNGACRQVQYL
Y1027 GACRQVQYLLTDLSP
Y1094 RGHFGCVYHGTLLDS
T1097 FGCVYHGTLLDSDGK
K1105 LLDSDGKKIHCAVKS
Y1160 SPLVVLPYMKHGDLR
K1162 LVVLPYMKHGDLRNF
K1191 GFGLQVAKGMKYLVS
K1191 GFGLQVAKGMKYLVS
K1194 LQVAKGMKYLVSKKF
Y1195 QVAKGMKYLVSKKFV
R1228 VADFGLARDMYDKEy
Y1231 FGLARDMYDKEyySV
K1233 LARDMYDKEyySVHN
Y1235-p RDMYDKEyySVHNKT
Y1236-p DMYDKEyySVHNKTG
S1237 MYDKEyySVHNKTGA
K1241 EyySVHNKTGAKLPV
T1242 yySVHNKTGAKLPVK
K1260 LESLQTQKFTTKSDV
T1290 PPYPDVNTFDITIYL
Y1308 RRLLQPEYCPDALYE
Y1314 EYCPDALYEVMLKCW
K1319 ALYEVMLKCWHPKAE
S1343 SRISSIFSTFIGEHY
T1344 RISSIFSTFIGEHYV
Y1350 STFIGEHYVHVNATY
T1356 HYVHVNATYVNVKCV
Y1357 YVHVNATYVNVKCVA
Y1366 NVKCVAPYPSLLPSQ
S1368 KCVAPYPSLLPSQDN
P1371 APYPSLLPSQDNIDG
S1372 PYPSLLPSQDNIDGE
3135 : Phospho-Met (Tyr1003) (13D11) Rabbit mAb
3077 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb
3126 : Phospho-Met (Tyr1234/1235) Antibody
3129 : Phospho-Met (Tyr1234/1235) (3D7) Rabbit mAb
4033 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Biotinylated)
4091 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
8564 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
12468 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (PE Conjugate)
3077 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb
3126 : Phospho-Met (Tyr1234/1235) Antibody
3129 : Phospho-Met (Tyr1234/1235) (3D7) Rabbit mAb
4033 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Biotinylated)
4091 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Sepharose Bead Conjugate)
8564 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (Alexa Fluor(R) 594 Conjugate)
12468 : Phospho-Met (Tyr1234/1235) (D26) XP(R) Rabbit mAb (PE Conjugate)
3121 : Phospho-Met (Tyr1349) Antibody
3133 : Phospho-Met (Tyr1349) (130H2) Rabbit mAb
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