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Protein Page:
TEAD3 (human)

Overview
TEAD3 Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; female pregnancy
Reference #:  Q99594 (UniProtKB)
Alt. Names/Synonyms: DTEF-1; ETFR-1; TEA domain family member 3; TEA domain family member 5; TEAD-3; TEAD3; TEAD5; TEF-5; TEF5; transcriptional enhancer factor 5; Transcriptional enhancer factor TEF-5; Transcriptional enhancer factor TEF-5 (DTEF-1)
Gene Symbols: TEAD3
Molecular weight: 48,676 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TEAD3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p SNSWNASssPGEARE
0 1 S11-p NSWNASssPGEARED
0 5 S148-p QNKFSPPsPLPQAVF
  mouse

 
S10 SNSWTANSSPGEARE
S11 NSWTANSSPGEARED
S148-p QNKFSPPsPLPQAVF
  rat

 
N10 SNSWTANNSPGEARE
S11 NSWTANNSPGEARED
S148 QNKFSPPSPLPQAVF
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