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JNK1
a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. Substrates include a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2, thus regulating AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Activity increased in obesity. Inhibition or mouse knockout increases insulin sensitivity. Part of NFB pathway involved in inflammation and cancer, and signals downstream of Ras, though possibly as an apoptotic negative regulator of growth. Four alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CMGC; CMGC group; MAPK family; JNK subfamily; MAPK/JNK subfamily |
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Cellular Component: nucleoplasm; mitochondrion; nucleus; cytosol
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Molecular Function: protein serine/threonine kinase activity; protein binding; histone deacetylase regulator activity; histone deacetylase binding; JUN kinase activity; ATP binding
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Biological Process: nerve growth factor receptor signaling pathway; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; regulation of protein localization; regulation of transcription factor activity; JNK cascade; response to stress; negative regulation of protein binding; toll-like receptor 4 signaling pathway; response to UV; regulation of histone deacetylation; ossification; MyD88-independent toll-like receptor signaling pathway; peptidyl-threonine phosphorylation; Toll signaling pathway; toll-like receptor 2 signaling pathway; JUN phosphorylation; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cadmium ion; toll-like receptor signaling pathway; innate immune response; negative regulation of apoptosis
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Reference #:
P45983 (UniProtKB)
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| Alt. Names/Synonyms: c-Jun N-terminal kinase 1; JNK; JNK-46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2; JUN N-terminal kinase; MAP kinase 8; MAPK 8; MAPK8; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; MK08; PRKM8; protein kinase JNK1; SAPK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1 |
| Gene Symbols: MAPK8 |
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Molecular weight: 48,296 Da
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Basal Isoelectric point: 6.43
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis
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B Cell Receptor Signaling
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Death Receptor Signaling
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ErbB/HER Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Mitochondrial Control of Apoptosis
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NF-kB Signaling
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Parkinson's Disease
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Toll-like Receptors Pathway
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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