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Protein Page:
EDC4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
EDC4 a protein required for the 5' a?? 3' pathway of mRNA decapping and degradation-based post-transcriptional gene silencing. The proteins involved in 5' a?? 3' mRNA decay include DCP2, DCP1A, EDC3, EDC4 and DDX6, and are concentrated in cytoplasmic structures called mRNA "processing bodies" (P-bodies). Shortening of the 3'-poly(A) tail and removal of PABP precedes cleavage of the 5'-mRNA cap by a complex containing decapping enzymes 1A and 2 (DCP1A/DCP2). EDC4 enhances the catalytic activity of DCP2 in vitro. Shown to be required for silencing by miRNAs in Drosophila melanogaster. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA processing
Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein binding
Biological Process: RNA metabolic process; gene expression; mRNA metabolic process; mRNA catabolic process, deadenylation-dependent decay
Reference #:  Q6P2E9 (UniProtKB)
Alt. Names/Synonyms: Autoantigen Ge-1; Autoantigen RCD-8; EDC4; enhancer of mRNA decapping 4; Enhancer of mRNA-decapping protein 4; Ge-1; HEDLS; Human enhancer of decapping large subunit; RCD-8
Gene Symbols: EDC4
Molecular weight: 151,661 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EDC4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MAsCAsIDIE
0 1 S6-p __MAsCAsIDIEDAT
0 1 D57-ca PDPLCSGdSTSANKT
0 1 K125-a VKIQPVAkyDWEQKY
0 1 K125-u VKIQPVAkyDWEQKY
0 1 Y126-p KIQPVAkyDWEQKYY
0 1 Y147-p VSNSFLAyAIRAANN
0 5 K287-u PVDVSQIkQGFIVVK
0 1 D485-ca LPAEEENdsLGADGT
0 3 S486-p PAEEENdsLGADGTH
0 1 A489 EENdsLGADGTHGAG
0 1 G491 NdsLGADGTHGAGAM
0 1 S565-p LGSAAHGsQPDLRRI
0 16 S583-p PAPADFLsLssEtKP
0 9 S585-p PADFLsLssEtKPKL
0 3 S586-p ADFLsLssEtKPKLM
0 8 T588-p FLsLssEtKPKLMTP
0 1 D662-ca LSPKLQLdGSLTMSS
0 1 S672 LTMSSSGSLQAsPRG
0 4 S676-p SSGSLQAsPRGLLPG
0 2 G679 SLQAsPRGLLPGLLP
0 10 T693-p PAPADKLtPKGPGQV
0 1 S708-p PTATSALsLELQEVE
0 11 S723-p PLGLPQAsPsRtRsP
0 9 S725-p GLPQAsPsRtRsPDV
0 11 T727-p PQAsPsRtRsPDVIs
0 36 S729-p AsPsRtRsPDVIssA
0 4 S734-p tRsPDVIssAStALs
0 2 S735-p RsPDVIssAStALsQ
0 1 T738-p DVIssAStALsQDIP
0 27 S741-p ssAStALsQDIPEIA
0 2 S780-p ASALHLLsPRPRPGP
0 4 P791 RPGPELGPQLGLDGG
0 3 T807-p GDGDRHNtPsLLEAA
0 2 S809-p GDRHNtPsLLEAALT
0 1 T816 sLLEAALTQEAstPD
0 1 S820-p AALTQEAstPDsQVW
0 9 T821-p ALTQEAstPDsQVWP
0 1 S824-p QEAstPDsQVWPTAP
0 15 S844-p TCSTLAEsPRNGLQE
0 119 Y863-p LAFHRPPyHLLQQRD
0 6 S871-p HLLQQRDsQDAsAEQ
0 4 A874 QQRDsQDAsAEQsDH
0 11 S875-p QRDsQDAsAEQsDHD
0 17 S879-p QDAsAEQsDHDDEVA
0 4 S887-p DHDDEVAsLAsAsGG
0 1 S890-p DEVAsLAsAsGGFGT
0 3 S892-p VAsLAsAsGGFGTKV
0 3 A901 GFGTKVPAPRLPAKD
0 1 S914-p KDWKTKGsPRTsPKL
0 1 S918-p TKGsPRTsPKLKRKS
0 1 S925 sPKLKRKSKKDDGDA
0 1 S967-p ELAELRHsQEELLQR
0 1 T1050-p IRDEIKKtVPPCVSR
0 1 S1067-p EPMAGQLsNSVAtKL
0 2 T1072-p QLsNSVAtKLTAVEG
0 2 K1157-u QQLESHMkSRKAREQ
0 2 S1380-p LQAEPHNsLGKAARR
0 2 S1389-p GKAARRLsLMLHGLV
0 2 S1399-p LHGLVTPsLP_____
  mouse

 
S3 _____MASCASIDIE
S6 __MASCASIDIEDAT
D57 PDPLSSGDGNSTNKP
K125 VKIQPVAKYDWEQKY
K125 VKIQPVAKYDWEQKY
Y126 KIQPVAKYDWEQKYY
Y147 VSNSFLAYAIRAANN
K287 PVDVSQIKQGFIVVK
D485 LPAEEENDsLGtEsS
S486-p PAEEENDsLGtEsSH
T489-p EENDsLGtEsSHGAG
S491-p NDsLGtEsSHGAGAL
S565 LASAAHGSQPDLRRI
S583 PAPADFLSLSSEtKP
S585 PADFLSLSSEtKPEL
S586 ADFLSLSSEtKPELM
T588-p FLSLSSEtKPELMTP
D665 LSPKLQLDGSLTLNS
S676-p TLNSSSSsLQAsPRs
S680-p SSSsLQAsPRsLLPG
S683-p sLQAsPRsLLPGLLP
I697 PGPADKLISKGPGQV
S712-p STAASALsLDLQEVE
S727-p PLGLPQAsPsRtRsP
S729-p GLPQAsPsRtRsPDV
T731-p PQAsPsRtRsPDVIs
S733-p AsPsRtRsPDVIssA
S738-p tRsPDVIssAStALs
S739-p RsPDVIssAStALsQ
T742-p DVIssAStALsQDIP
S745-p ssAStALsQDIPEIA
S785-p ASALHLLsPRPRQGP
S796-p RQGPELGsQLGLDGG
T812 GDGDRHSTPsLLEAA
S814-p GDRHSTPsLLEAALt
T821-p sLLEAALtQEVAtPD
A825 AALtQEVAtPDSQVW
T826-p ALtQEVAtPDSQVWP
S829 QEVAtPDSQVWPTAP
S849-p TCSTLTEsPRNGLQE
Y868 LAFHRPPYHLLQQRD
S876-p HLLQQRDsQDtsAEQ
T879-p QQRDsQDtsAEQsDH
S880-p QRDsQDtsAEQsDHD
S884-p QDtsAEQsDHDDEVA
S892-p DHDDEVAsLAsAsGG
S895-p DEVAsLAsAsGGFGS
S897-p VAsLAsAsGGFGSKI
T906-p GFGSKIPtPRLPSKD
S919-p KDWKTKGsPRTsPKL
S923-p TKGsPRTsPKLKRKs
S930-p sPKLKRKsKKDDGDS
N972 ELAELWHNQEELLQR
T1055 VRDEIKKTVPPCVSR
S1072 EPVAGQLSNSVATKL
T1077 QLSNSVATKLTAVEG
K1162-u QQLESHMkSRKAREQ
S1385 LQADPHNSLSKAARR
S1394 SKAARRLSLMLHGLV
S1404 LHGLVTPSLP_____
  rat

 
S3 _____MASCASIDIE
S6 __MASCASIDIEDAT
D57 PDPLSSGDGNSTSKP
K125 VKIQPVAKYDWEQKY
K125 VKIQPVAKYDWEQKY
Y126 KIQPVAKYDWEQKYY
Y147 VSNSFLAYAIRAANN
K287 PVDVSQIKQGFIVVK
D485 LPAEEESDSLGTESS
S486 PAEEESDSLGTESSH
T489 EESDSLGTESSHGAG
S491 SDSLGTESSHGAGTL
S565 LASAPHGSQPDLRRI
S583 PAPADFLSLSSETKP
S585 PADFLSLSSETKPKL
S586 ADFLSLSSETKPKLM
T588 FLSLSSETKPKLMTP
D667 LSPKLQLDGSLTISS
S677 LTISSSSSLQASPRS
S681 SSSSLQASPRSLLPG
S684 SLQASPRSLLPGLLP
I698 PGPADKLIPKGPGQV
S713 SSGTSALSLDLQEVE
S728 PLGLPQASPSRtRsP
S730 GLPQASPSRtRsPDV
T732-p PQASPSRtRsPDVIs
S734-p ASPSRtRsPDVIsSA
S739-p tRsPDVIsSASTALs
S740 RsPDVIsSASTALsQ
T743 DVIsSASTALsQDIP
S746-p sSASTALsQDIPEIA
S786 ASALHLLSPRPRQGP
S797 RQGPELSSQLGLDGG
T813 GDGDRHSTPSLLEAA
S815 GDRHSTPSLLEAALT
T822 SLLEAALTQEVATSD
A826 AALTQEVATSDSQVW
T827 ALTQEVATSDSQVWP
S830 QEVATSDSQVWPTAP
S850 TCSTLTESPRNGLQE
Y869 LAFHRPPYHLLQQHD
S877 HLLQQHDSQDTSAEQ
T880 QQHDSQDTSAEQSDH
S881 QHDSQDTSAEQSDHD
S885 QDTSAEQSDHDDEVA
S893 DHDDEVASLASASGG
S896 DEVASLASASGGFGS
S898 VASLASASGGFGSKI
T907 GFGSKIPTPRLPAKD
S920 KDWKTKGSPRTSPKL
S924 TKGSPRTSPKLKRKS
S931 SPKLKRKSKKDDGDS
N973 ELAELWHNQEELLQR
T1056 IRDEIKKTVPPCVSR
S1073 EPVAGQLSNSVATKL
T1078 QLSNSVATKLTAVEG
K1163 QQLDSHMKSRKAREQ
S1386 LQADPHNSLGKAARR
S1395 GKAARRLSLMLHGLV
S1405 LHGLVTPSLP_____
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