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Protein Page:
WNT5A (human)

Overview
WNT5A Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. Interacts with PORCN. Interacts with WLS. Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells. Belongs to the Wnt family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum lumen; Golgi lumen; plasma membrane; extracellular region
Molecular Function: protein domain specific binding; receptor tyrosine kinase-like orphan receptor binding; frizzled binding; cytokine activity; transcription factor activity; receptor agonist activity; frizzled-2 binding
Biological Process: activation of MAPK activity; embryonic skeletal development; positive regulation of transcription, DNA-dependent; negative chemotaxis; positive regulation of interleukin-1 beta secretion; negative regulation of synaptogenesis; Wnt receptor signaling pathway through beta-catenin; uterus development; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; negative regulation of BMP signaling pathway; neuron differentiation; positive regulation of fibroblast proliferation; determination of anterior/posterior axis, embryo; positive regulation of mesenchymal cell proliferation; positive regulation of macrophage activation; somitogenesis; cell fate commitment; urinary bladder development; olfactory bulb interneuron development; activation of protein kinase B; positive regulation of interleukin-6 production; vagina development; negative regulation of fat cell differentiation; keratinocyte differentiation; Wnt receptor signaling pathway, calcium modulating pathway; genitalia development; positive regulation of angiogenesis; positive regulation of protein catabolic process; midgut development; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; lens development in camera-type eye; axon guidance; wound healing; hypophysis morphogenesis; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of cytokine secretion during immune response; positive regulation of JNK cascade; palate development; negative regulation of axon extension involved in axon guidance; activation of JNK activity; response to organic substance; establishment of planar polarity; heart looping; negative regulation of epithelial cell proliferation; cervix development; Wnt receptor signaling pathway; positive regulation of meiosis; male gonad development; positive regulation of peptidyl-serine phosphorylation; positive regulation of cGMP metabolic process; positive regulation of ossification; convergent extension involved in organogenesis; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; cartilage development; ameboidal cell migration; neural tube closure; epithelial to mesenchymal transition; hindgut morphogenesis; positive regulation of inflammatory response; lung development
Reference #:  P41221 (UniProtKB)
Alt. Names/Synonyms: hWNT5A; Protein Wnt-5a; wingless-type MMTV integration site family, member 5A; WNT-5A protein; WNT5A
Gene Symbols: WNT5A
Molecular weight: 42,339 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WNT5A

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y86-p QKKLCHLyQDHMQyI
0 1 Y92-p LyQDHMQyIGEGAKt
0 1 T99-p yIGEGAKtGIKECQY
0 1 S116-p RHRRWNCstVDNtsV
0 1 T117-p HRRWNCstVDNtsVF
0 1 T121-p NCstVDNtsVFGRVM
0 1 S122-p CstVDNtsVFGRVMQ
  mouse

 
Y86 QKKLCHLYQDHMQYI
Y92 LYQDHMQYIGEGAKT
T99 YIGEGAKTGIKECQY
S116 RHRRWNCSTVDNTSV
T117 HRRWNCSTVDNTSVF
T121 NCSTVDNTSVFGRVM
S122 CSTVDNTSVFGRVMQ
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