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Protein Page:
FANCG (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
FANCG DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Defects in FANCG are a cause of Fanconi anemia complementation group G (FANCG). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Cellular Component: nucleoplasm; mitochondrion
Molecular Function: protein binding; damaged DNA binding
Biological Process: mitochondrion organization and biogenesis; response to radiation; ovarian follicle development; DNA repair; cell cycle checkpoint; spermatid development
Reference #:  O15287 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC9; FAG; FANCG; Fanconi anemia group G protein; Fanconi anemia, complementation group G; Protein FACG; X-ray repair complementing defective repair in Chinese hamster cells 9; X-ray repair, complementing defective, in Chinese hamster, 9; XRCC9
Gene Symbols: FANCG
Molecular weight: 68,554 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Select Structure to View Below

FANCG

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S383‑p, S387‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 1 S7-p _MSRQTTsVGSSCLD
2 0 S383-p DSSEPRFsPPPsPPG
2 0 S387-p PRFsPPPsPPGPCMP
0 2 K559-u FHLLQTLkRLDRRDE
  mouse

 
P7 _MSSQVIPALPKTFS
S388 GGSETRFSPPTSSLG
S392 TRFSPPTSSLGPCIP
K562 FYLLQTLKRLDRKNE
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