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EDC4 (human)

Overview EDC4 a protein required for the 5' a?? 3' pathway of mRNA decapping and degradation-based post-transcriptional gene silencing. The proteins involved in 5' a?? 3' mRNA decay include DCP2, DCP1A, EDC3, EDC4 and DDX6, and are concentrated in cytoplasmic structures called mRNA "processing bodies" (P-bodies). Shortening of the 3'-poly(A) tail and removal of PABP precedes cleavage of the 5'-mRNA cap by a complex containing decapping enzymes 1A and 2 (DCP1A/DCP2). EDC4 enhances the catalytic activity of DCP2 in vitro. Shown to be required for silencing by miRNAs in Drosophila melanogaster. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB. Protein type: RNA processing Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleolus; cytosol; nucleus Molecular Function: protein binding Biological Process: RNA metabolic process; gene expression; mRNA metabolic process; mRNA catabolic process, deadenylation-dependent decay Reference #:  Q6P2E9 (UniProtKB) Alt. Names/Synonyms: Autoantigen Ge-1; Autoantigen RCD-8; EDC4; enhancer of mRNA decapping 4; Enhancer of mRNA-decapping protein 4; Ge-1; HEDLS; Human enhancer of decapping large subunit; RCD-8 Gene Symbols: EDC4 Molecular weight: 151,661 Da Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below EDC4

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		D57-ca	PDPLCSGdSTSANKT
0	1		S106-p	EIVASSDssISsKAR
0	1		S107-p	IVASSDssISsKARG
0	1		S110-p	SSDssISsKARGSNK
0	1		K125-a	VKIQPVAkyDWEQKY
0	1		K125-u	VKIQPVAkyDWEQKY
0	1		Y126-p	KIQPVAkyDWEQKYY
0	1		Y147-p	VSNSFLAyAIRAANN
0	5		K287-u	PVDVSQIkQGFIVVK
0	1		D485-ca	LPAEEENdsLGADGT
0	3		S486-p	PAEEENdsLGADGTH
0	1		A489	EENdsLGADGTHGAG
0	1		G491	NdsLGADGTHGAGAM
0	1		S565-p	LGSAAHGsQPDLRRI
0	15		S583-p	PAPADFLsLssEtKP
0	8		S585-p	PADFLsLssEtKPKL
0	3		S586-p	ADFLsLssEtKPKLM
0	8		T588-p	FLsLssEtKPKLMTP
0	1		S613-p	QQITASPsSSSSGSS
0	1		D662-ca	LSPKLQLdGSLTMSS
0	1		S672	LTMSSSGSLQAsPRG
0	4		S676-p	SSGSLQAsPRGLLPG
0	2		G679	SLQAsPRGLLPGLLP
0	8		T693-p	PAPADKLtPKGPGQV
0	1		S708-p	PTATSALsLELQEVE
0	11		S723-p	PLGLPQAsPsRtRsP
0	9		S725-p	GLPQAsPsRtRsPDV
0	11		T727-p	PQAsPsRtRsPDVIs
0	35		S729-p	AsPsRtRsPDVIssA
0	4		S734-p	tRsPDVIssAStALs
0	2		S735-p	RsPDVIssAStALsQ
0	1		T738-p	DVIssAStALsQDIP
0	27		S741-p	ssAStALsQDIPEIA
0	2		S780-p	ASALHLLsPRPRPGP
0	4		P791	RPGPELGPQLGLDGG
0	3		T807-p	GDGDRHNtPsLLEAA
0	2		S809-p	GDRHNtPsLLEAALT
0	1		T816	sLLEAALTQEAstPD
0	1		S820-p	AALTQEAstPDsQVW
0	9		T821-p	ALTQEAstPDsQVWP
0	1		S824-p	QEAstPDsQVWPTAP
0	14		S844-p	TCSTLAEsPRNGLQE
0	118		Y863-p	LAFHRPPyHLLQQRD
0	4		S871-p	HLLQQRDsQDAsAEQ
0	4		A874	QQRDsQDAsAEQsDH
0	10		S875-p	QRDsQDAsAEQsDHD
0	16		S879-p	QDAsAEQsDHDDEVA
0	4		S887-p	DHDDEVAsLASAsGG
0	1		S890	DEVAsLASAsGGFGT
0	3		S892-p	VAsLASAsGGFGTKV
0	3		A901	GFGTKVPAPRLPAKD
0	1		S914-p	KDWKTKGsPRTsPKL
0	1		S918-p	TKGsPRTsPKLKRKS
0	1		S925	sPKLKRKSKKDDGDA
0	1		S1058-p	VPPCVSRsLEPMAGQ
0	1		S1067-p	EPMAGQLsNSVAtKL
0	2		T1072-p	QLsNSVAtKLTAVEG
0	1		Y1148-p	FRLGTQEyLQQLEsH
0	1		S1154-p	EyLQQLEsHMkSRKA
0	2		K1157-u	QQLEsHMkSRKAREQ
0	1		S1380-p	LQAEPHNsLGKAARR
0	2		S1389-p	GKAARRLsLMLHGLV
0	2		S1399-p	LHGLVTPsLP_____

	mouse
D57	PDPLSSGDGNSTNKP
S106	EIVASSDSSISSKAR
S107	IVASSDSSISSKARG
S110	SSDSSISSKARGSNK
K125	VKIQPVAKYDWEQKY
K125	VKIQPVAKYDWEQKY
Y126	KIQPVAKYDWEQKYY
Y147	VSNSFLAYAIRAANN
K287	PVDVSQIKQGFIVVK
D485	LPAEEENDsLGtEsS
S486-p	PAEEENDsLGtEsSH
T489-p	EENDsLGtEsSHGAG
S491-p	NDsLGtEsSHGAGAL
S565	LASAAHGSQPDLRRI
S583	PAPADFLSLSSEtKP
S585	PADFLSLSSEtKPEL
S586	ADFLSLSSEtKPELM
T588-p	FLSLSSEtKPELMTP
S616	SASPSSSSSSSSSSS
D665	LSPKLQLDGSLTLNS
S676-p	TLNSSSSsLQAsPRs
S680-p	SSSsLQAsPRsLLPG
S683-p	sLQAsPRsLLPGLLP
I697	PGPADKLISKGPGQV
S712-p	STAASALsLDLQEVE
S727-p	PLGLPQAsPSRtRsP
S729	GLPQAsPSRtRsPDV
T731-p	PQAsPSRtRsPDVIs
S733-p	AsPSRtRsPDVIssA
S738-p	tRsPDVIssAStALs
S739-p	RsPDVIssAStALsQ
T742-p	DVIssAStALsQDIP
S745-p	ssAStALsQDIPEIA
S785	ASALHLLSPRPRQGP
S796-p	RQGPELGsQLGLDGG
T812	GDGDRHSTPsLLEAA
S814-p	GDRHSTPsLLEAALt
T821-p	sLLEAALtQEVAtPD
A825	AALtQEVAtPDSQVW
T826-p	ALtQEVAtPDSQVWP
S829	QEVAtPDSQVWPTAP
S849-p	TCSTLTEsPRNGLQE
Y868	LAFHRPPYHLLQQRD
S876-p	HLLQQRDsQDtsAEQ
T879-p	QQRDsQDtsAEQsDH
S880-p	QRDsQDtsAEQsDHD
S884-p	QDtsAEQsDHDDEVA
S892-p	DHDDEVAsLAsAsGG
S895-p	DEVAsLAsAsGGFGS
S897-p	VAsLAsAsGGFGSKI
T906-p	GFGSKIPtPRLPSKD
S919	KDWKTKGSPRTSPKL
S923	TKGSPRTSPKLKRKs
S930-p	SPKLKRKsKKDDGDS
S1063	VPPCVSRSLEPVAGQ
S1072	EPVAGQLSNSVATKL
T1077	QLSNSVATKLTAVEG
Y1153	FRLGTQEYLQQLESH
S1159	EYLQQLESHMkSRKA
K1162-u	QQLESHMkSRKAREQ
S1385	LQADPHNSLSKAARR
S1394	SKAARRLSLMLHGLV
S1404	LHGLVTPSLP_____

	rat
D57	PDPLSSGDGNSTSKP
S106	EIVASSDSSISSKAR
S107	IVASSDSSISSKARG
S110	SSDSSISSKARGSNK
K125	VKIQPVAKYDWEQKY
K125	VKIQPVAKYDWEQKY
Y126	KIQPVAKYDWEQKYY
Y147	VSNSFLAYAIRAANN
K287	PVDVSQIKQGFIVVK
D485	LPAEEESDSLGTESS
S486	PAEEESDSLGTESSH
T489	EESDSLGTESSHGAG
S491	SDSLGTESSHGAGTL
S565	LASAPHGSQPDLRRI
S583	PAPADFLSLSSETKP
S585	PADFLSLSSETKPKL
S586	ADFLSLSSETKPKLM
T588	FLSLSSETKPKLMTP
S613	QQISASPSSSSSSSS
D667	LSPKLQLDGSLTISS
S677	LTISSSSSLQASPRS
S681	SSSSLQASPRSLLPG
S684	SLQASPRSLLPGLLP
I698	PGPADKLIPKGPGQV
S713	SSGTSALSLDLQEVE
S728	PLGLPQASPSRtRsP
S730	GLPQASPSRtRsPDV
T732-p	PQASPSRtRsPDVIs
S734-p	ASPSRtRsPDVIsSA
S739-p	tRsPDVIsSASTALs
S740	RsPDVIsSASTALsQ
T743	DVIsSASTALsQDIP
S746-p	sSASTALsQDIPEIA
S786	ASALHLLSPRPRQGP
S797	RQGPELSSQLGLDGG
T813	GDGDRHSTPSLLEAA
S815	GDRHSTPSLLEAALT
T822	SLLEAALTQEVATSD
A826	AALTQEVATSDSQVW
T827	ALTQEVATSDSQVWP
S830	QEVATSDSQVWPTAP
S850	TCSTLTESPRNGLQE
Y869	LAFHRPPYHLLQQHD
S877	HLLQQHDSQDTSAEQ
T880	QQHDSQDTSAEQSDH
S881	QHDSQDTSAEQSDHD
S885	QDTSAEQSDHDDEVA
S893	DHDDEVASLASASGG
S896	DEVASLASASGGFGS
S898	VASLASASGGFGSKI
T907	GFGSKIPTPRLPAKD
S920	KDWKTKGSPRTSPKL
S924	TKGSPRTSPKLKRKS
S931	SPKLKRKSKKDDGDS
S1064	VPPCVSRSLEPVAGQ
S1073	EPVAGQLSNSVATKL
T1078	QLSNSVATKLTAVEG
Y1154	FRLGTQEYLQQLDSH
S1160	EYLQQLDSHMKSRKA
K1163	QQLDSHMKSRKAREQ
S1386	LQADPHNSLGKAARR
S1395	GKAARRLSLMLHGLV
S1405	LHGLVTPSLP_____

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