Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
FANCG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FANCG DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Defects in FANCG are a cause of Fanconi anemia complementation group G (FANCG). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleolus; plasma membrane
Molecular Function: protein binding; damaged DNA binding
Biological Process: mitochondrion organization and biogenesis; response to radiation; ovarian follicle development; DNA repair; cell cycle checkpoint; spermatid development
Reference #:  O15287 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC9; FAG; FANCG; Fanconi anemia group G protein; Fanconi anemia, complementation group G; Protein FACG; X-ray repair complementing defective repair in Chinese hamster cells 9; X-ray repair, complementing defective, in Chinese hamster, 9; XRCC9
Gene Symbols: FANCG
Molecular weight: 68,554 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below

FANCG

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
activity, induced: S383‑p, S387‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 1 S7-p _MSRQTTsVGSSCLD
0 1 A30 LVRQAKVAQNSGLTL
0 1 T36 VAQNSGLTLRRQQLA
2 0 S383-p DSSEPRFsPPPsPPG
2 0 S387-p PRFsPPPsPPGPCMP
0 1 T557-p TYFHLLQtLkRLDRR
0 2 K559-ub FHLLQtLkRLDRRDE
  mouse

 
P7 _MSSQVIPALPKTFS
T35-p VRQAKQLtRDSRPsL
S41-p LtRDSRPsLRRQQSA
S388 GGSETRFSPPTSSLG
S392 TRFSPPTSSLGPCIP
T560 GSFYLLQTLKRLDRK
K562 FYLLQTLKRLDRKNE
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.