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Protein Page:
Lyn (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Lyn a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; EC 2.7.10.2; TK group; Src family
Cellular Component: Golgi apparatus; mitochondrial crista; mast cell granule; perinuclear region of cytoplasm; postsynaptic density; cytoplasm; plasma membrane; mitochondrial intermembrane space; cytosol; nucleus; lipid raft
Molecular Function: integrin binding; protein binding; enzyme binding; ubiquitin protein ligase binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; platelet-derived growth factor receptor binding; phosphoprotein binding; receptor signaling protein tyrosine kinase activity; glycosphingolipid binding; SH3 domain binding; ATP binding
Biological Process: regulation of mast cell degranulation; negative regulation of MAP kinase activity; viral reproduction; response to toxin; protein amino acid phosphorylation; response to organic cyclic substance; response to carbohydrate stimulus; regulation of B cell apoptosis; B cell receptor signaling pathway; erythrocyte differentiation; oligodendrocyte development; tolerance induction to self antigen; neurite development; response to drug; platelet activation; negative regulation of immune response; response to sterol depletion; immune response-regulating cell surface receptor signaling pathway; response to amino acid stimulus; regulation of erythrocyte differentiation; histamine secretion by mast cell; DNA damage response, signal transduction resulting in induction of apoptosis; T cell costimulation; cytokine secretion; leukocyte migration; regulation of mast cell activation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cytokine secretion; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; response to hormone stimulus; negative regulation of B cell proliferation; signal transduction; regulation of cytokine production; response to insulin stimulus; negative regulation of cell proliferation; regulation of cell adhesion mediated by integrin; platelet degranulation; negative regulation of protein amino acid phosphorylation; B cell homeostasis; positive regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; Fc receptor mediated inhibitory signaling pathway; response to axon injury; Fc receptor mediated stimulatory signaling pathway; regulation of B cell receptor signaling pathway; regulation of protein amino acid phosphorylation; negative regulation of myeloid leukocyte differentiation; negative regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphoinositide 3-kinase activity; positive regulation of cell motility; regulation of release of sequestered calcium ion into cytosol; positive regulation of tyrosine phosphorylation of STAT protein; regulation of inflammatory response; negative regulation of toll-like receptor 4 signaling pathway; cellular response to extracellular stimulus; innate immune response; blood coagulation; response to DNA damage stimulus; positive regulation of cell migration
Reference #:  P07948 (UniProtKB)
Alt. Names/Synonyms: FLJ26625; JTK8; LYN; Tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog
Gene Symbols: LYN
Molecular weight: 58,574 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Lyn

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: Y397‑p
enzymatic activity, induced: Y397‑p
enzymatic activity, inhibited: Y508‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K9-ub GCIKSKGkDsLsDDG
0 8 S11-p IKSKGkDsLsDDGVD
0 22 S13-p SKGkDsLsDDGVDLk
0 3 L19 LsDDGVDLkTQPVRN
0 15 K20-ub sDDGVDLkTQPVRNT
1 101 Y32-p RNTERTIyVRDPtSN
0 1 T37-p TIyVRDPtSNKQQRP
0 1 K59-ub PGQRFQTkDPEEQGD
0 4 Y117-p EGFIPSNyVAKLNTL
0 1 T135-p EWFFKDItRKDAERQ
0 1 S149-p QLLAPGNsAGAFLIR
0 1 S158-p GAFLIREsETLKGSF
0 771 Y193-p RSLDNGGyyISPRIT
0 527 Y194-p SLDNGGyyISPRITF
0 1 K213 DMIKHYQKQADGLCR
0 2 S228-p RLEKACIsPKPQKPW
0 3 S246-p AWEIPREsIKLVKRL
0 143 Y265-p FGEVWMGyyNNsTKV
0 18 Y266-p GEVWMGyyNNsTKVA
0 1 S269-p WMGyyNNsTKVAVKT
0 1 T270 MGyyNNsTKVAVKTL
0 125 Y306-p HDKLVRLyAVVTREE
0 168 Y316-p VTREEPIyIItEyMA
0 1 T319-p EEPIyIItEyMAKGS
0 1 Y321-p PIyIItEyMAKGSLL
13 2054 Y397-p RVIEDNEytAREGAK
0 13 T398-p VIEDNEytAREGAKF
0 1 T438-p ILLYEIVtyGKIPYP
0 1 Y439-p LLYEIVtyGKIPYPG
0 1 T448-p KIPYPGRtNADVMTA
0 12 Y460-p MTALSQGyRMPRVEN
0 724 Y473-p ENCPDELyDIMkMCW
0 2 K477-ub DELyDIMkMCWKEKA
0 1 T489 EKAEERPTFDYLQSV
0 3 Y501-p QSVLDDFytAtEGQy
0 4 T502-p SVLDDFytAtEGQyQ
0 9 T504-p LDDFytAtEGQyQQQ
11 1564 Y508-p ytAtEGQyQQQP___
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
2731 : Phospho-Lyn (Tyr507) Antibody
  Lyn iso2  
K9 GCIKSKGKDsLsDDG
S11-p IKSKGKDsLsDDGVD
S13-p SKGKDsLsDDGVDLk
L19 LsDDGVDLkTQPVPE
K20-ub sDDGVDLkTQPVPES
- gap
- gap
K38 PGQRFQTKDPEEQGD
Y96 EGFIPSNYVAKLNTL
T114 EWFFKDITRKDAERQ
S128 QLLAPGNSAGAFLIR
S137 GAFLIRESETLKGSF
Y172-p RSLDNGGyyISPRIT
Y173-p SLDNGGyyISPRITF
K192 DMIKHYQKQADGLCR
S207 RLEKACISPKPQKPW
S225 AWEIPRESIKLVKRL
Y244 FGEVWMGYYNNSTKV
Y245 GEVWMGYYNNSTKVA
S248 WMGYYNNSTKVAVKT
T249 MGYYNNSTKVAVKTL
Y285 HDKLVRLYAVVTREE
Y295 VTREEPIYIITEYMA
T298 EEPIYIITEYMAKGS
Y300 PIYIITEYMAKGSLL
Y376-p RVIEDNEyTAREGAK
T377 VIEDNEyTAREGAKF
T417 ILLYEIVTYGKIPYP
Y418 LLYEIVTYGKIPYPG
T427 KIPYPGRTNADVMTA
Y439 MTALSQGYRMPRVEN
Y452 ENCPDELYDIMKMCW
K456 DELYDIMKMCWKEKA
T468 EKAEERPTFDYLQSV
Y480 QSVLDDFYTATEGQy
T481 SVLDDFYTATEGQyQ
T483 LDDFYTATEGQyQQQ
Y487-p YTATEGQyQQQP___
  mouse

► Hide Isoforms
 
K9-ub GCIKSKRkDNLNDDE
N11 IKSKRkDNLNDDEVD
N13 SKRkDNLNDDEVDsk
S19-p LNDDEVDskTQPVRN
K20-ub NDDEVDskTQPVRNT
Y32-p RNTDRTIyVRDPTSN
T37 TIyVRDPTSNKQQRP
K59 PGQRFQTKDPEEQGD
Y117 EGFIPSNYVAKVNTL
T135 EWFFKDITRKDAERQ
S149 QLLAPGNSAGAFLIR
S158 GAFLIRESETLKGSF
Y193-p RSLDNGGyyISPRIT
Y194-p SLDNGGyyISPRITF
K213-ub DMIKHYQkQSDGLCR
S228 RLEKACISPKPQKPW
S246 AWEIPRESIKLVKKL
Y265-p FGEVWMGyyNNStKV
Y266-p GEVWMGyyNNStKVA
S269 WMGyyNNStKVAVKT
T270-p MGyyNNStKVAVKTL
Y306 HDKLVRLYAVVTKEE
Y316-p VTKEEPIyIITEFMA
T319 EEPIyIITEFMAKGS
F321 PIyIITEFMAKGSLL
Y397-p RVIEDNEytAREGAK
T398-p VIEDNEytAREGAKF
T438 ILLYEIVTYGKIPYP
Y439 LLYEIVTYGKIPYPG
T448 KIPYPGRTNADVMSA
Y460-p MSALSQGyRMPRMEN
Y473-p ENCPDELyDIMKMCW
K477 DELyDIMKMCWKEKA
T489-p EKAEERPtFDYLQSV
Y501 QSVLDDFYtATEGQy
T502-p SVLDDFYtATEGQyQ
T504 LDDFYtATEGQyQQQ
Y508-p YtATEGQyQQQP___
2101 : Phospho-Src Family (Tyr416) Antibody
6943 : Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
2731 : Phospho-Lyn (Tyr507) Antibody
  Lyn iso2  
K9 GCIKSKRKDNLNDDE
N11 IKSKRKDNLNDDEVD
N13 SKRKDNLNDDEVDsk
S19-p LNDDEVDskTQPVPE
K20-ub NDDEVDskTQPVPEF
- gap
- gap
K38 PGQRFQTKDPEEQGD
Y96 EGFIPSNYVAKVNTL
T114 EWFFKDITRKDAERQ
S128 QLLAPGNSAGAFLIR
S137 GAFLIRESETLKGSF
Y172 RSLDNGGYYISPRIT
Y173 SLDNGGYYISPRITF
K192 DMIKHYQKQSDGLCR
S207 RLEKACISPKPQKPW
S225 AWEIPRESIKLVKKL
Y244 FGEVWMGYYNNSTKV
Y245 GEVWMGYYNNSTKVA
S248 WMGYYNNSTKVAVKT
T249 MGYYNNSTKVAVKTL
Y285 HDKLVRLYAVVTKEE
Y295 VTKEEPIYIITEFMA
T298 EEPIYIITEFMAKGS
F300 PIYIITEFMAKGSLL
Y376 RVIEDNEYTAREGAK
T377 VIEDNEYTAREGAKF
T417 ILLYEIVTYGKIPYP
Y418 LLYEIVTYGKIPYPG
T427 KIPYPGRTNADVMSA
Y439 MSALSQGYRMPRMEN
Y452 ENCPDELYDIMKMCW
K456 DELYDIMKMCWKEKA
T468 EKAEERPTFDYLQSV
Y480 QSVLDDFYTATEGQY
T481 SVLDDFYTATEGQYQ
T483 LDDFYTATEGQYQQQ
Y487 YTATEGQYQQQP___
  rat

 
K9 GCIKSKRKDNLNDDG
N11 IKSKRKDNLNDDGVD
N13 SKRKDNLNDDGVDMK
M19 LNDDGVDMKTQPVRN
K20 NDDGVDMKTQPVRNT
Y32-p RNTDRTIyVRDPTSN
T37 TIyVRDPTSNKQQRP
K59 PGQRFQAKDPEEQGD
Y117 EGFIPSNYVAKVNTL
T135 EWFFKDITRKDAERQ
S149 QLLAPGNSAGAFLIR
S158 GAFLIRESETLKGSF
Y193-p RSLDNGGyyISPRIT
Y194-p SLDNGGyyISPRITF
K213 DMIKHYQKQSDGLCR
S228 RLEKACISPKPQKPW
S246 AWEIPRESIKLVKKL
Y265 FGEVWMGYYNNSTKV
Y266 GEVWMGYYNNSTKVA
S269 WMGYYNNSTKVAVKT
T270 MGYYNNSTKVAVKTL
Y306 HDKLVRLYAVVTKEE
Y316 VTKEEPIYIITEFMA
T319 EEPIYIITEFMAKGS
F321 PIYIITEFMAKGSLL
Y397-p RVIEDNEyTAREGAK
T398 VIEDNEyTAREGAKF
T438 ILLYEIVTYGKIPYP
Y439 LLYEIVTYGKIPYPG
T448 KIPYPGRTNADVMTA
Y460 MTALSQGYRMPRMEN
Y473 ENCPDELYDIMKMCW
K477 DELYDIMKMCWKESA
T489 ESAEERPTFDYLQSV
Y501 QSVLDDFYTATEGQy
T502 SVLDDFYTATEGQyQ
T504 LDDFYTATEGQyQQQ
Y508-p YTATEGQyQQQP___
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