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Protein Page:
JAK3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
JAK3 a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; Protein kinase, TK; TK group; JakA family
Cellular Component: cytoskeleton; membrane; endomembrane system; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding
Biological Process: positive regulation of immune response; negative regulation of interleukin-12 production; peptidyl-tyrosine phosphorylation; negative regulation of T-helper 1 cell differentiation; negative regulation of interleukin-10 production; negative regulation of FasL biosynthetic process; protein amino acid autophosphorylation; protein kinase cascade; positive regulation of activated T cell proliferation; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; tyrosine phosphorylation of Stat5 protein; regulation of apoptosis; tyrosine phosphorylation of STAT protein; negative regulation of dendritic cell cytokine production; elevation of cytosolic calcium ion concentration; B cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; T cell homeostasis; positive regulation of calcium ion transport; negative regulation of T cell activation; negative regulation of apoptosis; STAT protein nuclear translocation
Reference #:  P52333 (UniProtKB)
Alt. Names/Synonyms: JAK-3; JAK3; JAK3_HUMAN; JAKL; Janus kinase 3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); L-JAK; Leukocyte janus kinase; LJAK; Tyrosine-protein kinase JAK3
Gene Symbols: JAK3
Molecular weight: 125,099 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Jak/Stat/IL-6 Signaling  |  Tyrosine Kinases
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

JAK3
Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y904‑p, Y939‑p, Y980‑p
enzymatic activity, inhibited: Y981‑p
molecular association, regulation: Y785‑p, Y939‑p
phosphorylation: Y904‑p, Y939‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S5-p ___MAPPsEETPLIP
0 1 T8 MAPPsEETPLIPQRs
0 1 S15-p TPLIPQRsCsLLSTE
0 2 S17-p LIPQRsCsLLSTEAG
0 1 L19 PQRsCsLLSTEAGAL
0 1 S20 QRsCsLLSTEAGALH
0 1 T21 RsCsLLSTEAGALHV
0 2 K122-u CHRFGLRkDLASAIL
0 6 K157-u LPVGLSLkEQGECLS
0 1 K361-u DSQHFFCkEVAPPRL
0 1 T391-p FAINKLKtGGSRPGs
0 1 S398-p tGGSRPGsYVLRRSP
0 1 T472 DGVAVTLTSCCIPRP
0 1 S473 GVAVTLTSCCIPRPK
0 1 S498-p GHSPPTSsLVQPQSQ
0 2 Y506-p LVQPQSQyQLSQMTF
0 1 S568-p KHKNCMEsFLEAASL
0 1 K734-u SALDPAKkLQFYEDR
0 1 K748-a RQQLPAPkWTELALL
0 2 S782-p RDLNSLIsSDyELLS
4 72 Y785-p NSLIsSDyELLSDPT
0 2 K823-u IFEERHLkYISQLGK
1 0 Y904-p SLRLVMEyLPSGCLR
1 0 Y939-p QICKGMEyLGSRRCV
0 1 K972-u IADFGLAkLLPLDKD
2 6 Y980-p LLPLDKDyyVVREPG
2 3 Y981-p LPLDKDyyVVREPGQ
0 1 S1027 LFTYCDKSCSPSAEF
0 1 S1031 CDKSCSPSAEFLRMM
0 1 - gap
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
  mouse

► Hide Isoforms 		 
S5 ___MAPPSEEtPLIP
T8-p MAPPSEEtPLIPQRS
S15 tPLIPQRSCsLsssE
S17-p LIPQRSCsLsssEAG
S19-p PQRSCsLsssEAGAL
S20-p QRSCsLsssEAGALH
S21-p RSCsLsssEAGALHV
K122 CHRFGLRKDLTSAIL
K157 LPVGLSMKEQGEFLS
K358 DSRHYFCKEVAPPRL
A388 FAIHKLKAAGSLPGT
T395 AAGSLPGTYILRRSP
T469-p DGAALNLtsCCAPRP
S470-p GAALNLtsCCAPRPK
P495 GCTPAPAPGCSPSCC
C502 PGCSPSCCALTQLSF
S564 RHRNCMESFLEAASL
K730 TSLEPAKKLKFYEDQ
K744 QGQLPALKWTELAGL
T778 RDLNGLITSDyELLS
Y781-p NGLITSDyELLSDPT
K819 IFEERHLKYISLLGK
Y900 SLRLVMEYLPSGCLR
Y935 QICKGMEYLGARRCV
K968 IADFGLAKLLPLGKD
Y976-p LLPLGKDyyVVREPG
Y977-p LPLGKDyyVVREPGQ
S1023-p LFTYCDKsCSPsAEF
S1027-p CDKsCSPsAEFLRMM
- gap
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
  Jak3 iso2  
S5 ___MAPPSEETPLIP
T8 MAPPSEETPLIPQRS
S15 TPLIPQRSCsLsssE
S17-p LIPQRSCsLsssEAG
S19-p PQRSCsLsssEAGAL
S20-p QRSCsLsssEAGALH
S21-p RSCsLsssEAGALHV
K122 CHRFGLRKDLTSAIL
K157 LPVGLSMKEQGEFLS
K548 DSRHYFCKEVAPPRL
A607 FAIHKLKAAGSLPGT
T614 AAGSLPGTYILRRSP
T688-p DGAALNLtsCCAPRP
S689-p GAALNLtsCCAPRPK
P714 GCTPAPAPGCSPSCC
C721 PGCSPSCCALTQLSF
S783 RHRNCMESFLEAASL
K949 TSLEPAKKLKFYEDQ
K963 QGQLPALKWTELAGL
T997 RDLNGLITSDyELLS
Y1000-p NGLITSDyELLSDPT
K1038 IFEERHLKYISLLGK
Y1119 SLRLVMEYLPSGCLR
Y1154 QICKGMEYLGARRCV
K1187 IADFGLAKLLPLGKD
Y1195 LLPLGKDYYVVREPG
Y1196 LPLGKDYYVVREPGQ
S1242 LFTYCDKSCSPSAEF
S1246 CDKSCSPSAEFLRMM
- gap
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
5031 : Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb
  JAK3 iso3  
S5 ___MAPPSEETPLIP
T8 MAPPSEETPLIPQRS
S15 TPLIPQRSCSLSSSE
S17 LIPQRSCSLSSSEAG
S19 PQRSCSLSSSEAGAL
S20 QRSCSLSSSEAGALH
S21 RSCSLSSSEAGALHV
K122 CHRFGLRKDLTSAIL
K157 LPVGLSMKEQGEFLS
K546 DSRHYFCKEVAAPRL
A605 FAIHKLKAAASLPGT
T612 AAASLPGTYILRRSP
T685 DGAALNLTSCCAPRP
S686 GAALNLTSCCAPRPK
P711 GCTPAPAPGCSPSCC
C718 PGCSPSCCALTQLSF
S779 RHRNCMESFLEAASL
K945 TSLEPAKKLKFYEDQ
K959 QGQLPALKWTELAGL
T993 RDLNGLITSDYELLQ
Y996 NGLITSDYELLQTPH
K1033 HIEERHLKYISLLGK
Y1113 SLRLVMEYLPSGCLR
Y1148 QICKGMEYLGARRCV
K1181 IADFGLAKLLPLGKD
Y1189 LLPLGKDYYVVREPG
Y1190 LPLGKDYYVVREPGQ
S1236 LFTYCDKSCSPSAEF
S1240 CDKSCSPSAEFLRMM
T1292-p LCVAPSRtTGQPSAP
  rat

 
S5 ___MAPPSEETPLIS
T8 MAPPSEETPLISQRS
S15 TPLISQRSCSLSSSE
S17 LISQRSCSLSSSEAG
S19 SQRSCSLSSSEAGAL
S20 QRSCSLSSSEAGALH
S21 RSCSLSSSEAGALHV
K122 CHRFGLHKDLTSAIL
K157 LPVGLSLKDQGEFLS
K358 DSRHFFCKEVAPPRL
A388 FAIHKLKAAGSLPGS
S395 AAGSLPGSYILRRSP
T469 DGTALNLTSCCVPRP
S470 GTALNLTSCCVPRPK
P495 GRNPTPAPGHSPSCC
C502 PGHSPSCCALTKLSF
S564 RHQNCMESFLEAASL
K730 TSLEPAKKLKFYEDR
K744 RGQLPALKWTELEGL
T778 RDLNGLITSDyELLS
Y781-p NGLITSDyELLSDPT
K819 IFEERHLKYISLLGK
Y900 ELRLVMEYLPSGCLR
Y935 QICKGMEYLGARRCV
K968 IADFGLAKLLPLGKD
Y976 LLPLGKDYYVVRVPG
Y977 LPLGKDYYVVRVPGQ
S1023 LFTYSDKSCSPSTEF
S1027 SDKSCSPSTEFLRMI
- gap
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