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Protein Page:
LIMK1 (human)

Overview
LIMK1 a TKL kinase of the LISK family which mediates Rho signaling to cytoskeleton. Contains two N-terminal LIM motifs. Phosphorylated and activated by PAK1 and ROCK, downstream effectors of Rho. May be involved in brain development. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes. The LIM domain interacts with the cytoplasmic domain of NRG1. Binds ROCK1. Interacts with slingshot 1. Overexpressed in prostate tumors and prostate and breast cancer cell lines; manipulation of activity correlates with invasiveness in breast and prostate cancer models. Located within the 7q11.2 amplicon associated with metastatic prostate cancer. Loss of one copy of LIMK1 is the likely cause of visuospatial cognition defects seen in small chromosomal deletions associated with dominant Williams-Beuren syndrome Three splice variant have been identified. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, TKL; TKL group; LISK family; LIMK subfamily
Cellular Component: neuron projection; focal adhesion; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; protein binding; zinc ion binding; protein heterodimerization activity; heat shock protein binding; ATP binding; protein kinase activity
Biological Process: nervous system development; axon guidance; positive regulation of axon extension; negative regulation of ubiquitin-protein ligase activity; innate immune response; positive regulation of actin filament bundle formation; signal transduction; actin cytoskeleton organization and biogenesis; protein amino acid phosphorylation; Rho protein signal transduction
Reference #:  P53667 (UniProtKB)
Alt. Names/Synonyms: LIM domain kinase 1; LIM motif-containing protein kinase; LIMK; LIMK-1; LIMK1
Gene Symbols: LIMK1
Molecular weight: 72,585 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LIMK1

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S323‑p
activity, induced: T508‑p
enzymatic activity, induced: S323‑p, T508‑p
molecular association, regulation: T508‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 9 S210-p GVDPGCMsPDVKNSI
0 4 T229-p RILEINGtPIRNVPL
0 1 T253-p TSRLLQLtLEHDPHD
0 1 T270-p GHGLGPEtSPLsSPA
0 1 S271 HGLGPEtSPLsSPAY
0 1 S274-p GPEtSPLsSPAYTPS
0 1 S275 PEtSPLsSPAYTPSG
0 1 T279 PLsSPAYTPSGEAGs
0 1 S286-p TPSGEAGssARQKPV
0 1 S287-p PSGEAGssARQKPVL
0 4 S296-p RQKPVLRsCsIDRsP
0 11 S298-p KPVLRsCsIDRsPGA
0 5 S302-p RsCsIDRsPGAGsLG
0 3 S307-p DRsPGAGsLGsPAsQ
1 17 S310-p PGAGsLGsPAsQRKD
0 1 S313-p GsLGsPAsQRKDLGR
1 0 S323-p KDLGRSEsLRVVCRP
0 4 S337-p PHRIFRPsDLIHGEV
0 1 Y415-p RLNFITEyIKGGTLR
19 1 T508-p PDRKKRYtVVGNPYW
0 1 S534-p DEKVDVFsFGIVLCE
0 1 S637-p ETYRRGEsGLPAHPE
3841 : Phospho-LIMK1 (Thr508)/LIMK2 (Thr505) Antibody
  mouse

 
S210-p GVDPGCMsPDVKNSI
T229 RILEINGTPIRNVPL
T253 TSRLLQLTLEHDPHD
P270 GHGPVSDPsPLSsPV
S271-p HGPVSDPsPLSsPVH
S274 VSDPsPLSsPVHtPS
S275-p SDPsPLSsPVHtPSG
T279-p PLSsPVHtPSGQAAS
S286 tPSGQAASSARQKPV
S287 PSGQAASSARQKPVL
S296-p RQKPVLRsCsIDTsP
S298-p KPVLRsCsIDTsPGT
S302-p RsCsIDTsPGTSSLA
S307 DTsPGTSSLAsPASQ
S310-p PGTSSLAsPASQRKD
S313 SSLAsPASQRKDLGR
S323 KDLGRSESLRVVCRP
S337 PHRIFRPSDLIHGEV
Y415 RLNFITEYIKGGTLR
T508-p PDRKKRYtVVGNPYW
S534 DEKVDVFSFGIVLCE
S637 ETYRRGESSLPAHPE
3841 : Phospho-LIMK1 (Thr508)/LIMK2 (Thr505) Antibody
  rat

 
S210 GVDPGCMSPDVKNSI
T229 RILEINGTPIRNVPL
T253 TSRLLQLTLEHDPHD
P270 GHGPVSDPSPLASPV
S271 HGPVSDPSPLASPVH
A274 VSDPSPLASPVHTPS
S275 SDPSPLASPVHTPSG
T279 PLASPVHTPSGQAGS
S286 TPSGQAGSSARQKPV
S287 PSGQAGSSARQKPVL
S296 RQKPVLRSCSIDTSP
S298 KPVLRSCSIDTSPGA
S302 RSCSIDTSPGAGSLV
S307 DTSPGAGSLVSPASQ
S310 PGAGSLVSPASQRKD
S313 GSLVSPASQRKDLGR
S323 KDLGRSESLRVVCRP
S337 PHRIFRPSDLIHGEV
Y415 RLNFITEYIKGGTLR
T508-p PDRKKRYtVVGNPYW
S534 DEKVDVFSFGIVLCE
S637 ETYRRGESSLPAHPE
3841 : Phospho-LIMK1 (Thr508)/LIMK2 (Thr505) Antibody
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