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Protein Page:
WNT5A (human)

WNT5A Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes. Interacts with PORCN. Interacts with WLS. Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells. Belongs to the Wnt family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 3p21-p14
Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; Golgi lumen; endoplasmic reticulum lumen; extracellular region; plasma membrane
Molecular Function: protein domain specific binding; receptor tyrosine kinase-like orphan receptor binding; frizzled binding; cytokine activity; receptor agonist activity; transcription factor activity; frizzled-2 binding
Biological Process: activation of MAPK activity; positive regulation of transcription, DNA-dependent; embryonic skeletal development; negative chemotaxis; positive regulation of endocytosis; positive regulation of interleukin-1 beta secretion; Wnt receptor signaling pathway through beta-catenin; negative regulation of synaptogenesis; uterus development; negative regulation of BMP signaling pathway; activation of NF-kappaB transcription factor; neuron differentiation; positive regulation of fibroblast proliferation; determination of anterior/posterior axis, embryo; midbrain development; positive regulation of mesenchymal cell proliferation; positive regulation of macrophage activation; somitogenesis; cell fate commitment; urinary bladder development; olfactory bulb interneuron development; activation of protein kinase B; vagina development; positive regulation of interleukin-6 production; negative regulation of fat cell differentiation; keratinocyte differentiation; genitalia development; positive regulation of angiogenesis; Wnt receptor signaling pathway, calcium modulating pathway; positive regulation of protein catabolic process; midgut development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; embryonic digit morphogenesis; negative regulation of melanin biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; lens development in camera-type eye; axon guidance; wound healing; negative regulation of fibroblast growth factor receptor signaling pathway; hypophysis morphogenesis; positive regulation of cytokine secretion during immune response; palate development; negative regulation of axon extension involved in axon guidance; activation of JNK activity; response to organic substance; establishment of planar polarity; heart looping; negative regulation of epithelial cell proliferation; cervix development; Wnt receptor signaling pathway; positive regulation of meiosis; male gonad development; positive regulation of peptidyl-serine phosphorylation; positive regulation of ossification; positive regulation of cGMP metabolic process; convergent extension involved in organogenesis; positive regulation of interferon-gamma production; positive regulation of chemokine biosynthetic process; ameboidal cell migration; cartilage development; epithelial to mesenchymal transition; hindgut morphogenesis; positive regulation of inflammatory response; lung development
Disease: Robinow Syndrome, Autosomal Dominant
Reference #:  P41221 (UniProtKB)
Alt. Names/Synonyms: hWNT5A; Protein Wnt-5a; wingless-type MMTV integration site family, member 5A; WNT-5A protein; WNT5A
Gene Symbols: WNT5A
Molecular weight: 42,339 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 S116-p RHRRWNCstVDNtsV
0 1 T117-p HRRWNCstVDNtsVF
0 1 T121-p NCstVDNtsVFGRVM
0 1 S122-p CstVDNtsVFGRVMQ

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