a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf, Mos and Cot kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK1 and ERK2. An essential component of MAP kinase signal transduction pathways involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Protein kinase, STE; Kinase, protein; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 15q22.1-q22.33
Cellular Component: dendrite cytoplasm; Golgi apparatus; microtubule; focal adhesion; mitochondrion; endoplasmic reticulum; early endosome; perikaryon; cell cortex; cytosol; perinuclear region of cytoplasm; axon; late endosome; cytoplasm; plasma membrane; microtubule organizing center; nucleus
Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; Ras GTPase binding; receptor signaling protein tyrosine phosphatase activity; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; mitogen-activated protein kinase kinase kinase binding; ATP binding; protein kinase activity
Biological Process: activation of MAPKK activity; nerve growth factor receptor signaling pathway; activation of MAPK activity; protein heterooligomerization; negative regulation of homotypic cell-cell adhesion; response to glucocorticoid stimulus; cell motility involved in cell locomotion; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; neuron differentiation; toll-like receptor 5 signaling pathway; small GTPase mediated signal transduction; cell cycle arrest; toll-like receptor 4 signaling pathway; mitosis; fibroblast growth factor receptor signaling pathway; toll-like receptor 2 signaling pathway; keratinocyte differentiation; regulation of stress-activated MAPK cascade; regulation of vascular smooth muscle contraction; response to oxidative stress; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; axon guidance; peptidyl-tyrosine phosphorylation; pathogenesis; chemotaxis; signal transduction; toll-like receptor 10 signaling pathway; negative regulation of cell proliferation; positive regulation of Ras GTPase activity; positive regulation of RNA elongation from RNA polymerase II promoter; vesicle transport along microtubule; response to axon injury; Golgi inheritance; epidermal growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; melanosome transport; MyD88-dependent toll-like receptor signaling pathway; cell proliferation; Ras protein signal transduction; insulin receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of Ras protein signal transduction; vascular endothelial growth factor receptor signaling pathway; cell motility; positive regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.