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Protein Page:
NOT3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NOT3 The CCR4-NOT complex functions as general transcription regulation complex. Belongs to the CNOT2/3/5 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: nucleus; cytosol; CCR4-NOT complex
Molecular Function: protein binding
Biological Process: regulation of translation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA metabolic process; RNA-mediated gene silencing; gene expression; mRNA metabolic process; mRNA catabolic process, deadenylation-dependent decay; trophectodermal cell differentiation
Reference #:  O75175 (UniProtKB)
Alt. Names/Synonyms: CCR4-associated factor 3; CCR4-NOT transcription complex subunit 3; CCR4-NOT transcription complex, subunit 3; CNOT3; KIAA0691; LENG2; Leukocyte receptor cluster member 2; NOT3; NOT3 (negative regulator of transcription 3, yeast) homolog; NOT3H
Gene Symbols: CNOT3
Molecular weight: 81,872 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NOT3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S104-p ETKTKAYsKEGLGLA
0 2 S194-p LRMLDNDsILVDAIR
0 6 S291-p DDKKRGRstDsEVsQ
0 12 T292-p DKKRGRstDsEVsQs
0 3 S294-p KRGRstDsEVsQsPA
0 4 S297-p RstDsEVsQsPAKNG
0 12 S299-p tDsEVsQsPAKNGSK
0 1 S436 YSSVVADSPAEVALS
0 1 S506-p PLPVNPPsSPTPSFS
0 3 A531 GPPQFSTAPEIKAPE
0 2 S542-p KAPEPLSsLKSMAER
0 1 R635-m1 PSDSERIrQYLPRNP
0 1 K737-u EKWGQRKkEGFTFEY
  mouse

 
S104 ETKTKAYSKEGLGLA
S194-p LRMLDNDsILVDAIR
S291 DDKKRGRStDsEVSQ
T292-p DKKRGRStDsEVSQs
S294-p KRGRStDsEVSQsPA
S297 RStDsEVSQsPAKNG
S299-p tDsEVSQsPAKNGSK
S434-p YSSVVADsPAEVTLS
S504 PLPVNPPSSPTPSFS
T529-p GPPQFSTtPEIKAPE
S540 KAPEPLSSLKSMAER
R633 PSDSERIRQYLPRNP
K735 EKWGQRKKEGFTFEY
  rat

 
S104 ETKTKAYSKEGLGLA
S194 LRMLDNDSILVDAIR
S291 DDKKRGRSTDSEVSQ
T292 DKKRGRSTDSEVSQs
S294 KRGRSTDSEVSQsPA
S297 RSTDSEVSQsPAKNG
S299-p TDSEVSQsPAKNGSK
S434 YSSVVADSPAEVALS
S504 PLPVNPPSSPTPSFS
T529 GPPQFSTTPEIKAPE
S540 KAPEPLSSLKSMAER
R633 PSDSERIRQYLPRNP
K735 EKWGQRKKEGFTFEY
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