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Protein Page:
POU4F2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
POU4F2 Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons. Belongs to the POU transcription factor family. Class- 4 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nuclear speck; nucleus
Molecular Function: chromatin binding
Biological Process: neuron differentiation; axon guidance; estrogen receptor signaling pathway; sensory perception of sound; transcription, DNA-dependent; retina development in camera-type eye; axon extension; MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; neuromuscular process controlling balance; positive regulation of cell differentiation; retinal ganglion cell axon guidance
Reference #:  Q12837 (UniProtKB)
Alt. Names/Synonyms: Brain-3B; Brain-specific homeobox/POU domain protein 3B; Brn-3B; BRN3.2; BRN3B; Brn3b POU domain transcription factor; PO4F2; POU class 4 homeobox 2; POU domain class 4 transcription factor 2; POU domain protein; POU domain, class 4, transcription factor 2; POU4F2
Gene Symbols: POU4F2
Molecular weight: 43,087 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Select Structure to View Below

POU4F2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S43-p SSAPIAPsAsSPSSS
0 1 S45-p APIAPsAsSPSSSSN
0 1 S76-p RSSSSSSsGSSGGGG
0 2 S84-p GSSGGGGsEAMRRAC
0 1 K266-ac EAFAERFkQRRIkLG
0 1 K271-ac RFkQRRIkLGVTQAD
0 1 K345 ELFNGAEKKRKRTSI
0 1 K346 LFNGAEKKRKRTSIA
  mouse

 
S43 SSAPAAPSASSPSSS
S45 APAAPSASSPSSSSN
G78 SSSSSGSGGSGGGGG
S86 GSGGGGGSEAMRRAC
K268 EAFAERFKQRRIKLG
K273 RFKQRRIKLGVTQAD
K347-ac ELFNGAEkkRKRTSI
K348-ac LFNGAEkkRKRTSIA
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