a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; Met family
Cellular Component: extracellular space; postsynaptic membrane; cell soma; integral to plasma membrane; flagellum; postsynaptic density; cytoplasm; basal plasma membrane; integral to membrane; plasma membrane; excitatory synapse
Molecular Function: protein binding; phospholipase binding; protein heterodimerization activity; protein-tyrosine kinase activity; protein complex binding; beta-catenin binding; phosphoinositide 3-kinase binding; hepatocyte growth factor receptor activity; ATP binding
Biological Process: lactation; axon guidance; central nervous system neuron differentiation; activation of MAPK activity; protein amino acid autophosphorylation; myoblast proliferation; neuron migration; signal transduction; response to organic cyclic substance; cell surface receptor linked signal transduction; pancreas development; response to wounding; oligodendrocyte development; placenta development; response to drug; positive regulation of mitosis; male gonad development; muscle cell migration; myotube differentiation; cell aging; positive regulation of dendrite morphogenesis; liver development; positive regulation of peptidyl-serine phosphorylation; cell proliferation; sperm motility; branching morphogenesis of a tube; adult behavior; brain development; positive regulation of DNA replication; response to acid
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.