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Protein Page:
JAK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JAK3 a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family
Cellular Component: cytoskeleton; membrane; endomembrane system; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding
Biological Process: negative regulation of interleukin-12 production; peptidyl-tyrosine phosphorylation; negative regulation of T-helper 1 cell differentiation; negative regulation of interleukin-10 production; negative regulation of FasL biosynthetic process; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; negative regulation of dendritic cell cytokine production; tyrosine phosphorylation of STAT protein; B cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; T cell homeostasis; negative regulation of T cell activation; STAT protein nuclear translocation
Reference #:  P52333 (UniProtKB)
Alt. Names/Synonyms: JAK-3; JAK3; JAK3_HUMAN; JAKL; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); L-JAK; Leukocyte janus kinase; LJAK; Tyrosine-protein kinase JAK3
Gene Symbols: JAK3
Molecular weight: 125,099 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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JAK3

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
enzymatic activity, induced: Y904‑p, Y939‑p, Y980‑p
enzymatic activity, inhibited: Y981‑p
molecular association, regulation: Y785‑p, Y939‑p
phosphorylation: Y904‑p, Y939‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S5-p ___MAPPsEEtPLIP
0 2 T8-p MAPPsEEtPLIPQRs
0 1 S15-p tPLIPQRsCsLLSTE
0 2 S17-p LIPQRsCsLLSTEAG
0 1 L19 PQRsCsLLSTEAGAL
0 1 S20 QRsCsLLSTEAGALH
0 1 T21 RsCsLLSTEAGALHV
0 2 K122-ub CHRFGLRkDLASAIL
0 6 K157-ub LPVGLSLkEQGECLS
0 1 K361-ub DSQHFFCkEVAPPRL
0 1 T391-p FAINKLKtGGSRPGs
0 1 S398-p tGGSRPGsYVLRRSP
0 1 T472 DGVAVTLTSCCIPRP
0 1 S473 GVAVTLTSCCIPRPK
0 1 S498-p GHSPPTSsLVQPQSQ
0 1 Y506-p LVQPQSQyQLSQMTF
0 1 Y536-p HGSFTKIyRGCRHEV
0 1 S568-p KHKNCMEsFLEAASL
0 1 S663-p AREGADGsPPFIKLS
0 1 K734-ub SALDPAKkLQFYEDR
0 1 K748-ac RQQLPAPkWTELALL
0 2 S782-p RDLNSLIsSDyELLS
3 71 Y785-p NSLIsSDyELLSDPT
0 2 K823-ub IFEERHLkYISQLGK
1 0 Y904-p SLRLVMEyLPSGCLR
0 1 Y929-p DASRLLLySsQICKG
0 1 S931-p SRLLLySsQICKGME
1 0 Y939-p QICKGMEyLGSRRCV
0 1 K972-ub IADFGLAkLLPLDKD
4 6 Y980-p LLPLDKDyyVVREPG
3 5 Y981-p LPLDKDyyVVREPGQ
0 1 S1027 LFTYCDKSCSPSAEF
0 1 S1031 CDKSCSPSAEFLRMM
0 1 - gap
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
  mouse

► Hide Isoforms
 
S5 ___MAPPSEEtPLIP
T8-p MAPPSEEtPLIPQRS
S15 tPLIPQRSCsLsssE
S17-p LIPQRSCsLsssEAG
S19-p PQRSCsLsssEAGAL
S20-p QRSCsLsssEAGALH
S21-p RSCsLsssEAGALHV
K122 CHRFGLRKDLTSAIL
K157 LPVGLSMKEQGEFLS
K358 DSRHYFCKEVAPPRL
A388 FAIHKLKAAGSLPGT
T395 AAGSLPGTYILRRSP
T469-p DGAALNLtsCCAPRP
S470-p GAALNLtsCCAPRPK
P495 GCTPAPAPGCSPSCC
C502 PGCSPSCCALTQLSF
F532 HGSFTKIFRGRRREV
S564 RHRNCMESFLEAASL
N659 AREGGDGNPPFIKLS
K730 TSLEPAKKLKFYEDQ
K744 QGQLPALKWTELAGL
T778 RDLNGLITSDyELLS
Y781-p NGLITSDyELLSDPT
K819 IFEERHLKYISLLGK
Y900 SLRLVMEYLPSGCLR
F925 HTDRLLLFAWQICKG
W927 DRLLLFAWQICKGME
Y935 QICKGMEYLGARRCV
K968 IADFGLAKLLPLGKD
Y976-p LLPLGKDyyVVREPG
Y977-p LPLGKDyyVVREPGQ
S1023-p LFTYCDKsCSPsAEF
S1027-p CDKsCSPsAEFLRMM
- gap
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
  JAK3 iso2  
S5 ___MAPPSEETPLIP
T8 MAPPSEETPLIPQRS
S15 TPLIPQRSCsLsssE
S17-p LIPQRSCsLsssEAG
S19-p PQRSCsLsssEAGAL
S20-p QRSCsLsssEAGALH
S21-p RSCsLsssEAGALHV
K122 CHRFGLRKDLTSAIL
K157 LPVGLSMKEQGEFLS
K548 DSRHYFCKEVAPPRL
A607 FAIHKLKAAGSLPGT
T614 AAGSLPGTYILRRSP
T688-p DGAALNLtsCCAPRP
S689-p GAALNLtsCCAPRPK
P714 GCTPAPAPGCSPSCC
C721 PGCSPSCCALTQLSF
F751 HGSFTKIFRGRRREV
S783 RHRNCMESFLEAASL
N878 AREGGDGNPPFIKLS
K949 TSLEPAKKLKFYEDQ
K963 QGQLPALKWTELAGL
T997 RDLNGLITSDyELLS
Y1000-p NGLITSDyELLSDPT
K1038 IFEERHLKYISLLGK
Y1119 SLRLVMEYLPSGCLR
F1144 HTDRLLLFAWQICKG
W1146 DRLLLFAWQICKGME
Y1154 QICKGMEYLGARRCV
K1187 IADFGLAKLLPLGKD
Y1195 LLPLGKDYYVVREPG
Y1196 LPLGKDYYVVREPGQ
S1242 LFTYCDKSCSPSAEF
S1246 CDKSCSPSAEFLRMM
- gap
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
  JAK3 iso3  
S5 ___MAPPSEETPLIP
T8 MAPPSEETPLIPQRS
S15 TPLIPQRSCSLSSSE
S17 LIPQRSCSLSSSEAG
S19 PQRSCSLSSSEAGAL
S20 QRSCSLSSSEAGALH
S21 RSCSLSSSEAGALHV
K122 CHRFGLRKDLTSAIL
K157 LPVGLSMKEQGEFLS
K546 DSRHYFCKEVAAPRL
A605 FAIHKLKAAASLPGT
T612 AAASLPGTYILRRSP
T685 DGAALNLTSCCAPRP
S686 GAALNLTSCCAPRPK
P711 GCTPAPAPGCSPSCC
C718 PGCSPSCCALTQLSF
F747 HGSFTKIFRGRRREV
S779 RHRNCMESFLEAASL
N874 AREGGDGNPPFIKLS
K945 TSLEPAKKLKFYEDQ
K959 QGQLPALKWTELAGL
T993 RDLNGLITSDYELLQ
Y996 NGLITSDYELLQTPH
K1033 HIEERHLKYISLLGK
Y1113 SLRLVMEYLPSGCLR
F1138 HTDRLLLFAWQICKG
W1140 DRLLLFAWQICKGME
Y1148 QICKGMEYLGARRCV
K1181 IADFGLAKLLPLGKD
Y1189 LLPLGKDYYVVREPG
Y1190 LPLGKDYYVVREPGQ
S1236 LFTYCDKSCSPSAEF
S1240 CDKSCSPSAEFLRMM
T1292-p LCVAPSRtTGQPSAP
  rat

 
S5 ___MAPPSEETPLIS
T8 MAPPSEETPLISQRS
S15 TPLISQRSCSLSSSE
S17 LISQRSCSLSSSEAG
S19 SQRSCSLSSSEAGAL
S20 QRSCSLSSSEAGALH
S21 RSCSLSSSEAGALHV
K122 CHRFGLHKDLTSAIL
K157 LPVGLSLKDQGEFLS
K358 DSRHFFCKEVAPPRL
A388 FAIHKLKAAGSLPGS
S395 AAGSLPGSYILRRSP
T469 DGTALNLTSCCVPRP
S470 GTALNLTSCCVPRPK
P495 GRNPTPAPGHSPSCC
C502 PGHSPSCCALTKLSF
F532 HGSFTKIFHGHRREV
S564 RHQNCMESFLEAASL
N659 AREGVDGNPPFIKLS
K730 TSLEPAKKLKFYEDR
K744 RGQLPALKWTELEGL
T778 RDLNGLITSDyELLS
Y781-p NGLITSDyELLSDPT
K819 IFEERHLKYISLLGK
Y900 ELRLVMEYLPSGCLR
F925 HNDRLLLFAWQICKG
W927 DRLLLFAWQICKGME
Y935 QICKGMEYLGARRCV
K968 IADFGLAKLLPLGKD
Y976 LLPLGKDYYVVRVPG
Y977 LPLGKDYYVVRVPGQ
S1023 LFTYSDKSCSPSTEF
S1027 SDKSCSPSTEFLRMI
- gap
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