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Protein Page:
SOX1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SOX1 Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Mainly expressed in the developing central nervous system. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; forebrain neuron development; neuron migration; lens morphogenesis in camera-type eye; ventral spinal cord interneuron specification
Reference #:  O00570 (UniProtKB)
Alt. Names/Synonyms: SOX1; SRY (sex determining region Y)-box 1; SRY-related HMG-box gene 1; Transcription factor SOX-1
Gene Symbols: SOX1
Molecular weight: 39,023 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SOX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K83-ac MHNSEISkRLGAEWK
0 1 K131 RKTKTLLKkDKYSLA
0 2 K132-ac KTKTLLKkDKYSLAG
0 1 S325 VKSEPSGSPPAPAHS
0 1 S332 SPPAPAHSRAPCPGD
  mouse

 
K83 MHNSEISKRLGAEWK
K131-ac RKTKTLLkkDKYSLA
K132-ac KTKTLLkkDKYSLAG
S325-p VKSEPSGsPPAPAHs
S332-gl sPPAPAHsRAPCPGD
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