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Protein Page:
TEAD3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TEAD3 Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex
Molecular Function: protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; female pregnancy
Reference #:  Q99594 (UniProtKB)
Alt. Names/Synonyms: DTEF-1; ETFR-1; TEA domain family member 3; TEA domain family member 5; TEAD-3; TEAD3; TEAD5; TEF-5; TEF5; transcriptional enhancer factor 5; Transcriptional enhancer factor TEF-5; Transcriptional enhancer factor TEF-5 (DTEF-1)
Gene Symbols: TEAD3
Molecular weight: 48,676 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TEAD3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S10-p SNSWNASssPGEARE
0 1 S11-p NSWNASssPGEARED
0 6 S148-p QNKFSPPsPLPQAVF
0 1 S175-p LGQQPGPsQDIKPFA
0 1 K279-ac YDKFPEKkGGLkELY
0 1 K283-ac PEKkGGLkELYEKGP
  mouse

 
S10 SNSWTANSSPGEARE
S11 NSWTANSSPGEARED
S148-p QNKFSPPsPLPQAVF
S175 LGQQPGPSQDIKPFA
K283 YDKFPEKKGGLKELY
K287 PEKKGGLKELYEKGP
  rat

 
N10 SNSWTANNSPGEARE
S11 NSWTANNSPGEARED
S148 QNKFSPPSPLPQAVF
S174 LGQQPGPSQDIKPFA
K281 YDKFPEKKGGLKELY
K285 PEKKGGLKELYEKGP
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