Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PROTOR2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PROTOR2 May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. Belongs to the PROTOR family. May replace PROTOR1 in the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: mitochondrion; TORC2 complex
Molecular Function: ubiquitin protein ligase binding
Biological Process: positive regulation of phosphoinositide 3-kinase cascade; negative regulation of protein amino acid phosphorylation; positive regulation of protein amino acid phosphorylation; negative regulation of signal transduction
Reference #:  Q6MZQ0 (UniProtKB)
Alt. Names/Synonyms: FLJ14213; FLJ22630; MGC16218; proline rich 5 like; Protein observed with Rictor-2; Protor-2; PROTOR2; PRR5L
Gene Symbols: PRR5L
Molecular weight: 40,836 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PROTOR2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 8 S28-p RPRPRFMsSPVLSDL
0 2 K86-u ENIRRLLkSELGSFI
0 1 T236-p SFSGPTYtLARRHSR
  mouse

 
S28-p RPRPRFMsSPVLSEL
K86 ESIRRLLKSELGSFI
S236 SCSGPTYSLARRHSR
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.