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Protein Page:
PROTOR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PROTOR2 May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. Belongs to the PROTOR family. May replace PROTOR1 in the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: mitochondrion; TORC2 complex
Molecular Function: ubiquitin protein ligase binding
Biological Process: positive regulation of phosphoinositide 3-kinase cascade; negative regulation of protein amino acid phosphorylation; positive regulation of protein amino acid phosphorylation; negative regulation of signal transduction
Reference #:  Q6MZQ0 (UniProtKB)
Alt. Names/Synonyms: FLJ14213; FLJ22630; MGC16218; proline rich 5 like; Protein observed with Rictor-2; Protor-2; PROTOR2; PRR5L
Gene Symbols: PRR5L
Molecular weight: 40,836 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PROTOR2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 9 S28-p RPRPRFMssPVLSDL
0 1 S29-p PRPRFMssPVLSDLP
0 2 K86-ub ENIRRLLkSELGSFI
0 1 Y96-p LGSFITDyFQNQLLA
0 2 S181-p DLLLLAQskLPSSIV
0 1 K182-ac LLLLAQskLPSSIVQ
0 1 S231-p ISGDRSFsGPtYtLA
0 1 T234-p DRSFsGPtYtLARRH
0 1 T236-p SFsGPtYtLARRHSR
  mouse

 
S28-p RPRPRFMssPVLSEL
S29-p PRPRFMssPVLSELP
K86 ESIRRLLKSELGSFI
Y96 LGSFITDYFQNQLLA
S181 DVLLLAQSKLPSSVI
K182 VLLLAQSKLPSSVIQ
S231 ISGDRSCSGPTYSLA
T234 DRSCSGPTYSLARRH
S236 SCSGPTYSLARRHSR
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