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Protein Page:
RAC3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RAC3 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. Highest levels in brain, also detected in heart, placenta and pancreas. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric, Rho; G protein, monomeric; Motility/polarity/chemotaxis
Cellular Component: filamentous actin; neuron projection; growth cone; cell soma; perinuclear region of cytoplasm; lamellipodium; plasma membrane; endomembrane system; cytosol
Molecular Function: GTPase activity; protein binding; GTP binding; calcium-dependent protein binding
Biological Process: regulation of small GTPase mediated signal transduction; GTP catabolic process; small GTPase mediated signal transduction; positive regulation of cell adhesion mediated by integrin; cell projection biogenesis; neuromuscular process controlling balance; actin cytoskeleton organization and biogenesis; neurite development
Reference #:  P60763 (UniProtKB)
Alt. Names/Synonyms: p21-Rac3; RAC3; Ras-related C3 botulinum toxin substrate 3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); rho family, small GTP binding protein Rac3
Gene Symbols: RAC3
Molecular weight: 21,379 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RAC3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K96-u SFENVRAkWYPEVRH
0 1 K153-u AREIGSVkYLECSAL
0 4 T161-p YLECSALtQRGLktV
0 5 K166-u ALtQRGLktVFDEAI
0 12 T167-p LtQRGLktVFDEAIR
0 27 K183-u VLCPPPVkkPGKKCT
0 20 K184-u LCPPPVkkPGKKCTV
  mouse

 
K96-u SFENVRAkWYPEVRH
K153 AREIGSVKYLECSAL
T161-p YLECSALtQRGLktV
K166-u ALtQRGLktVFDEAI
T167-p LtQRGLktVFDEAIR
K183-u VLCPPPVkkPGKKCT
K184-u LCPPPVkkPGKKCTV
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