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VEGFR-2 (human)

Overview VEGFR-2 a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability. Note: This description may include information from UniProtKB. Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; TK group; VEGFR family Cellular Component: integral to plasma membrane; early endosome; cytoplasmic membrane-bound vesicle; extracellular region; plasma membrane; nucleus; external side of plasma membrane Molecular Function: integrin binding; vascular endothelial growth factor receptor activity; protein binding; protein-tyrosine kinase activity; growth factor binding; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; Hsp90 protein binding; ATP binding Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; protein amino acid autophosphorylation; cell maturation; calcium ion homeostasis; regulation of cell shape; positive regulation of MAPKKK cascade; ovarian follicle development; positive regulation of focal adhesion formation; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; angiogenesis; vasculogenesis; endothelial cell differentiation; cell fate commitment; embryonic hemopoiesis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; cell migration during sprouting angiogenesis; branching morphogenesis of a tube; virus-host interaction; positive regulation of endothelial cell proliferation; lymph vessel development; vascular endothelial growth factor receptor signaling pathway; surfactant homeostasis; alveolus development; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis; positive regulation of cell migration; positive regulation of nitric-oxide synthase biosynthetic process Reference #:  P35968 (UniProtKB) Alt. Names/Synonyms: CD309; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1; KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Protein-tyrosine kinase receptor flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; VEGFR; VEGFR-2; VEGFR2; VGFR2 Gene Symbols: KDR Molecular weight: 151,527 Da Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below VEGFR-2 1VR2 - A=806-1171 (human) 1Y6A - A=806-1171 (human) 1Y6B - A=806-1171 (human) 1YWN - A=806-1171 (human) 2OH4 - A=992-1171 (human) 2P2H - A=815-1171 (human) 2P2I - A/B=815-1171 (human) 2QU5 - A=990-1171 (human) 2QU6 - A/B=990-1171 (human) 2RL5 - A=990-1171 (human) 2X1W - O/M/N/L=120-326 (human) 2X1X - R=120-326 (human) 2XIR - A=990-1171 (human) 3B8Q - A/B=990-1171 (human) 3B8R - A/B=990-1171 (human) 3BE2 - A=990-1171 (human) 3C7Q - A=806-1171 (human) 3CJF - A=994-1168 (human) 3CJG - A=994-1168 (human) 3CP9 - A=990-1171 (human) 3CPB - A=990-1171 (human) 3CPC - A=990-1171 (human) 3DTW - A/B=990-1171 (human) 3EFL - A/B=990-1171 (human) 3EWH - A=990-1171 (human) 3KVQ - A=657-764 (human) 3S35 - X=220-338 (human) 3S36 - X=220-338 (human) 3S37 - X=220-338 (human) 3U6J - A=815-1171 (human) 3V2A - R=1-764 (human) 3V6B - R=132-548 (human) 3VHE - A=811-1169 (human) 3VHK - A=806-1171 (human) 3VID - A=813-1168 (human) 3VNT - A=806-1171 (human) 3VO3 - A=806-1171 (human) 4AG8 - A=990-1171 (human) 4AGC - A=990-1171 (human) 4AGD - A=990-1171 (human) 4ASD - A=990-1171 (human) 4ASE - A=787-1171 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1VR2 1Y6A 1Y6B 1YWN 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 4AG8 4AGC 4AGD 4ASD 4ASE  |  ENZYME  |  Phospho3D  |  DISEASE 191306 602089  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: Y1059‑p cell differentiation, altered: Y1059‑p cell growth, altered: Y1059‑p, Y1175‑p cell growth, induced: Y1059‑p cell motility, altered: Y951‑p, Y1214‑p cytoskeletal reorganization: Y1214‑p signaling pathway regulation: Y1175‑p transcription, altered: Y1175‑p activation: Y801‑p, Y951‑p enzymatic activity, induced: Y951‑p, Y996‑p, Y1054‑p, Y1059‑p, Y1175‑p, Y1214‑p molecular association, regulation: Y801‑p, Y951‑p, Y996‑p, Y1054‑p, Y1059‑p, Y1175‑p, Y1214‑p phosphorylation: Y801‑p, Y951‑p, Y1059‑p, Y1175‑p receptor internalization, altered: Y951‑p, Y996‑p, Y1054‑p, Y1059‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S618	KLNATMFSNSTNDIL
0	1		S620	NATMFSNSTNDILIM
0	1		T621	ATMFSNSTNDILIME
0	1		S711-p	NETLVEDsGIVLKDG
0	1		K798	RANGGELKTGyLSIV
4	3		Y801-p	GGELKTGyLSIVMDP
0	1		K826	RLPYDASKWEFPRDR
0	1		K858	ADAFGIDKTATCRTV
0	1		R863	IDKTATCRTVAVKML
0	1		K949	GARFRQGKDyVGAIP
12	4		Y951-p	RFRQGKDyVGAIPVD
0	1		K960-a	GAIPVDLkRRLDSIT
0	1		K960	GAIPVDLKRRLDSIT
0	1		S975	SSQSSASSGFVEEKs
0	1		S982-p	SGFVEEKsLsDVEEE
0	1		S984-p	FVEEKsLsDVEEEEA
5	0		Y996-p	EEAPEDLyKDFLTLE
1	0		Y1008	TLEHLICYSFQVAKG
0	1		K1039	RNILLSEKNVVKICD
12	104		Y1054-p	FGLARDIyKDPDyVR
15	107		Y1059-p	DIyKDPDyVRKGDAR
0	1		K1062	KDPDyVRKGDARLPL
24	0		Y1175-p	AQQDGKDyIVLPISE
1	0		S1190	TLSMEEDSGLSLPTS
1	0		S1193	MEEDSGLSLPTSPVS
12	60		Y1214-p	VCDPKFHyDNtAGIS
0	2		T1217-p	PKFHyDNtAGISQyL
0	2		Y1223-p	NtAGISQyLQNSKRK
0	1		S1231	LQNSKRKSRPVsVKt
0	2		S1235-p	KRKSRPVsVKtFEDI
0	2		T1238-p	SRPVsVKtFEDIPLE
0	2		S1279-p	LEDRTKLsPsFGGMV
0	1		S1281-p	DRTKLsPsFGGMVPs
0	1		S1288-p	sFGGMVPsKsRESVA
0	1		K1289	FGGMVPsKsRESVAS
0	1		S1290-p	GGMVPsKsRESVASE

	mouse
S616-p	KLNGTMFsNstNDIL
S618-p	NGTMFsNstNDILIV
T619-p	GTMFsNstNDILIVA
S709	NETLVEDSGIVLRDG
K796-u	RANEGELkTGYLSIV
Y799	EGELkTGYLSIVMDP
K824-u	RLPYDASkWEFPRDR
K856-u	ADAFGIDkTATCkTV
K861-u	IDkTATCkTVAVKML
K947-u	GARFRQGkDyVGELS
Y949-p	RFRQGkDyVGELSVD
K958	GELSVDLKRRLDSIT
K958-u	GELSVDLkRRLDSIT
S973-p	SSQSSASsGFVEEKS
S980	sGFVEEKSLSDVEEE
S982	FVEEKSLSDVEEEEA
Y994	EEASEELYKDFLTLE
Y1006-p	TLEHLICySFQVAKG
K1037-u	RNILLSEkNVVKICD
Y1052-p	FGLARDIyKDPDyVR
Y1057-p	DIyKDPDyVRkGDAR
K1060-a	KDPDyVRkGDARLPL
Y1173-p	AQQDGKDyIVLPMSE
S1188-p	TLSMEEDsGLsLPTS
S1191-p	MEEDsGLsLPTSPVS
Y1212-p	VCDPKFHyDNTAGIS
T1215	PKFHyDNTAGISHYL
Y1221	NTAGISHYLQNSKRK
S1229-p	LQNSKRKsRPVsVKt
S1233-p	KRKsRPVsVKtFEDI
T1236-p	sRPVsVKtFEDIPLE
S1277	LEDRNKLSPSFGGMM
S1279	DRNKLSPSFGGMMPS
S1286	SFGGMMPSkSRESVA
K1287-u	FGGMMPSkSRESVAS
S1288	GGMMPSkSRESVASE

	rat
S614	KLNGTVFSNSTNDIL
S616	NGTVFSNSTNDILIV
T617	GTVFSNSTNDILIVA
S707	NETLVEDSGIVLKDG
K794	RANEGELKTGyLSIV
Y797-p	EGELKTGyLSIVMDP
K822	RLPYDASKWEFPRDR
K854	ADAFGIDKTATCKTV
K859	IDKTATCKTVAVKML
K945	GARFRSGKDYVGELS
Y947	RFRSGKDYVGELSVD
K956	GELSVDLKRRLDSIT
K956	GELSVDLKRRLDSIT
S971	SSQSSASSGFVEEKS
S978	SGFVEEKSLSDVEEE
S980	FVEEKSLSDVEEEEA
Y992	EEASEELYKDFLTLE
Y1004	TLEHLICYSFQVAKG
K1035	RNILLSEKNVVKICD
Y1050-p	FGLARDIyKDPDyVR
Y1055-p	DIyKDPDyVRKGDPR
K1058	KDPDyVRKGDPRLPL
Y1171-p	AQQDGKDyIVLPMSE
S1186	TLSMEEDSGLSLPTS
S1189	MEEDSGLSLPTSPVS
Y1210-p	VCDPKFHyDNTAGIS
T1213	PKFHyDNTAGISHyL
Y1219-p	NTAGISHyLQNSKRK
S1227	LQNSKRKSRPVSVKT
S1231	KRKSRPVSVKTFEDI
T1234	SRPVSVKTFEDIPLE
S1275	LEDRNKLSPSFGGMM
S1277	DRNKLSPSFGGMMPS
S1284	SFGGMMPSKSRESVA
K1285	FGGMMPSKSRESVAS
S1286	GGMMPSKSRESVASE

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