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WNT5A
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. Interacts with PORCN. Interacts with WLS. Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells. Belongs to the Wnt family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
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Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; cytoplasm; plasma membrane
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Molecular Function: protein domain specific binding; receptor tyrosine kinase-like orphan receptor binding; frizzled binding; cytokine activity; receptor agonist activity; transcription factor activity; frizzled-2 binding
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Biological Process: prostate gland development; activation of MAPK activity; embryonic skeletal development; positive regulation of transcription, DNA-dependent; response to glucocorticoid stimulus; negative chemotaxis; positive regulation of interleukin-1 beta secretion; Wnt receptor signaling pathway through beta-catenin; negative regulation of synaptogenesis; uterus development; metestrus; negative regulation of BMP signaling pathway; activation of NF-kappaB transcription factor; neuron differentiation; positive regulation of fibroblast proliferation; determination of anterior/posterior axis, embryo; positive regulation of mesenchymal cell proliferation; positive regulation of macrophage activation; somitogenesis; urinary bladder development; olfactory bulb interneuron development; activation of protein kinase B; vagina development; positive regulation of interleukin-6 production; digestive tract morphogenesis; response to testosterone stimulus; negative regulation of fat cell differentiation; keratinocyte differentiation; genitalia development; Wnt receptor signaling pathway, calcium modulating pathway; positive regulation of angiogenesis; positive regulation of protein catabolic process; midgut development; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; alveolus development; negative regulation of apoptosis; lens development in camera-type eye; axon guidance; wound healing; negative regulation of fibroblast growth factor receptor signaling pathway; hypophysis morphogenesis; positive regulation of cytokine secretion during immune response; positive regulation of JNK cascade; dorsal/ventral axis specification; palate development; negative regulation of axon extension involved in axon guidance; response to estradiol stimulus; activation of JNK activity; response to organic substance; establishment of planar polarity; heart looping; negative regulation of epithelial cell proliferation; cervix development; Wnt receptor signaling pathway; positive regulation of meiosis; Wnt receptor signaling pathway, planar cell polarity pathway; male gonad development; positive regulation of peptidyl-serine phosphorylation; positive regulation of ossification; positive regulation of cGMP metabolic process; positive regulation of interferon-gamma production; convergent extension involved in organogenesis; response to hyperoxia; positive regulation of chemokine biosynthetic process; cartilage development; ameboidal cell migration; neural tube closure; epithelial to mesenchymal transition; hindgut morphogenesis; positive regulation of inflammatory response
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Reference #:
P41221 (UniProtKB)
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| Alt. Names/Synonyms: hWNT5A; Protein Wnt-5a; wingless-type MMTV integration site family, member 5A; WNT-5A protein; WNT5A |
| Gene Symbols: WNT5A |
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Molecular weight: 42,339 Da
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Basal Isoelectric point: 8.83
Predict pI for various phosphorylation states
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CST Pathways:
ESC Pluripotency and Differentiation
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mTOR Signaling
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Regulation of Microtubule Dynamics
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Translation: eIF4E and p70S6K
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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