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Protein Page:
VEGFR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VEGFR2 a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; TK group; VEGFR family
Cellular Component: Golgi apparatus; integral to plasma membrane; cytoplasmic membrane-bound vesicle; early endosome; plasma membrane; extracellular region; cell junction; nucleus; endosome; lipid raft; external side of plasma membrane
Molecular Function: integrin binding; vascular endothelial growth factor receptor activity; protein binding; protein-tyrosine kinase activity; growth factor binding; Hsp90 protein binding; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding
Biological Process: extracellular matrix organization and biogenesis; positive regulation of positive chemotaxis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; cell maturation; calcium ion homeostasis; regulation of cell shape; ovarian follicle development; positive regulation of focal adhesion formation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; angiogenesis; vasculogenesis; endothelial cell differentiation; cell fate commitment; embryonic hemopoiesis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; cell migration during sprouting angiogenesis; branching morphogenesis of a tube; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; lymph vessel development; surfactant homeostasis; alveolus development; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis; positive regulation of cell migration; positive regulation of nitric-oxide synthase biosynthetic process
Reference #:  P35968 (UniProtKB)
Alt. Names/Synonyms: CD309; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1; KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Protein-tyrosine kinase receptor flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; VEGFR; VEGFR-2; VEGFR2; VGFR2
Gene Symbols: KDR
Molecular weight: 151,527 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VEGFR2

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: Y1059‑p
cell differentiation, altered: Y1059‑p
cell growth, altered: Y1059‑p, Y1175‑p
cell growth, induced: Y1059‑p
cell motility, altered: Y951‑p, Y1214‑p
cytoskeletal reorganization: Y1214‑p
signaling pathway regulation: Y1175‑p
transcription, altered: Y1175‑p
activity, induced: Y801‑p, Y951‑p
enzymatic activity, induced: Y951‑p, Y996‑p, Y1054‑p, Y1059‑p, Y1175‑p, Y1214‑p
molecular association, regulation: Y801‑p, Y951‑p, Y996‑p, Y1054‑p, Y1059‑p, Y1175‑p, Y1214‑p
phosphorylation: Y801‑p, Y951‑p, Y1059‑p, Y1175‑p
receptor internalization, altered: Y951‑p, Y996‑p, Y1054‑p, Y1059‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S618 KLNATMFSNSTNDIL
0 1 S620 NATMFSNSTNDILIM
0 1 T621 ATMFSNSTNDILIME
0 1 S711-p NETLVEDsGIVLKDG
0 1 K798 RANGGELKTGyLSIV
4 3 Y801-p GGELKTGyLSIVMDP
0 1 K826 RLPYDASKWEFPRDR
0 1 K858 ADAFGIDKTATCRTV
0 1 R863 IDKTATCRTVAVKML
0 1 K949 GARFRQGKDyVGAIP
13 4 Y951-p RFRQGKDyVGAIPVD
0 1 K960-ac GAIPVDLkRRLDSIT
0 1 K960 GAIPVDLKRRLDSIT
0 1 S975 SSQSSASSGFVEEKs
0 1 S982-p SGFVEEKsLsDVEEE
0 1 S984-p FVEEKsLsDVEEEEA
7 0 Y996-p EEAPEDLyKDFLTLE
1 0 Y1008 TLEHLICYSFQVAKG
0 1 K1039 RNILLSEKNVVKICD
12 104 Y1054-p FGLARDIyKDPDyVR
15 108 Y1059-p DIyKDPDyVRKGDAR
0 1 K1062 KDPDyVRKGDARLPL
25 0 Y1175-p AQQDGKDyIVLPISE
1 0 S1190 TLSMEEDSGLSLPTS
1 0 S1193 MEEDSGLSLPTSPVS
12 60 Y1214-p VCDPKFHyDNtAGIS
0 2 T1217-p PKFHyDNtAGISQyL
0 1 Y1223-p NtAGISQyLQNSKRK
0 1 S1231 LQNSKRKSRPVsVKt
0 2 S1235-p KRKSRPVsVKtFEDI
0 2 T1238-p SRPVsVKtFEDIPLE
0 2 S1279-p LEDRTKLsPsFGGMV
0 1 S1281-p DRTKLsPsFGGMVPs
0 1 S1288-p sFGGMVPsKsRESVA
0 1 K1289 FGGMVPsKsRESVAS
0 1 S1290-p GGMVPsKsRESVASE
2471 : Phospho-VEGF Receptor 2 (Tyr951) Antibody
2476 : Phospho-VEGF Receptor 2 (Tyr951) (7H11) Mouse mAb
4991 : Phospho-VEGF Receptor 2 (Tyr951) (15D2) Rabbit mAb
2474 : Phospho-VEGF Receptor 2 (Tyr996) Antibody
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
2478 : Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb
3770 : Phospho-VEGF Receptor 2 (Tyr1175) (D5B11) Rabbit mAb
2477 : Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb
  mouse

 
S616-p KLNGTMFsNstNDIL
S618-p NGTMFsNstNDILIV
T619-p GTMFsNstNDILIVA
S709 NETLVEDSGIVLRDG
K796-ub RANEGELkTGYLSIV
Y799 EGELkTGYLSIVMDP
K824-ub RLPYDASkWEFPRDR
K856-ub ADAFGIDkTATCkTV
K861-ub IDkTATCkTVAVKML
K947-ub GARFRQGkDyVGELS
Y949-p RFRQGkDyVGELSVD
K958 GELSVDLKRRLDSIT
K958-ub GELSVDLkRRLDSIT
S973-p SSQSSASsGFVEEKS
S980 sGFVEEKSLSDVEEE
S982 FVEEKSLSDVEEEEA
Y994-p EEASEELyKDFLTLE
Y1006-p TLEHLICySFQVAKG
K1037-ub RNILLSEkNVVKICD
Y1052-p FGLARDIyKDPDyVR
Y1057-p DIyKDPDyVRkGDAR
K1060-ac KDPDyVRkGDARLPL
Y1173-p AQQDGKDyIVLPMSE
S1188-p TLSMEEDsGLsLPTS
S1191-p MEEDsGLsLPTSPVS
Y1212-p VCDPKFHyDNTAGIS
T1215 PKFHyDNTAGISHYL
Y1221 NTAGISHYLQNSKRK
S1229-p LQNSKRKsRPVsVKt
S1233-p KRKsRPVsVKtFEDI
T1236-p sRPVsVKtFEDIPLE
S1277 LEDRNKLSPSFGGMM
S1279 DRNKLSPSFGGMMPS
S1286 SFGGMMPSkSRESVA
K1287-ub FGGMMPSkSRESVAS
S1288 GGMMPSkSRESVASE
2471 : Phospho-VEGF Receptor 2 (Tyr951) Antibody
2476 : Phospho-VEGF Receptor 2 (Tyr951) (7H11) Mouse mAb
4991 : Phospho-VEGF Receptor 2 (Tyr951) (15D2) Rabbit mAb
2474 : Phospho-VEGF Receptor 2 (Tyr996) Antibody
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
2478 : Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb
3770 : Phospho-VEGF Receptor 2 (Tyr1175) (D5B11) Rabbit mAb
2477 : Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb
  rat

 
S614 KLNGTVFSNSTNDIL
S616 NGTVFSNSTNDILIV
T617 GTVFSNSTNDILIVA
S707 NETLVEDSGIVLKDG
K794 RANEGELKTGyLSIV
Y797-p EGELKTGyLSIVMDP
K822 RLPYDASKWEFPRDR
K854 ADAFGIDKTATCKTV
K859 IDKTATCKTVAVKML
K945 GARFRSGKDYVGELS
Y947 RFRSGKDYVGELSVD
K956 GELSVDLKRRLDSIT
K956 GELSVDLKRRLDSIT
S971 SSQSSASSGFVEEKS
S978 SGFVEEKSLSDVEEE
S980 FVEEKSLSDVEEEEA
Y992 EEASEELYKDFLTLE
Y1004 TLEHLICYSFQVAKG
K1035 RNILLSEKNVVKICD
Y1050-p FGLARDIyKDPDyVR
Y1055-p DIyKDPDyVRKGDPR
K1058 KDPDyVRKGDPRLPL
Y1171-p AQQDGKDyIVLPMSE
S1186 TLSMEEDSGLSLPTS
S1189 MEEDSGLSLPTSPVS
Y1210-p VCDPKFHyDNTAGIS
T1213 PKFHyDNTAGISHYL
Y1219 NTAGISHYLQNSKRK
S1227 LQNSKRKSRPVSVKT
S1231 KRKSRPVSVKTFEDI
T1234 SRPVSVKTFEDIPLE
S1275 LEDRNKLSPSFGGMM
S1277 DRNKLSPSFGGMMPS
S1284 SFGGMMPSKSRESVA
K1285 FGGMMPSKSRESVAS
S1286 GGMMPSKSRESVASE
3817 : Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
2478 : Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb
3770 : Phospho-VEGF Receptor 2 (Tyr1175) (D5B11) Rabbit mAb
2477 : Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb
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