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Protein Page:
PPM1D (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PPM1D a magnesium-dependent Ser/Thr phosphatase. A p53-induced phosphatase that interacts with the nuclear isoform of uracil DNA glycosylase, UNG2, and suppresses base excision repair. Might contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Nuclear receptor co-regulator
Cellular Component: nucleus
Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity
Biological Process: negative regulation of cell proliferation; response to radiation; response to bacterium; G2/M transition of mitotic cell cycle; protein amino acid dephosphorylation
Reference #:  O15297 (UniProtKB)
Alt. Names/Synonyms: p53-induced protein phosphatase 1; PP2C-delta; PPM1D; Protein phosphatase 1D; protein phosphatase 1D magnesium-dependent, delta isoform; protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium-dependent 1 delta; protein phosphatase Wip1; protein phosphatase, Mg2+/Mn2+ dependent, 1D; wild-type p53-induced phosphatase 1; WIP1
Gene Symbols: PPM1D
Molecular weight: 66,675 Da
Basal Isoelectric point: 9.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PPM1D

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K19-u FSDQGGRkYMEDVTQ
0 3 S40-p PTAEEKPsPRRSLsQ
1 1 S46-p PsPRRSLsQPLPPRP
1 0 S54-p QPLPPRPsPAALPGG
1 1 S85-p PLPDAGAsPAPSRCC
0 2 K238-u LGGSVMNkSGVNRVV
0 2 Y308-p LDPQKHKyIILGSDG
1 0 T529-p KAQEIERtPPTNFKR
1 0 S543-p RTLEESNsGPLMKKH
  mouse

 
K19 FSDQGGRKYMEDVTQ
A40 PAAEDKPAPVPRRAL
A46 PAPVPRRALGLPATP
- under review  
S78 PAPDAAASLPAGRCC
K231 LGGSVMNKSGVNRVV
Y301 LDPRKHKYIILGSDG
T522 KAQEVERTPPANFKR
S536 RTLEESNSGPLMKKH
  rat

 
K19 FSDQGGRKYMEDVTQ
A40 PAAEDKPAPVPRRAL
A46 PAPVPRRALGLPATP
- under review  
S78 PAPDAAASLPAGRCC
K231 LGGSVMNKSGVNRVV
Y301 LDPQKHKYIILGSDG
T522 KAQEVERTPPANFKR
S536 RTLEESNSGPLMKKH
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