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Protein Page:
AKAP13 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
AKAP13 Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Rac/Rho; Adaptor/scaffold
Cellular Component: perinuclear region of cytoplasm; cytoplasm
Molecular Function: transferase activity; Rho GTPase binding; metal ion binding; protein kinase A binding; protein complex scaffold; kinase activity
Biological Process: nuclear export; regulation of protein kinase activity; phosphorylation
Reference #:  E9Q394 (UniProtKB)
Alt. Names/Synonyms: 1700026G02Rik; 5730522G15Rik; 5830460E08Rik; A kinase (PRKA) anchor protein 13; AKAP-Lbc; Akap13; BRX; Ht31; LBC; MCG15699, isoform CRA_c; PROTO-LB; PROTO-LBC; type II cAMP-dependent protein kinase anchoring protein Ht31
Gene Symbols: Akap13
Molecular weight: 303,976 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Select Structure to View Below

AKAP13

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K135-u DVNSLDEkVALAFRH
0 2 T180 RLGLLRLTWFLLQKP
0 1 K186 LTWFLLQKPGGRGAL
0 1 K286-u NIQQQLMkTNLKQMD
0 1 S386-p GEEAEPAsAMDsGsA
0 1 S390-p EPAsAMDsGsASHQD
0 1 S392-p AsAMDsGsASHQDSC
0 1 T578-p RGCEGGTtsDQSsPV
0 1 S579-p GCEGGTtsDQSsPVL
0 1 S583-p GTtsDQSsPVLPAAA
0 3 - gap
0 2 S784 SSFSLASSPESESVT
0 1 T807 PSQKEKGTATPQLHR
0 1 T809 QKEKGTATPQLHRTT
0 2 S856-p RTSMGNTsPVGIGGE
0 1 S867-p IGGEQEGssPTATLE
0 1 S868-p GGEQEGssPTATLEV
0 1 M934 EDVHSSEMSREDQRt
0 2 T941-p MSREDQRtPPSGQEI
0 10 - gap
0 1 T969 EEKAQQHTPSACLKT
0 1 N1102 IPISELLNQEKQMTP
0 4 S1200 ASIPAEESNATTVST
0 3 T1204 AEESNATTVSTQAAD
0 2 S1218-p DVPTRADsIEETATR
0 1 S1377 SLLASKQSSECRSFI
0 2 S1455-p DRHSSHGsDVSLPQT
0 5 S1473-p NRSRNHQsANGFFSP
0 4 S1524-p FLRSSMRsLsPFRRH
0 14 S1526-p RSSMRsLsPFRRHsW
2 20 S1532-p LsPFRRHsWGPGKNA
0 2 S1567-p RPPIHRRsFsLEGLT
0 11 S1569-p PIHRRsFsLEGLTGG
0 1 S1594-p EMSSANSsELRNPFG
0 10 S1608-p GGEEQRNsLMsLsEE
0 13 S1611-p EQRNsLMsLsEEHLE
0 11 S1613-p RNsLMsLsEEHLEPD
0 11 K1637 QQTCYRSKQQGFNYC
0 1 Y1643 SKQQGFNYCTSAISS
0 7 S1713-p TKVSRTFsYIRNKMS
0 25 S1839-p QPKERPRsAVLLADE
0 1 A1847 AVLLADEATAAPMFT
0 4 A1850 LADEATAAPMFTNRR
0 3 S1858 PMFTNRRSQQSVSLS
0 1 S1867-p QSVSLSKsVsIQNIT
0 2 S1869-p VSLSKsVsIQNITGV
0 27 S1892-p TWKFLSHstDsLNKI
0 4 T1893-p WKFLSHstDsLNKIC
0 20 S1895-p FLSHstDsLNKICKV
0 1 S1908-p KVNESTEsLTDEGVG
0 2 Y2078 VNYFKDLYTKDKRFQ
0 2 Y2168 KVRLGEIYTKTDSKS
0 1 S2175 YTKTDSKSIMRMKSG
0 1 S2241 FASLDHKSTVISLKK
0 1 T2242 ASLDHKSTVISLKKL
0 5 S2308-p DEDEGIPsENEEEKK
0 7 S2353 FRDMTECSTPLPEDC
0 19 T2354 RDMTECSTPLPEDCs
0 19 S2361-p TPLPEDCsPtHsPRV
0 10 T2363-p LPEDCsPtHsPRVLF
0 5 S2365-p EDCsPtHsPRVLFRS
0 4 S2372 sPRVLFRSNtEEALK
0 58 T2374-p RVLFRSNtEEALKGG
0 301 T2431-p SLPRRAEtFGGFDCH
0 8 C2437 EtFGGFDCHQMNASK
0 16 S2462-p QDLRRTEsDSGLKKG
0 8 S2525-p TEKVLTRsAsRPssL
0 18 S2527-p KVLTRsAsRPssLIE
0 8 S2530-p TRsAsRPssLIEQEK
0 18 S2531-p RsAsRPssLIEQEKQ
0 105 S2663-p GRLMRIPsFLPNsDE
0 13 N2667 RIPsFLPNsDEFSSP
0 1 S2668-p IPsFLPNsDEFSSPS
0 40 S2673 PNsDEFSSPSAPSVT
0 2 S2675 sDEFSSPSAPSVTKS
0 5 S2678 FSSPSAPSVTKSGSL
0 25 S2692-p LDSELSVsPKRNsIS
1 0 S2697-p SVsPKRNsISRTQKD
0 1 S2724 TKVPEGQSQAPSSTS
0 1 S2729 GQSQAPSSTSTSTRL
  human

► Hide Isoforms
 
K135 DVNSLDKKLVLAFRH
T180-p RLGLLRLtWFLLQkP
K186-u LtWFLLQkPGGRGAL
K288 NIQQQLMKTNLKQMD
P387 GEEVEPAPIVDSGTV
S391 EPAPIVDSGTVSDQD
T393 APIVDSGTVSDQDSC
- gap
- gap
S586 DAPVDQNSVVIPAAA
Y604-p ISDGLEPyTLLAAGI
S790-p STFSLANsPGSESVT
T813-p PSQKEKGtAtPELHT
T815-p QKEKGtAtPELHTAT
S864 QHGMGNTSLTGLGGE
- gap
- gap
T946-p ENALSSGtLQEEQRt
T953-p tLQEEQRtPPPGQDT
S983-p KALQLSNsPGAsSAF
S987-p LSNsPGAsSAFLKAE
S1123-p LIPNVLLsQEKNAVL
S1226-p PPSGRERsTPsLPCM
S1229-p GRERsTPsLPCMVSA
L1247 PLPKGADLIEEAASR
S1411-p SLLASKQsPECENFL
S1489 DRHSSHGSDVSLSQI
S1507-p NRSRDRQsLDGFYSH
S1557 VLRSSMRSLsPFRRH
S1559-p RSSMRSLsPFRRHsW
S1565-p LsPFRRHsWGPGKNA
S1600-p RPPIHRRsFsLEGLT
S1602-p PIHRRsFsLEGLTGG
E1628 EVSSANAEELRHPFS
S1642-p SGEERVDsLVsLsEE
S1645-p ERVDsLVsLsEEDLE
S1647-p VDsLVsLsEEDLESD
K1670-m1 QQICHRSkQQGFNyC
Y1676-p SkQQGFNyCTSAISS
S1750-p TKVSRTFsYIKNKMS
S1876-p QPKERPRsAVLLVDE
T1884-p AVLLVDEtATtPIFA
T1887-p LVDEtATtPIFANRR
S1895-p PIFANRRsQQSVSLS
S1904-p QSVSLSKsVsIQNIT
S1906-p VSLSKsVsIQNITGV
S1929-p TWKFLSHstDsLNKI
T1930-p WKFLSHstDsLNKIS
S1932-p FLSHstDsLNKISKV
S1945 KVNESTESLTDEGVG
Y2115-p VNYFKDLyAKDKRFQ
Y2205-p KVRLNEIyTKTDSKs
S2212-p yTKTDSKsIMRMKSG
S2278-p FASLDQKstVISLKK
T2279-p ASLDQKstVISLKKL
S2345-p DEDEGIPsENEEEKK
S2390-p FRDMAECstPLPEDC
T2391-p RDMAECstPLPEDCs
S2398-p tPLPEDCsPtHsPRV
T2400-p LPEDCsPtHsPRVLF
S2402-p EDCsPtHsPRVLFRs
S2409-p sPRVLFRsNtEEALK
T2411-p RVLFRsNtEEALKGG
T2467-p SLPRRAEtFGGFDsH
S2473-p EtFGGFDsHQMNASK
S2498-p QDLRRTEsDSGLKKG
S2561-p SERALTRsLsRPssL
S2563-p RALTRsLsRPssLIE
S2566-p TRsLsRPssLIEQEK
S2567-p RsLsRPssLIEQEKQ
S2699-p TKLMRIPsFFPsPEE
S2703-p RIPsFFPsPEEPPsP
P2704 IPsFFPsPEEPPsPs
S2709-p PsPEEPPsPsAPsIA
S2711-p PEEPPsPsAPsIAKS
S2714-p PPsPsAPsIAKSGSL
S2728-p LDSELSVsPKRNsIS
S2733-p SVsPKRNsISRTHKD
S2761-p NKGPEGQsQAPAsTS
S2766-p GQsQAPAsTSASTRL
  AKAP13 iso2  
K135 DVNSLDKKLVLAFRH
T180 RLGLLRLTWFLLQKP
K186 LTWFLLQKPGGRGAL
K288 NIQQQLMKTNLKQMD
P387 GEEVEPAPIVDSGTV
S391 EPAPIVDSGTVSDQD
T393 APIVDSGTVSDQDSC
- gap
- gap
S586 DAPVDQNSVVIPAAA
Y604 ISDGLEPYTLLAAGI
S790 STFSLANSPGSESVT
T813 PSQKEKGTATPELHT
T815 QKEKGTATPELHTAT
S864 QHGMGNTSLTGLGGE
- gap
- gap
T946 ENALSSGTLQEEQRT
T953 TLQEEQRTPPPGQDT
S983 KALQLSNSPGASSAF
S987 LSNSPGASSAFLKAE
S1123 LIPNVLLSQEKNAVL
S1226 PPSGRERSTPSLPCM
S1229 GRERSTPSLPCMVSA
L1247 PLPKGADLIEEAASR
S1411 SLLASKQSPECENFL
S1489 DRHSSHGSDVSLSQI
S1507 NRSRDRQSLDGFYSH
S1557 VLRSSMRSLSPFRRH
S1559 RSSMRSLSPFRRHSW
S1565 LSPFRRHSWGPGKNA
S1604 SADFNYRSFSLEGLT
S1606 DFNYRSFSLEGLTGG
E1632 EVSSANAEELRHPFS
S1646 SGEERVDSLVSLSEE
S1649 ERVDSLVSLSEEDLE
S1651 VDSLVSLSEEDLESD
K1674 QQICHRSKQQGFNYC
Y1680 SKQQGFNYCTSAISS
S1754 TKVSRTFSYIKNKMS
S1880 QPKERPRSAVLLVDE
T1888 AVLLVDETATTPIFA
T1891 LVDETATTPIFANRR
S1899 PIFANRRSQQSVSLS
S1908 QSVSLSKSVSIQNIT
S1910 VSLSKSVSIQNITGV
S1933 TWKFLSHSTDSLNKI
T1934 WKFLSHSTDSLNKIS
S1936 FLSHSTDSLNKISKV
S1949 KVNESTESLTDEGVG
Y2119 VNYFKDLYAKDKRFQ
Y2209 KVRLNEIYTKTDSKS
S2216 YTKTDSKSIMRMKSG
S2282 FASLDQKSTVISLKK
T2283 ASLDQKSTVISLKKL
S2349 DEDEGIPSENEEEKK
S2394 FRDMAECSTPLPEDC
T2395 RDMAECSTPLPEDCS
S2402 TPLPEDCSPTHSPRV
T2404 LPEDCSPTHSPRVLF
S2406 EDCSPTHSPRVLFRS
S2413 SPRVLFRSNTEEALK
T2415 RVLFRSNTEEALKGG
T2471 SLPRRAETFGGFDSH
S2477 ETFGGFDSHQMNASK
S2502 QDLRRTESDSGLKKG
S2565 SERALTRSLSRPSSL
S2567 RALTRSLSRPSSLIE
S2570 TRSLSRPSSLIEQEK
S2571 RSLSRPSSLIEQEKQ
S2703 TKLMRIPSFFPSPEE
S2707 RIPSFFPSPEEPPSP
P2708 IPSFFPSPEEPPSPS
S2713 PSPEEPPSPSAPSIA
S2715 PEEPPSPSAPSIAKS
S2718 PPSPSAPSIAKSGSL
S2732 LDSELSVSPKRNSIS
S2737 SVSPKRNSISRTHKD
S2765 NKGPEGQSQAPASTS
S2770 GQSQAPASTSASTRL
  AKAP13 iso4  
K135 DVNSLDKKLVLAFRH
T180 RLGLLRLTWFLLQKP
K186 LTWFLLQKPGGRGAL
K288 NIQQQLMKTNLKQMD
P387 GEEVEPAPIVDSGTV
S391 EPAPIVDSGTVSDQD
T393 APIVDSGTVSDQDSC
- gap
- gap
S586 DAPVDQNSVVIPAAA
Y604 ISDGLEPYTLLAAGI
S790 STFSLANSPGSESVT
T813 PSQKEKGTATPELHT
T815 QKEKGTATPELHTAT
S864 QHGMGNTSLTGLGGE
- gap
- gap
T946 ENALSSGTLQEEQRT
T953 TLQEEQRTPPPGQDT
S983 KALQLSNSPGASSAF
S987 LSNSPGASSAFLKAE
S1123 LIPNVLLSQEKNAVL
S1226 PPSGRERSTPSLPCM
S1229 GRERSTPSLPCMVSA
L1247 PLPKGADLIEEAASR
S1411 SLLASKQSPECENFL
S1489 DRHSSHGSDVSLSQI
S1507 NRSRDRQSLDGFYSH
S1557 VLRSSMRSLSPFRRH
S1559 RSSMRSLSPFRRHSW
S1565 LSPFRRHSWGPGKNA
S1582 DAEMNHRSFSLEGLT
S1584 EMNHRSFSLEGLTGG
E1610 EVSSANAEELRHPFS
S1624 SGEERVDSLVSLSEE
S1627 ERVDSLVSLSEEDLE
S1629 VDSLVSLSEEDLESD
K1652 QQICHRSKQQGFNYC
Y1658 SKQQGFNYCTSAISS
S1732 TKVSRTFSYIKNKMS
S1858 QPKERPRSAVLLVDE
T1866 AVLLVDETATTPIFA
T1869 LVDETATTPIFANRR
S1877 PIFANRRSQQSVSLS
S1886 QSVSLSKSVSIQNIT
S1888 VSLSKSVSIQNITGV
S1911 TWKFLSHSTDSLNKI
T1912 WKFLSHSTDSLNKIS
S1914 FLSHSTDSLNKISKV
S1927 KVNESTESLTDEGTD
Y2095 VNYFKDLYAKDKRFQ
Y2185 KVRLNEIYTKTDSKS
S2192 YTKTDSKSIMRMKSG
S2258 FASLDQKSTVISLKK
T2259 ASLDQKSTVISLKKL
S2325 DEDEGIPSENEEEKK
S2370 FRDMAECSTPLPEDC
T2371 RDMAECSTPLPEDCS
S2378 TPLPEDCSPTHSPRV
T2380 LPEDCSPTHSPRVLF
S2382 EDCSPTHSPRVLFRS
S2389 SPRVLFRSNTEEALK
T2391 RVLFRSNTEEALKGG
T2447 SLPRRAETFGGFDSH
S2453 ETFGGFDSHQMNASK
S2478 QDLRRTESDSGLKKG
S2541 SERALTRSLSRPSSL
S2543 RALTRSLSRPSSLIE
S2546 TRSLSRPSSLIEQEK
S2547 RSLSRPSSLIEQEKQ
S2679 TKLMRIPSFFPSPEE
S2683 RIPSFFPSPEEPPSP
P2684 IPSFFPSPEEPPSPS
S2689 PSPEEPPSPSAPSIA
S2691 PEEPPSPSAPSIAKS
S2694 PPSPSAPSIAKSGSL
S2708 LDSELSVSPKRNSIS
S2713 SVSPKRNSISRTHKD
S2741 NKGPEGQSQAPASTS
S2746 GQSQAPASTSASTRL
  rat

 
K135 DVNSLDEKVALAFRH
T180 RLGLLRLTWFLLQKP
K186 LTWFLLQKPGGRGAL
K286 NIQQQLMKTNLKQMD
S375 GEGVEPASAVDSRSA
S379 EPASAVDSRSASHQD
S381 ASAVDSRSASHQDSC
T567 RGCEGGITSDQSSQV
S568 GCEGGITSDQSSQVL
S572 GITSDQSSQVLPAAA
- gap
S776 SSFSLASSPESESVT
T799 SSQKEKGTATPQLHR
T801 QKEKGTATPQLHRAP
S848 QTSMGNTSPVGVGEQ
S858 GVGEQEGSSLTATLE
S859 VGEQEGSSLTATLEV
M925 EDVHSSEMSREDQRt
T932-p MSREDQRtPPPGQEI
S962 KALQHSNSPDTPSAC
T965 QHSNSPDTPSACLQT
N1092 KDISDLLNQEKKTTP
S1191 ASVPGEESNVTTVLG
T1195 GEESNVTTVLGMVST
S1213 DGPPGADSIEETATR
S1372 SLLASKQSSECRSFI
S1450 DRHSSHGSDVSLPQT
S1468 NRSRNHQSSNGFFSH
S1518 FLRNSMRSLSPFRRH
S1520 RNSMRSLSPFRRHsW
S1526-p LSPFRRHsWGPGKNA
S1583 NADFNIRSFSLEGLT
S1585 DFNIRSFSLEGLTGG
S1611 EISSANSSELRNPFS
S1625 SGEEQRSSLMSLSEE
S1628 EQRSSLMSLSEEHLE
S1630 RSSLMSLSEEHLEPD
K1654 QQTCYRSKQQGFNYC
Y1660 SKQQGFNYCTSAISS
S1730 TKVSRTFSYIRNKMS
S1838 QPKERPRSAVLLAEE
A1846 AVLLAEEAIAAPMFT
A1849 LAEEAIAAPMFTNRR
S1857 PMFTNRRSQQSVSLS
S1866 QSVSLSKSVSIQNIT
S1868 VSLSKSVSIQNITGV
S1891-p TWKFLSHsTDSLNKI
T1892 WKFLSHsTDSLNKIC
S1894 FLSHsTDSLNKICKV
S1907 KVNESTESLTDEGVG
Y2077 VNYFKDLYTKDKRFQ
Y2167 KVRLGEIYTKTDSKS
S2174 YTKTDSKSIMRMKSG
S2225 FASLDHKSTVISLKK
T2226 ASLDHKSTVISLKKL
S2292 DEDEGIPSENEEEKR
S2337 FRDMTECSTPLPEDC
T2338 RDMTECSTPLPEDCS
S2345 TPLPEDCSPTHSPRM
T2347 LPEDCSPTHSPRMLF
S2349 EDCSPTHSPRMLFRS
S2356 SPRMLFRSNTEEALK
T2358 RMLFRSNTEEALKGG
T2415 SLPRRAETFGGFDCH
C2421 ETFGGFDCHQLNASK
S2446-p QDLRRTEsDSGLKKG
S2509 TEKVLTRSASRPSSL
S2511 KVLTRSASRPSSLIE
S2514 TRSASRPSSLIEQEK
S2515 RSASRPSSLIEQEKQ
S2647 GRLMRVPSFLPNSDE
N2651 RVPSFLPNSDEFSLL
S2652 VPSFLPNSDEFSLLS
L2657 PNSDEFSLLSTPSIT
S2659 SDEFSLLSTPSITKS
S2662 FSLLSTPSITKSGSL
S2676-p LDSELSVsPKRNSIS
S2681 SVsPKRNSISRTQKD
S2708 TKVPEGQSQAPSSTS
S2713 GQSQAPSSTSTSTRL
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