a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 220.127.116.11; Protein kinase, CAMK; Autophagy; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; LKB subfamily
Cellular Component: protein complex; membrane; mitochondrion; cytoplasm; cytosol; nucleus
Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; p53 binding; magnesium ion binding; protein kinase activator activity; LRR domain binding; ATP binding
Biological Process: Golgi localization; response to glucagon stimulus; protein heterooligomerization; protein amino acid autophosphorylation; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; response to lipid; protein amino acid phosphorylation; anoikis; positive regulation of gluconeogenesis; negative regulation of cell proliferation; regulation of fatty acid biosynthetic process; vasculature development; tissue homeostasis; regulation of fatty acid oxidation; regulation of cell growth; cell cycle arrest; regulation of Wnt receptor signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein kinase B signaling cascade; axonogenesis; establishment of cell polarity; positive regulation of protein kinase activity; energy reserve metabolic process; insulin receptor signaling pathway; autophagy; positive regulation of axonogenesis; response to ionizing radiation; negative regulation of cell growth; response to DNA damage stimulus; spermatid development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.