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Protein Page:
SEPT3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SEPT3 belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. This gene encodes three transcript variants resulting in three distinct isoforms. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; Cytoskeletal protein; Cell cycle regulation
Cellular Component: presynaptic membrane; cytosol; cell junction
Molecular Function: GTP binding
Biological Process: cytokinesis; cell cycle
Reference #:  Q9UH03 (UniProtKB)
Alt. Names/Synonyms: bK250D10.3; MGC133218; neuronal-specific septin 3; Neuronal-specific septin-3; SEP3; SEPT3; septin 3
Gene Symbols: SEPT3
Molecular weight: 40,704 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
Select Structure to View Below

SEPT3
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S70-p NIMVVGQsGLGKSTL
0 1 S84-p LVNTLFKsQVsRKAs
0 1 S87-p TLFKsQVsRKAssWN
1 1 S91-p sQVsRKAssWNREEK
0 1 S92-p QVsRKAssWNREEKI
0 1 K98 ssWNREEKIPKTVEI
0 1 K101 NREEKIPKTVEIKAI
0 2 K118-u VIEEGGVkMKLTVID
0 1 K155 EQYEKFLKEEVNIAR
0 1 K226-a EFKQRVRkELEVNGI
0 2 K226-u EFKQRVRkELEVNGI
0 1 K268 FAVVGSDKEYQVNGK
0 1 - gap
  mouse

► Hide Isoforms 		 
S70 NIMVVGQSGLGKSTL
S84 LVNTLFKSQVSRKAS
S87 TLFKSQVSRKASSWN
S91 SQVSRKASSWNREEk
S92 QVSRKASSWNREEkI
K98-u SSWNREEkIPkTVEI
K101-u NREEkIPkTVEIKAI
K118-u VIEEGGVkMKLTVID
K155-u EQYEKFLkEEVNIAR
K226 EFKQRVRKELEVNGI
K226-u EFKQRVRkELEVNGI
K268-u FAVVGSDkEYQVNGK
- gap
  SEPT3 iso3  
S57 NIMVVGQSGLGKSTL
S71 LVNTLFKSQVSRKAS
S74 TLFKSQVSRKASSWN
S78 SQVSRKASSWNREEK
S79 QVSRKASSWNREEKI
K85 SSWNREEKIPKTVEI
K88 NREEKIPKTVEIKAI
K105 VIEEGGVKMKLTVID
K142 EQYEKFLKEEVNIAR
- gap
- gap
K246 FAVVGSDKEYQVNGK
S455-p QNKKLCAsLKRSGEG
  rat

 
S70 NIMVVGQSGLGKSTL
S84 LVNTLFKSQVSRKAs
S87 TLFKSQVSRKAsSWN
S91-p SQVSRKAsSWNREEK
S92 QVSRKAsSWNREEKI
K98 sSWNREEKIPKTVEI
K101 NREEKIPKTVEIKAI
K118 VIEEGGVKMKLTVID
K155 EQYEKFLKEEVNIAR
K226 EFKQRVRKELEVNGI
K226 EFKQRVRKELEVNGI
K268 FAVVGSDKEYQVNGK
- gap
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